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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.cell.2010.02.024openalex-snapshot
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
inferredcites →https://doi.org/10.1016/j.cub.2004.06.054openalex-snapshot
Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton
inferredcites →https://doi.org/10.1016/j.devcel.2011.07.016openalex-snapshot
Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
inferredcites →https://doi.org/10.1016/j.semcdb.2011.08.008openalex-snapshot
The 14-3-3 proteins in regulation of cellular metabolism
inferredcites →https://doi.org/10.1016/s0092-8674(02)00808-5openalex-snapshot
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
inferredcites →https://doi.org/10.1016/s0092-8674(02)00833-4openalex-snapshot
Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action
inferredcites →https://doi.org/10.1016/s0898-6568(00)00131-5openalex-snapshot
14-3-3 proteins: regulation of subcellular localization by molecular interference
inferredcites →https://doi.org/10.1038/emboj.2011.257openalex-snapshot
Regulation of TFEB and V‐ATPases by mTORC1
inferredcites →https://doi.org/10.1038/nature09076openalex-snapshot
Termination of autophagy and reformation of lysosomes regulated by mTOR
inferredcites →https://doi.org/10.1038/ncb0910-814openalex-snapshot
Eaten alive: a history of macroautophagy
inferredcites →https://doi.org/10.1038/nrm3025openalex-snapshot
mTOR: from growth signal integration to cancer, diabetes and ageing
inferredcites →https://doi.org/10.1073/pnas.0809136105openalex-snapshot
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
inferredcites →https://doi.org/10.1074/jbc.m107694200openalex-snapshot
Intracellular Sensing of Amino Acids in Xenopus laevis Oocytes Stimulates p70 S6 Kinase in a Target of Rapamycin-dependent Manner
inferredcites →https://doi.org/10.1091/mbc.e06-05-0470openalex-snapshot
Microphthalmia-associated Transcription Factor Interactions with 14-3-3 Modulate Differentiation of Committed Myeloid Precursors
inferredcites →https://doi.org/10.1091/mbc.e08-12-1248openalex-snapshot
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
inferredcites →https://doi.org/10.1091/mbc.e09-09-0756openalex-snapshot
The Late Endosome is Essential for mTORC1 Signaling
inferredcites →https://doi.org/10.1093/hmg/ddr306openalex-snapshot
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
inferredcites →https://doi.org/10.1093/nar/gkg584openalex-snapshot
Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs
inferredcites →https://doi.org/10.1111/j.1600-0854.2011.01249.xopenalex-snapshot
The New Faces of Endocytosis in Signaling
inferredcites →https://doi.org/10.1126/science.1157535openalex-snapshot
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
inferredcites →https://doi.org/10.1126/science.1174447openalex-snapshot
A Gene Network Regulating Lysosomal Biogenesis and Function
inferredcites →https://doi.org/10.1126/science.1204592openalex-snapshot
TFEB Links Autophagy to Lysosomal Biogenesis
inferredcites →https://doi.org/10.1126/stke.2422004re10openalex-snapshot
14-3-3 Proteins: A Number of Functions for a Numbered Protein
inferredcites →https://doi.org/10.1128/mcb.05430-11openalex-snapshot
Relieving Autophagy and 4EBP1 from Rapamycin Resistance
inferredcites →https://doi.org/10.1146/annurev-genet-102808-114910openalex-snapshot
Regulation Mechanisms and Signaling Pathways of Autophagy
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3222openalex-snapshot
CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells
inferredcites →https://doi.org/10.1172/jci34739openalex-snapshot
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
inferredcites →https://doi.org/10.1371/journal.pbio.1000038openalex-snapshot
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
inferredcites →https://doi.org/10.4161/auto.5.7.9296openalex-snapshot
Atg101, a novel mammalian autophagy protein interacting with Atg13
inferredcites →https://doi.org/10.4161/cc.8.24.10263openalex-snapshot
Lysosomal enhancement: A CLEAR answer to cellular degradative needs
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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The Novel Tfeb Agonist Desloratadine Promotes Lipid Clearance by Activating the Autophagy-Lysosome Pathway
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Transcription factor EB controls both motogenic and mitogenic cell activities
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Multifaceted activities of transcription factor EB in cancer onset and progression
