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Benefits of Ascorbic Acid in Association with Low-Dose Benznidazole in Treatment of Chagas Disease

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.1955.02960240042010aopenalex-snapshot

AMERICAN TRYPANOSOMIASIS (CHAGAS' DISEASE)

inferredcites →https://doi.org/10.1002/jcp.1041430116openalex-snapshot

Cytoskeleton as a target in menadione‐induced oxidative stress in cultured mammalian cells. I. Biochemical and immunocytochemical features

inferredcites →https://doi.org/10.1007/s00240-016-0868-7openalex-snapshot

Ascorbic acid intake and oxalate synthesis

inferredcites →https://doi.org/10.1007/s00281-012-0351-7openalex-snapshot

Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease

inferredcites →https://doi.org/10.1007/s00436-015-4488-xopenalex-snapshot

Trypanosoma cruzi infection and benznidazole therapy independently stimulate oxidative status and structural pathological remodeling of the liver tissue in mice

inferredcites →https://doi.org/10.1007/springerreference_85791openalex-snapshot

Chagas Disease or American Trypanosomiasis

inferredcites →https://doi.org/10.1016/0006-2952(84)90511-2openalex-snapshot

Reductive metabolism and activation of benznidazole

inferredcites →https://doi.org/10.1016/0006-2952(86)90565-4openalex-snapshot

The biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms

inferredcites →https://doi.org/10.1016/j.actatropica.2014.07.005openalex-snapshot

Trypanosoma cruzi strains cause different myocarditis patterns in infected mice

inferredcites →https://doi.org/10.1016/j.biochi.2015.12.014openalex-snapshot

Oxidative theory of atherosclerosis and antioxidants

inferredcites →https://doi.org/10.1016/j.ejphar.2017.01.036openalex-snapshot

Nebivolol prevents ethanol-induced reactive oxygen species generation and lipoperoxidation in the rat kidney by regulating NADPH oxidase activation and expression

inferredcites →https://doi.org/10.1016/j.exppara.2016.09.015openalex-snapshot

Hepatic injury associated with Trypanosoma cruzi infection is attenuated by treatment with 15-deoxy-Δ 12,14 prostaglandin J 2

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2004.08.018openalex-snapshot

Oxidative damage during chagasic cardiomyopathy development: role of mitochondrial oxidant release and inefficient antioxidant defense

inferredcites →https://doi.org/10.1016/j.idc.2012.03.002openalex-snapshot

American Trypanosomiasis (Chagas Disease)

inferredcites →https://doi.org/10.1016/j.idh.2017.07.004openalex-snapshot

Pharmacist intervention in patients receiving treatment for Chagas disease: An emerging challenge for non-endemic countries

inferredcites →https://doi.org/10.1016/j.ijcard.2006.11.118openalex-snapshot

Antioxidant therapy attenuates oxidative stress in chronic cardiopathy associated with Chagas' disease

inferredcites →https://doi.org/10.1016/j.ijpddr.2015.12.001openalex-snapshot

Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain

inferredcites →https://doi.org/10.1016/j.micinf.2008.06.013openalex-snapshot

Tissue-specific oxidative imbalance and mitochondrial dysfunction during Trypanosoma cruzi infection in mice

inferredcites →https://doi.org/10.1016/j.mrrev.2015.12.003openalex-snapshot

How Trypanosoma cruzi deals with oxidative stress: Antioxidant defence and DNA repair pathways

inferredcites →https://doi.org/10.1016/s0140-6736(16)30171-4openalex-snapshot

Neglected tropical diseases: progress towards addressing the chronic pandemic

inferredcites →https://doi.org/10.1038/nrmicro1249openalex-snapshot

The Trypanosoma cruzi–host-cell interplay: location, invasion, retention

inferredcites →https://doi.org/10.1051/parasite/2014012openalex-snapshot

Chagas disease in the 21st Century: a public health success or an emerging threat?

inferredcites →https://doi.org/10.1056/nejmoa1507574openalex-snapshot

Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy

inferredcites →https://doi.org/10.1056/nejmra1410150openalex-snapshot

Chagas’ Disease

inferredcites →https://doi.org/10.1073/pnas.90.17.7915openalex-snapshot

Oxidants, antioxidants, and the degenerative diseases of aging.

