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Combretastatins: from natural products to drug discovery

https://doi.org/10.1039/b306797c
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-1-4615-3492-1openalex-snapshot
Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development
inferredcites →https://doi.org/10.1007/bf01954881openalex-snapshot
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
inferredcites →https://doi.org/10.1007/s002590050382openalex-snapshot
Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4
inferredcites →https://doi.org/10.1016/0040-4039(95)01987-sopenalex-snapshot
Total synthesis of natural (−)-combretastatin D-1.
inferredcites →https://doi.org/10.1016/0041-0101(81)90003-9openalex-snapshot
Crystallization and toxicology of T34: A major toxin from Florida's red tide organism (Ptychodiscus brevis)
inferredcites →https://doi.org/10.1016/0378-8741(92)90004-bopenalex-snapshot
Inventory of plants used in traditional medicine in Somalia. II. Plants of the families Combretaceae to Labiatae
inferredcites →https://doi.org/10.1016/s0002-9394(14)75794-0openalex-snapshot
Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy
inferredcites →https://doi.org/10.1016/s0002-9440(10)64930-9openalex-snapshot
Inhibition of Proliferative Retinopathy by the Anti-Vascular Agent Combretastatin-A4
inferredcites →https://doi.org/10.1016/s0040-4039(00)73369-7openalex-snapshot
Synthesis of combretastatin D-2. An efficient route to caffrane macrolactones
inferredcites →https://doi.org/10.1016/s0040-4039(00)74692-2openalex-snapshot
Synthesis of combretastatin D-2+
inferredcites →https://doi.org/10.1016/s0040-4039(00)93554-8openalex-snapshot
First synthesis of a strained 14-membered biaryl ether lactone by macrolactonization
inferredcites →https://doi.org/10.1016/s0040-4039(01)94157-7openalex-snapshot
A synthetic method for formyl→ethynyl conversion (RCHO→RCCH or RCCR′)
inferredcites →https://doi.org/10.1016/s0040-4039(96)01461-xopenalex-snapshot
A general and convenient synthetic method of geometrically pure (Z)-1-bromo-1-alkenes
inferredcites →https://doi.org/10.1016/s0360-3016(02)03924-xopenalex-snapshot
The development of combretastatin A4 phosphate as a vascular targeting agent
inferredcites →https://doi.org/10.1016/s0360-3016(98)00320-4openalex-snapshot
Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy
inferredcites →https://doi.org/10.1016/s0960-894x(01)00436-xopenalex-snapshot
The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4
inferredcites →https://doi.org/10.1016/s0960-894x(02)00850-8openalex-snapshot
Structure–activity and crystallographic analysis of benzophenone derivatives—the potential anticancer agents
inferredcites →https://doi.org/10.1016/s0960-894x(03)00206-3openalex-snapshot
Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4
inferredcites →https://doi.org/10.1021/bi00443a031openalex-snapshot
Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin
inferredcites →https://doi.org/10.1021/ja00233a037openalex-snapshot
Antineoplastic agents. 160. Isolation and structure of combretastatin D-1: a cell growth inhibitory macrocyclic lactone from Combretum caffrum
inferredcites →https://doi.org/10.1021/jm00010a011openalex-snapshot
Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6
inferredcites →https://doi.org/10.1021/jm00112a036openalex-snapshot
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization
inferredcites →https://doi.org/10.1021/jm010523xopenalex-snapshot
Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation
inferredcites →https://doi.org/10.1021/jm980101wopenalex-snapshot
Novel Combretastatin Analogues Effective against Murine Solid Tumors: Design and Structure−Activity Relationships
inferredcites →https://doi.org/10.1021/jm9807149openalex-snapshot
Antineoplastic Agents. 410. Asymmetric Hydroxylation of trans-Combretastatin A-4
inferredcites →https://doi.org/10.1021/jo00013a024openalex-snapshot
Total synthesis of combretastatin D-2: intramolecular Ullmann macrocyclization reaction
inferredcites →https://doi.org/10.1021/jo00097a052openalex-snapshot
Synthesis of (.+-.)-Combretastatin D-1 and Combretastatin D-2
