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Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/anie.200200534openalex-snapshot
Chemistry and Biology of Biosynthetic Diels–Alder Reactions
inferredcites →https://doi.org/10.1002/hlca.201500176openalex-snapshot
A Novel Alkaloid from Aspidosperma pyricollum (Apocynaceae) and Complete 1H and 13C Chemical Shift Assignments
inferredcites →https://doi.org/10.1002/mrc.1039openalex-snapshot
A new stereoisomer of stemmadenine alkaloid from Tabernaemontana heyneana
inferredcites →https://doi.org/10.1007/978-1-4684-0823-2_9openalex-snapshot
Laboratory Models for the Biogenesis of Indole Alkaloids
inferredcites →https://doi.org/10.1007/bf00269710openalex-snapshot
Indole alkaloid accumulation and tryptophan decarboxylase activity in Catharanthus roseus cells cultured in three different media
inferredcites →https://doi.org/10.1007/s00299-009-0722-2openalex-snapshot
Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylase
inferredcites →https://doi.org/10.1007/s00425-002-0867-5openalex-snapshot
Immunocytological localization of two enzymes involved in berberine biosynthesis
inferredcites →https://doi.org/10.1007/s00709-003-0003-9openalex-snapshot
Peroxidase from Catharanthus roseus (L.) G. Don and the biosynthesis of ?-3?,4?-anhydrovinblastine: a specific role for a multifunctional enzyme
inferredcites →https://doi.org/10.1016/0003-2697(84)90782-6openalex-snapshot
A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids
inferredcites →https://doi.org/10.1016/0031-9422(75)85372-6openalex-snapshot
Alcaloides du Cabucala torulosa
inferredcites →https://doi.org/10.1016/0031-9422(75)85373-8openalex-snapshot
Alcaloides des feuilles du Pandaca minutiflora
inferredcites →https://doi.org/10.1016/0031-9422(90)80208-xopenalex-snapshot
Alkaloids from leaves and bark ofAlstonia scholaris in the Philippines
inferredcites →https://doi.org/10.1016/b978-0-12-404634-4.00009-7openalex-snapshot
Using a Virus-Derived System to Manipulate Plant Natural Product Biosynthetic Pathways
inferredcites →https://doi.org/10.1016/b978-0-12-408061-4.00001-8openalex-snapshot
Towards Complete Elucidation of Monoterpene Indole Alkaloid Biosynthesis Pathway
inferredcites →https://doi.org/10.1016/bs.mie.2016.02.013openalex-snapshot
Prequels to Synthetic Biology
inferredcites →https://doi.org/10.1016/j.abb.2008.01.027openalex-snapshot
The growing VAO flavoprotein family
inferredcites →https://doi.org/10.1016/j.chembiol.2015.02.006openalex-snapshot
Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism
inferredcites →https://doi.org/10.1016/j.phytochem.2011.07.001openalex-snapshot
A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus
inferredcites →https://doi.org/10.1016/j.phytochem.2014.07.023openalex-snapshot
Phytochemical genomics of the Madagascar periwinkle: Unravelling the last twists of the alkaloid engine
inferredcites →https://doi.org/10.1016/j.plaphy.2014.07.004openalex-snapshot
Selection and validation of reference genes for transcript normalization in gene expression studies in Catharanthus roseus
inferredcites →https://doi.org/10.1016/s0040-4020(01)97545-3openalex-snapshot
Regio- and stereospecific models for the biosynthesis of the indole alkaloids—II
inferredcites →https://doi.org/10.1021/ar50029a002openalex-snapshot
Biosynthesis of the indole alkaloids
inferredcites →https://doi.org/10.1021/ja00778a074openalex-snapshot
Regio- and stereospecific models for the biosynthesis of the indole alkaloids. Corynanthe-Aspidosperma relation
inferredcites →https://doi.org/10.1021/ja00860a023openalex-snapshot
Biosynthesis of Indole Alkaloids. The Aspidosperma and Iboga Bases
inferredcites →https://doi.org/10.1021/ja809842bopenalex-snapshot
Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues
inferredcites →https://doi.org/10.1021/jacs.7b13292openalex-snapshot
A Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology
inferredcites →https://doi.org/10.1021/np900595vopenalex-snapshot
Melodinines A−G, Monoterpenoid Indole Alkaloids from Melodinus henryi
