On the public citation graph

CYP46A1-dependent and independent effects of efavirenz treatment

https://doi.org/10.1093/braincomms/fcaa180

0 signed · 105 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cmdc.201700730openalex-snapshot

Probing Ligand Structure–Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8‐Hydroxyefavirenz Exhibit Divergence in Activation

inferredcites →https://doi.org/10.1002/cne.21605openalex-snapshot

Neuronal expression and subcellular localization of cholesterol 24‐hydroxylase in the mouse brain

inferredcites →https://doi.org/10.1002/jemt.10339openalex-snapshot

ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex

inferredcites →https://doi.org/10.1007/s00401-019-02019-7openalex-snapshot

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia

inferredcites →https://doi.org/10.1007/s12011-019-01945-7openalex-snapshot

The Effect of Selenium on CYP450 Isoform Activity and Expression in Pigs

inferredcites →https://doi.org/10.1007/s13311-019-00737-0openalex-snapshot

CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice

inferredcites →https://doi.org/10.1016/0003-9861(54)90501-9openalex-snapshot

Studies on ACTH action in perfused bovine adrenals: The site of action of ACTH in corticosteroidogenesis

inferredcites →https://doi.org/10.1016/0006-8993(68)90234-5openalex-snapshot

Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study

inferredcites →https://doi.org/10.1016/j.arr.2016.04.004openalex-snapshot

Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system

inferredcites →https://doi.org/10.1016/j.atherosclerosis.2008.09.016openalex-snapshot

Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice

inferredcites →https://doi.org/10.1016/j.bcp.2013.04.002openalex-snapshot

Agonism of human pregnane X receptor by rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse transcriptase inhibitors

inferredcites →https://doi.org/10.1016/j.biochi.2012.06.016openalex-snapshot

On the formation and possible biological role of 25-hydroxycholesterol

inferredcites →https://doi.org/10.1016/j.cellsig.2011.11.016openalex-snapshot

Eph receptors at synapses: Implications in neurodegenerative diseases

inferredcites →https://doi.org/10.1016/j.ejphar.2017.07.016openalex-snapshot

Efavirenz: What is known about the cellular mechanisms responsible for its adverse effects

inferredcites →https://doi.org/10.1016/j.neuint.2017.11.007openalex-snapshot

Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: Potential effects of vitamin D on brain steroidogenesis

inferredcites →https://doi.org/10.1016/j.neuron.2008.10.014openalex-snapshot

Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity

inferredcites →https://doi.org/10.1016/j.neuropharm.2017.06.026openalex-snapshot

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.pharep.2017.04.018openalex-snapshot

Possible anti-depressant effect of efavirenz and pro-depressive-like effect of voriconazole in specified doses in various experimental models of depression in mice

inferredcites →https://doi.org/10.1016/j.phrs.2016.04.028openalex-snapshot

Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz

inferredcites →https://doi.org/10.1016/j.placenta.2004.06.012openalex-snapshot

Progesterone synthesis by the human placenta

inferredcites →https://doi.org/10.1016/j.tins.2014.02.010openalex-snapshot

Telomere shortening in neurological disorders: an abundance of unanswered questions

inferredcites →https://doi.org/10.1016/s0021-9258(17)43166-8openalex-snapshot

Hydroxylations in biosynthesis of bile acids. Isolation of a cytochrome P-450 from rabbit liver mitochondria catalyzing 26-hydroxylation of C27-steroids.

inferredcites →https://doi.org/10.1016/s0021-9258(19)70620-6openalex-snapshot

Intracellular movement of cholesterol in rat adrenal cells. Kinetics and effects of inhibitors.

inferredcites →https://doi.org/10.1016/s0021-9258(19)81335-2openalex-snapshot

Purification and characterization of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol 27-hydroxylase from female rat liver mitochondria.

inferredcites →https://doi.org/10.1016/s0022-2275(20)32188-xopenalex-snapshot

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

inferredcites →https://doi.org/10.1016/s1043-2760(01)00503-3openalex-snapshot

Neurosteroids: biochemistry and clinical significance

inferredcites →https://doi.org/10.1021/ac0346297openalex-snapshot

Neurosteroids in Rat Brain: Extraction, Isolation, and Analysis by Nanoscale Liquid Chromatography−Electrospray Mass Spectrometry

inferredcites →https://doi.org/10.1038/22768openalex-snapshot

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

inferredcites →https://doi.org/10.1038/24790openalex-snapshot

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

inferredcites →https://doi.org/10.1038/990141openalex-snapshot

A telomerase component is defective in the human disease dyskeratosis congenita

inferredcites →https://doi.org/10.1038/mt.2009.175openalex-snapshot

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

inferredcites →https://doi.org/10.1038/nn994openalex-snapshot

Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling

inferredcites →https://doi.org/10.1038/npp.2013.135openalex-snapshot

The HIV Antiretroviral Drug Efavirenz has LSD-Like Properties

inferredcites →https://doi.org/10.1038/s41598-017-04355-8openalex-snapshot

Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor

inferredcites →https://doi.org/10.1038/s41598-017-17204-5openalex-snapshot

QuPath: Open source software for digital pathology image analysis

inferredcites →https://doi.org/10.1073/pnas.0813349106openalex-snapshot

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

inferredcites →https://doi.org/10.1073/pnas.93.18.9799openalex-snapshot

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation.