inferredcites →https://doi.org/10.1097/mjt.0000000000000137openalex-snapshot

Impact of the Use of Benznidazole Followed by Antioxidant Supplementation in the Prevalence of Ventricular Arrhythmias in Patients With Chronic Chagas Disease: Pilot Study

inferredcites →https://doi.org/10.1111/jphp.12451openalex-snapshot

Modulation of oxidative and inflammatory cardiac response by nonselective 1- and 2-cyclooxygenase inhibitor and benznidazole in mice

inferredcites →https://doi.org/10.1128/aac.00745-15openalex-snapshot

New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: a Pilot Short-Term Follow-Up Study with Adult Patients

inferredcites →https://doi.org/10.1128/aac.05135-11openalex-snapshot

Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

inferredcites →https://doi.org/10.1155/2014/831841openalex-snapshot

Biology of Ageing and Role of Dietary Antioxidants

inferredcites →https://doi.org/10.1159/000222245openalex-snapshot

Cardioprotective Actions of Ascorbic Acid during Isoproterenol-Induced Acute Myocardial Infarction in Rats

inferredcites →https://doi.org/10.1161/jaha.113.000539openalex-snapshot

Pathogenesis of Chagas Cardiomyopathy: Role of Inflammation and Oxidative Stress

inferredcites →https://doi.org/10.1172/jci58525openalex-snapshot

Oxidative stress fuels Trypanosoma cruzi infection in mice

inferredcites →https://doi.org/10.1179/135100001101536328openalex-snapshot

Time-dependent oxidative stress caused by benznidazole

inferredcites →https://doi.org/10.1371/journal.pntd.0000931openalex-snapshot

International Study to Evaluate PCR Methods for Detection of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients

inferredcites →https://doi.org/10.1371/journal.pntd.0003207openalex-snapshot

Ruthenium Complex with Benznidazole and Nitric Oxide as a New Candidate for the Treatment of Chagas Disease

inferredcites →https://doi.org/10.1371/journal.pntd.0003464openalex-snapshot

Trypanosoma cruzi Infection Is a Potent Risk Factor for Non-alcoholic Steatohepatitis Enhancing Local and Systemic Inflammation Associated with Strong Oxidative Stress and Metabolic Disorders

inferredcites →https://doi.org/10.1371/journal.pone.0185033openalex-snapshot

Risk factors for treatment interruption and severe adverse effects to benznidazole in adult patients with Chagas disease

inferredcites →https://doi.org/10.1586/14787210.7.2.157openalex-snapshot

Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities

inferredcites →https://doi.org/10.1586/17512433.2014.909282openalex-snapshot

Potential new clinical therapies for Chagas disease

inferredcites →https://doi.org/10.1590/0037-8682-0248-2013openalex-snapshot

The present situation, challenges, and perspectives regarding the production and utilization of effective drugs against human Chagas disease

inferredcites →https://doi.org/10.1590/0074-0276140156openalex-snapshot

Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity

inferredcites →https://doi.org/10.1590/s0036-46652012000600006openalex-snapshot

Effects of vitamin C supplementation on acute phase Chagas disease in experimentally infected mice with Trypanosoma cruzi QM1 strain

inferredcites →https://doi.org/10.1590/s0074-02762010000200022openalex-snapshot

In vitro and in vivo experimental models for drug screening and development for Chagas disease

inferredcites →https://doi.org/10.3390/diseases4030028openalex-snapshot

Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention

inferredcites →https://doi.org/10.3390/ijms17081328openalex-snapshot

Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies

inferredcites →https://doi.org/10.4103/0253-7613.84952openalex-snapshot

Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats

inferredcites →https://doi.org/10.4269/ajtmh.2008.79.427openalex-snapshot

Rural Triatoma rubrovaria from Southern Brazil Harbors Trypanosoma cruzi of Lineage IIc

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4746016openalex-extracted

Chagas Disease: History, Pathophysiology and Therapeutic Treatment

inferred← citeshttps://doi.org/10.1016/j.actatropica.2021.106210openalex-snapshot