inferredcites →https://doi.org/10.1021/jo00296a043openalex-snapshot
Antineoplastic agents. 206. Structure of the cytostatic macrocyclic lactone combretastatin D-2
inferredcites →https://doi.org/10.1021/jo015959zopenalex-snapshot
Novel Syntheses of Cis and Trans Isomers of Combretastatin A-4
inferredcites →https://doi.org/10.1038/35025220openalex-snapshot
Angiogenesis in cancer and other diseases
inferredcites →https://doi.org/10.1039/js8682100181openalex-snapshot
XXIII.—On the hydride of aceto-salicyl
inferredcites →https://doi.org/10.1039/js8773100388openalex-snapshot
XI.—On the formation of coumarin and of cinnamic and of other analogous acids from the aromatic aldehydes
inferredcites →https://doi.org/10.1139/v82-202openalex-snapshot
Isolation and structure of combretastatin
inferredcites →https://doi.org/10.1139/v87-399openalex-snapshot
Isolation, structure, and synthesis of combretastatin A-2, A-3, and B-2
inferredcites →https://doi.org/10.1167/iovs.02-0985openalex-snapshot
Combretastatin A-4 Phosphate Suppresses Development and Induces Regression of Choroidal Neovascularization
inferredcites →https://doi.org/10.5860/choice.31-5446openalex-snapshot
Handbook of African medicinal plants

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Design, Synthesis, Anti-Proliferative and Molecular Docking Studies of Combretastatin A4 Analogues with 2-Azetidinone Moiety
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The Mechanism of the Interactions of Pironetin Analog/Combretastatin A‐4 Hybrids with Tubulin
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Mechanism and Applications of the Photoredox Catalytic Coupling of Benzyl Bromides
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Combretastatins: From Natural Products to Drug Discovery
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Cis‐Stilbene Derived Furopyranones Show Potent Antiproliferative Activity by Inducing G2/M Arrest
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Synthesis and Structure–Activity Relationships of Constrained Heterocyclic Analogues of Combretastatin A4
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3‐Substituted 2‐Phenylimidazo[2,1‐b]benzothiazoles: Synthesis, Anticancer Activity, and Inhibition of Tubulin Polymerization
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Iso CombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity
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Regioselective Synthesis of 4,5‐Diaryl‐1‐methyl‐1H‐imidazoles Including Highly Cytotoxic Derivatives by Pd‐Catalyzed Direct C‐5 Arylation of 1‐Methyl‐1H‐imidazole with Aryl Bromides
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Design and Synthesis of Pironetin Analogue/Combretastatin A‐4 Hybrids and Evaluation of Their Cytotoxic Activity
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Drugs that target dynamic microtubules: A new molecular perspective
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Base‐Promoted Heterogeneous Reusable Copper Fluorapatite (CuFAP) Catalyzed Facile Synthesis of 1,2‐Diarylethanols via C(sp3)‐H Functionalization of Nitrotoluene
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Design, Synthesis, and Molecular Docking Studies of 2‐Azetidinone‐Based Combretastatin A‐4 Analogues with Anticancer Activity
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Transition Metal‐Catalyzed Dicarbofunctionalization of Unactivated Olefins
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Synthesis of Biologically Active Heterocyclic Stilbene and Chalcone Analogs of Combretastatin
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Drug Discovery From Natural Sources
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Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin
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Natural Products in Cancer Chemoprevention and Chemotherapy
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Drug Discovery in Africa
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The National Cancer Institute and Natural Product-Based Drug Discovery in Africa
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Biodiversity and Therapeutic Potential of Medicinal Plants
