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Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/0005-2760(92)90287-6openalex-snapshot
The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages
inferredcites →https://doi.org/10.1016/0092-8674(81)90340-8openalex-snapshot
Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
inferredcites →https://doi.org/10.1016/j.bbalip.2016.10.009openalex-snapshot
Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages
inferredcites →https://doi.org/10.1016/j.cell.2011.04.005openalex-snapshot
Macrophages in the Pathogenesis of Atherosclerosis
inferredcites →https://doi.org/10.1016/j.cell.2015.01.036openalex-snapshot
A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
inferredcites →https://doi.org/10.1016/j.celrep.2016.10.062openalex-snapshot
BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks
inferredcites →https://doi.org/10.1016/j.coph.2016.02.006openalex-snapshot
Atherosclerosis — do we know enough already to prevent it?
inferredcites →https://doi.org/10.1016/j.devcel.2011.07.016openalex-snapshot
Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
inferredcites →https://doi.org/10.1016/j.devcel.2011.10.007openalex-snapshot
Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1
inferredcites →https://doi.org/10.1016/j.devcel.2012.04.019openalex-snapshot
A Molecular Network for the Transport of the TI-VAMP/VAMP7 Vesicles from Cell Center to Periphery
inferredcites →https://doi.org/10.1016/j.devcel.2015.02.011openalex-snapshot
BORC, a Multisubunit Complex that Regulates Lysosome Positioning
inferredcites →https://doi.org/10.1016/j.ebiom.2021.103504openalex-snapshot
Shotgun mass spectrometry-based lipid profiling identifies and distinguishes between chronic inflammatory diseases
inferredcites →https://doi.org/10.1016/j.tem.2016.11.002openalex-snapshot
Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation
inferredcites →https://doi.org/10.1016/s0021-9150(97)00094-4openalex-snapshot
The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage
inferredcites →https://doi.org/10.1016/s0021-9258(18)98717-xopenalex-snapshot
Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages
inferredcites →https://doi.org/10.1016/s0022-2275(20)31654-0openalex-snapshot
Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux
inferredcites →https://doi.org/10.1016/s0022-2275(20)32515-3openalex-snapshot
Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species
inferredcites →https://doi.org/10.1016/s0022-2275(20)39175-6openalex-snapshot
Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester.
inferredcites →https://doi.org/10.1016/s0891-5849(99)00220-8openalex-snapshot
Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products
inferredcites →https://doi.org/10.1016/s0960-9822(01)00531-0openalex-snapshot
The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors
inferredcites →https://doi.org/10.1017/s1431927608080069openalex-snapshot
Lysosomal Cholesterol Accumulation Inhibits Subsequent Hydrolysis of Lipoprotein Cholesteryl Ester
inferredcites →https://doi.org/10.1021/ja01339a054openalex-snapshot
Studies of Polymerization and Ring Formation. XIX.1 Many-Membered Cyclic Anhydrides
inferredcites →https://doi.org/10.1038/nature08938openalex-snapshot
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
inferredcites →https://doi.org/10.1038/ncb3324openalex-snapshot
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
inferredcites →https://doi.org/10.1038/ni.2639openalex-snapshot
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
inferredcites →https://doi.org/10.1038/s41586-018-0198-8openalex-snapshot
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice
inferredcites →https://doi.org/10.1073/pnas.84.7.1921openalex-snapshot
Tubular lysosome morphology and distribution within macrophages depend on the integrity of cytoplasmic microtubules.
inferredcites →https://doi.org/10.1080/15548627.2016.1179405openalex-snapshot
TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages
inferredcites →https://doi.org/10.1080/15548627.2018.1434373openalex-snapshot
TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis
inferredcites →https://doi.org/10.1080/15548627.2018.1535292openalex-snapshot
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration
inferredcites →https://doi.org/10.1080/21541248.2016.1235004openalex-snapshot
Rab3a and Rab10 are regulators of lysosome exocytosis and plasma membrane repair
inferredcites →https://doi.org/10.1083/jcb.113.1.123openalex-snapshot
Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.
