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Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/path.5403openalex-snapshot
Biology and therapeutic targeting of tumour‐associated macrophages
inferredcites →https://doi.org/10.1006/meth.2001.1262openalex-snapshot
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
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Profiling Tumor Infiltrating Immune Cells with CIBERSORT
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Creation of PDX-Bearing Humanized Mice to Study Immuno-oncology
inferredcites →https://doi.org/10.1016/j.ccell.2017.03.006openalex-snapshot
Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression
inferredcites →https://doi.org/10.1016/j.ccr.2005.10.012openalex-snapshot
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
inferredcites →https://doi.org/10.1016/j.cell.2020.03.048openalex-snapshot
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer
inferredcites →https://doi.org/10.1016/j.immuni.2005.01.004openalex-snapshot
The Src Family Kinases Hck and Fgr Negatively Regulate Neutrophil and Dendritic Cell Chemokine Signaling via PIR-B
inferredcites →https://doi.org/10.1016/j.immuni.2018.09.024openalex-snapshot
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12
inferredcites →https://doi.org/10.1016/j.immuni.2019.04.010openalex-snapshot
Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy
inferredcites →https://doi.org/10.1016/j.jim.2019.04.007openalex-snapshot
An optimized protocol to determine the engulfment of cancer cells by phagocytes using flow cytometry and fluorescence microscopy
inferredcites →https://doi.org/10.1016/j.trecan.2018.09.001openalex-snapshot
The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
inferredcites →https://doi.org/10.1038/nature19834openalex-snapshot
PI3Kγ is a molecular switch that controls immune suppression
inferredcites →https://doi.org/10.1038/nature22396openalex-snapshot
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
inferredcites →https://doi.org/10.1038/nbt.4096openalex-snapshot
Integrating single-cell transcriptomic data across different conditions, technologies, and species
inferredcites →https://doi.org/10.1038/ncomms7139openalex-snapshot
Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition
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Stromal contribution to the colorectal cancer transcriptome
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Inflammation meets cancer, with NF-κB as the matchmaker
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CIS is a potent checkpoint in NK cell–mediated tumor immunity
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Robust enumeration of cell subsets from tissue expression profiles
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LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy
inferredcites →https://doi.org/10.1038/s41573-018-0007-yopenalex-snapshot
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
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Perivascular macrophages in health and disease
inferredcites →https://doi.org/10.1038/s41590-018-0276-yopenalex-snapshot
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
inferredcites →https://doi.org/10.1073/pnas.1720948115openalex-snapshot
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment
inferredcites →https://doi.org/10.1084/jem.190.3.355openalex-snapshot
Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation
inferredcites →https://doi.org/10.1084/jem.20020873openalex-snapshot
Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response
inferredcites →https://doi.org/10.1084/jem.20062648openalex-snapshot
Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen
inferredcites →https://doi.org/10.1084/jem.20130930openalex-snapshot
Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks
inferredcites →https://doi.org/10.1101/326470openalex-snapshot
The UCSC Xena platform for public and private cancer genomics data visualization and interpretation
inferredcites →https://doi.org/10.1101/cshperspect.a021857openalex-snapshot
CSF-1 Receptor Signaling in Myeloid Cells
inferredcites →https://doi.org/10.1101/gad.8.4.387openalex-snapshot
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.