inferredcites →https://doi.org/10.1021/ol102709sopenalex-snapshot
Total Synthesis of (+)-Condylocarpine, (+)-Isocondylocarpine, and (+)-Tubotaiwine
inferredcites →https://doi.org/10.1023/b:bile.0000025879.53632.f2openalex-snapshot
Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine
inferredcites →https://doi.org/10.1038/nature11692openalex-snapshot
An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis
inferredcites →https://doi.org/10.1038/nchem.1798openalex-snapshot
Biogenetically inspired synthesis and skeletal diversification of indole alkaloids
inferredcites →https://doi.org/10.1038/nchembio.1717openalex-snapshot
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy
inferredcites →https://doi.org/10.1038/ncomms12116openalex-snapshot
Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
inferredcites →https://doi.org/10.1038/nmeth.4197openalex-snapshot
Salmon provides fast and bias-aware quantification of transcript expression
inferredcites →https://doi.org/10.1038/nplants.2016.208openalex-snapshot
An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole
inferredcites →https://doi.org/10.1038/nprot.2016.136openalex-snapshot
The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
inferredcites →https://doi.org/10.1038/s41467-017-00154-xopenalex-snapshot
A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
inferredcites →https://doi.org/10.1038/s41598-018-29077-3openalex-snapshot
Ranking genome-wide correlation measurements improves microarray and RNA-seq based global and targeted co-expression networks
inferredcites →https://doi.org/10.1038/srep40453openalex-snapshot
Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses
inferredcites →https://doi.org/10.1039/b512615kopenalex-snapshot
Chemistry and biology of monoterpene indole alkaloid biosynthesis
inferredcites →https://doi.org/10.1039/c2969000665bopenalex-snapshot
Total synthesis of (±)-tubotaiwine (dihydrocondylocarpine)
inferredcites →https://doi.org/10.1073/pnas.1501821112openalex-snapshot
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast
inferredcites →https://doi.org/10.1073/pnas.1719979115openalex-snapshot
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19 E -geissoschizine
inferredcites →https://doi.org/10.1080/00304948.2011.629563openalex-snapshot
Progress in the Synthesis of Iboga-alkaloids and their Congeners
inferredcites →https://doi.org/10.1093/nar/gkh340openalex-snapshot
MUSCLE: multiple sequence alignment with high accuracy and high throughput
inferredcites →https://doi.org/10.1093/nar/gkm047openalex-snapshot
A versatile ligation-independent cloning method suitable for high-throughput expression screening applications
inferredcites →https://doi.org/10.1093/nar/gks1154openalex-snapshot
ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions
inferredcites →https://doi.org/10.1103/physreve.70.066111openalex-snapshot
Finding community structure in very large networks
inferredcites →https://doi.org/10.1104/pp.107.106377openalex-snapshot
TRBO: A High-Efficiency Tobacco Mosaic Virus RNA-Based Overexpression Vector
inferredcites →https://doi.org/10.1111/j.1365-313x.2008.03612.xopenalex-snapshot
Multicolor bimolecular fluorescence complementation reveals simultaneous formation of alternative CBL/CIPK complexes in planta
inferredcites →https://doi.org/10.1111/j.1742-4658.2010.07994.xopenalex-snapshot
The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans‐tonoplast translocations of intermediate metabolites
inferredcites →https://doi.org/10.1111/tpj.12827openalex-snapshot
Genome‐guided investigation of plant natural product biosynthesis
inferredcites →https://doi.org/10.1111/tpj.13868openalex-snapshot
A BAHD acyltransferase catalyzing 19‐O‐acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids
inferredcites →https://doi.org/10.1139/v82-187openalex-snapshot
Dihydropyridines in synthesis and biosynthesis. IV. Dehydrosecodine, in vitro precursor of indole alkaloids
inferredcites →https://doi.org/10.1186/1471-2229-10-182openalex-snapshot
Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"?
