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Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/em.2860050512openalex-snapshot

Mutagenicity of nitrofuran derivatives: Review

inferredcites →https://doi.org/10.1002/j.1460-2075.1990.tb07462.xopenalex-snapshot

Trypanosoma cruzi glycosomal glyceraldehyde‐3‐phosphate dehydrogenase does not conform to the ‘hotspot’ topogenic signal model.

inferredcites →https://doi.org/10.1006/abbi.2000.2127openalex-snapshot

Quantitative Structure–Activity Relationships in Two-Electron Reduction of Nitroaromatic Compounds by Enterobacter cloacae NAD(P)H:Nitroreductase

inferredcites →https://doi.org/10.1016/0003-2697(77)90597-8openalex-snapshot

The use of Girard-T reagent in a rapid and sensitive method for measuring glyoxal and certain other α-dicarbonyl compounds

inferredcites →https://doi.org/10.1016/0003-9861(82)90383-6openalex-snapshot

Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations

inferredcites →https://doi.org/10.1016/0006-2952(86)90005-5openalex-snapshot

Induction of DNA strand breaks by reduced nitroimidazoles

inferredcites →https://doi.org/10.1016/0006-2952(86)90565-4openalex-snapshot

The biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms

inferredcites →https://doi.org/10.1016/0006-2952(87)90181-xopenalex-snapshot

Nitroimidazole bioreductive metabolism

inferredcites →https://doi.org/10.1016/0006-2952(90)90086-zopenalex-snapshot

Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules

inferredcites →https://doi.org/10.1016/0009-2797(82)90105-3openalex-snapshot

Drug residue formation from ronidazole, a 5-nitroimidazole. I. Characterization of in vitro protein alkylation

inferredcites →https://doi.org/10.1016/0009-2797(85)90011-0openalex-snapshot

Properties of 2-hydroxylaminoimidazoles and their implications for the biological effects of 2-nitroimidazoles

inferredcites →https://doi.org/10.1016/j.actatropica.2006.10.004openalex-snapshot

Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole

inferredcites →https://doi.org/10.1016/j.actatropica.2008.04.011openalex-snapshot

Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2005.06.021openalex-snapshot

The presence of four iron-containing superoxide dismutase isozymes in Trypanosomatidae: Characterization, subcellular localization, and phylogenetic origin in Trypanosoma brucei

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2005.06.022openalex-snapshot

Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei

inferredcites →https://doi.org/10.1016/j.molbiopara.2005.08.009openalex-snapshot

Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects

inferredcites →https://doi.org/10.1016/j.molbiopara.2008.09.005openalex-snapshot

Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes

inferredcites →https://doi.org/10.1016/j.molbiopara.2010.11.010openalex-snapshot

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

inferredcites →https://doi.org/10.1016/s0006-2952(02)01663-5openalex-snapshot

Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives

inferredcites →https://doi.org/10.1016/s0021-9258(17)44193-7openalex-snapshot

Hydrogenosomal ferredoxin of the anaerobic protozoon, Tritrichomonas foetus.

inferredcites →https://doi.org/10.1016/s0021-9258(18)50687-6openalex-snapshot

Oxygen-sensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes.

inferredcites →https://doi.org/10.1016/s0026-895x(25)10179-xopenalex-snapshot

Biochemistry of misonidazole reduction by NADPH-cytochrome c (P-450) reductase.

inferredcites →https://doi.org/10.1016/s0026-895x(25)14090-xopenalex-snapshot

The Reductive Metabolism of Metronidazole and Ronidazole by Aerobic Liver Microsomes

inferredcites →https://doi.org/10.1016/s0166-6851(98)00127-3openalex-snapshot

Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole

inferredcites →https://doi.org/10.1021/bi00679a013openalex-snapshot

Mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates

inferredcites →https://doi.org/10.1021/tx00009a004openalex-snapshot

Covalent interaction of 5-nitroimidazoles with DNA and protein in vitro: mechanism of reductive activation