inferredcites →https://doi.org/10.1083/jcb.130.4.821openalex-snapshot
Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.
inferredcites →https://doi.org/10.1083/jcb.137.1.93openalex-snapshot
Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells
inferredcites →https://doi.org/10.1083/jcb.149.4.889openalex-snapshot
Role of Tetanus Neurotoxin Insensitive Vesicle-Associated Membrane Protein (Ti-Vamp) in Vesicular Transport Mediating Neurite Outgrowth
inferredcites →https://doi.org/10.1083/jcb.200208154openalex-snapshot
Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells
inferredcites →https://doi.org/10.1083/jcb.200311054openalex-snapshot
Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis
inferredcites →https://doi.org/10.1083/jcb.200606077openalex-snapshot
Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150Glued, ORP1L, and the receptor βlll spectrin
inferredcites →https://doi.org/10.1083/jcb.200811005openalex-snapshot
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Glued and late endosome positioning
inferredcites →https://doi.org/10.1083/jcb.201003021openalex-snapshot
Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes
inferredcites →https://doi.org/10.1083/jcb.201208152openalex-snapshot
Lysosomal storage disorders: The cellular impact of lysosomal dysfunction
inferredcites →https://doi.org/10.1083/jcb.201507112openalex-snapshot
The position of lysosomes within the cell determines their luminal pH
inferredcites →https://doi.org/10.1083/jcb.201511093openalex-snapshot
A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair
inferredcites →https://doi.org/10.1091/mbc.4.12.1251openalex-snapshot
Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif.
inferredcites →https://doi.org/10.1091/mbc.e15-05-0272openalex-snapshot
mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells
inferredcites →https://doi.org/10.1093/clinchem/20.4.482openalex-snapshot
Preparation and Evaluation of a Water-Soluble Cholesterol Standard
inferredcites →https://doi.org/10.1096/fj.06-7924comopenalex-snapshot
Cathepsin cysteine proteases in cardiovascular disease
inferredcites →https://doi.org/10.1097/00041433-199710000-00005openalex-snapshot
Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis
inferredcites →https://doi.org/10.1111/tra.12587openalex-snapshot
Mechanisms of lysosomal positioning and movement
inferredcites →https://doi.org/10.1126/science.1174447openalex-snapshot
A Gene Network Regulating Lysosomal Biogenesis and Function
inferredcites →https://doi.org/10.1126/science.1204592openalex-snapshot
TFEB Links Autophagy to Lysosomal Biogenesis
inferredcites →https://doi.org/10.1126/scisignal.2002790openalex-snapshot
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
inferredcites →https://doi.org/10.1126/scisignal.2004754openalex-snapshot
The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
inferredcites →https://doi.org/10.1146/annurev.bi.52.070183.001255openalex-snapshot
LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis
inferredcites →https://doi.org/10.1152/physrev.00047.2003openalex-snapshot
Role of Oxidative Modifications in Atherosclerosis
inferredcites →https://doi.org/10.1161/01.atv.18.2.177openalex-snapshot
Uptake of Oxidized LDL by Macrophages Results in Partial Lysosomal Enzyme Inactivation and Relocation
inferredcites →https://doi.org/10.1161/01.res.34.2.233openalex-snapshot
Modification of the Effects of Hypertension on Lysosomes and Connective Tissue in the Rat Aorta
inferredcites →https://doi.org/10.1161/01.res.46.4.520openalex-snapshot
Characterization of cell populations isolated from aortas of rhesus monkeys with experimental atherosclerosis.