inferredcites →https://doi.org/10.1186/s12864-015-1678-yopenalex-snapshot
Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome
inferredcites →https://doi.org/10.1371/journal.pone.0052506openalex-snapshot
Development of Transcriptomic Resources for Interrogating the Biosynthesis of Monoterpene Indole Alkaloids in Medicinal Plant Species
inferredcites →https://doi.org/10.3987/rev-11-sr(p)4openalex-snapshot
Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New, Bioactive Compounds
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.phytochem.2020.112626zenodo-depositor-declared
P450 variations bifurcate the early terpene indole alkaloid pathway in Catharanthus roseus and Camptotheca acuminata
inferred← citeshttps://doi.org/10.1016/j.phytochem.2021.112662zenodo-depositor-declared
Chemotaxonomic investigation of Apocynaceae for retronecine-type pyrrolizidine alkaloids using HPLC-MS/MS
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Cytochrome P450 catalyses the 29-carboxyl group formation of celastrol
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Molecular and biochemical characterization of Catharanthus roseus perivine-N-methyltransferase
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Synthesis of 8‐Hydroxygeraniol
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Selective RNA Processing and Stabilization are Multi‐Layer and Stoichiometric Regulators of Gene Expression in Escherichia coli
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Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism**
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Synthetic Modulation of an Unstable Dehydrosecodine‐type Intermediate and Its Encapsulation into a Confined Cavity Enable Its X‐ray Crystallographic Observation
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Novel Biocatalysts from Specialized Metabolism
inferred← citeshttps://doi.org/10.1002/anie.202005380openalex-snapshot
TiCl3‐Mediated Synthesis of 2,3,3‐Trisubstituted Indolenines: Total Synthesis of (+)‐1,2‐Dehydroaspidospermidine, (+)‐Condyfoline, and (−)‐Tubifoline
inferred← citeshttps://doi.org/10.1002/anie.202210934openalex-snapshot
Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism**
inferred← citeshttps://doi.org/10.1002/anie.202305122openalex-snapshot
Synthetic Modulation of an Unstable Dehydrosecodine‐type Intermediate and Its Encapsulation into a Confined Cavity Enable Its X‐ray Crystallographic Observation
inferred← citeshttps://doi.org/10.1002/anie.202309284openalex-snapshot
Novel Biocatalysts from Specialized Metabolism
inferred← citeshttps://doi.org/10.1002/cbic.201800768openalex-snapshot
Harnessing the Chemistry of the Indole Heterocycle to Drive Discoveries in Biology and Medicine
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Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities
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Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis
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Biocatalytic Strategies towards [4+2] Cycloadditions
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Puzzling Out the Colchicine Biosynthetic Pathway
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The evolution and history of Vinca alkaloids: From the Big Bang to the treatment of pediatric acute leukemia
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Metabolomics analysis reveals both plant variety and choice of hormone treatment modulate vinca alkaloid production in Catharanthus roseus
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A Biolistic-Mediated Virus-Induced Gene Silencing in Apocynaceae to Map Biosynthetic Pathways of Alkaloids
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Investigating Plant Biosynthetic Pathways Using Heterologous Gene Expression: Yeast as a Heterologous Host
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Predicting Monoterpene Indole Alkaloid-Related Genes from Expression Data with Artificial Neural Networks
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Discovery and Characterization of Oxidative Enzymes Involved in Monoterpenoid Indole Alkaloid Biosynthesis
