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Isolation and structure of combretastatin

https://doi.org/10.1139/v82-202
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inferredcites →https://doi.org/10.1016/0006-2952(83)90163-6openalex-snapshot
Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin
inferredcites →https://doi.org/10.1080/00397918308080891openalex-snapshot
Synthesis of (±) Combretastatin

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Starvation tactics for solid tumors: tumor blood flow interruption via a combretastatin derivative (Cderiv), and its microcirculation mechanism
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Pyrazoles, isoxazoles, and 1,2,3-triazoles as analogs of the natural cytostatic combretastatin A-4: efficient routes of synthesis, tubulin inhibition, and cytotoxicity
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Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin
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Cornigerine, a potent antimitotic colchicum alkaloid of unusual structure
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Bioactive stilbenes from plants
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Drug-linker constructs bearing unique dual-mechanism tubulin binding payloads tethered through cleavable and non-cleavable linkers
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Three dihydroisocoumarin glucosides from Hydrangea macrophylla subsp. serrata
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Phenolic constituents of Coelogyne ovalis
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Plants used against cancer – an extension of the work of Jonathan Hartwell
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The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4
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A new anti-tubulin agent containing the benzo[b]thiophene ring system
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Leishmanicidal activity of combretastatin analogues and heteroanalogues
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Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on β-tubulin
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Synthesis and biological evaluation of aryl azide derivatives of combretastatin a-4 as molecular probes for tubulin
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Simple Flavones Possessing Complex Biological Activity
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Antibacterial activities and bioactive compounds of the ethyl acetate extract of the sea cucumberHolothuria forskalifrom Tunisian coasts
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Chalcone: A Privileged Structure in Medicinal Chemistry
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Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Iso combretastatins and Phenstatins as Antitumor Agents
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Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
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Synthesis and Cytotoxicity Studies of Stilbene Long-Chain Fatty Acid Conjugates
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Catalytic sp3C–CN Bond Cleavage: Ni-Mediated Phosphorylation of Alkylnitriles
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Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization
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Combretastatin A4-β-Galactosyl Conjugates for Ovarian Cancer Prodrug Monotherapy
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First Divergent Total Synthesis of (±)-Nobilin D and Structurally Related Bibenzyl Natural Products
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Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin
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Heterocyclic and Phenyl Double-Bond-Locked Combretastatin Analogues Possessing Potent Apoptosis-Inducing Activity in HL60 and in MDR Cell Lines
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Design and Synthesis of Cyclopropylamide Analogues of Combretastatin-A4 as Novel Microtubule-Stabilizing Agents
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Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents
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Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents
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Preparation of New Anti-Tubulin Ligands through a Dual-Mode, Addition−Elimination Reaction to a Bromo-Substituted α,β-Unsaturated Sulfoxide
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Novel Syntheses of Cis and Trans Isomers of Combretastatin A-4
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p,p-Dihydroxydihydrostilbenophanes Related to Antimitotic Combretastatins. Conformational Analysis and Its Relationship to Tubulin Inhibition
