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Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3

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1 of the 95 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1038/mp.2016.139 (notice 2020-08-11).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Critical Issues and Optimized Practices in Quantification of Protein Abundance Level to Determine Interindividual Variability in DMET Proteins by LC‐MS/MS Proteomics
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Proteomic approaches to evaluate protein s‐nitrosylation in disease
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Quality control in mass spectrometry‐based proteomics
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Causes of oxidative stress in Alzheimer disease
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inferredcites →https://doi.org/10.1016/b978-0-12-815868-5.00013-xopenalex-snapshot
Linkage of atypical protein kinase C to Alzheimer disease
inferredcites →https://doi.org/10.1016/bs.ampbs.2018.01.004openalex-snapshot
The Inflammasome: Regulation of Nitric Oxide and Antimicrobial Host Defence
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Absence of the Autophagy Adaptor SQSTM1/p62 Causes Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy
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Ascorbic acid reduction of microtubule protein disulfides and its relevance to protein S-nitrosylation assays
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Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling
inferredcites →https://doi.org/10.1016/j.cell.2007.10.036openalex-snapshot
The Classical Complement Cascade Mediates CNS Synapse Elimination
inferredcites →https://doi.org/10.1016/j.cell.2016.04.001openalex-snapshot
Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
inferredcites →https://doi.org/10.1016/j.cell.2020.01.027openalex-snapshot
Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains
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Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease
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The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.jalz.2018.04.008openalex-snapshot
Understanding the impact of sex and gender in Alzheimer's disease: A call to action
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Site specific identification of endogenous S-nitrosocysteine proteomes
inferredcites →https://doi.org/10.1016/j.molcel.2010.07.002openalex-snapshot
Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death
inferredcites →https://doi.org/10.1016/j.molcel.2018.05.024openalex-snapshot
S-Nitrosylation Targets GSNO Reductase for Selective Autophagy during Hypoxia Responses in Plants
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Role of complement in neurodegeneration and neuroinflammation
inferredcites →https://doi.org/10.1016/j.nbd.2003.10.010openalex-snapshot
Expression of nitric oxide system in clinically evaluated cases of Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.nbd.2009.05.015openalex-snapshot
Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease
inferredcites →https://doi.org/10.1016/j.neuron.2019.12.015openalex-snapshot
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression
inferredcites →https://doi.org/10.1016/j.pneurobio.2011.11.005openalex-snapshot
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.redox.2017.10.014openalex-snapshot
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.tcb.2017.01.001openalex-snapshot
Autophagy Receptors and Neurodegenerative Diseases
inferredcites →https://doi.org/10.1016/j.tibs.2019.08.002openalex-snapshot
Post-translational Modifications of Key Machinery in the Control of Mitophagy
inferredcites →https://doi.org/10.1016/j.tips.2015.10.002openalex-snapshot
Protein S -Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases
inferredcites →https://doi.org/10.1016/s1074-5521(96)90133-7openalex-snapshot
Generation of nitric oxide from S-nitrosothiols using protein-bound Cu2+ sources
inferredcites →https://doi.org/10.1016/s1474-4422(16)00067-3openalex-snapshot
Sex differences in Alzheimer's disease and other dementias
inferredcites →https://doi.org/10.1021/acschemneuro.8b00516openalex-snapshot
SQSTM1/p62: A Potential Target for Neurodegenerative Disease
inferredcites →https://doi.org/10.1021/ja401565wopenalex-snapshot
Mechanism-Based Triarylphosphine-Ester Probes for Capture of Endogenous RSNOs
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Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
inferredcites →https://doi.org/10.1038/469156aopenalex-snapshot
Bring on the biomarkers
inferredcites →https://doi.org/10.1038/mp.2016.139openalex-snapshot
RETRACTED ARTICLE: p62 improves AD-like pathology by increasing autophagy
inferredcites →https://doi.org/10.1038/mp.2016.220openalex-snapshot
Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors
inferredcites →https://doi.org/10.1038/mp.2017.151openalex-snapshot
The complement system: a gateway to gene–environment interactions in schizophrenia pathogenesis
inferredcites →https://doi.org/10.1038/nature12825openalex-snapshot
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
inferredcites →https://doi.org/10.1038/nature14036openalex-snapshot
PLD3 and sporadic Alzheimer's disease risk
inferredcites →https://doi.org/10.1038/nature21030openalex-snapshot
PLD3 gene and processing of APP
inferredcites →https://doi.org/10.1038/nbt.1545openalex-snapshot
Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture
inferredcites →https://doi.org/10.1038/nbt1235openalex-snapshot
Protein biomarker discovery and validation: the long and uncertain path to clinical utility
inferredcites →https://doi.org/10.1038/ncomms10242openalex-snapshot
Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
inferredcites →https://doi.org/10.1038/nn.4608openalex-snapshot
Necroptosis activation in Alzheimer's disease
inferredcites →https://doi.org/10.1038/nrm3143openalex-snapshot
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
inferredcites →https://doi.org/10.1038/nrneurol.2009.54openalex-snapshot
Brain-derived neurotrophic factor in neurodegenerative diseases
inferredcites →https://doi.org/10.1038/nrneurol.2016.68openalex-snapshot
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Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function
inferredcites →https://doi.org/10.1038/s41380-020-0776-7openalex-snapshot
NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models
inferredcites →https://doi.org/10.1038/s41398-019-0388-7openalex-snapshot
S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy
inferredcites →https://doi.org/10.1038/s41467-017-00085-7openalex-snapshot
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis
inferredcites →https://doi.org/10.1038/s41467-019-10182-4openalex-snapshot
Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique
inferredcites →https://doi.org/10.1038/s41586-019-1195-2openalex-snapshot
Single-cell transcriptomic analysis of Alzheimer’s disease
inferredcites →https://doi.org/10.1038/s41586-019-1769-zopenalex-snapshot
NLRP3 inflammasome activation drives tau pathology
inferredcites →https://doi.org/10.1038/s41586-019-1895-7openalex-snapshot
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease
inferredcites →https://doi.org/10.1038/s41590-018-0179-yopenalex-snapshot
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing
inferredcites →https://doi.org/10.1038/s41591-020-0815-6openalex-snapshot
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
inferredcites →https://doi.org/10.1038/s41593-020-0635-5openalex-snapshot
Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain
inferredcites →https://doi.org/10.1038/s41598-020-70383-6openalex-snapshot
Systems biology reveals reprogramming of the S-nitroso-proteome in the cortical and striatal regions of mice during aging process
inferredcites →https://doi.org/10.1073/pnas.1306832110openalex-snapshot
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
inferredcites →https://doi.org/10.1073/pnas.1521318113openalex-snapshot
S -nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration
inferredcites →https://doi.org/10.1073/pnas.2025847118openalex-snapshot
Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia
inferredcites →https://doi.org/10.1074/jbc.r110.101618openalex-snapshot
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
inferredcites →https://doi.org/10.1074/mcp.m111.009993openalex-snapshot
The Human Proteome Project: Current State and Future Direction
inferredcites →https://doi.org/10.1074/mcp.m113.036079openalex-snapshot
Global Analysis of S-nitrosylation Sites in the Wild Type (APP) Transgenic Mouse Brain-Clues for Synaptic Pathology
inferredcites →https://doi.org/10.1080/15548627.2017.1320467openalex-snapshot
Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia
inferredcites →https://doi.org/10.1089/ars.2017.7403openalex-snapshot
Protein S-Nitrosylation: Determinants of Specificity and Enzymatic Regulation of S-Nitrosothiol-Based Signaling
inferredcites →https://doi.org/10.1093/bib/bbx031openalex-snapshot
Identification of differentially expressed peptides in high-throughput proteomics data
inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a021883openalex-snapshot
Ascorbic Acid and Reducing Agents Regulate the Fates and Functions of S-Nitrosothiols
inferredcites →https://doi.org/10.1111/jnc.14635openalex-snapshot
Mass spectrometry: A platform for biomarker discovery and validation for Alzheimer's and Parkinson's diseases
inferredcites →https://doi.org/10.1111/jnc.14870openalex-snapshot
Quantitative proteomics of synaptosome S‐nitrosylation in Alzheimer’s disease
inferredcites →https://doi.org/10.1126/sciadv.aay8828openalex-snapshot
A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease
inferredcites →https://doi.org/10.1126/science.1256070openalex-snapshot
Intracellular sensing of complement C3 activates cell autonomous immunity
inferredcites →https://doi.org/10.1126/science.aad8373openalex-snapshot
Complement and microglia mediate early synapse loss in Alzheimer mouse models
inferredcites →https://doi.org/10.1126/scitranslmed.aaf6295openalex-snapshot
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
inferredcites →https://doi.org/10.1126/scitranslmed.aal2074openalex-snapshot
Neurodegeneration: From cellular concepts to clinical applications
inferredcites →https://doi.org/10.1186/1742-2094-9-220openalex-snapshot
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice
inferredcites →https://doi.org/10.1186/s13195-014-0070-5openalex-snapshot
PLD3 is accumulated on neuritic plaques in Alzheimer’s disease brains
inferredcites →https://doi.org/10.1212/wnl.44.6.1090openalex-snapshot
Electron transport chain defects in Alzheimer's disease brain
inferredcites →https://doi.org/10.1248/bpb.b16-00350openalex-snapshot
Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease
inferredcites →https://doi.org/10.1523/jneurosci.0829-08.2008openalex-snapshot
Complement C3 Deficiency Leads to Accelerated Amyloid Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice
inferredcites →https://doi.org/10.1523/jneurosci.1508-21.2022openalex-snapshot
S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia
inferredcites →https://doi.org/10.1523/jneurosci.1871-20.2020openalex-snapshot
α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss
inferredcites →https://doi.org/10.1523/jneurosci.21-06-01809.2001openalex-snapshot
Estrogen Prevents the Lipopolysaccharide-Induced Inflammatory Response in Microglia
inferredcites →https://doi.org/10.2174/1568026615666150114160543openalex-snapshot
Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection
inferredcites →https://doi.org/10.31887/dcns.2016.18.4/ceppersonopenalex-snapshot
Considering sex and gender in Alzheimer disease and other dementias
inferredcites →https://doi.org/10.3233/jad-161088openalex-snapshot
Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
inferredcites →https://doi.org/10.3233/jad-180205openalex-snapshot
Rare Variants in PLD3 Increase Risk for Alzheimer’s Disease in Han Chinese
inferredcites →https://doi.org/10.3389/fimmu.2017.01805openalex-snapshot
Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans
inferredcites →https://doi.org/10.3389/fimmu.2019.00362openalex-snapshot
Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System
inferredcites →https://doi.org/10.3389/fnagi.2019.00315openalex-snapshot
Sex and Gender Driven Modifiers of Alzheimer’s: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risks
inferredcites →https://doi.org/10.3389/fncel.2018.00215openalex-snapshot
Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10)
inferredcites →https://doi.org/10.3390/biomedicines8050124openalex-snapshot
Sex Differences in Biological Processes and Nitrergic Signaling in Mouse Brain

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/alz.13546openalex-snapshot
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Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1186/s13195-024-01492-xopenalex-snapshot
Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.1186/s40035-025-00514-4openalex-snapshot
SIK2-mediated phosphorylation of GABARAPL2 facilitates autophagosome–lysosome fusion and rescues neurodegeneration in an Alzheimer’s disease model
inferred← citeshttps://doi.org/10.1371/journal.pone.0331204openalex-snapshot
Global trends in Alzheimer’s disease and other dementias in adults aged 55 and above (1992–2021): An age-period-cohort analysis based on the GBD 2021
inferred← citeshttps://doi.org/10.14283/jpad.2024.21openalex-snapshot
Global Burden of Dementia Death from 1990 to 2019, with Projections to 2050: An Analysis of 2019 Global Burden of Disease Study
inferred← citeshttps://doi.org/10.17826/cumj.1311596openalex-snapshot
The level of dementia biomarkers in type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.3389/fendo.2023.1153719openalex-snapshot
Proteome profiling of endogenous and potential S-nitrosylation in colorectal cancer
inferred← citeshttps://doi.org/10.3389/fnagi.2024.1301854openalex-snapshot
Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities
inferred← citeshttps://doi.org/10.3389/fncir.2023.1099467openalex-snapshot
Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer’s disease: Mechanistic insights and potential therapies
inferred← citeshttps://doi.org/10.3389/fneur.2023.1119298openalex-snapshot
MCP-1 levels in astrocyte-derived exosomes are changed in preclinical stage of Alzheimer's disease
inferred← citeshttps://doi.org/10.3389/fnmol.2025.1665802openalex-snapshot
The transcriptional and cellular landscape of cognitive resilience to Alzheimer’s disease
inferred← citeshttps://doi.org/10.3390/jpm16050246openalex-snapshot
The Bright and Dark Sides of Nitric Oxide in Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.6000/1929-6029.2025.14.50openalex-snapshot
Determination of Alzheimer's Disease Stages by Artificial Learning Algorithms
inferred← citeshttps://doi.org/10.6084/m9.figshare.24630273openalex-snapshot
Additional file 1 of Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.6084/m9.figshare.26085125openalex-snapshot
Additional file 1 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26085212openalex-snapshot
Additional file 2 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737956openalex-snapshot
Additional file 3 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737959openalex-snapshot
Additional file 4 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737962openalex-snapshot
Additional file 5 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737965openalex-snapshot
Additional file 6 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737968openalex-snapshot
Additional file 7 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737971openalex-snapshot
Additional file 8 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737974openalex-snapshot
Additional file 9 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737977openalex-snapshot
Additional file 10 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737980openalex-snapshot
Additional file 11 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737983openalex-snapshot
Additional file 12 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.6084/m9.figshare.26737986openalex-snapshot
Additional file 13 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
inferred← citeshttps://doi.org/10.61373/bm025r.0050openalex-snapshot
Blocking nitric oxide production for glioblastoma: A targeted therapeutic approach
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