inferred← citeshttps://doi.org/10.1007/978-1-0716-2349-7_12openalex-snapshot
Ancestral Sequence Reconstruction for Exploring Alkaloid Evolution
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TARGETing Transcriptional Regulation in the Medicinal Plant Catharanthus roseus
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A Rapid and Efficient Vacuum-Based Agroinfiltration Protocol for Transient Gene Overexpression in Leaves of Catharanthus roseus
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Semisynthesis of Bis-Indole Alkaloid (−)-Melodinine K Enabled by a Combination of Biotransformation and Chemical Synthesis
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RNA-seq Analysis of Monoterpene Indole Alkaloid Biosynthetic Pathway Elucidation in Catharanthus roseus
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Catharanthus roseus Monoterpenoid Indole Alkaloid Pathway Engineering in Yeast
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Catharanthus roseus Monoterpenoid Indole Alkaloid Pathway Engineering in Yeast
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Voacangine/coronaridine hydroxylases catalyze C19-hydroxylation in iboga alkaloid synthesis
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De novo biosynthesis of Astragalus bioactive isoflavonoid calycosin-7-glucoside in yeast
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Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110918openalex-snapshot
Biotechnological approaches to the production of plant-derived promising anticancer agents: An update and overview
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2020.107635openalex-snapshot
Next-generation metabolic engineering approaches towards development of plant cell suspension cultures as specialized metabolite producing biofactories
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2021.107871openalex-snapshot
Marine drugs: Biology, pipelines, current and future prospects for production
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2023.108266openalex-snapshot
Progress and prospect: Biosynthesis of plant natural products based on plant chassis
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2026.109044openalex-snapshot
Programmable plant chassis for sustainable biomanufacturing of high-value natural products
inferred← citeshttps://doi.org/10.1016/j.cbpa.2020.09.006openalex-snapshot
Synthetic biology for natural product drug production and engineering
inferred← citeshttps://doi.org/10.1016/j.cbpa.2024.102504openalex-snapshot
Discovery and evolution of [4 + 2] cyclases
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115715openalex-snapshot
Systems and synthetic biology for plant natural product pathway elucidation
inferred← citeshttps://doi.org/10.1016/j.chmed.2023.01.007openalex-snapshot
Strategies on biosynthesis and production of bioactive compounds in medicinal plants
inferred← citeshttps://doi.org/10.1016/j.chmed.2025.11.008openalex-snapshot
Herbgenomics: Unraveling natural product biosynthesis in traditional Chinese medicine
inferred← citeshttps://doi.org/10.1016/j.cogsc.2021.100567openalex-snapshot
Supplying plant natural products by yeast cell factories
inferred← citeshttps://doi.org/10.1016/j.copbio.2019.11.017openalex-snapshot
Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs
inferred← citeshttps://doi.org/10.1016/j.copbio.2020.01.008openalex-snapshot
Current state of aromatics production using yeast: achievements and challenges
inferred← citeshttps://doi.org/10.1016/j.copbio.2024.103098openalex-snapshot
Emerging trends in production of plant natural products and new-to-nature biopharmaceuticals in yeast
inferred← citeshttps://doi.org/10.1016/j.copbio.2024.103137openalex-snapshot
Cutting-edge plant natural product pathway elucidation
inferred← citeshttps://doi.org/10.1016/j.copbio.2025.103374openalex-snapshot
Advances in the microbial biosynthesis of therapeutic terpenoids
inferred← citeshttps://doi.org/10.1016/j.copbio.2025.103425openalex-snapshot
Advances in artificial biosynthesis of bioactive plant natural products
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e28078openalex-snapshot