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CA-4, a natural cis-stilbene compound with potential insecticidal activity
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YSL-12, a novel microtubule-destabilizing agent, exerts potent anti-tumor activity against colon cancer in vitro and in vivo
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Pyrazoles, isoxazoles, and 1,2,3-triazoles as analogs of the natural cytostatic combretastatin A-4: efficient routes of synthesis, tubulin inhibition, and cytotoxicity
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Synthesis, Crystal Structure and Cytotoxic Properties of Nitrocombretastatins (E)- and (Z)-5-(4-Methoxy-3-nitrostyryl)-1,2,3-trimethoxybenzene
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Synthesis and Antiproliferative Activity Evaluation of Aryl(Hetaryl)Cyclopentenone Analogs of Combretastatin A-4
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Unveiling the future reservoir of anti-cancer molecule—Combretastatin A4 from callus and cell aggregate suspension culture of flame creeper (Combretum microphyllum): growth, exudation and elicitation studies
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Ni(II)/Al(0) mediated benzylic $$\hbox {Csp}^{3}$$-$$\hbox {Csp}^{3}$$ coupling in aqueous media
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Anticancer Drugs Targeting Tubulin and Microtubules
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Anticancer Drugs Targeting Tubulin and Microtubules
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Combretastatins: Plant Anticancer Phenolics
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A comprehensive review of the ethnomedicinal uses, phytochemistry, and pharmacology of potential anticancer plants of the flora of Africa
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Identification of novel 1-indolyl acetate-5-nitroimidazole derivatives of combretastatin A-4 as potential tubulin polymerization inhibitors
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Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates
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Bioactive Indanes: Design, synthesis and bioactivity investigation of 2,2-substituted Indane derivatives, a new bioactive Indane scaffold
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New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation
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4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents
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The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4
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1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin
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E-Combretastatin and E-resveratrol structural modifications: Antimicrobial and cancer cell growth inhibitory β-E-nitrostyrenes
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Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1
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Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A–1
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Synthesis and biological evaluation of enantiomerically pure cyclopropyl analogues of combretastatin A4
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Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents
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Synthesis of combretastatin A-4 O-alkyl derivatives and evaluation of their cytotoxic, antiangiogenic and antitelomerase activity
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A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin
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C8c–C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties
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Novel imidazole-based combretastatin A-4 analogues: Evaluation of their in vitro antitumor activity and molecular modeling study of their binding to the colchicine site of tubulin
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Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs
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One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their antiproliferative and Src kinase inhibitory activities
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Testing the 1,1,3,3-tetramethyldisiloxane linker in olefin metathesis
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Plant-derived compounds in clinical trials
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Mitotic drug targets and the development of novel anti-mitotic anticancer drugs
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Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs
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Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4
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Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects
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In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4
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Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted iso combretastatin A-4 analogs
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Design and synthesis of novel 2′-hydroxy group substituted 2-pyridone derivatives as anticancer agents
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Discovery and molecular modeling of novel 1-indolyl acetate – 5-Nitroimidazole targeting tubulin polymerization as antiproliferative agents
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Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity
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Synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones as potent antitumor agents
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Combretastatin A-4 analogues with benzoxazolone scaffold: Synthesis, structure and biological activity
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Indole-fused azepines and analogues as anticancer lead molecules: Privileged findings and future directions
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Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation
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Bi- and bisbibenzyls from the roots of Dichapetalum heudelotii and their antiproliferative activities
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Resveratrol dimers, nutritional components in grape wine, are selective ROS scavengers and weak Nrf2 activators
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Botanicals from the leaves of Acacia sieberiana had better cytotoxic effects than isolated phytochemicals towards MDR cancer cells lines
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Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles
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Antimitotic Inhibitors
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In vitro cytotoxic, antileishmanial and antifungal activities of ethnopharmacologically selected Gabonese plants
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Medicinal plant Combretum leprosum mart ameliorates motor, biochemical and molecular alterations in a Parkinson's disease model induced by MPTP
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Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4
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Antinociceptive properties of the ethanolic extract and of the triterpene 3β,6β,16β-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice
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Cytotoxicity and mode of action of a naturally occurring naphthoquinone, 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone towards multi-factorial drug-resistant cancer cells
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Role of plants in anticancer drug discovery
inferred← citeshttps://doi.org/10.1016/j.saa.2007.10.052openalex-snapshot
Vibrational spectra and ab initio molecular orbital calculations of the novel anti-cancer drug combretastatin A-4 prodrug
inferred← citeshttps://doi.org/10.1016/j.tet.2004.09.026openalex-snapshot