inferredcites →https://doi.org/10.1038/35016103openalex-snapshot

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

inferredcites →https://doi.org/10.1042/bj20060882openalex-snapshot

Trypanothione-dependent glyoxalase I in Trypanosoma cruzi

inferredcites →https://doi.org/10.1042/bj2690001openalex-snapshot

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

inferredcites →https://doi.org/10.1046/j.1365-2958.1998.00806.xopenalex-snapshot

Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen‐insensitive NADPH nitroreductase

inferredcites →https://doi.org/10.1073/pnas.0711014105openalex-snapshot

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

inferredcites →https://doi.org/10.1074/jbc.m111.230847openalex-snapshot

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

inferredcites →https://doi.org/10.1086/605091openalex-snapshot

An Estimate of the Burden of Chagas Disease in the United States

inferredcites →https://doi.org/10.1111/j.1742-4658.2008.06788.xopenalex-snapshot

A comparative study of methylglyoxal metabolism in trypanosomatids

inferredcites →https://doi.org/10.1111/j.1742-4658.2009.07060.xopenalex-snapshot

Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori

inferredcites →https://doi.org/10.1128/aac.00332-10openalex-snapshot

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

inferredcites →https://doi.org/10.1128/aac.01213-09openalex-snapshot

Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase

inferredcites →https://doi.org/10.1128/aac.01360-06openalex-snapshot

Deletion of the Trypanosoma brucei Superoxide Dismutase Gene sodb1 Increases Sensitivity to Nifurtimox and Benznidazole

inferredcites →https://doi.org/10.1128/aac.49.12.5033-5036.2005openalex-snapshot

Alternative Pathway of Metronidazole Activation in Trichomonas vaginalis Hydrogenosomes

inferredcites →https://doi.org/10.1139/v89-331openalex-snapshot

4,5-Dihydro-4,5-dihydroxyimidazoles as products of the reduction of 2-nitroimidazoles. HPLC assay and demonstration of equilibrium transfer of glyoxal to guanine

inferredcites →https://doi.org/10.1155/2009/463575openalex-snapshot

Genotoxicity Revaluation of Three Commercial Nitroheterocyclic Drugs: Nifurtimox, Benznidazole, and Metronidazole

inferredcites →https://doi.org/10.1172/jci33945openalex-snapshot

Kinetoplastids: related protozoan pathogens, different diseases

inferredcites →https://doi.org/10.1191/0960327106het653oaopenalex-snapshot

Toxic Side Effects of Drugs Used to Treat Chagas’ Disease (American Trypanosomiasis)

inferredcites →https://doi.org/10.1289/ehp.8564199openalex-snapshot

Mechanism of Toxicity of Nitro Compounds Used in the Chemotherapy of Trichomoniasis

inferredcites →https://doi.org/10.1289/ehp.8564309openalex-snapshot

Some Reactions and Properties of Nitro Radical-Anions Important in Biology and Medicine

inferredcites →https://doi.org/10.1371/journal.pbio.0050211openalex-snapshot

Nitroimidazole Action in Entamoeba histolytica: A Central Role for Thioredoxin Reductase

inferredcites →https://doi.org/10.1515/dmdi.2008.23.1-2.125openalex-snapshot

PROTEIN AND NUCLEOTIDE DAMAGE BY GLYOXAL AND METHYLGLYOXAL IN PHYSIOLOGICAL SYSTEMS - ROLE IN AGEING AND DISEASE

inferredcites →https://doi.org/10.1590/s0074-02762009000900042openalex-snapshot

The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease

inferredcites →https://doi.org/10.2174/138945008786786082openalex-snapshot

Glyoxalase Pathway of Trypanosomatid Parasites: A Promising Chemotherapeutic Target

inferredcites →https://doi.org/10.2307/3282883openalex-snapshot

Continuous Cultivation of Trypanosoma brucei Blood Stream Forms in a Medium Containing a Low Concentration of Serum Protein without Feeder Cell Layers

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Transcriptome and Functional Genomics Reveal the Participation of Adenine Phosphoribosyltransferase in Trypanosoma cruzi Resistance to Benznidazole

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Expression Analysis of Thirteen Genes in Response to Nifurtimox and Benznidazole in Mexican Isolates of Trypanosoma cruzi by Digital PCR

