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Assessment of cholesterol homeostasis in the living human brain

https://doi.org/10.1126/scitranslmed.adc9967
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
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Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease
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Efavirenz as a cholesterol‐targeting drug for AD
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Sex modifies the APOE ‐related risk of developing Alzheimer disease
inferredcites →https://doi.org/10.1002/jcc.21334openalex-snapshot
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
inferredcites →https://doi.org/10.1007/s00406-017-0838-2openalex-snapshot
Donepezil effects on cholesterol and oxysterol plasma levels of Alzheimer’s disease patients
inferredcites →https://doi.org/10.1007/s13311-019-00731-6openalex-snapshot
Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases
inferredcites →https://doi.org/10.1016/j.apsb.2021.11.014openalex-snapshot
Discovery of a highly specific 18F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination
inferredcites →https://doi.org/10.1016/j.bcp.2012.12.007openalex-snapshot
Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.biochi.2018.04.026openalex-snapshot
Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders
inferredcites →https://doi.org/10.1016/j.brainres.2010.06.011openalex-snapshot
Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes
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Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer’s disease: A CREDOS study
inferredcites →https://doi.org/10.1016/j.nbd.2013.03.013openalex-snapshot
Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression
inferredcites →https://doi.org/10.1016/j.nbd.2021.105346openalex-snapshot
Disturbances of brain cholesterol metabolism: A new excitotoxic process associated with status epilepticus
inferredcites →https://doi.org/10.1016/j.neulet.2005.11.046openalex-snapshot
Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?
inferredcites →https://doi.org/10.1016/j.neulet.2007.08.014openalex-snapshot
Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders
inferredcites →https://doi.org/10.1016/j.neulet.2012.01.017openalex-snapshot
Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
inferredcites →https://doi.org/10.1016/j.neuroimage.2008.10.058openalex-snapshot
A population-average MRI-based atlas collection of the rhesus macaque
inferredcites →https://doi.org/10.1016/j.neuroimage.2019.116163openalex-snapshot
A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model
inferredcites →https://doi.org/10.1016/j.neuron.2004.08.043openalex-snapshot
The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease
inferredcites →https://doi.org/10.1016/j.neuron.2005.01.040openalex-snapshot
Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice
inferredcites →https://doi.org/10.1016/j.phrs.2021.105886openalex-snapshot
Development of a triazolobenzodiazepine-based PET probe for subtype-selective vasopressin 1A receptor imaging
inferredcites →https://doi.org/10.1016/j.stem.2018.12.013openalex-snapshot
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
inferredcites →https://doi.org/10.1016/j.trci.2015.07.001openalex-snapshot
Marked gender differences in progression of mild cognitive impairment over 8 years
inferredcites →https://doi.org/10.1016/s0022-2275(20)31996-9openalex-snapshot
24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)
inferredcites →https://doi.org/10.1016/s0022-2275(20)32188-xopenalex-snapshot
Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
inferredcites →https://doi.org/10.1016/s0022-2275(20)32393-2openalex-snapshot
Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface
inferredcites →https://doi.org/10.1016/s0022-3956(01)00050-4openalex-snapshot
24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
inferredcites →https://doi.org/10.1016/s0140-6736(20)30367-6openalex-snapshot
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
inferredcites →https://doi.org/10.1021/acs.jmedchem.1c00864openalex-snapshot
Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H)
inferredcites →https://doi.org/10.1038/mt.2009.175openalex-snapshot
Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease
inferredcites →https://doi.org/10.1038/ncb1001-905openalex-snapshot
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide
inferredcites →https://doi.org/10.1038/nm0309-253openalex-snapshot
Getting a handle on Huntington's disease: the case for cholesterol
inferredcites →https://doi.org/10.1038/nrd1007openalex-snapshot
Molecular imaging in drug discovery and development
inferredcites →https://doi.org/10.1038/nrd2290openalex-snapshot
Molecular imaging in drug development
inferredcites →https://doi.org/10.1038/nrn3012openalex-snapshot
Linking lipids to Alzheimer's disease: cholesterol and beyond
inferredcites →https://doi.org/10.1038/nrneurol.2011.132openalex-snapshot
Cholesterol metabolism in Huntington disease
inferredcites →https://doi.org/10.1038/s41557-018-0031-xopenalex-snapshot
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
inferredcites →https://doi.org/10.1038/s41598-020-74036-6openalex-snapshot
Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice
inferredcites →https://doi.org/10.1038/sj.jcbfm.9600493openalex-snapshot
Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands
inferredcites →https://doi.org/10.1038/sj.mp.4001109openalex-snapshot
Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
inferredcites →https://doi.org/10.1073/pnas.0600316103openalex-snapshot
Brain cholesterol turnover required for geranylgeraniol production and learning in mice
inferredcites →https://doi.org/10.1073/pnas.0803717105openalex-snapshot
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain
inferredcites →https://doi.org/10.1073/pnas.1917421117openalex-snapshot
Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism
inferredcites →https://doi.org/10.1073/pnas.2102191118openalex-snapshot
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol
inferredcites →https://doi.org/10.1073/pnas.93.18.9799openalex-snapshot
Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation.