Synthesis and in vitro antitumor activity of substituted anthracene-1,4-diones
inferred← citeshttps://doi.org/10.1016/j.tet.2006.05.024openalex-snapshot
Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions
inferred← citeshttps://doi.org/10.1016/j.tet.2007.02.075openalex-snapshot
Synthesis and biological activity of vicinal diaryl-substituted 1H-imidazoles
inferred← citeshttps://doi.org/10.1016/j.tet.2012.05.075openalex-snapshot
Homocoupling of benzyl halides catalyzed by POCOP–nickel pincer complexes
inferred← citeshttps://doi.org/10.1016/j.tet.2013.04.073openalex-snapshot
Straightforward synthesis of substituted dibenzyl derivatives
inferred← citeshttps://doi.org/10.1016/j.tet.2013.05.020openalex-snapshot
Conformational analysis of E/Z-isomeric pairs of rosuvastatin and its lactonized analogues
inferred← citeshttps://doi.org/10.1016/j.tetlet.2010.04.039openalex-snapshot
Synthesis of antimicrotubule dibenzoxepines
inferred← citeshttps://doi.org/10.1016/j.tetlet.2011.08.061openalex-snapshot
Synthesis of phosphates and phosphates–acetates hybrids of green tea polyphenol (−)-epigallocatechine-3-gallate (EGCG) and its G ring deoxy analogs as potential anticancer prodrugs
inferred← citeshttps://doi.org/10.1016/j.tetlet.2015.03.106openalex-snapshot
Reductive homocoupling of benzylic halides in aqueous medium using recyclable alumina-supported nickel nanoparticles
inferred← citeshttps://doi.org/10.1016/j.tetlet.2016.06.092openalex-snapshot
An unprecedented oxidative intermolecular homo coupling reaction between two sp3C–sp3C centers under metal-free condition
inferred← citeshttps://doi.org/10.1016/j.tetlet.2017.12.057openalex-snapshot
Advances in chemoselective and/or stereoselective semihydrogenation of alkynes
inferred← citeshttps://doi.org/10.1016/j.tips.2006.04.006openalex-snapshot
Angiogenesis: from plants to blood vessels
inferred← citeshttps://doi.org/10.1016/s1875-5364(13)60002-3openalex-snapshot
Novel anticancer agents from plant sources
inferred← citeshttps://doi.org/10.1021/acs.joc.0c02374openalex-snapshot
Metal-Free Addition of Benzyl Halides to Aldehydes Using Super Electron Donors: Access to 3,4-Dihydroisocoumarins and 1,2-Diarylethanols
inferred← citeshttps://doi.org/10.1021/acs.joc.2c00074openalex-snapshot
Addition of Benzyl Halides to Aldehydes and Imines Using Photoactivated TDAE: Access to 3,4-Dihydroisocoumarins, 1,2-Diarylethanols, and 1,2-Diarylcarbamates under Metal-Free Conditions
inferred← citeshttps://doi.org/10.1021/acs.joc.3c01949openalex-snapshot
CS2/KOH System-Promoted Stereoselective Synthesis of (E)-Alkenes from Diarylalkynes and a “Hidden” Zinin-Type Reduction of Nitroarenes into Arylamines
inferred← citeshttps://doi.org/10.1021/acs.joc.6b02586openalex-snapshot
Syntheses of Combretastatins D-1, D-2, and D-4 via Ring Contraction by Flash Vacuum Pyrolysis
inferred← citeshttps://doi.org/10.1021/acs.organomet.0c00074openalex-snapshot
A Bidentate Ru(II)-NC Complex as a Catalyst for Semihydrogenation of Alkynes to (E)-Alkenes with Ethanol
inferred← citeshttps://doi.org/10.1021/acs.orglett.4c01609openalex-snapshot
Visible-Light-Induced Oxidative Decarboxylative Coupling of Phenylacetic Acid Derivatives Using SF6 as an Oxidant
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b00148openalex-snapshot
Water as a Hydrogenating Agent: Stereodivergent Pd-Catalyzed Semihydrogenation of Alkynes
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b03780openalex-snapshot
Photoswitching off the Antiproliferative Activity of Combretastatin A-4 Analogues
inferred← citeshttps://doi.org/10.1021/acscatal.1c00102openalex-snapshot
Rationally Designed Metal Cocatalyst for Selective Photosynthesis of Bibenzyls via Dehalogenative C–C Homocoupling
inferred← citeshttps://doi.org/10.1021/acscatal.4c04400openalex-snapshot
Direct Deoxygenative Homocoupling of Alcohols to Access C(sp 3 )–C(sp 3 ) Bonds via Synergistic Ruthenium/Nickel Catalysis
inferred← citeshttps://doi.org/10.1021/acscatal.5c02437openalex-snapshot
Enabling Efficient Synthesis of Dihydrostilbenoid via Palladium-Catalyzed Redox-Neutral Deacylative Arylation
inferred← citeshttps://doi.org/10.1021/acscatal.6b01045openalex-snapshot