inferredcites →https://doi.org/10.1073/pnas.96.1.266openalex-snapshot

Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ

inferredcites →https://doi.org/10.1073/pnas.96.13.7238openalex-snapshot

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

inferredcites →https://doi.org/10.1074/jbc.273.51.34316openalex-snapshot

cDNA Cloning of Mouse and Human Cholesterol 25-Hydroxylases, Polytopic Membrane Proteins That Synthesize a Potent Oxysterol Regulator of Lipid Metabolism

inferredcites →https://doi.org/10.1074/jbc.m116.774760openalex-snapshot

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum

inferredcites →https://doi.org/10.1074/jbc.m303415200openalex-snapshot

Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover

inferredcites →https://doi.org/10.1074/jbc.m402324200openalex-snapshot

Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease

inferredcites →https://doi.org/10.1089/neu.2007.0444openalex-snapshot

Cortical Injury Increases Cholesterol 24S Hydroxylase (Cyp46) Levels in the Rat Brain

inferredcites →https://doi.org/10.1093/brain/awv384openalex-snapshot

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

inferredcites →https://doi.org/10.1093/brain/awz174openalex-snapshot

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease

inferredcites →https://doi.org/10.1093/braincomms/fcaa043openalex-snapshot

Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes

inferredcites →https://doi.org/10.1093/hmg/ddv268openalex-snapshot

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

inferredcites →https://doi.org/10.1093/jac/dkv183openalex-snapshot

Efavirenz and the CNS: what we already know and questions that need to be answered

inferredcites →https://doi.org/10.1096/fj.201900092ropenalex-snapshot

The key genes, phosphoproteins, processes, and pathways affected by efavirenz‐activated CYP46A1 in the amyloid‐decreasing paradigm of efavirenz treatment

inferredcites →https://doi.org/10.1111/j.1460-9568.2005.04551.xopenalex-snapshot

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1

inferredcites →https://doi.org/10.1111/j.1471-4159.2009.05917.xopenalex-snapshot

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

inferredcites →https://doi.org/10.1111/jne.12351openalex-snapshot

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

inferredcites →https://doi.org/10.1111/jne.12561openalex-snapshot

Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid

inferredcites →https://doi.org/10.1124/dmd.118.081398openalex-snapshot

Regulation of Cytosolic Sulfotransferases in Models of Human Hepatocyte Development

inferredcites →https://doi.org/10.1124/jpet.106.112136openalex-snapshot

Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

inferredcites →https://doi.org/10.1124/pr.117.013706openalex-snapshot

Adverse Neuropsychiatric Events and Recreational Use of Efavirenz and Other HIV-1 Antiretroviral Drugs

inferredcites →https://doi.org/10.1134/s036211971304004xopenalex-snapshot

Neurosteroid dehydroepiandrosterone and brain function

inferredcites →https://doi.org/10.1159/000479571openalex-snapshot

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

inferredcites →https://doi.org/10.1161/01.atv.0000120374.59826.1bopenalex-snapshot

Brain Cholesterol: Long Secret Life Behind a Barrier

inferredcites →https://doi.org/10.1167/iovs.10-6021openalex-snapshot

Cholestenoic Acid Is an Important Elimination Product of Cholesterol in the Retina: Comparison of Retinal Cholesterol Metabolism with That in the Brain

inferredcites →https://doi.org/10.1186/preaccept-1013335856130984openalex-snapshot

Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer¿s disease correlates with pathology

inferredcites →https://doi.org/10.1194/jlr.m017244openalex-snapshot

Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

inferredcites →https://doi.org/10.1194/jlr.m200071-jlr200openalex-snapshot

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

inferredcites →https://doi.org/10.1194/jlr.m200293-jlr200openalex-snapshot

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation

inferredcites →https://doi.org/10.1194/jlr.m400244-jlr200openalex-snapshot

Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain

inferredcites →https://doi.org/10.1194/jlr.m500024-jlr200openalex-snapshot

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain

inferredcites →https://doi.org/10.1194/jlr.m600497-jlr200openalex-snapshot

Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols

inferredcites →https://doi.org/10.1194/jlr.m600529-jlr200openalex-snapshot

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid

inferredcites →https://doi.org/10.1194/jlr.r016675openalex-snapshot

Early steps in steroidogenesis: intracellular cholesterol trafficking

inferredcites →https://doi.org/10.1210/er.2015-1036openalex-snapshot

The Regulation of Steroid Action by Sulfation and Desulfation

inferredcites →https://doi.org/10.1371/journal.pone.0049293openalex-snapshot

On the Mechanism of Synaptic Depression Induced by CaMKIIN, an Endogenous Inhibitor of CaMKII