inferredcites →https://doi.org/10.1073/pnas.95.11.6460openalex-snapshot
Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
inferredcites →https://doi.org/10.1073/pnas.96.13.7238openalex-snapshot
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
inferredcites →https://doi.org/10.1074/jbc.m110.143313openalex-snapshot
Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain
inferredcites →https://doi.org/10.1074/jbc.m111.274142openalex-snapshot
Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease
inferredcites →https://doi.org/10.1074/jbc.m116.723577openalex-snapshot
Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity
inferredcites →https://doi.org/10.1074/jbc.m303415200openalex-snapshot
Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover
inferredcites →https://doi.org/10.1093/brain/awv166openalex-snapshot
CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease
inferredcites →https://doi.org/10.1093/brain/awv384openalex-snapshot
CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease
inferredcites →https://doi.org/10.1093/brain/awz174openalex-snapshot
CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease
inferredcites →https://doi.org/10.1093/braincomms/fcaa180openalex-snapshot
CYP46A1-dependent and independent effects of efavirenz treatment
inferredcites →https://doi.org/10.1097/00004647-199609000-00008openalex-snapshot
Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
inferredcites →https://doi.org/10.1097/00041433-200104000-00003openalex-snapshot
Cholesterol metabolism in the brain
inferredcites →https://doi.org/10.1111/nan.12286openalex-snapshot
Evidence for altered cholesterol metabolism in H untington's disease post mortem brain tissue
inferredcites →https://doi.org/10.1126/science.1066724openalex-snapshot
Cholesterol--Making or Breaking the Synapse
inferredcites →https://doi.org/10.1126/science.1219988openalex-snapshot
The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol
inferredcites →https://doi.org/10.1126/science.294.5545.1354openalex-snapshot
CNS Synaptogenesis Promoted by Glia-Derived Cholesterol
inferredcites →https://doi.org/10.1186/1471-2377-11-121openalex-snapshot
Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study
inferredcites →https://doi.org/10.1371/journal.pone.0184382openalex-snapshot
Plasma sterols and depressive symptom severity in a population-based cohort
inferredcites →https://doi.org/10.2967/jnumed.118.221051openalex-snapshot
Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor–Targeted PET Imaging
inferredcites →https://doi.org/10.3389/fneur.2018.00756openalex-snapshot
24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome
inferredcites →https://doi.org/10.3390/antiox10050740openalex-snapshot
The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease
inferredcites →https://doi.org/10.37349/ent.2021.00013openalex-snapshot
Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases
inferredcites →https://doi.org/10.4061/2010/723782openalex-snapshot
Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Platinum Glutamate Acid Complex as a Peroxidase Mimic: High Activity, Controllable Chemical Modification, and Application in Biosensor
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Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission
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Brain cholesterol therapy for Huntington's disease – Does it make sense?
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Quantitative analysis of [18F]CHL2310, a novel PET ligand for cholesterol 24-Hydroxylase, in nonhuman primate brain
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Preclinical development of [18F]TAAR1-2203 as a PET radioligand for imaging TAAR1 expression and receptor occupancy
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Head-to-head comparison of [18F]CHL2205 versus [18F]T008 as PET radioligands to study brain cholesterol homeostasis in rodent models and nonhuman primates
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Potential Use of the Cholesterol Transfer Inhibitor U18666A as a Potent Research Tool for the Study of Cholesterol Mechanisms in Neurodegenerative Disorders
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CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature
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Recent advances in photochemistry for positron emission tomography imaging
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SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity
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KaiXinSan improves learning and memory impairment by regulating cholesterol homeostasis in mice overloaded with 27-OHC
inferred← citeshttps://doi.org/10.1016/j.nbd.2026.107381openalex-snapshot
Longitudinal and combined assessment of 24(S)-hydroxycholesterol and Neurofilament light chain in the early stages of Huntington's disease
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2026.111078openalex-snapshot
Disruption of dopamine transmission by cholesterol depletion is associated with alterations in protein lipid raft partitioning and actin dynamics
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Quantitative assessment of translocator protein (TSPO) in the non-human primate brain and clinical translation of [18F]LW223 as a TSPO-targeted PET radioligand
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The Niemann-Pick type diseases – A synopsis of inborn errors in sphingolipid and cholesterol metabolism
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Intra- and inter-individual variation of the human lipidome
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Evaluation of [18F]RoSMA-18-d6 as a CB2 PET Radioligand in Nonhuman Primates
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5c00740openalex-snapshot
Radiosynthesis and Evaluation of 18 F-Labeled Deuterated Radioligand for Positron Emission Tomography Imaging of Cholesterol 24-Hydroxylase
inferred← citeshttps://doi.org/10.1021/acsptsci.4c00683openalex-snapshot
Development of a Novel 18F-Labeled Radioligand for Imaging Cholesterol 24-Hydroxylase with Positron Emission Tomography
inferred← citeshttps://doi.org/10.1038/d41573-022-00182-3openalex-snapshot
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Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol
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inferred← citeshttps://doi.org/10.1126/sciadv.adj1354openalex-snapshot
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Additional file 1 of Step-by-step optimisation of the radiosynthesis of the brain HDAC6 radioligand [18F]FSW-100 for clinical applications
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