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TFEB, Master Regulator of Cellular Clearance
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CO as a Protective Mediator of Liver Injury
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Gal3‐CaN‐Smurf1 Complex Sequestrates FLCN‐FNIPs to Facilitate TFEB Activation in Response to Endomembrane Damage
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ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function
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Myricetin Induces Protective Autophagy by Inhibiting the Phosphorylation of mTOR in HepG2 Cells
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TFEB attenuates hyperglycemia‐induced retinal capillary endothelial cells injury via autophagy regulation
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Emerging in Diabetic Cardiomyopathy: Molecular Pathways and Targets for Therapeutic Intervention
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Dynorphin B Promotes Autophagy and Cytotoxicity in Thyroid Cancer Cells via the mTORC1‐TFE3 Axis
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Curcumin‐induced autophagy and nucleophagy in Spodoptera frugiperda Sf9 insect cells occur via PI3K/AKT/TOR pathways
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Phosphorylated mTORC1 represses autophagic‐related mRNA translation in neurons exposed to ischemia‐reperfusion injury
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Exenatide improves random‐pattern skin flap survival via TFE3 mediated autophagy augment
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Lysosome signaling in cell survival and programmed cell death for cellular homeostasis
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Daytime‐Restricted Feeding Alleviates D ‐Galactose‐Induced Aging in Mice and Regulates the AMPK and mTORC1 Activities
inferred← citeshttps://doi.org/10.1002/jimd.12267openalex-snapshot
Emerging roles of autophagy in hepatic tumorigenesis and therapeutic strategies in glycogen storage disease type Ia: A review
inferred← citeshttps://doi.org/10.1002/mc.23105openalex-snapshot
YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma
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Farnesoid X Receptor (FXR) Regulates mTORC1 Signaling and Autophagy by Inhibiting SESN2 Expression
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Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB
inferred← citeshttps://doi.org/10.1002/path.5875openalex-snapshot
GPNMB expression identifies TSC1 /2/ mTOR ‐associated and MiT family translocation‐driven renal neoplasms
inferred← citeshttps://doi.org/10.1002/pmic.70058openalex-snapshot
Proteomics Insights Into Lysosome Biogenesis and Maturation
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Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review
inferred← citeshttps://doi.org/10.1002/sctm.20-0386openalex-snapshot
Elevated Glucosylsphingosine in Gaucher Disease induced Pluripotent Stem Cell Neurons Deregulates Lysosomal Compartment through Mammalian Target of Rapamycin Complex 1
inferred← citeshttps://doi.org/10.1002/smll.202507517openalex-snapshot
Nanoparticle‐Mediated Modulation of Bulk and Selective Autophagy: From Mechanistic Activation to Clinical Perspectives
inferred← citeshttps://doi.org/10.1002/stem.3359openalex-snapshot
Maintenance of Neural Stem-Progenitor Cells by the Lysosomal Biosynthesis Regulators TFEB and TFE3 in the Embryonic Mouse Telencephalon
inferred← citeshttps://doi.org/10.1007/978-1-4614-6561-4_12openalex-snapshot
Autophagy and Cancer Drug Discovery
inferred← citeshttps://doi.org/10.1007/978-3-319-28637-2_12openalex-snapshot
The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria
inferred← citeshttps://doi.org/10.1007/978-3-319-53774-0_9openalex-snapshot
Autophagy in Liver Homeostasis
inferred← citeshttps://doi.org/10.1007/978-981-15-0602-4_3openalex-snapshot
Regulation of Autophagy by mTOR Signaling Pathway
inferred← citeshttps://doi.org/10.1007/978-981-15-7586-0_5openalex-snapshot
Regulatory Roles of Autophagy in Cancer
inferred← citeshttps://doi.org/10.1007/978-981-16-4525-9_1openalex-snapshot
Molecular Processes and Regulation of Autophagy
inferred← citeshttps://doi.org/10.1007/978-981-16-7977-3_11openalex-snapshot
Autophagy in Aging and Longevity
inferred← citeshttps://doi.org/10.1007/978-981-97-4584-5_16openalex-snapshot
Mitophagy Responds to the Environmental Temperature and Regulates Mitochondrial Mass in Adipose Tissues
inferred← citeshttps://doi.org/10.1007/s00018-014-1565-8openalex-snapshot
Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis
inferred← citeshttps://doi.org/10.1007/s00018-021-03813-xopenalex-snapshot
A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis
inferred← citeshttps://doi.org/10.1007/s00018-023-04778-9openalex-snapshot
A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila
inferred← citeshttps://doi.org/10.1007/s00018-024-05337-6openalex-snapshot
Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation
inferred← citeshttps://doi.org/10.1007/s00018-024-05385-yopenalex-snapshot
Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia
inferred← citeshttps://doi.org/10.1007/s00109-020-01934-7openalex-snapshot
TCF21: a critical transcription factor in health and cancer
inferred← citeshttps://doi.org/10.1007/s00109-021-02117-8openalex-snapshot
Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1
inferred← citeshttps://doi.org/10.1007/s00109-022-02256-6openalex-snapshot
Transcription factor EB inhibits non-alcoholic fatty liver disease through fibroblast growth factor 21
inferred← citeshttps://doi.org/10.1007/s00109-023-02337-0openalex-snapshot
TFEB: a double-edged sword for tumor metastasis
inferred← citeshttps://doi.org/10.1007/s00109-023-02411-7openalex-snapshot
PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy
inferred← citeshttps://doi.org/10.1007/s00109-024-02512-xopenalex-snapshot
Deciphering metabolic shifts in Gaucher disease type 1: a multi-omics study
inferred← citeshttps://doi.org/10.1007/s00401-014-1361-4openalex-snapshot
Autophagy in neuronal cells: general principles and physiological and pathological functions
inferred← citeshttps://doi.org/10.1007/s00401-024-02707-zopenalex-snapshot
Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases
inferred← citeshttps://doi.org/10.1007/s00421-024-05503-5openalex-snapshot
The biphasic activity of autophagy and heat shock protein response in peripheral blood mononuclear cells following acute resistance exercise in resistance-trained males
inferred← citeshttps://doi.org/10.1007/s00726-014-1775-2openalex-snapshot
Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis
inferred← citeshttps://doi.org/10.1007/s00726-016-2171-xopenalex-snapshot
Rag GTPase in amino acid signaling
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Taurine is an amino acid with the ability to activate autophagy in adipocytes
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Transcription factor EB (TFEB) promotes autophagy in early brain injury after subarachnoid hemorrhage in rats
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Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma
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Research progress on programmed cell death of cardiomyocytes in pressure-overload hypertrophic cardiomyopathy
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The mammalian target of rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways
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By restoring autophagic flux and improving mitochondrial function, corosolic acid protects against Dox-induced cardiotoxicity
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Glycans in autophagy, endocytosis and lysosomal functions
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Protein degradation-associated mechanisms that are affected in Alzheimer´s disease
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The role of AMPK in metabolism and its influence on DNA damage repair
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Endosomes, lysosomes, and the role of endosomal and lysosomal biogenesis in cancer development
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The impact of DAPK1 and mTORC1 signaling association on autophagy in cancer
inferred← citeshttps://doi.org/10.1007/s11033-025-10986-2openalex-snapshot
Exploring the effects of ROS on PI3K/AKT/mTOR signalling in pediatric low-grade glioma and therapeutic strategies
inferred← citeshttps://doi.org/10.1007/s11033-026-12177-zopenalex-snapshot
Regulatory mechanisms of post-translational modifications on autophagic flux in neurons following ischemic stroke
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ERK inhibition in glioblastoma is associated with autophagy activation and tumorigenesis suppression
inferred← citeshttps://doi.org/10.1007/s11357-025-01851-yopenalex-snapshot
Failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging
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Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages
inferred← citeshttps://doi.org/10.1007/s11481-021-09990-7openalex-snapshot
Lysosomal Stress Response (LSR): Physiological Importance and Pathological Relevance
inferred← citeshttps://doi.org/10.1007/s12013-022-01097-xopenalex-snapshot
The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex
inferred← citeshttps://doi.org/10.1007/s12026-014-8535-yopenalex-snapshot
Chronic infection by Leishmania amazonensis mediated through MAPK ERK mechanisms
inferred← citeshttps://doi.org/10.1007/s12035-024-04182-9openalex-snapshot
Rottlerin Enhances the Autophagic Degradation of Phosphorylated Tau in Neuronal Cells
inferred← citeshttps://doi.org/10.1007/s12035-025-04901-wopenalex-snapshot
Upregulating mTOR/S6 K Pathway by CASTOR1 Promotes Astrocyte Proliferation and Myelination in Gpam−/−-induced mouse model of cerebral palsy
inferred← citeshttps://doi.org/10.1007/s12094-022-02804-zopenalex-snapshot
Autophagy in acute myeloid leukemia: a paradoxical role in chemoresistance
inferred← citeshttps://doi.org/10.1007/s12272-023-01460-3openalex-snapshot
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1007/s12640-019-00027-9openalex-snapshot
Dynasore Suppresses mTORC1 Activity and Induces Autophagy to Regulate the Clearance of Protein Aggregates in Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.1007/s13105-020-00746-0openalex-snapshot
A current view of molecular dissection in autophagy machinery
inferred← citeshttps://doi.org/10.1007/s13238-017-0409-3openalex-snapshot
mTORC1 signaling in hepatic lipid metabolism
inferred← citeshttps://doi.org/10.1007/s13277-016-5073-3openalex-snapshot
MiR-21 modulates radiosensitivity of cervical cancer through inhibiting autophagy via the PTEN/Akt/HIF-1α feedback loop and the Akt-mTOR signaling pathway
inferred← citeshttps://doi.org/10.1007/s13402-020-00550-4openalex-snapshot
Activation of dopamine receptor D1 inhibits glioblastoma tumorigenicity by regulating autophagic activity
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Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?
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The Importance of Autophagy in Cardioprotection
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SnRK1 and TOR: central regulators of autophagy in plant energy stress responses
inferred← citeshttps://doi.org/10.1016/b978-0-12-394447-4.30035-9openalex-snapshot
mTORC1: Upstream and Downstream
inferred← citeshttps://doi.org/10.1016/b978-0-12-420024-1.00025-4openalex-snapshot
TRPML1-Dependent Processes as Therapeutic Targets
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11410-2openalex-snapshot
Aging in Drosophila melanogaster
inferred← citeshttps://doi.org/10.1016/b978-0-12-802167-5.00014-1openalex-snapshot
Regulation of Macroautophagy by Nutrients and Metabolites
inferred← citeshttps://doi.org/10.1016/b978-0-12-802167-5.00021-9openalex-snapshot
Adaptation to Amino Acid Availability
inferred← citeshttps://doi.org/10.1016/b978-0-12-810422-4.00003-8openalex-snapshot
Molecular Mechanisms of Postmeal Regulation of Muscle Anabolism
inferred← citeshttps://doi.org/10.1016/b978-0-12-812146-7.00009-3openalex-snapshot
Mechanistic Target of Rapamycin
inferred← citeshttps://doi.org/10.1016/b978-0-12-815889-0.00017-9openalex-snapshot
Graphene-Triggered Autophagy: The Savior or Slayer
inferred← citeshttps://doi.org/10.1016/b978-0-12-817990-1.00050-0openalex-snapshot
Autophagy and aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-820538-9.00002-8openalex-snapshot
Autophagy-dependent cell death; therapeutic target or chance encounter? Recent insights into the mechanisms of death by self-consumption
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00182-6openalex-snapshot
mTORC1: Upstream and Downstream
inferred← citeshttps://doi.org/10.1016/b978-0-12-822003-0.00007-3openalex-snapshot
The role of lysosomes in autophagy
inferred← citeshttps://doi.org/10.1016/b978-0-323-90142-0.00001-3openalex-snapshot
mTOR signaling and autophagy regulation
inferred← citeshttps://doi.org/10.1016/b978-0-323-90142-0.00002-5openalex-snapshot
AMPK signaling in autophagy induction
inferred← citeshttps://doi.org/10.1016/b978-0-323-90142-0.00008-6openalex-snapshot
Lysosomes in autophagy induction and cellular homeostasis
inferred← citeshttps://doi.org/10.1016/b978-0-323-99879-6.00006-7openalex-snapshot
Autophagy and metabolic regulation in cancer and its application in drug discovery
inferred← citeshttps://doi.org/10.1016/b978-0-443-13820-1.00030-xopenalex-snapshot
Pathobiology of Non-neovascular Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1016/b978-0-443-15260-3.00003-xopenalex-snapshot