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The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2)

inferred← citeshttps://doi.org/10.1016/j.toxlet.2023.02.001openalex-snapshot

Major benznidazole metabolites in patients treated for Chagas disease: Mass spectrometry-based identification, structural analysis and detoxification pathways

inferred← citeshttps://doi.org/10.1017/s003118201300022xopenalex-snapshot

Genetic dissection of drug resistance in trypanosomes

inferred← citeshttps://doi.org/10.1017/s0031182014000882openalex-snapshot

Therapeutic responses to different anti-Trypanosoma cruzidrugs in experimental infection by benznidazole-resistant parasite stock

inferred← citeshttps://doi.org/10.1017/s0031182015001419openalex-snapshot

In vitro trichomonacidal activity and preliminary in silico chemometric studies of 5-nitroindazolin-3-one and 3-alkoxy-5-nitroindazole derivatives

inferred← citeshttps://doi.org/10.1017/s0031182019000970openalex-snapshot

Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?

inferred← citeshttps://doi.org/10.1021/acs.analchem.5b04032openalex-snapshot

Mass Spectrometry Imaging of the Hypoxia Marker Pimonidazole in a Breast Tumor Model

inferred← citeshttps://doi.org/10.1021/acs.est.5c04614openalex-snapshot

Multiscale-Information-Embedded Universal Toxicity Prediction Framework

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01745openalex-snapshot

Design and Synthesis of Novel 3-Nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted Analogs as Promising Antitrypanosomatid Agents: Evaluation of In Vitro Activity against Chagas Disease and Leishmaniasis

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00143openalex-snapshot

Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00147openalex-snapshot

Nitro-Group-Containing Drugs

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00468openalex-snapshot

Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00651openalex-snapshot

In Vivo Biological Evaluation of a Synthetic Royleanone Derivative as a Promising Fast-Acting Trypanocidal Agent by Inducing Mitochondrial-Dependent Necrosis

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.4c00811openalex-snapshot

Semisynthetic Ecdysteroid Cinnamate Esters and tert-Butyl Oxime Ether Derivatives with Trypanocidal Activity

inferred← citeshttps://doi.org/10.1021/acsinfecdis.1c00048openalex-snapshot

Selenium Derivatives as Promising Therapy for Chagas Disease: In Vitro and In Vivo Studies

inferred← citeshttps://doi.org/10.1021/acsinfecdis.2c00569openalex-snapshot

Genetic Characterization of Trypanosoma cruzi I Populations from an Oral Chagas Disease Outbreak in Venezuela: Natural Resistance to Nitroheterocyclic Drugs

inferred← citeshttps://doi.org/10.1021/acsinfecdis.5c00900openalex-snapshot

Identification of Antifungal Agents AR-12 and Fosmanogepix as Anti- Trypanosoma cruzi Drugs through an Enhanced Fluorogenic β-Galactosidase Phenotypic Screening Assay

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.8b00347openalex-snapshot

Nongenotoxic 3-Nitroimidazo[1,2- a ]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.9b00566openalex-snapshot

New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi

inferred← citeshttps://doi.org/10.1021/acsomega.4c11645openalex-snapshot

Synthesis and Biological Evaluation of 4-(4-Nitrophenyl)-1H-1,2,3-triazole Derivatives as Antitrypanosomal Agents

inferred← citeshttps://doi.org/10.1021/acsomega.5c06619openalex-snapshot

Design, Synthesis, and Trypanosomicidal Evaluation of Eugenol-Based Azole Hybrids: Discovery of an In Vitro Active and Selective Compound

inferred← citeshttps://doi.org/10.1021/acsomega.5c09284openalex-snapshot

Contribution to the Chemotherapy of Human Trypanosomiasis: Design, Synthesis, and Biological Evaluation of Dimeric 2-Nitroimidazoles against Trypanosoma cruzi Amastigotes and Bloodstream Trypanosoma brucei

inferred← citeshttps://doi.org/10.1021/jm3011004openalex-snapshot

Phthalazine Derivatives Containing Imidazole Rings Behave as Fe-SOD Inhibitors and Show Remarkable Anti- T. cruzi Activity in Immunodeficient-Mouse Mode of Infection