The Madagascar palm genome provides new insights on the evolution of Apocynaceae specialized metabolism
inferred← citeshttps://doi.org/10.1016/j.ibmb.2019.103212openalex-snapshot
A cytochrome P450 from the mustard leaf beetles hydroxylates geraniol, a key step in iridoid biosynthesis
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.11.249openalex-snapshot
Gene coexpression networks allow the discovery of two strictosidine synthases underlying monoterpene indole alkaloid biosynthesis in Uncaria rhynchophylla
inferred← citeshttps://doi.org/10.1016/j.indcrop.2020.112746openalex-snapshot
In vitro anticancer potential of aerial parts of Ipomoea horsfalliae hook in different human cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.indcrop.2025.120605openalex-snapshot
The plant platform for natural products synthesis: Tobacco
inferred← citeshttps://doi.org/10.1016/j.indcrop.2025.120907openalex-snapshot
Analysis of biosynthetic pathways to areca alkaloids in Areca catechu
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109599openalex-snapshot
Chromosome-level Alstonia scholaris genome unveils evolutionary insights into biosynthesis of monoterpenoid indole alkaloids
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.102237openalex-snapshot
Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases
inferred← citeshttps://doi.org/10.1016/j.jbc.2025.111120openalex-snapshot
Conserved early steps of stemmadenine biosynthesis
inferred← citeshttps://doi.org/10.1016/j.jplph.2023.154169openalex-snapshot
SPOTLIGHT: Alpha carbonic anhydrases join the club of alkaloid biosynthetic enzymes
inferred← citeshttps://doi.org/10.1016/j.mec.2022.e00215openalex-snapshot
Improved protein glycosylation enabled heterologous biosynthesis of monoterpenoid indole alkaloids and their unnatural derivatives in yeast
inferred← citeshttps://doi.org/10.1016/j.medj.2022.10.006openalex-snapshot
Fields to fermentors: Brewing botanical chemotherapeutic precursors using genetically engineered yeast
inferred← citeshttps://doi.org/10.1016/j.molp.2026.05.022openalex-snapshot
Characterization of the entry steps in diterpenoid alkaloid biosynthesis
inferred← citeshttps://doi.org/10.1016/j.ncrops.2023.10.001openalex-snapshot
TomAP: A multi-omics data analysis platform for advancing functional genomics research in tomatoes
inferred← citeshttps://doi.org/10.1016/j.pbi.2022.102186openalex-snapshot
Compartmentalization at the interface of primary and alkaloid metabolism
inferred← citeshttps://doi.org/10.1016/j.pbi.2022.102200openalex-snapshot
More than a Catharanthus plant: A multicellular and pluri-organelle alkaloid-producing factory
inferred← citeshttps://doi.org/10.1016/j.pbi.2022.102330openalex-snapshot
Leveraging synthetic biology and metabolic engineering to overcome obstacles in plant pathway elucidation
inferred← citeshttps://doi.org/10.1016/j.pbi.2023.102368openalex-snapshot
Convergent and divergent evolution of plant chemical defenses
inferred← citeshttps://doi.org/10.1016/j.pbi.2023.102379openalex-snapshot
Integration of discovery and engineering in plant alkaloid research: Recent developments in elucidation, reconstruction, and repurposing biosynthetic pathways
inferred← citeshttps://doi.org/10.1016/j.pbi.2024.102626openalex-snapshot
New frontiers in the biosynthesis of psychoactive specialized metabolites
inferred← citeshttps://doi.org/10.1016/j.pbi.2024.102638openalex-snapshot
β-Glucosidases in specialized metabolism: Towards a new understanding of the gatekeepers of plant chemical arsenal
inferred← citeshttps://doi.org/10.1016/j.phytochem.2018.12.017openalex-snapshot
Inter-organ transport of secologanin allows assembly of monoterpenoid indole alkaloids in a Catharanthus roseus mutant
inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113422openalex-snapshot
A lesion-mimic mutant of Catharanthus roseus accumulates the opioid agonist, akuammicine
inferred← citeshttps://doi.org/10.1016/j.plaphy.2023.02.039openalex-snapshot
Establishment of recombinant Catharanthus roseus stem cells stably overexpressing ORCA4 for terpenoid indole alkaloids biosynthesis
inferred← citeshttps://doi.org/10.1016/j.plaphy.2023.108070openalex-snapshot