Mitochondrial quality control and the microphthalmia/transcription factor E (MiTF/TFE) family
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2023.09.004openalex-snapshot
Crosstalk between the mTOR pathway and primary cilia in human diseases
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2018.06.001openalex-snapshot
Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2025.10.008openalex-snapshot
Eat, Heal, Repeat: How zebrafish master regeneration
inferred← citeshttps://doi.org/10.1016/bs.mcb.2014.11.011openalex-snapshot
TFEB and the CLEAR network
inferred← citeshttps://doi.org/10.1016/bs.mcb.2020.10.017openalex-snapshot
Monitoring TFEB translocation
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Methods to Monitor and Manipulate TFEB Activity During Autophagy
inferred← citeshttps://doi.org/10.1016/bs.pbr.2020.07.005openalex-snapshot
Effects of caloric restriction on retinal aging and neurodegeneration
inferred← citeshttps://doi.org/10.1016/j.abb.2018.11.004openalex-snapshot
Mitochondrial breakdown in skeletal muscle and the emerging role of the lysosomes
inferred← citeshttps://doi.org/10.1016/j.acthis.2021.151841openalex-snapshot
A new insight into cell biological and biochemical changes through aging
inferred← citeshttps://doi.org/10.1016/j.aehs.2025.08.005openalex-snapshot
Resistance training as a modulator of autophagy in skeletal muscle: A systematic review of molecular mechanisms and adaptive responses
inferred← citeshttps://doi.org/10.1016/j.ajhg.2025.08.004openalex-snapshot
Pathogenic variants in TMEM184B cause a neurodevelopmental syndrome associated with alteration of metabolic signaling
inferred← citeshttps://doi.org/10.1016/j.ajpath.2018.03.006openalex-snapshot
Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose
inferred← citeshttps://doi.org/10.1016/j.ajpath.2025.05.010openalex-snapshot
Folliculin Deletion in the Mouse Kidney Results in Cystogenesis of the Loops of Henle via Aberrant TFEB Activation
inferred← citeshttps://doi.org/10.1016/j.apsb.2021.03.039openalex-snapshot
Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR
inferred← citeshttps://doi.org/10.1016/j.apsb.2021.07.021openalex-snapshot
Therapeutic regulation of autophagy in hepatic metabolism
inferred← citeshttps://doi.org/10.1016/j.apsb.2021.12.012openalex-snapshot
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway
inferred← citeshttps://doi.org/10.1016/j.apsb.2022.01.017openalex-snapshot
Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy
inferred← citeshttps://doi.org/10.1016/j.apsb.2024.06.022openalex-snapshot
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.743118openalex-snapshot
Histidine deficiency-induced hepatic steatosis in teleost fish probably linked to the formimidoyltransferase cyclodeaminase
inferred← citeshttps://doi.org/10.1016/j.aquatox.2021.105859openalex-snapshot
Real-time in vitro monitoring of the subcellular toxicity of inorganic Hg and methylmercury in zebrafish cells
inferred← citeshttps://doi.org/10.1016/j.arr.2016.04.009openalex-snapshot
The crucial impact of lysosomes in aging and longevity
inferred← citeshttps://doi.org/10.1016/j.arr.2016.07.002openalex-snapshot
The endocytic pathway in microglia during health, aging and Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.arr.2019.100940openalex-snapshot
Mitochondria in the signaling pathways that control longevity and health span
inferred← citeshttps://doi.org/10.1016/j.arr.2021.101464openalex-snapshot
Autophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives
inferred← citeshttps://doi.org/10.1016/j.arr.2023.101985openalex-snapshot
TFEB is a central regulator of the aging process and age-related diseases
inferred← citeshttps://doi.org/10.1016/j.arr.2024.102428openalex-snapshot
Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.arr.2024.102572openalex-snapshot
14–3-3 protein and its isoforms: A common diagnostic marker for Alzheimer’s disease, Parkinson’s disease and glaucomatous neurodegeneration
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103033openalex-snapshot
Role of lysosomal morphology in aging and age-related diseases
inferred← citeshttps://doi.org/10.1016/j.bbadis.2015.08.005openalex-snapshot
Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.165970openalex-snapshot
The anti-tumor agent, Dp44mT, promotes nuclear translocation of TFEB via inhibition of the AMPK-mTORC1 axis
inferred← citeshttps://doi.org/10.1016/j.bbadis.2022.166455openalex-snapshot
Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
inferred← citeshttps://doi.org/10.1016/j.bbadis.2023.166915openalex-snapshot