inferred← citeshttps://doi.org/10.1021/jm500018mopenalex-snapshot

Optimization of Antitrypanosomatid Agents: Identification of Nonmutagenic Drug Candidates with in Vivo Activity

inferred← citeshttps://doi.org/10.1038/nmicrobiol.2016.92openalex-snapshot

Drug resistance in eukaryotic microorganisms

inferred← citeshttps://doi.org/10.1038/nrd.2018.46openalex-snapshot

The expanding role of prodrugs in contemporary drug design and development

inferred← citeshttps://doi.org/10.1038/s41467-025-60989-7openalex-snapshot

ToxACoL: an endpoint-aware and task-focused compound representation learning paradigm for acute toxicity assessment

inferred← citeshttps://doi.org/10.1038/s41573-024-00914-7openalex-snapshot

The landscape of small-molecule prodrugs

inferred← citeshttps://doi.org/10.1038/s41598-017-14986-6openalex-snapshot

Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole

inferred← citeshttps://doi.org/10.1038/s41598-020-73848-wopenalex-snapshot

ZIF-8 as a promising drug delivery system for benznidazole: development, characterization, in vitro dialysis release and cytotoxicity

inferred← citeshttps://doi.org/10.1038/srep35351openalex-snapshot

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

inferred← citeshttps://doi.org/10.1039/c6md00035eopenalex-snapshot

New hydrazones of 5-nitro-2-furaldehyde with adamantanealkanohydrazides: synthesis and in vitro trypanocidal activity

inferred← citeshttps://doi.org/10.1039/d0md00122hopenalex-snapshot

Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases

inferred← citeshttps://doi.org/10.1039/d2cs00957aopenalex-snapshot

Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates

inferred← citeshttps://doi.org/10.1042/bcj20180232openalex-snapshot

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism

inferred← citeshttps://doi.org/10.1074/jbc.m113.494781openalex-snapshot

An Essential Type I Nitroreductase from Leishmania major Can Be Used to Activate Leishmanicidal Prodrugs

inferred← citeshttps://doi.org/10.1080/07391102.2023.2272750openalex-snapshot

The Amaryllidaceae alkaloid, montanine, is a potential inhibitor of the Trypanosoma cruzi trans-sialidase enzyme

inferred← citeshttps://doi.org/10.1080/10406638.2022.2150653openalex-snapshot

Synthesis, Characterization and Theoretical Investigations on the Molecular Structure, Electronic Property and anti-Trypanosomal Activity of Benzenesulphonamide-Based Carboxamide and Its Derivatives

inferred← citeshttps://doi.org/10.1080/13543776.2021.1970746openalex-snapshot

Why do few drug delivery systems to combat neglected tropical diseases reach the market? An analysis from the technology’s stages

inferred← citeshttps://doi.org/10.1080/14656566.2019.1650915openalex-snapshot

An evaluation of benznidazole as a Chagas disease therapeutic

inferred← citeshttps://doi.org/10.1080/14787210.2021.1834849openalex-snapshot

Benznidazole for the treatment of Chagas disease

inferred← citeshttps://doi.org/10.1080/17460441.2024.2349155openalex-snapshot

New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi , the causative agent of Chagas disease

inferred← citeshttps://doi.org/10.1093/jac/dkv376openalex-snapshot

Nitroheterocyclic drug resistance mechanisms inTrypanosoma brucei

inferred← citeshttps://doi.org/10.1098/rsos.170773openalex-snapshot

Prostaglandin F2α synthase in Trypanosoma cruzi plays critical roles in oxidative stress and susceptibility to benznidazole

inferred← citeshttps://doi.org/10.1101/2020.03.26.009753openalex-snapshot

Thiol efflux mediated by an ABCC-like transporter participates for Trypanosoma cruzi adaptation to environmental and chemotherapeutic stresses

inferred← citeshttps://doi.org/10.1101/2023.08.23.554400openalex-snapshot

Trypanosoma cruzi persisters that survive benznidazole treatment in vitro and in vivo are in a transient non-replicative state

inferred← citeshttps://doi.org/10.1101/2023.10.09.561529openalex-snapshot

Fexinidazole induced cytotoxicity is distinct from related anti-trypanosome nitroaromatic drugs