Direct trans -Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow
inferred← citeshttps://doi.org/10.1021/acsenergylett.3c00771openalex-snapshot
The Dark Side of Lead-Free Metal Halide Nanocrystals: Substituent-Modulated Photocatalytic Activity in Benzyl Bromide Reduction
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5c00129openalex-snapshot
Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization
inferred← citeshttps://doi.org/10.1021/acsomega.1c01083openalex-snapshot
Substrate-Controlled Cu(OAc)2-Catalyzed Stereoselective Semi-Reduction of Alkynes with MeOH as the Hydrogen Source
inferred← citeshttps://doi.org/10.1021/acsomega.2c05077openalex-snapshot
Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors
inferred← citeshttps://doi.org/10.1021/acsomega.9b02191openalex-snapshot
Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application
inferred← citeshttps://doi.org/10.1021/acsptsci.3c00239openalex-snapshot
3,4-Diarylisoxazoles─Analogues of Combretastatin A-4: Design, Synthesis, and Biological Evaluation In Vitro and In Vivo
inferred← citeshttps://doi.org/10.1021/acssuschemeng.4c08612openalex-snapshot
S N Ar Reactions Using Continuous Plug Flow... in Aqueous Biphasic Media
inferred← citeshttps://doi.org/10.1021/cc800032qopenalex-snapshot
Diaryl Ether and Diaryl Thioether Syntheses on Solid Supports via Copper (I)-Mediated Coupling
inferred← citeshttps://doi.org/10.1021/jacs.3c02301openalex-snapshot
Catalytic, Z -Selective, Semi-Hydrogenation of Alkynes with a Zinc–Anilide Complex
inferred← citeshttps://doi.org/10.1021/jm049802lopenalex-snapshot
Concise Synthesis and Structure−Activity Relationships of Combretastatin A-4 Analogues, 1-Aroylindoles and 3-Aroylindoles, as Novel Classes of Potent Antitubulin Agents
inferred← citeshttps://doi.org/10.1021/jm060616kopenalex-snapshot
2-Amino and 2‘-Aminocombretastatin Derivatives as Potent Antimitotic Agents
inferred← citeshttps://doi.org/10.1021/jm101115uopenalex-snapshot
Synthesis and Evaluation of Azetidinone Analogues of Combretastatin A-4 as Tubulin Targeting Agents
inferred← citeshttps://doi.org/10.1021/jm900968sopenalex-snapshot
Vascular Disrupting Activity of Tubulin-Binding 1,5-Diaryl-1H-imidazoles
inferred← citeshttps://doi.org/10.1021/jo062492popenalex-snapshot
Couplings of Benzylic Halides Mediated by Titanocene Chloride: Synthesis of Bibenzyl Derivatives
inferred← citeshttps://doi.org/10.1021/jo701406dopenalex-snapshot
A Concise Synthesis of Substituted Stilbenes and Styrenes from Propargylic Phosphonium Salts by a Cobalt-Catalyzed Diels−Alder/Wittig Olefination Reaction Sequence
inferred← citeshttps://doi.org/10.1021/jo900632aopenalex-snapshot
Synthetic Approaches to Amino Analogues of N-Acetylcolchinol
inferred← citeshttps://doi.org/10.1021/np9002146openalex-snapshot
Antineoplastic Agents. 579. Synthesis and Cancer Cell Growth Evaluation of E-Stilstatin 3: A Resveratrol Structural Modification
inferred← citeshttps://doi.org/10.1021/np9004486openalex-snapshot
An Efficient Synthetic Strategy for Obtaining 4-Methoxy Carbon Isotope Labeled Combretastatin A-4 Phosphate and Other Z-Combretastatins
inferred← citeshttps://doi.org/10.1021/ol800163zopenalex-snapshot
Highly Enantioselective Dynamic Kinetic Resolution of 1,2−Diarylethanols by a Lipase−Ruthenium Couple
inferred← citeshttps://doi.org/10.1038/s41467-021-23971-7openalex-snapshot
C(sp3)−C(sp3) bond formation via nickel-catalyzed deoxygenative homo-coupling of aldehydes/ketones mediated by hydrazine
inferred← citeshttps://doi.org/10.1038/s41598-025-90888-2openalex-snapshot
Investigating blood–brain barrier penetration and neurotoxicity of natural products for central nervous system drug development
inferred← citeshttps://doi.org/10.1038/sj.bjp.0706276openalex-snapshot
4‐Amino‐5‐benzoyl‐2‐(4‐methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin‐microtubule system
inferred← citeshttps://doi.org/10.1039/b402985mopenalex-snapshot
Natural products to drugs: natural product derived compounds in clinical trials
inferred← citeshttps://doi.org/10.1039/b505955kopenalex-snapshot
Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives
inferred← citeshttps://doi.org/10.1039/b513515jopenalex-snapshot