inferredcites →https://doi.org/10.1126/scitranslmed.3004387openalex-snapshot
A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
inferredcites →https://doi.org/10.1126/scitranslmed.abd4550openalex-snapshot
Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan deposition
inferredcites →https://doi.org/10.1158/0008-5472.can-15-1122openalex-snapshot
STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-16-3261openalex-snapshot
First-in-Human Study of AMG 820, a Monoclonal Anti-Colony-Stimulating Factor 1 Receptor Antibody, in Patients with Advanced Solid Tumors
inferredcites →https://doi.org/10.1158/1078-0432.ccr-19-1868openalex-snapshot
Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade
inferredcites →https://doi.org/10.1158/2326-6066.cir-17-0150openalex-snapshot
Neoadjuvant Interferons: Critical for Effective PD-1–Based Immunotherapy in TNBC
inferredcites →https://doi.org/10.1158/2326-6066.cir-17-0258openalex-snapshot
Combination of CD40 Agonism and CSF-1R Blockade Reconditions Tumor-Associated Macrophages and Drives Potent Antitumor Immunity
inferredcites →https://doi.org/10.1158/2326-6066.cir-19-0623openalex-snapshot
Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice
inferredcites →https://doi.org/10.1161/atvbaha.116.307592openalex-snapshot
Perivascular Macrophages Limit Permeability
inferredcites →https://doi.org/10.1182/blood-2005-08-3300openalex-snapshot
Essential role of PI3Kδ and PI3Kγ in thymocyte survival
inferredcites →https://doi.org/10.1189/jlb.2a0815-344rropenalex-snapshot
Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration
inferredcites →https://doi.org/10.1242/dmm.017830openalex-snapshot
Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer
inferredcites →https://doi.org/10.1242/jcs.232405openalex-snapshot
Adhesion, motility and matrix-degrading gene expression changes in CSF-1-induced mouse macrophage differentiation
inferredcites →https://doi.org/10.1371/journal.ppat.1007866openalex-snapshot
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues
inferredcites →https://doi.org/10.18632/oncotarget.4199openalex-snapshot
Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells
inferredcites →https://doi.org/10.2196/27633openalex-snapshot
Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation
inferredcites →https://doi.org/10.3389/fonc.2018.00049openalex-snapshot
Targeting Macrophages in Cancer: From Bench to Bedside
inferredcites →https://doi.org/10.3389/fphar.2020.581011openalex-snapshot
Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo
inferredcites →https://doi.org/10.4049/jimmunol.1001950openalex-snapshot
IFN Regulatory Factor 8 Restricts the Size of the Marginal Zone and Follicular B Cell Pools
inferredcites →https://doi.org/10.4049/jimmunol.1100967openalex-snapshot
Hck Tyrosine Kinase Regulates TLR4-Induced TNF and IL-6 Production via AP-1
inferredcites →https://doi.org/10.4049/jimmunol.175.5.2880openalex-snapshot
The Lyn Tyrosine Kinase Differentially Regulates Dendritic Cell Generation and Maturation
inferredcites →https://doi.org/10.4049/jimmunol.177.1.604openalex-snapshot
The Src Family Kinases Hck and Fgr Are Dispensable for Inside-Out, Chemoattractant-Induced Signaling Regulating β2 Integrin Affinity and Valency in Neutrophils, but Are Required for β2 Integrin-Mediated Outside-In Signaling Involved in Sustained Adhesion
inferredcites →https://doi.org/10.4049/jimmunol.2000835openalex-snapshot
A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155497openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.prp.2023.154534openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41467-023-40086-3openalex-snapshot
HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy
inferred← citeshttps://doi.org/10.1038/s41467-023-42215-4openalex-snapshot
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Generation of novel lipid metabolism-based signatures to predict prognosis and immunotherapy response for colorectal adenocarcinoma
inferred← citeshttps://doi.org/10.1101/2022.10.07.511364openalex-snapshot
The proto-oncogene c-Src phosphorylates cGAS to reduce DNA binding and activation
inferred← citeshttps://doi.org/10.1126/scitranslmed.abq3558openalex-snapshot
Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy
inferred← citeshttps://doi.org/10.1172/jci.insight.167270openalex-snapshot
The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response
inferred← citeshttps://doi.org/10.1186/s12943-022-01656-zopenalex-snapshot
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inferred← citeshttps://doi.org/10.1186/s12964-026-02871-7openalex-snapshot
Hematopoietic cell kinase regulates microglial/macrophage activation to drive neuroinflammation after traumatic brain injury
inferred← citeshttps://doi.org/10.1186/s42358-024-00427-2openalex-snapshot
Hck promotes IL-1β-induced extracellular matrix degradation, inflammation, and apoptosis in osteoarthritis via activation of the JAK-STAT3 signaling pathway
inferred← citeshttps://doi.org/10.26508/lsa.202302411openalex-snapshot
Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1709102openalex-snapshot
The myeloid SRC family kinase HCK regulates breast cancer growth by activating tumor-associated macrophage-led invasion and inhibiting cytotoxic T cell activity
inferred← citeshttps://doi.org/10.3389/fonc.2022.984560openalex-snapshot
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Spatial-Niche Perspective on the Heterogeneity and Functional Reprogramming of Tumor-Associated Macrophages in Digestive System Tumors
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Research Into the Metastatic Mechanisms of Circulating Tumour Cells and The Application Value of Src/FN1 Pathway Inhibitors
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