Unlocking secrets of nature's chemists: Potential of CRISPR/Cas-based tools in plant metabolic engineering for customized nutraceutical and medicinal profiles
inferred← citeshttps://doi.org/10.1016/j.plaphy.2025.109841openalex-snapshot
Promiscuous and regiospecific Vinca minor hydroxylases for opioid akuammine biosynthesis and monoterpenoid indole alkaloid diversification
inferred← citeshttps://doi.org/10.1016/j.plaphy.2025.110161openalex-snapshot
Regiospecific hydroxylase and O-methyltransferase for the biosynthesis of anticancer alkaloids in Tabernaemontana elegans (toad tree)
inferred← citeshttps://doi.org/10.1016/j.plaphy.2025.110714openalex-snapshot
Yohimban acetylation in Rauvolfia is mediated by a leaf-specific acetyltransferase in reserpine biosynthetic gene cluster
inferred← citeshttps://doi.org/10.1016/j.plaphy.2026.111179openalex-snapshot
Heterologous expression of CrMATE1 increases flux of intermediates in monoterpenoid indole alkaloid pathway
inferred← citeshttps://doi.org/10.1016/j.sajb.2019.01.032openalex-snapshot
Influence of seasonal and ontogenic parameters on the pattern of key terpenoid indole alkaloids biosynthesized in the leaves of Catharanthus roseus
inferred← citeshttps://doi.org/10.1016/j.tchem.2022.100013openalex-snapshot
Enzymatic intermolecular Diels-Alder reactions in synthesis: From nature to design
inferred← citeshttps://doi.org/10.1016/j.tibtech.2018.11.013openalex-snapshot
Tackling Cancer with Yeast-Based Technologies
inferred← citeshttps://doi.org/10.1016/j.tibtech.2020.06.012openalex-snapshot
Biotechnological Exploration of Transformed Root Culture for Value-Added Products
inferred← citeshttps://doi.org/10.1016/j.tips.2019.12.006openalex-snapshot
Identifying Missing Biosynthesis Enzymes of Plant Natural Products
inferred← citeshttps://doi.org/10.1016/j.trac.2025.118288openalex-snapshot
Spatial metabolomics boost understanding the molecular targets and pathways of active components of traditional Chinese medicine in situ and in vivo
inferred← citeshttps://doi.org/10.1016/j.trecan.2020.02.004openalex-snapshot
Towards the Microbial Production of Plant-Derived Anticancer Drugs
inferred← citeshttps://doi.org/10.1016/j.xplc.2021.100229openalex-snapshot
Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells
inferred← citeshttps://doi.org/10.1016/j.xplc.2022.100323openalex-snapshot
Exploiting plant transcriptomic databases: Resources, tools, and approaches
inferred← citeshttps://doi.org/10.1016/j.xplc.2023.100661openalex-snapshot
A near-complete genome assembly of Catharanthus roseus and insights into its vinblastine biosynthesis and high susceptibility to the Huanglongbing pathogen
inferred← citeshttps://doi.org/10.1016/j.ymben.2023.02.009openalex-snapshot
Deciphering the network of cholesterol biosynthesis in Paris polyphylla laid a base for efficient diosgenin production in plant chassis
inferred← citeshttps://doi.org/10.1016/j.ymben.2024.06.007openalex-snapshot
Metabolic engineering of Pichia pastoris for overproduction of cis-trans nepetalactol
inferred← citeshttps://doi.org/10.1016/s1875-5364(20)60002-4openalex-snapshot
Genes functional identification and synthetic biology of natural products
inferred← citeshttps://doi.org/10.1021/acs.accounts.4c00315openalex-snapshot
Hunting for the Intermolecular Diels–Alderase
inferred← citeshttps://doi.org/10.1021/acs.biochem.4c00320openalex-snapshot
Biosynthetic Strategies of Berberine Bridge Enzyme-like Flavoprotein Oxidases toward Structural Diversification in Natural Product Biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.biochem.5c00234openalex-snapshot
A Tight-Knit Family: The Medium-Chain Dehydrogenase/Reductases of Monoterpene Indole Alkaloid Biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.chemrev.4c00687openalex-snapshot
Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications
inferred← citeshttps://doi.org/10.1021/acs.jafc.0c04885openalex-snapshot
Biomimetic Synthesis of Iridoid Alkaloids as Novel Leads for Fungicidal and Insecticidal Agents
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00310openalex-snapshot
Synthesis of (−)-Melodinine K: A Case Study of Efficiency in Natural Product Synthesis