inferred← citeshttps://doi.org/10.1111/bcp.14700openalex-snapshot

Review of pharmacological options for the treatment of Chagas disease

inferred← citeshttps://doi.org/10.1111/jphp.12451openalex-snapshot

Modulation of oxidative and inflammatory cardiac response by nonselective 1- and 2-cyclooxygenase inhibitor and benznidazole in mice

inferred← citeshttps://doi.org/10.1111/mmi.13767openalex-snapshot

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

inferred← citeshttps://doi.org/10.1111/mmi.13773openalex-snapshot

Cherchez l'Electron

inferred← citeshttps://doi.org/10.1111/mmi.13830openalex-snapshot

Aldo‐keto reductase and alcohol dehydrogenase contribute to benznidazole natural resistance in Trypanosoma cruzi

inferred← citeshttps://doi.org/10.1111/mmi.14763openalex-snapshot

Unraveling the antitrypanosomal mechanism of benznidazole and related 2‐nitroimidazoles: From prodrug activation to DNA damage

inferred← citeshttps://doi.org/10.1126/scitranslmed.adu4564openalex-snapshot

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease

inferred← citeshttps://doi.org/10.1128/aac.00514-18openalex-snapshot

Benefits of Ascorbic Acid in Association with Low-Dose Benznidazole in Treatment of Chagas Disease

inferred← citeshttps://doi.org/10.1128/aac.00520-15openalex-snapshot

Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging

inferred← citeshttps://doi.org/10.1128/aac.00779-15openalex-snapshot

Concomitant Benznidazole and Suramin Chemotherapy in Mice Infected with a Virulent Strain of Trypanosoma cruzi

inferred← citeshttps://doi.org/10.1128/aac.01135-20openalex-snapshot

Adverse Events Associated with Nifurtimox Treatment for Chagas Disease in Children and Adults

inferred← citeshttps://doi.org/10.1128/aac.01227-12openalex-snapshot

Targeting the Substrate Preference of a Type I Nitroreductase To Develop Antitrypanosomal Quinone-Based Prodrugs

inferred← citeshttps://doi.org/10.1128/aac.01459-13openalex-snapshot

Evaluating Aziridinyl Nitrobenzamide Compounds as Leishmanicidal Prodrugs

inferred← citeshttps://doi.org/10.1128/aac.02046-12openalex-snapshot

Evaluating 5-Nitrofurans as Trypanocidal Agents

inferred← citeshttps://doi.org/10.1128/aac.02185-15openalex-snapshot

Putative Role of the Aldo-Keto Reductase from Trypanosoma cruzi in Benznidazole Metabolism

inferred← citeshttps://doi.org/10.1128/aac.02531-12openalex-snapshot

Modulation of Biotransformation Systems and ABC Transporters by Benznidazole in Rats

inferred← citeshttps://doi.org/10.1128/aac.02765-14openalex-snapshot

Nitro/Nitrosyl-Ruthenium Complexes Are Potent and Selective Anti-Trypanosoma cruzi Agents Causing Autophagy and Necrotic Parasite Death

inferred← citeshttps://doi.org/10.1128/cmr.00153-23openalex-snapshot

Transforming the chemotherapy of human African trypanosomiasis

inferred← citeshttps://doi.org/10.1128/mbio.01788-17openalex-snapshot

Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins

inferred← citeshttps://doi.org/10.1128/spectrum.04132-25openalex-snapshot

Revisiting cysteine protease function in Trypanosoma cruzi : implications for parasite egress and differentiation

inferred← citeshttps://doi.org/10.1155/2020/9081813openalex-snapshot

Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease

inferred← citeshttps://doi.org/10.1155/2021/2642807openalex-snapshot

A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

inferred← citeshttps://doi.org/10.11606/d.42.2018.tde-09032023-180834openalex-snapshot

Busca de novos compostos anti->i /i< e mapeamento da resistência natural a benznidazol em tripanossomatídeos

inferred← citeshttps://doi.org/10.11606/d.60.2020.tde-19122019-082308openalex-snapshot

