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A genome-wide genetic screen uncovers determinants of human pigmentation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Cre‐mediated recombination in the skin melanocyte lineage
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Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates
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The Evolutionary History of Human Skin Pigmentation
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Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data
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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
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Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution
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An Unexpectedly Complex Architecture for Skin Pigmentation in Africans
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Modeling Neural Crest Induction, Melanocyte Specification, and Disease-Related Pigmentation Defects in hESCs and Patient-Specific iPSCs
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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
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Inhibition of PAX3 by TGF-β Modulates Melanocyte Viability
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Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability
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Proteomic and Bioinformatic Characterization of the Biogenesis and Function of Melanosomes
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Genome-wide detection and characterization of positive selection in human populations
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A global reference for human genetic variation
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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
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Two newly identified genetic determinants of pigmentation in Europeans
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Partitioning heritability by functional annotation using genome-wide association summary statistics
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Interspecies difference in the regulation of melanocyte development by SOX10 and MITF
inferredcites →https://doi.org/10.1073/pnas.0803488105openalex-snapshot
Electron tomography of early melanosomes: Implications for melanogenesis and the generation of fibrillar amyloid sheets
inferredcites →https://doi.org/10.1073/pnas.1600108113openalex-snapshot
TPC2 controls pigmentation by regulating melanosome pH and size
inferredcites →https://doi.org/10.1073/pnas.191184798openalex-snapshot
A model for melanosome biogenesis based on the purification and analysis of early melanosomes
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Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells✪
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COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A
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The variant call format and VCFtools
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Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates
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Melanosome Biogenesis in the Pigmentation of Mammalian Skin
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KLF6 Gene and Early Melanoma Development in a Collagen I-Rich Extracellular Environment
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The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
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GENCODE reference annotation for the human and mouse genomes
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Expression of KLF6-SV2 in colorectal cancer and its impact on proliferation and apoptosis
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Expanded Analysis of Pigmentation Genetics in UK Biobank
inferredcites →https://doi.org/10.1101/cshperspect.a017046openalex-snapshot
Melanocytes and Their Diseases
inferredcites →https://doi.org/10.1101/gr.134890.111openalex-snapshot
Personal and population genomics of human regulatory variation
inferredcites →https://doi.org/10.1101/gr.154831.113openalex-snapshot
Estimating and interpreting F ST : The impact of rare variants
inferredcites →https://doi.org/10.1101/gr.233304.117openalex-snapshot
Cell-type–specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes
inferredcites →https://doi.org/10.1111/j.1365-2818.1993.tb03313.xopenalex-snapshot
Measurement of co‐localization of objects in dual‐colour confocal images
inferredcites →https://doi.org/10.1111/j.1365-2818.2006.01706.xopenalex-snapshot
A guided tour into subcellular colocalization analysis in light microscopy
inferredcites →https://doi.org/10.1111/j.1600-0749.2006.00345.xopenalex-snapshot
The physical and chemical properties of eumelanin
inferredcites →https://doi.org/10.1111/pcmr.12743openalex-snapshot
A curated gene list for expanding the horizons of pigmentation biology