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c00062openalex-snapshot
Gelstriamine A, a Triamino Monoterpene Indole Alkaloid with a Caged 6/5/7/6/6/5 Scaffold and Analgesic Alkaloids from Gelsemium elegans Stems
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.3c00092openalex-snapshot
Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition
inferred← citeshttps://doi.org/10.1021/acs.joc.8b01544openalex-snapshot
Synthesis of 8-Hydroxygeraniol
inferred← citeshttps://doi.org/10.1021/acs.joc.9b01835openalex-snapshot
Hunterines A–C, Three Unusual Monoterpenoid Indole Alkaloids from Hunteria zeylanica
inferred← citeshttps://doi.org/10.1021/acs.jpca.6c00619openalex-snapshot
Wolfium Bond Catalysis: Electronic Reprogramming and Transition State Stabilization in Aza-Diels–Alder Reactions
inferred← citeshttps://doi.org/10.1021/acs.orglett.1c00206openalex-snapshot
Early and Late Steps of Quinine Biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.orglett.3c03972openalex-snapshot
Combination of Machine Learning and Empirical Computation for the Structural Validation of Trirosaline, a Natural Trimeric Monoterpene Indole Alkaloid from Catharanthus roseus
inferred← citeshttps://doi.org/10.1021/acs.orglett.8b02961openalex-snapshot
Theionbrunonines A and B: Dimeric Vobasine Alkaloids Tethered by a Thioether Bridge from Mostuea brunonis
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b03785openalex-snapshot
Melocochines A and B, Two Alkaloids from the Fruits of Melodinus cochinchinensis
inferred← citeshttps://doi.org/10.1021/acscatal.2c05247openalex-snapshot
Unusual Dioxygen-Dependent Reactions Catalyzed by Nonheme Iron Enzymes in Natural Product Biosynthesis
inferred← citeshttps://doi.org/10.1021/acschembio.2c00905openalex-snapshot
Out With a Bang: Celebrating Global Chemical Biology
inferred← citeshttps://doi.org/10.1021/acschembio.5c00485openalex-snapshot
Protein–Protein Interactions Modulate a Key Branch Point in Monoterpene Indole Alkaloid Biosynthesis
inferred← citeshttps://doi.org/10.1021/acsomega.2c04591openalex-snapshot
Theoretical Investigation of the Biogenetic Pathway for Formation of Antibacterial Indole Alkaloids fromVoacanga africana
inferred← citeshttps://doi.org/10.1021/acssuschemeng.5c11338openalex-snapshot
Reconstruction of the Early Stage Paclitaxel Biosynthesis Pathway in Escherichia coli by Integrating Enzyme and Metabolic Engineering Approaches
inferred← citeshttps://doi.org/10.1021/acssynbio.0c00346openalex-snapshot
Efficient Biosynthesis of (2S)-Eriodictyol from (2S)-Naringenin in Saccharomyces cerevisiae through a Combination of Promoter Adjustment and Directed Evolution
inferred← citeshttps://doi.org/10.1021/acssynbio.1c00315openalex-snapshot
Toward the Heterologous Biosynthesis of Plant Natural Products: Gene Discovery and Characterization
inferred← citeshttps://doi.org/10.1021/acssynbio.2c00135openalex-snapshot
MULTI-SCULPT: Multiplex Integration via Selective, CRISPR-Mediated, Ultralong Pathway Transformation in Yeast for Plant Natural Product Synthesis
inferred← citeshttps://doi.org/10.1021/acssynbio.2c00434openalex-snapshot
Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in Nicotiana benthamiana
inferred← citeshttps://doi.org/10.1021/acssynbio.9b00455openalex-snapshot
Extrachromosomal Genetic Engineering of the Marine Diatom Phaeodactylum tricornutum Enables the Heterologous Production of Monoterpenoids
inferred← citeshttps://doi.org/10.1021/cbe.6c00087openalex-snapshot
Harnessing CYP71 Enzymes for Terpenoid Indole Alkaloid Production: A Synthetic Biology Perspective from Discovery to Application
inferred← citeshttps://doi.org/10.1021/jacs.0c08879openalex-snapshot
Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis
inferred← citeshttps://doi.org/10.1021/jacs.1c02004openalex-snapshot
Total Synthesis of (−)-Strictosidine and Interception of Aryne Natural Product Derivatives “Strictosidyne” and “Strictosamidyne”
inferred← citeshttps://doi.org/10.1021/jacs.1c04980openalex-snapshot
A General Iridium-Catalyzed Reductive Dienamine Synthesis Allows a Five-Step Synthesis of Catharanthine via the Elusive Dehydrosecodine