Drug associations as alternative and complementary therapy for neglected tropical diseases

inferred← citeshttps://doi.org/10.1016/j.arabjc.2021.103641openalex-snapshot

Synthesis and study of the trypanocidal activity of catechol-containing 3-arylcoumarins, inclusion in β-cyclodextrin complexes and combination with benznidazole

inferred← citeshttps://doi.org/10.1016/j.arcmed.2024.103084openalex-snapshot

New Drugs and Promising Drug Combinations in the Treatment of Chagas Disease in Brazil: A Systematic Review and Meta-Analysis

inferred← citeshttps://doi.org/10.1016/j.biopha.2018.10.057openalex-snapshot

In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex

inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115855openalex-snapshot

Trypanocidal activity of new 1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine derivatives: Synthesis, in vitro and in vivo studies

inferred← citeshttps://doi.org/10.1016/j.ijpddr.2019.11.004openalex-snapshot

Current trends in the pharmacological management of Chagas disease

inferred← citeshttps://doi.org/10.1016/j.imbio.2020.152024openalex-snapshot

Hypothyroidism impairs the host immune response during the acute phase of Chagas disease

inferred← citeshttps://doi.org/10.1017/s0031182021001001openalex-snapshot

Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment

inferred← citeshttps://doi.org/10.1021/acsinfecdis.8b00284openalex-snapshot

Organometallic Gold(III) Complex [Au(Hdamp)(L14)]+ (L1 = SNS-Donating Thiosemicarbazone) as a Candidate to New Formulations against Chagas Disease

inferred← citeshttps://doi.org/10.1080/13543776.2023.2176219openalex-snapshot

Are patents important indicators of innovation for Chagas disease treatment?

inferred← citeshttps://doi.org/10.1080/14760584.2021.1969230openalex-snapshot

Oxidative stress implications for therapeutic vaccine development against Chagas disease

inferred← citeshttps://doi.org/10.1080/17460441.2022.2117295openalex-snapshot

Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?

inferred← citeshttps://doi.org/10.1093/jac/dkac093openalex-snapshot

Mitigation of benznidazole toxicity and oxidative stress following ascorbic acid supplementation in an adult traveller with chronic indeterminate Chagas’ disease

inferred← citeshttps://doi.org/10.1139/cjpp-2020-0473openalex-snapshot

Melatonin decreases circulating Trypanosoma cruzi load with no effect on tissue parasite replication

inferred← citeshttps://doi.org/10.1155/2019/8301569openalex-snapshot

Phenothiazinium Dyes Are Active againstTrypanosoma cruziIn Vitro

inferred← citeshttps://doi.org/10.1155/2020/9081813openalex-snapshot

Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease

inferred← citeshttps://doi.org/10.11606/t.60.2022.tde-01072022-084441openalex-snapshot

Consequências do hipotireoidismo na doença de Chagas experimental

inferred← citeshttps://doi.org/10.11606/t.60.2022.tde-05102022-112652openalex-snapshot

Estudo sobre o efeito tripanocida e antioxidante do ácido ascórbico no tratamento da doença de Chagas experimental

inferred← citeshttps://doi.org/10.1371/journal.pntd.0007980openalex-snapshot

Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways

inferred← citeshttps://doi.org/10.1371/journal.pntd.0012612openalex-snapshot

Heart function enhancement by an Nrf2-activating antioxidant in acute Y-strain Chagas disease, but not in chronic Colombian or Y-strain

inferred← citeshttps://doi.org/10.1371/journal.ppat.1012012openalex-snapshot

Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease

inferred← citeshttps://doi.org/10.2147/jep.s267378openalex-snapshot

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

inferred← citeshttps://doi.org/10.3389/fmicb.2020.563320openalex-snapshot

Priming Astrocytes With HIV-Induced Reactive Oxygen Species Enhances Their Trypanosoma cruzi Infection

inferred← citeshttps://doi.org/10.3390/antiox10071022openalex-snapshot

The Use of Antioxidants as Potential Co-Adjuvants to Treat Chronic Chagas Disease

inferred← citeshttps://doi.org/10.5772/intechopen.104231openalex-snapshot

Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning

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