Deciphering disease signatures and molecular targets in vascular Ehlers-Danlos syndrome through transcriptome and miRNome sequencing of dermal fibroblasts
inferred← citeshttps://doi.org/10.1016/j.bbadis.2024.167287openalex-snapshot
Rapamycin promotes the intestinal barrier repair in ulcerative colitis via the mTOR/PBLD/AMOT signaling pathway
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2024.195005openalex-snapshot
Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression
inferred← citeshttps://doi.org/10.1016/j.bbalip.2016.01.006openalex-snapshot
Autophagy, lipophagy and lysosomal lipid storage disorders
inferred← citeshttps://doi.org/10.1016/j.bbalip.2016.09.004openalex-snapshot
Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes
inferred← citeshttps://doi.org/10.1016/j.bbalip.2023.159364openalex-snapshot
Acteoside improves adipocyte browning by CDK6-mediated mTORC1-TFEB pathway
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2014.02.010openalex-snapshot
MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2018.06.011openalex-snapshot
mTORC1 pathway in DNA damage response
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2018.06.014openalex-snapshot
Glutamine-dependent lysosome homeostatic changes induced by starvation and lysosome inhibition
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2018.11.001openalex-snapshot
STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2019.01.013openalex-snapshot
Autophagy in cardiomyopathies
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2020.118889openalex-snapshot
Aminoacyl-tRNA synthetases and amino acid signaling
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2021.119059openalex-snapshot
The role of GSK3 in metabolic pathway perturbations in cancer
inferred← citeshttps://doi.org/10.1016/j.bbapap.2012.12.010openalex-snapshot
Beyond control of protein translation: What we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR)
inferred← citeshttps://doi.org/10.1016/j.bbcan.2014.10.007openalex-snapshot
mTOR signaling in tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189342openalex-snapshot
mTOR inhibitors in targeting autophagy and autophagy-associated signaling for cancer cell death and therapy
inferred← citeshttps://doi.org/10.1016/j.bbi.2026.106914openalex-snapshot
Peripheral nerve injury-induced upregulation of acyl-CoA synthetase 2 contributes to neuropathic pain via mediating microglial autophagy disruption in the spinal dorsal horn
inferred← citeshttps://doi.org/10.1016/j.bbih.2022.100510openalex-snapshot
Transcriptomic changes in autophagy-related genes are inversely correlated with inflammation and are associated with multiple sclerosis lesion pathology
inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.02.026openalex-snapshot
WITHDRAWN: Clearance of lysosomal glycogen accumulation by transcription factor EB (TFEB) in muscle cells from lysosomal alpha-glucosidase deficient mice
inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.11.021openalex-snapshot
α-ketoglutarate suppresses immediate early gene expression in cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.12.038openalex-snapshot
The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.149472openalex-snapshot
Role of TFEB-autophagy lysosomal pathway in palmitic acid induced renal tubular epithelial cell injury
inferred← citeshttps://doi.org/10.1016/j.bcp.2017.12.018openalex-snapshot
Current mechanistic insights into the CCCP-induced cell survival response
inferred← citeshttps://doi.org/10.1016/j.bcp.2018.11.016openalex-snapshot
Clomiphene citrate induces nuclear translocation of the TFEB transcription factor and triggers apoptosis by enhancing lysosomal membrane permeabilization
inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114904openalex-snapshot
Trehalose protects against cisplatin-induced cochlear hair cell damage by activating TFEB-mediated autophagy
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116115openalex-snapshot
Potential role of modulating autophagy levels in sensorineural hearing loss
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117781openalex-snapshot
Cannabinoids and the autophagy-related signaling in brain tumors: from mechanistic insights to therapeutic frontiers in glioblastoma
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2021.09.017openalex-snapshot
Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.bioadv.2026.215205openalex-snapshot
Ursolic acid-loaded bioactive nanoagents alleviate DNCB-induced atopic dermatitis symptoms by facilitating autophagy and antioxidant defenses