A new approach to combretastatin D 2
inferred← citeshttps://doi.org/10.1039/b514294fopenalex-snapshot
Natural products to drugs: natural product-derived compounds in clinical trials
inferred← citeshttps://doi.org/10.1039/b515270dopenalex-snapshot
Synthesis of polymetallic macrocyclic terpene-derived hybrids
inferred← citeshttps://doi.org/10.1039/b905960aopenalex-snapshot
Natural stilbenes: an overview
inferred← citeshttps://doi.org/10.1039/c2ra21096gopenalex-snapshot
Exploiting conformationally restricted N,N′-dimethyl-N,N′-diarylureas as biologically active CC double bond analogues: synthesis and biological evaluation of combretastatin A-4 analogues
inferred← citeshttps://doi.org/10.1039/c3md00357dopenalex-snapshot
Combretastatin A-4 inspired novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines as tubulin polymerization inhibitors, antimitotic and anticancer agents
inferred← citeshttps://doi.org/10.1039/c3ob40420jopenalex-snapshot
Scope and limitations of the Heck–Matsuda-coupling of phenol diazonium salts and styrenes: a protecting-group economic synthesis of phenolic stilbenes
inferred← citeshttps://doi.org/10.1039/c4md00115jopenalex-snapshot
Synthesis and evaluation of a series of quinolinyl trans-cyanostilbene analogs as anticancer agents
inferred← citeshttps://doi.org/10.1039/c5md00219bopenalex-snapshot
Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents
inferred← citeshttps://doi.org/10.1039/c6dt00252hopenalex-snapshot
Cyclopentadienyl nickel( ii ) N,C-chelating benzothiazolyl NHC complexes: synthesis, characterization and application in catalytic C–C bond formation reactions
inferred← citeshttps://doi.org/10.1039/c7md00227kopenalex-snapshot
Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents
inferred← citeshttps://doi.org/10.1039/c7sc04351aopenalex-snapshot
Ni-catalysed regioselective 1,2-diarylation of unactivated olefins by stabilizing Heck intermediates as pyridylsilyl-coordinated transient metallacycles
inferred← citeshttps://doi.org/10.1039/c8cc09714copenalex-snapshot
Ligand-controlled iridium-catalyzed semihydrogenation of alkynes with ethanol: highly stereoselective synthesis of E - and Z -alkenes
inferred← citeshttps://doi.org/10.1039/c9md00458kopenalex-snapshot
Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents
inferred← citeshttps://doi.org/10.1039/d2gc02799bopenalex-snapshot
Efficient heterogeneous photocatalytic C–C coupling of halogenated arenes mediated by metal cocatalyst
inferred← citeshttps://doi.org/10.1039/d3gc03290fopenalex-snapshot
CO 2 promoted photoredox/Ni-catalyzed semi-reduction of alkynes with H 2 O
inferred← citeshttps://doi.org/10.1073/pnas.0405578102openalex-snapshot
Karyotypic “state” as a potential determinant for anticancer drug discovery
inferred← citeshttps://doi.org/10.1080/07391102.2018.1497543openalex-snapshot
Anticancer activity, calf thymus DNA and human serum albumin binding properties of Farnesiferol C from Ferula pseudalliacea
inferred← citeshttps://doi.org/10.1080/07391102.2022.2134212openalex-snapshot
Natural product inspired leads in the discovery of anticancer agents: an update
inferred← citeshttps://doi.org/10.1080/13543776.2016.1215435openalex-snapshot
Resveratrol derivatives: an updated patent review (2012-2015)
inferred← citeshttps://doi.org/10.1111/cbdd.12184openalex-snapshot
Synthesis of Methoxy‐substituted Chalcones and in vitro Evaluation of their Anticancer Potential
inferred← citeshttps://doi.org/10.1111/cpr.12143openalex-snapshot
Plant natural products: from traditional compounds to new emerging drugs in cancer therapy
inferred← citeshttps://doi.org/10.1111/j.1747-0285.2010.01064.xopenalex-snapshot
Docking, Synthesis, and in vitro Evaluation of Antimitotic Estrone Analogs
inferred← citeshttps://doi.org/10.1134/s1068162015010033openalex-snapshot
Synthesis of new combretastatin A-4 analogues and study of their anti-inflammatory activity
inferred← citeshttps://doi.org/10.1177/1934578x0900401203openalex-snapshot
A New β-D-Glucopyranosyl 2-Oxo-urs-12-en-28-oate from the Cameroonian Plant Combretum bracteatum
inferred← citeshttps://doi.org/10.1186/s12906-015-0543-5openalex-snapshot