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Combretastatin Dinitrogen-Substituted Stilbene Analogues as Tubulin-Binding and Vascular-Disrupting Agents
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Gordon M. Cragg, D.Phil., D.Sc. ( h.c .): A Man for All Natural Products
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cis-Restricted 3-Aminopyrazole Analogues of Combretastatins: Synthesis from Plant Polyalkoxybenzenes and Biological Evaluation in the Cytotoxicity and Phenotypic Sea Urchin Embryo Assays
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Synthesis of a 2-Aryl-3-aroyl Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent
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Special Issue in Honor of Professor George Robert Pettit
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Antineoplastic Agents. 565. Synthesis of Combretastatin D-2 Phosphate and Dihydro-combretastatin D-2
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Antineoplastic Agents. 579. Synthesis and Cancer Cell Growth Evaluation of E-Stilstatin 3: A Resveratrol Structural Modification
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Quantitative Structure–Activity Relationship Analysis of Combretastatins: A Class of Novel Antimitotic Agents
inferred← citeshttps://doi.org/10.1038/s41598-022-05958-6openalex-snapshot
Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies
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Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site
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Combretastatins: from natural products to drug discovery
inferred← citeshttps://doi.org/10.1039/b905960aopenalex-snapshot
Natural stilbenes: an overview
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Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications
inferred← citeshttps://doi.org/10.1039/c4ob02449dopenalex-snapshot
Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers
inferred← citeshttps://doi.org/10.1039/c4ob02606copenalex-snapshot
Synthesis of phenstatin/isocombretastatin–chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers
inferred← citeshttps://doi.org/10.1039/c4ra07998aopenalex-snapshot
The convenient aqueous synthesis and biological evaluation of ortho-(3,4,5-trimethoxybenzoyl)-acetanilides as novel anti-cancer agents
inferred← citeshttps://doi.org/10.1039/c5md00139kopenalex-snapshot
Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents
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Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents
inferred← citeshttps://doi.org/10.1039/c5ob00232jopenalex-snapshot
Synthesis of 2-anilinopyridyl–triazole conjugates as antimitotic agents
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Photoswitchable anticancer activity via trans–cis isomerization of a combretastatin A-4 analog
inferred← citeshttps://doi.org/10.1039/c5ra19270fopenalex-snapshot
Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents
inferred← citeshttps://doi.org/10.1039/c6ob02507bopenalex-snapshot
Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors
inferred← citeshttps://doi.org/10.1039/c6ra16948aopenalex-snapshot
The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors
inferred← citeshttps://doi.org/10.1039/c8cp05375hopenalex-snapshot
Influence of charge transfer on the isomerisation of stilbene derivatives for application in cancer therapy
inferred← citeshttps://doi.org/10.1039/d1ra07922kopenalex-snapshot
Design, synthesis, docking study and anticancer evaluation of new trimethoxyphenyl pyridine derivatives as tubulin inhibitors and apoptosis inducers
inferred← citeshttps://doi.org/10.1039/d3np00053bopenalex-snapshot
Discovery, synthesis, activities, structure–activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review
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Recherche de substances naturelles à activité thérapeutique (2)
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Polyalkoxyflavonoids as inhibitors of cell division
inferred← citeshttps://doi.org/10.1074/jbc.m103990200openalex-snapshot
G2 DNA Damage Checkpoint Inhibition and Antimitotic Activity of 13-Hydroxy-15-oxozoapatlin
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Synthesis of (±) Combretastatin
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Synthesis of (±)-Isocombretastatins A-C
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Natural product inspired leads in the discovery of anticancer agents: an update
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Combretastatin-based compounds with therapeutic characteristics: a patent review
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Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity
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Synthesis of novel spin-labelled combretastatin A-4 derivatives as potential antineoplastic agents
inferred← citeshttps://doi.org/10.1081/cnv-120016408openalex-snapshot
Cancer Drug Development in Europe: A Selection of New Agents Under Development at the European Drug Development Network
inferred← citeshttps://doi.org/10.1107/s0108270102003669openalex-snapshot
2-(3-tert-Butyldimethylsiloxy-4-methoxyphenyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)indole
inferred← citeshttps://doi.org/10.1107/s0108270103010667openalex-snapshot
(E)-1-(2-Hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene
inferred← citeshttps://doi.org/10.1107/s205322962001236xopenalex-snapshot
Two new polymorphic forms of combretastatin A-4, an antitumour agent
inferred← citeshttps://doi.org/10.1111/cas.12477openalex-snapshot
Prevention of cancer recurrence in tumor margins by stopping microcirculation in the tumor and tumor–host interface
inferred← citeshttps://doi.org/10.1111/cbdd.14239openalex-snapshot
Silicon switch: Carbon–silicon Bioisosteric replacement as a strategy to modulate the selectivity, physicochemical, and drug‐like properties in anticancer pharmacophores
inferred← citeshttps://doi.org/10.1111/j.1747-0285.2011.01176.xopenalex-snapshot
Design, Synthesis, and Cytotoxicity of Novel 3‐Arylidenones Derived from Alicyclic Ketones
inferred← citeshttps://doi.org/10.1126/science.aad6080openalex-snapshot
Catalytic conjunctive cross-coupling enabled by metal-induced metallate rearrangement
inferred← citeshttps://doi.org/10.1134/s1070363225606052openalex-snapshot
Design, Synthesis, and Antimicrobial Activity Evaluation of 5-(3/4-Hydroxybenzylidene)thiazolidine-2,4-dione Derivatives
inferred← citeshttps://doi.org/10.1134/s1070363225608257openalex-snapshot
Synthesis and Study of the Structure and Cytotoxicity of Five-Membered Cyclic Structural Analogs of Combretastatin A4
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-0364-3openalex-snapshot
Cardiovascular Safety Profile of Combretastatin A4 Phosphate in a Single-Dose Phase I Study in Patients with Advanced Cancer
inferred← citeshttps://doi.org/10.11606/d.75.2015.tde-07052015-112219openalex-snapshot
Estudo de relações quantitativas estrutura-atividade de chalconas análogas à combretastatina A4
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Planejamento de inibidores da polimerização de microtúbulos: predição da atividade biológica de um grupo de chalconas e proposição de novas estruturas
inferred← citeshttps://doi.org/10.1200/jco.2003.05.185openalex-snapshot
Phase I Clinical Trial of Weekly Combretastatin A4 Phosphate: Clinical and Pharmacokinetic Results
inferred← citeshttps://doi.org/10.1200/jco.2003.05.187openalex-snapshot
Combretastatin A4 Phosphate Has Tumor Antivascular Activity in Rat and Man as Demonstrated by Dynamic Magnetic Resonance Imaging
inferred← citeshttps://doi.org/10.1201/9780203027097.ax1openalex-snapshot
Appendix
inferred← citeshttps://doi.org/10.1201/9781420039658.ch3openalex-snapshot
The Discovery and Development of the Combretastatins
inferred← citeshttps://doi.org/10.1201/b11185-4openalex-snapshot
The Discovery and Development of the Combretastatins
inferred← citeshttps://doi.org/10.1201/b11185-7openalex-snapshot
The Discovery and Development of the Combretastatins
inferred← citeshttps://doi.org/10.1201/b11196-3openalex-snapshot
Discovery of Potential Anticancer Agents from Aquatic Cyanobacteria, Filamentous Fungi, and Tropical Plants
inferred← citeshttps://doi.org/10.1293/tox.2016-0012openalex-snapshot
Combretastatin A4 disodium phosphate-induced myocardial injury
inferred← citeshttps://doi.org/10.1293/tox.2018-0023openalex-snapshot
Histopathological and functional changes in a single-dose model of combretastatin A4 disodium phosphate-induced myocardial damage in rats
inferred← citeshttps://doi.org/10.14295/vetor.v33i2.15742openalex-snapshot
Combretastatina-A1 e derivados: estudo teórico das propriedades ópticas não lineares
inferred← citeshttps://doi.org/10.1517/13543776.2014.859247openalex-snapshot
Tubulin inhibitors: a patent review
inferred← citeshttps://doi.org/10.1517/17460441.2.3.361openalex-snapshot
Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development
inferred← citeshttps://doi.org/10.17159/0379-4350/2017/v70a10openalex-snapshot
Great South African molecules: the case for mycothiol
inferred← citeshttps://doi.org/10.21608/odr.2022.156180.1008openalex-snapshot
Combretastatin A-4 analogs: Past, present, and future directions
inferred← citeshttps://doi.org/10.2174/1570180817999200905092444openalex-snapshot
Structural Investigations of Aroylindole Derivatives through 3D-QSAR and Multiple Pharmacophore Modeling for the Search of Novel Colchicines Inhibitor
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