inferred← citeshttps://doi.org/10.1016/j.biocel.2025.106865openalex-snapshot
Escin alleviates DNCB-induced atopic dermatitis-like symptoms by promoting autophagy activation and tight junction barrier restoration
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107466openalex-snapshot
Autophagy mediated targeting degradation, a promising strategy in drug development
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107764openalex-snapshot
Unlocking lysosomal acidity to activate membranolytic module for accurately cancer theranostics
inferred← citeshttps://doi.org/10.1016/j.biopha.2015.06.003openalex-snapshot
The update on transcriptional regulation of autophagy in normal and pathologic cells: A novel therapeutic target
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.02.103openalex-snapshot
The tumor suppressor p53 regulates autophagosomal and lysosomal biogenesis in lung cancer cells by targeting transcription factor EB
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110272openalex-snapshot
Emerging role of transcription factor EB in mitochondrial quality control
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110887openalex-snapshot
Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110965openalex-snapshot
Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116790openalex-snapshot
Targeting autophagy in diabetic cardiomyopathy: From molecular mechanisms to pharmacotherapy
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117297openalex-snapshot
Tetrahydrocurcumin ameliorates hepatic steatosis by restoring hepatocytes lipophagy through mTORC1-TFEB pathway in nonalcoholic steatohepatitis
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117313openalex-snapshot
The autophagy-targeting compound V46 enhances antimicrobial responses to Mycobacteroides abscessus by activating transcription factor EB
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118181openalex-snapshot
Notoginsenoside Ft1 induces lysosomal cell death and apoptosis by inhibiting the PI3K/AKT/mTOR pathway in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118237openalex-snapshot
The mTOR pathway in Gliomas: From molecular insights to targeted therapies
inferred← citeshttps://doi.org/10.1016/j.brainres.2021.147768openalex-snapshot
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.canlet.2019.12.005openalex-snapshot
The covalent CDK7 inhibitor THZ1 enhances temsirolimus-induced cytotoxicity via autophagy suppression in human renal cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216599openalex-snapshot
Emerging roles of lysosome homeostasis (repair, lysophagy and biogenesis) in cancer progression and therapy
inferred← citeshttps://doi.org/10.1016/j.canlet.2024.216728openalex-snapshot
Pharmacological approaches for targeting lysosomes to induce ferroptotic cell death in cancer
inferred← citeshttps://doi.org/10.1016/j.cbi.2024.110990openalex-snapshot
Autophagic-lysosomal damage induced by swainsonine is protected by trehalose through activation of TFEB-regulated pathway in renal tubular epithelial cells
inferred← citeshttps://doi.org/10.1016/j.cbi.2024.111132openalex-snapshot
Dehydroandrographolide ameliorates doxorubicin-mediated cardiotoxicity by regulating autophagy through the mTOR-TFEB pathway
inferred← citeshttps://doi.org/10.1016/j.ceb.2015.04.014openalex-snapshot
Beyond indigestion: emerging roles for lysosome-based signaling in human disease
inferred← citeshttps://doi.org/10.1016/j.ceb.2017.02.012openalex-snapshot
mTORC1 signaling and the metabolic control of cell growth
inferred← citeshttps://doi.org/10.1016/j.ceb.2026.102627openalex-snapshot
Neighbors who talk: Mitochondria-lysosome crosstalk in homeostasis
inferred← citeshttps://doi.org/10.1016/j.cell.2017.02.004openalex-snapshot
mTOR Signaling in Growth, Metabolism, and Disease
inferred← citeshttps://doi.org/10.1016/j.cell.2022.04.013openalex-snapshot
mTOR substrate phosphorylation in growth control
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.04.052openalex-snapshot
An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.04.063openalex-snapshot
Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.02.102openalex-snapshot
The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.02.058openalex-snapshot
The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108371openalex-snapshot
TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109000openalex-snapshot
Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal
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