inferred← citeshttps://doi.org/10.1021/jacs.1c10205openalex-snapshot
Biopatterned Reorganization of Alkaloids Enabled by Ring-Opening Functionalization of Tertiary Amines
inferred← citeshttps://doi.org/10.1021/jacs.2c08107openalex-snapshot
Recycling Upstream Redox Enzymes Expands the Regioselectivity of Cycloaddition in Pseudo-Aspidosperma Alkaloid Biosynthesis
inferred← citeshttps://doi.org/10.1021/jacs.2c10838openalex-snapshot
Post-Cyclization Skeletal Rearrangements in Plant Triterpenoid Biosynthesis by a Pair of Branchpoint Isomerases
inferred← citeshttps://doi.org/10.1021/jacs.4c11213openalex-snapshot
Plants Utilize a Protection/Deprotection Strategy in Limonoid Biosynthesis: A “Missing Link” Carboxylesterase Boosts Yields and Provides Insights into Furan Formation
inferred← citeshttps://doi.org/10.1021/jacs.5c02863openalex-snapshot
Enzymatic Basis of Stereochemical Control in Reserpine Biosynthesis
inferred← citeshttps://doi.org/10.1021/jacs.5c02990openalex-snapshot
Collective Biosynthesis of Plant Spirooxindole Alkaloids through Enzyme Discovery and Engineering
inferred← citeshttps://doi.org/10.1021/jacs.5c22242openalex-snapshot
Biosynthesis of Xyloketals: Furanochromene Skeleton Formed via Heterodimerization of Two Orsellinic Acid-Branched Metabolites
inferred← citeshttps://doi.org/10.1021/jacs.9b05999openalex-snapshot
Biosynthesis of an Anti-Addiction Agent from the Iboga Plant
inferred← citeshttps://doi.org/10.1038/d41586-022-02256-zopenalex-snapshot
Engineered yeast brews precursors of anticancer drug vinblastine
inferred← citeshttps://doi.org/10.1038/s41467-019-09848-wopenalex-snapshot
Synthetic biology strategies for microbial biosynthesis of plant natural products
inferred← citeshttps://doi.org/10.1038/s41467-021-21853-6openalex-snapshot
Versatility in acyltransferase activity completes chicoric acid biosynthesis in purple coneflower
inferred← citeshttps://doi.org/10.1038/s41467-022-31100-1openalex-snapshot
A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis
inferred← citeshttps://doi.org/10.1038/s41467-024-44797-zopenalex-snapshot
De novo biosynthesis of antiarrhythmic alkaloid ajmaline
inferred← citeshttps://doi.org/10.1038/s41467-025-57280-0openalex-snapshot
A concise enzyme cascade enables the manufacture of natural and halogenated protoberberine alkaloids
inferred← citeshttps://doi.org/10.1038/s41467-025-57448-8openalex-snapshot
A long road ahead to reliable and complete medicinal plant genomes
inferred← citeshttps://doi.org/10.1038/s41467-025-58904-1openalex-snapshot
Aerobic oxidative bromination and iodination enabled by alloxan and ascorbic acid to mimic flavin-dependent halogenases
inferred← citeshttps://doi.org/10.1038/s41467-025-65543-zopenalex-snapshot
Ancient gene clusters govern the initiation of monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion
inferred← citeshttps://doi.org/10.1038/s41467-026-68816-3openalex-snapshot
Chemically guided single-cell transcriptomics reveals sulfotransferase-mediated scaffold remodeling in securinine biosynthesis
inferred← citeshttps://doi.org/10.1038/s41477-022-01291-yopenalex-snapshot
Single-cell RNA sequencing provides a high-resolution roadmap for understanding the multicellular compartmentation of specialized metabolism
inferred← citeshttps://doi.org/10.1038/s41557-022-01117-6openalex-snapshot
An NmrA-like enzyme-catalysed redox-mediated Diels–Alder cycloaddition with anti-selectivity
inferred← citeshttps://doi.org/10.1038/s41576-021-00363-7openalex-snapshot
Mining genomes to illuminate the specialized chemistry of life
inferred← citeshttps://doi.org/10.1038/s41586-022-05157-3openalex-snapshot
A microbial supply chain for production of the anti-cancer drug vinblastine
inferred← citeshttps://doi.org/10.1038/s41589-019-0446-8openalex-snapshot
Aromatization of natural products by a specialized detoxification enzyme
inferred← citeshttps://doi.org/10.1038/s41589-019-0460-xopenalex-snapshot
Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids
inferred← citeshttps://doi.org/10.1038/s41589-020-00669-3openalex-snapshot
Rerouting plant terpene biosynthesis enables momilactone pathway elucidation
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