Estudos estruturais da enzima nitrorredutase de Trypanosoma cruzi: caracterização do mecanismo de ativação dos pró-fármacos benznidazol e nifurtimox

inferred← citeshttps://doi.org/10.11606/t.60.2014.tde-15052014-084203openalex-snapshot

Caracterização estrutural e funcional das isoformas da enzima fumarato hidratase de Trypanosoma cruzi

inferred← citeshttps://doi.org/10.11606/t.60.2019.tde-24052019-154809openalex-snapshot

Síntese de novas quinazolinas para tratamento de tumores sob hipóxia e nitroimidazol para diagnóstico por PET

inferred← citeshttps://doi.org/10.11606/t.60.2019.tde-27102021-110709openalex-snapshot

Determinação >i /i< e >i /i< do efeito tripanocida de corantes fenotiazínicos na infecção por >i /i<

inferred← citeshttps://doi.org/10.11606/t.60.2022.tde-05102022-112652openalex-snapshot

Estudo sobre o efeito tripanocida e antioxidante do ácido ascórbico no tratamento da doença de Chagas experimental

inferred← citeshttps://doi.org/10.11606/t.9.2021.tde-13052022-105310openalex-snapshot

Planejamento e desenvolvimento de novos compostos com atividade frente a >i /i< spp: Síntese, avaliação da atividade e toxicidade de derivados 5-nitro-2-furfurilidênicos e estudos de relações estrutura-atividade

inferred← citeshttps://doi.org/10.1177/1087057114546896openalex-snapshot

Discovery of New Uncompetitive Inhibitors of Glucose-6-Phosphate Dehydrogenase

inferred← citeshttps://doi.org/10.1186/s13071-019-3485-9openalex-snapshot

Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole

inferred← citeshttps://doi.org/10.1186/s13071-023-05775-4openalex-snapshot

Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations

inferred← citeshttps://doi.org/10.1186/s40360-015-0010-4openalex-snapshot

Trypanocidal effect of the benzyl ester of N-propyl oxamate: a bi-potential prodrug for the treatment of experimental Chagas disease

inferred← citeshttps://doi.org/10.1371/journal.pntd.0001951openalex-snapshot

Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

inferred← citeshttps://doi.org/10.1371/journal.pntd.0002844openalex-snapshot

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

inferred← citeshttps://doi.org/10.1371/journal.pntd.0003707openalex-snapshot

The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence

inferred← citeshttps://doi.org/10.1371/journal.pntd.0005169openalex-snapshot

Quantitative Laser Biospeckle Method for the Evaluation of the Activity of Trypanosoma cruzi Using VDRL Plates and Digital Analysis

inferred← citeshttps://doi.org/10.1371/journal.pntd.0008068openalex-snapshot

Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites

inferred← citeshttps://doi.org/10.1371/journal.pntd.0009978openalex-snapshot

Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease

inferred← citeshttps://doi.org/10.1371/journal.pntd.0010845openalex-snapshot

Disruption of multiple copies of the Prostaglandin F2alpha synthase gene affects oxidative stress response and infectivity in Trypanosoma cruzi

inferred← citeshttps://doi.org/10.1371/journal.pntd.0012968openalex-snapshot

Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease

inferred← citeshttps://doi.org/10.1371/journal.pntd.0013522openalex-snapshot

Population pharmacokinetic-pharmacodynamic analysis of benznidazole monotherapy and combination therapy with fosravuconazole in chronic Chagas disease (BENDITA)

inferred← citeshttps://doi.org/10.1371/journal.pntd.0013647openalex-snapshot

Fexinidazole results in specific effects on DNA synthesis and DNA damage in the African trypanosome

inferred← citeshttps://doi.org/10.1371/journal.ppat.1005971openalex-snapshot

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

inferred← citeshttps://doi.org/10.1371/journal.ppat.1006928openalex-snapshot

ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart

inferred← citeshttps://doi.org/10.1371/journal.ppat.1011627openalex-snapshot

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

inferred← citeshttps://doi.org/10.14393/ufu.di.2015.13openalex-snapshot

Impacto da galectina-3 no curso da infecção experimental por Trypanosoma cruzi

inferred← citeshttps://doi.org/10.14393/ufu.di.2023.8121openalex-snapshot

A proteína P21 de Trypanosoma cruzi das cepas G e Y apresenta atividade pleiotrópica na invasão, multiplicação celular, eclosão in vitro e no parasitismo tecidual in vivo