inferredcites →https://doi.org/10.1126/science.1066326openalex-snapshot
KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer
inferredcites →https://doi.org/10.1126/science.1116238openalex-snapshot
SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans
inferredcites →https://doi.org/10.1126/science.1190371openalex-snapshot
Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
inferredcites →https://doi.org/10.1126/science.aan8433openalex-snapshot
Loci associated with skin pigmentation identified in African populations
inferredcites →https://doi.org/10.1126/science.ade6289openalex-snapshot
A genome-wide genetic screen uncovers determinants of human pigmentation
inferredcites →https://doi.org/10.1146/annurev-genom-083118-015230openalex-snapshot
The Genetics of Human Skin and Hair Pigmentation
inferredcites →https://doi.org/10.1158/0008-5472.can-04-0185openalex-snapshot
Kruppel-Like Factor 6 Is Frequently Down-Regulated and Induces Apoptosis in Non-Small Cell Lung Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-04-0731openalex-snapshot
Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas
inferredcites →https://doi.org/10.1172/jci77084openalex-snapshot
Krüppel-like factor 6 regulates mitochondrial function in the kidney
inferredcites →https://doi.org/10.1177/0300060513499092openalex-snapshot
Krüppel-like factor 6 in the progression and prognosis of malignant melanoma
inferredcites →https://doi.org/10.1186/1471-2105-10-48openalex-snapshot
GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
inferredcites →https://doi.org/10.1186/gb-2012-13-9-248openalex-snapshot
Human pigmentation genes under environmental selection
inferredcites →https://doi.org/10.1371/journal.pgen.1000298openalex-snapshot
Genome-Wide siRNA-Based Functional Genomics of Pigmentation Identifies Novel Genes and Pathways That Impact Melanogenesis in Human Cells
inferredcites →https://doi.org/10.1371/journal.pgen.1000592openalex-snapshot
Evolutionary Processes Acting on Candidate cis-Regulatory Regions in Humans Inferred from Patterns of Polymorphism and Divergence
inferredcites →https://doi.org/10.1371/journal.pgen.1003372openalex-snapshot
Genetic Architecture of Skin and Eye Color in an African-European Admixed Population
inferredcites →https://doi.org/10.1371/journal.pgen.1003644openalex-snapshot
A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors
inferredcites →https://doi.org/10.1371/journal.pone.0021800openalex-snapshot
REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
inferredcites →https://doi.org/10.15252/embj.201593411openalex-snapshot
Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes
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Overcoming Chemoresistance: Altering pH of Cellular Compartments by Chloroquine and Hydroxychloroquine
inferredcites →https://doi.org/10.7554/elife.58615openalex-snapshot
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Hyperspectral Imaging Combined With Machine Learning Methods to Quantify the Facial Skin Melanin and Erythema
inferred← citeshttps://doi.org/10.1002/jez.b.70032openalex-snapshot
Beyond the Classics: The Synergy of AI and Genomics Reveals an Expanded Repertoire of Pigmentation Genes
inferred← citeshttps://doi.org/10.1007/978-3-032-14644-1_12openalex-snapshot
Hyperpigmentation Agents
inferred← citeshttps://doi.org/10.1007/s11084-026-09750-8openalex-snapshot
Translational zebrafish model for molecular and developmental pathways of melanogenesis and pigmentation dysfunctions in humans
inferred← citeshttps://doi.org/10.1007/s43657-023-00142-wopenalex-snapshot
Expert Consensus on Big Data Collection of Skin and Appendage Disease Phenotypes in Chinese
inferred← citeshttps://doi.org/10.1016/j.ajhg.2024.08.023openalex-snapshot
Modeling recent positive selection using identity-by-descent segments
inferred← citeshttps://doi.org/10.1016/j.ajhg.2026.02.024openalex-snapshot
BLOC1S1 variants cause lysosomal and autophagic defects resulting in a hypomyelinating leukodystrophy with epileptic encephalopathy
inferred← citeshttps://doi.org/10.1016/j.ajps.2026.101184openalex-snapshot
Janus microneedles enabling orderly vitiligo treatment through spatiotemporal sequential promoting melanogenesis to transfer via PAR2 activation
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2024.741344openalex-snapshot
Integrative transcriptomics and metabolomics analysis provide insight into the formation of skin pigmentation diversity in Chinese soft-shelled turtle (Pelodiscus sinensis)
inferred← citeshttps://doi.org/10.1016/j.bmc.2026.118648openalex-snapshot
A general tyrosinase-responsive prodrug strategy: design and synthesis of melanoma-selective anticancer agents
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116675openalex-snapshot
A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma
inferred← citeshttps://doi.org/10.1016/j.fbio.2025.107630openalex-snapshot
Anti-melanogenic effect and mechanism of oxypaeoniflorin derived from edible Paeonia ostii flower on melanogenesis in B16F10 cells and zebrafish