inferredcites →https://doi.org/10.1161/atvbaha.108.179697openalex-snapshot
Oxidized Low-Density Lipoprotein and Atherosclerosis
inferredcites →https://doi.org/10.1161/atvbaha.114.303342openalex-snapshot
Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae
inferredcites →https://doi.org/10.1161/atvbaha.120.316063openalex-snapshot
Low LAL (Lysosomal Acid Lipase) Expression by Smooth Muscle Cells Relative to Macrophages as a Mechanism for Arterial Foam Cell Formation
inferredcites →https://doi.org/10.1161/circresaha.108.192880openalex-snapshot
Lipoprotein Accumulation in Macrophages via Toll-Like Receptor-4–Dependent Fluid Phase Uptake
inferredcites →https://doi.org/10.1161/circresaha.110.223875openalex-snapshot
Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity
inferredcites →https://doi.org/10.1172/jci117490openalex-snapshot
Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages.
inferredcites →https://doi.org/10.1194/jlr.m600390-jlr200openalex-snapshot
Effects of cellular cholesterol loading on macrophage foam cell lysosome acidification
inferredcites →https://doi.org/10.1194/jlr.r800087-jlr200openalex-snapshot
The LDL modification hypothesis of atherogenesis: an update
inferredcites →https://doi.org/10.1242/jcs.142604openalex-snapshot
The Rab-interacting lysosomal protein (RILP) regulates vacuolar ATPase acting on the V1G1 subunit
inferredcites →https://doi.org/10.1242/jcs.175323openalex-snapshot
RILP regulates vacuolar ATPase through interaction with the V1G1 subunit
inferredcites →https://doi.org/10.1242/jcs.254631openalex-snapshot
Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cell homeostasis
inferredcites →https://doi.org/10.1371/journal.pone.0034822openalex-snapshot
Molecular Etiology of Atherogenesis – In Vitro Induction of Lipidosis in Macrophages with a New LDL Model
inferredcites →https://doi.org/10.1523/jneurosci.4436-11.2012openalex-snapshot
Absence of TI-VAMP/Vamp7 Leads to Increased Anxiety in Mice
inferredcites →https://doi.org/10.3389/fcell.2021.658995openalex-snapshot
Lysosome (Dys)function in Atherosclerosis—A Big Weight on the Shoulders of a Small Organelle
inferredcites →https://doi.org/10.3389/fphys.2018.00654openalex-snapshot
Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis
inferredcites →https://doi.org/10.4049/jimmunol.178.11.7199openalex-snapshot
Tubulation of Class II MHC Compartments Is Microtubule Dependent and Involves Multiple Endolysosomal Membrane Proteins in Primary Dendritic Cells
inferredcites →https://doi.org/10.4161/auto.19653openalex-snapshot
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
inferredcites →https://doi.org/10.4161/cc.8.24.10263openalex-snapshot
Lysosomal enhancement: A CLEAR answer to cellular degradative needs
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4760648openalex-extracted
Cholesterol Metabolism-Mediated Immune Regulation and Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1007/s10571-025-01646-xopenalex-snapshot
Interaction Between Microglial Lipid Droplet Metabolism and Immune Polarisation After Stroke: Mechanisms and Therapeutic Prospects
inferred← citeshttps://doi.org/10.1016/j.jlr.2023.100419openalex-snapshot
Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation
inferred← citeshttps://doi.org/10.1016/j.jlr.2025.100825openalex-snapshot
Glucosylated cholesterol accumulates in atherosclerotic lesions and impacts macrophage immune response
inferred← citeshttps://doi.org/10.1016/j.tcb.2024.04.008openalex-snapshot
Role of lipids in interorganelle communication
inferred← citeshttps://doi.org/10.1038/s41467-026-69900-4openalex-snapshot
VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement
inferred← citeshttps://doi.org/10.1038/s44318-024-00177-3openalex-snapshot
Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling
inferred← citeshttps://doi.org/10.1038/s44319-025-00613-3openalex-snapshot
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling
inferred← citeshttps://doi.org/10.1080/10715762.2024.2403038openalex-snapshot
Low density lipoprotein oxidized under lysosomal conditions decreases arterial vasodilatation
inferred← citeshttps://doi.org/10.1111/tra.70026openalex-snapshot
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
inferred← citeshttps://doi.org/10.3390/cells12242826openalex-snapshot
Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts
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