inferred← citeshttps://doi.org/10.14393/ufu.te.2019.1238openalex-snapshot

Propriedades biológicas das proteínas Galectina-3 e rP21 na infecção por Trypanosoma cruzi in vitro e in vivo

inferred← citeshttps://doi.org/10.1515/znb-2020-0108openalex-snapshot

A study of antituberculosis activities and crystal structures of (E)-2-[2-(arylidene)hydrazinyl]pyrimidine and (E)-N 1-(arylidene)pyrimidine-2-carbohydrazide derivatives

inferred← citeshttps://doi.org/10.1517/17460441.2012.668520openalex-snapshot

Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease

inferred← citeshttps://doi.org/10.1586/17512433.2014.909282openalex-snapshot

Potential new clinical therapies for Chagas disease

inferred← citeshttps://doi.org/10.1590/0074-02760220164openalex-snapshot

Genomic surveillance: a potential shortcut for effective Chagas disease management

inferred← citeshttps://doi.org/10.1590/0074-02760250296openalex-snapshot

In vitro anti-Trypanosomatid activity and chemical profile of crude extracts of Chromolaena hookeriana and Campuloclinium macrocephalum (Asteraceae)

inferred← citeshttps://doi.org/10.1590/s2175-97902019000218034openalex-snapshot

Presence of benznidazole conjugated metabolites in urine identified by β-glucuronidase treatment

inferred← citeshttps://doi.org/10.2174/0929867325666180426164352openalex-snapshot

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

inferred← citeshttps://doi.org/10.2174/1568026622666220912101332openalex-snapshot

Mechanism of Action and Implication of Naphthoquinone as Potent Anti-trypanosomal Drugs

inferred← citeshttps://doi.org/10.2174/1570180816666181031125946openalex-snapshot

Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities

inferred← citeshttps://doi.org/10.2174/9789815324785125010006openalex-snapshot

Chagas Diseases: State of the Art and New Perspectives

inferred← citeshttps://doi.org/10.2174/9789815324785125010007openalex-snapshot

Novel Agents against Human African Trypanosomiasis: Updates on Medicinal Chemistry and Target Identification

inferred← citeshttps://doi.org/10.22159/ijap.2021v13i6.42794openalex-snapshot

LATENTIATED PRODRUG APPROACH OF DRUGS: AN OVERVIEW

inferred← citeshttps://doi.org/10.29327/2335218.1.3-8openalex-snapshot

Avaliação panorâmica da doença de chagas na América Latina

inferred← citeshttps://doi.org/10.31038/jppr.2019233openalex-snapshot

Cruzain Inhibitors as Prominent Molecules with The Potential to become Drug Candidates against Chagas Disease

inferred← citeshttps://doi.org/10.3389/fchem.2026.1815438openalex-snapshot

Trypanosomatid parasites, translational research in a One Health, One World environment

inferred← citeshttps://doi.org/10.3389/fcimb.2019.00435openalex-snapshot

Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in Trypanosoma cruzi

inferred← citeshttps://doi.org/10.3389/fcimb.2022.749476openalex-snapshot

Trypanosoma cruzi Mitochondrial Peroxiredoxin Promotes Infectivity in Macrophages and Attenuates Nifurtimox Toxicity

inferred← citeshttps://doi.org/10.3389/fddsv.2023.1185679openalex-snapshot

The critical role of mode of action studies in kinetoplastid drug discovery

inferred← citeshttps://doi.org/10.3389/fphar.2026.1812023openalex-snapshot

Structure-enabled enhancement of potency in a metronidazole–benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole

inferred← citeshttps://doi.org/10.3390/biom11020267openalex-snapshot

Nitroaromatic Antibiotics as Nitrogen Oxide Sources

inferred← citeshttps://doi.org/10.3390/biom13040637openalex-snapshot

Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates

inferred← citeshttps://doi.org/10.3390/books978-3-03928-964-6openalex-snapshot

Human African Trypanosomiasis (Sleeping Sickness)

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