The in vitro cytotoxic activity of ethno-pharmacological important plants of Darjeeling district of West Bengal against different human cancer cell lines
inferred← citeshttps://doi.org/10.1186/s12906-016-1387-3openalex-snapshot
Evaluation of phytochemicals, antioxidant activity and amelioration of pulmonary fibrosis with Phyllanthus emblica leaves
inferred← citeshttps://doi.org/10.1201/9781420039658.ch3openalex-snapshot
The Discovery and Development of the Combretastatins
inferred← citeshttps://doi.org/10.1201/b11185-4openalex-snapshot
The Discovery and Development of the Combretastatins
inferred← citeshttps://doi.org/10.1201/b11185-7openalex-snapshot
The Discovery and Development of the Combretastatins
inferred← citeshttps://doi.org/10.1208/aapsj080228openalex-snapshot
Drug Discovery From Natural Sources
inferred← citeshttps://doi.org/10.1371/journal.pone.0179115openalex-snapshot
Nanoscale quantification of the biophysical characterization of combretastatin A-4-treated tumor cells using atomic force microscopy
inferred← citeshttps://doi.org/10.1515/hc.2010.003openalex-snapshot
Synthesis of novel benzo[ b ]furans and benzo[ b ]thiophenes: analogs of combretastatin and resveratrol
inferred← citeshttps://doi.org/10.1515/ncrs-2015-0180openalex-snapshot
Crystal structure of 1-(2-chlorophenyl)-2-(2-nitrophenyl)ethan-1-ol, C14H12ClNO3
inferred← citeshttps://doi.org/10.1515/znc-2023-0087openalex-snapshot
Antioxidant and antibacterial effects of a new macrocyclic bis(bibenzyl) ether from Combretum molle (Combretaceae)
inferred← citeshttps://doi.org/10.1586/14737140.6.10.1433openalex-snapshot
Drug target interaction of tubulin-binding drugs in cancer therapy
inferred← citeshttps://doi.org/10.18632/oncotarget.17549openalex-snapshot
Microtubule inhibitor, SP-6-27 inhibits angiogenesis and induces apoptosis in ovarian cancer cells
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2584226/v1openalex-snapshot
Synergy of monoatomic copper and oxygen vacancy formed in-situ on ultrathin TiO2(B) nanosheet for efficient photocatalytic dehalogenative C−C coupling synthesis of bibenzyl
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3515239/v1openalex-snapshot
Computational repurposing of Trimethoprim: molecular docking and molecular dynamics simulation studies suggest a potential inhibition of colchicine-binding site.
inferred← citeshttps://doi.org/10.2174/1570180819666220901093732openalex-snapshot
Considering the Conception of Nanotechnology Integrated on Herbal Formulation for the Management of Cancer
inferred← citeshttps://doi.org/10.2174/157340709787580928openalex-snapshot
Phenanthroindolizidines and Phenanthroquinolizidines: Promising Alkaloids for Anti-Cancer Therapy
inferred← citeshttps://doi.org/10.2174/187152061310131206162302openalex-snapshot
Discovery and Hit to Lead Optimization of Novel Combretastatin A-4 Analogues: Dependence of C-Linker Length and Hybridization
inferred← citeshttps://doi.org/10.22270/jddt.v2i3.190openalex-snapshot
COMBINATION OF NATURAL DRUGS: AN EMERGING TREND IN CANCER CHEMOTHERAPY
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1390907openalex-snapshot
Research progress of SIRTs activator resveratrol and its derivatives in autoimmune diseases
inferred← citeshttps://doi.org/10.3389/fphar.2017.00343openalex-snapshot
Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets
inferred← citeshttps://doi.org/10.3390/antibiotics9060336openalex-snapshot
Stilbenoids: A Natural Arsenal against Bacterial Pathogens
inferred← citeshttps://doi.org/10.3390/cells9051083openalex-snapshot
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
inferred← citeshttps://doi.org/10.3390/life13071422openalex-snapshot
Bioactive Phytoconstituents and Their Therapeutic Potentials in the Treatment of Haematological Cancers: A Review
inferred← citeshttps://doi.org/10.3390/molecules13112717openalex-snapshot
Bioactive Pentacyclic Triterpenes from the Stems of Combretum laxum
inferred← citeshttps://doi.org/10.3390/molecules170910708openalex-snapshot
An Improved Synthesis of 1,2-Diarylethanols under Conventional Heating and Ultrasound Irradiation
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