inferredcites →https://doi.org/10.1523/jneurosci.0131-13.2013openalex-snapshot

Phosphorylation of Threonine-19 of PSD-95 by GSK-3 is Required for PSD-95 Mobilization and Long-Term Depression

inferredcites →https://doi.org/10.1523/jneurosci.1202-06.2006openalex-snapshot

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

inferredcites →https://doi.org/10.1523/jneurosci.2619-13.2013openalex-snapshot

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator ofN-Methyl-d-Aspartate Receptors

inferredcites →https://doi.org/10.15252/embj.201899771openalex-snapshot

Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling

inferredcites →https://doi.org/10.15252/embr.201948143openalex-snapshot

NPC1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP46A1 activation

inferredcites →https://doi.org/10.15252/emmm.201810233openalex-snapshot

Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection

inferredcites →https://doi.org/10.15252/emmm.201910924openalex-snapshot

Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma

inferredcites →https://doi.org/10.18632/oncotarget.13049openalex-snapshot

Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress

inferredcites →https://doi.org/10.3109/02699052.2015.1035330openalex-snapshot

Progesterone and vitamin D combination therapy modulates inflammatory response after traumatic brain injury

inferredcites →https://doi.org/10.3389/fendo.2018.00183openalex-snapshot

Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids

inferredcites →https://doi.org/10.3389/fnins.2018.00084openalex-snapshot

Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4137501openalex-extracted

inferred← citeshttps://doi.org/10.1007/s11064-025-04563-zopenalex-snapshot

Frequency-Dependent Mechanism of 24-Hydroxycholesterol-Mediated Modulation of Neurotransmitter Release at the Mouse Neuromuscular Junction: The Role of Reactive Oxygen Species

inferred← citeshttps://doi.org/10.1007/s13311-021-01079-6openalex-snapshot

Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux

inferred← citeshttps://doi.org/10.1016/j.bbadis.2023.166993openalex-snapshot

Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration

inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116442openalex-snapshot

Artificial intelligence-driven drug repositioning uncovers efavirenz as a modulator of α-synuclein propagation: Implications in Parkinson’s disease

inferred← citeshttps://doi.org/10.1016/j.biopha.2026.119470openalex-snapshot

CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature

inferred← citeshttps://doi.org/10.1016/j.chmed.2022.06.012openalex-snapshot

New insights into effects of Kaixin Powder on depression via lipid metabolism related adiponectin signaling pathway

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114612openalex-snapshot

Design and Synthesis of Aryl-Piperidine Derivatives as Potent and Selective PET Tracers for Cholesterol 24-Hydroxylase (CH24H)

inferred← citeshttps://doi.org/10.1016/j.jlr.2024.100555openalex-snapshot

Unbiased insights into the multiplicity of the CYP46A1 brain effects in 5XFAD mice treated with low dose-efavirenz

inferred← citeshttps://doi.org/10.1016/j.nbd.2025.107029openalex-snapshot

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

inferred← citeshttps://doi.org/10.1016/j.xcrm.2023.101278openalex-snapshot

Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis

inferred← citeshttps://doi.org/10.1021/acsptsci.4c00229openalex-snapshot

Challenges and Opportunities for Consideration of Efavirenz Drug Repurposing for Alzheimer’s Disease Therapeutics

inferred← citeshttps://doi.org/10.1038/s42255-025-01379-7openalex-snapshot

Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke

inferred← citeshttps://doi.org/10.1101/2025.11.29.689498openalex-snapshot

Alternative Anastrozole Target CYP4V2 Impairs Neurons in Preclinical Models of Inherited Tauopathy

inferred← citeshttps://doi.org/10.1126/scitranslmed.adc9967openalex-snapshot

Assessment of cholesterol homeostasis in the living human brain

inferred← citeshttps://doi.org/10.3389/fnagi.2021.696778openalex-snapshot

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

inferred← citeshttps://doi.org/10.3389/fphar.2021.650027openalex-snapshot

Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances

inferred← citeshttps://doi.org/10.3389/fphar.2022.902254openalex-snapshot

Low-Dose Anti-HIV Drug Efavirenz Mitigates Retinal Vascular Lesions in a Mouse Model of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/biology10101003openalex-snapshot

Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis

inferred← citeshttps://doi.org/10.3390/ijms23147669openalex-snapshot

Increased Acetylcholine Levels and Other Brain Effects in 5XFAD Mice after Treatment with 8,14-Dihydroxy Metabolite of Efavirenz

inferred← citeshttps://doi.org/10.37349/ent.2021.00013openalex-snapshot

Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases

inferred← citeshttps://doi.org/10.62641/aep.v52i5.1723openalex-snapshot

Calycosin-7-O-β-D-Glucoside Ameliorates Palmitate-Induced Lipid Accumulation in HT22 Cells

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.