inferred← citeshttps://doi.org/10.1016/j.gim.2024.101097openalex-snapshot
Biallelic loss-of-function variants of SLC12A9 cause lysosome dysfunction and a syndromic neurodevelopmental disorder
inferred← citeshttps://doi.org/10.1016/j.isci.2025.112373openalex-snapshot
Insights into human melanocyte development and characteristics through pluripotent stem cells combined with single-cell sequencing
inferred← citeshttps://doi.org/10.1016/j.jdermsci.2026.04.005openalex-snapshot
COMMD3 mediates melanin synthesis through both clusterin-PAX3 axis and copper-dependent tyrosinase activity in skin pigmentation
inferred← citeshttps://doi.org/10.1016/j.jdsct.2024.100045openalex-snapshot
A cutting-edge atomization-based methodology for enhancing formulation ability to resist photoaging
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Deoxycorticosterone acetate–induced acceleration of embryogenesis and oxidative and metabolic stresses in zebrafish
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Disentangling Race from Skin Color in Modern Biology and Medicine
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A single-cell transcriptome atlas of Lueyang black-bone chicken skin
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Dynamic changes in the skin transcriptome for the melanin pigmentation in embryonic chickens
inferred← citeshttps://doi.org/10.1021/acsami.5c10110openalex-snapshot
Tetrahedral Framework Nucleic Acids as Thermal Loading Nanocarriers for Enhanced Inhibition of Melanin Synthesis
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Endogenous tyrosinase-catalyzed therapeutics
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Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7
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MFF budding from mitochondria regulates melanosome size and maturation
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The antioxidant stress effect of granulin precursor in vitiligo
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Deciphering the molecular basis of skin color variation through transcriptomics and machine learning
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Uncovering the molecular mechanisms of amelanotic/hypopigmented primary cutaneous melanoma
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Structural and Evolutionary Relationships of Melanin Cascade Proteins in Cnidarian Innate Immunity
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inferred← citeshttps://doi.org/10.1101/2024.06.28.601235openalex-snapshot
Label-Free Melanoma Phenotype Classification Using Artificial Intelligence-Based Morphological Profiling
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The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis
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Genomic bases of short-term evolution in the wild revealed by long-term monitoring and population-scale sequencing
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Genetics of Skin, Hair, and Eye Color in Human Pigmentation Disorders
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Advances in Skin Whitening Agents: Mechanisms, Clinical Applications, and Future Perspectives
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Prospective Isolation According to Melanin Pigment Content of Melanoma Cells With Heterogeneous Potentials for Disease Propagation
inferred← citeshttps://doi.org/10.1111/pcmr.70080openalex-snapshot
QUILPEN Provides Independent and Label‐Free Single‐Cell Quantification of Pigmentation Dynamics and Organelle Content
inferred← citeshttps://doi.org/10.1111/pcmr.70105openalex-snapshot
Heme Oxygenase‐1 Differentially Controls Pigmentation in Physiological and Pathological Melanogenesis
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Genome-wide association study reveals genetic architecture and evolution of human retinal pigmentation
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Tissue-specific inflammation induces cell state plasticity with oncogenic addiction in mucosal melanoma
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A 14-bp motif in the KIT active promoter region is critical for melanin accumulation in yaks, mice, and humans
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Development of a Digital Image-Based Method to Screen Molecules That Regulate Melanization
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Implications of Altered Endosomal–Lysosomal Biogenesis in Melanoma Pathogenesis
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Isabelline coloration: a heretofore unrecognized chromatic aberration in bighorn sheep
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MiRNA-24 downregulates KLF6 affecting STAT3 protein expression and phosphorylation regulating melanogenesis in cashmere goat coat
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CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across diverse cell types
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Understanding genetic variants in context
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