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Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease
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1 of the 200 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1007/s13277-014-2342-x (notice 2017-04-20).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cncr.25796openalex-snapshotInduction of MUC5AC mucin by conjugated bile acids in the esophagus involves the phosphatidylinositol 3‐kinase/protein kinase C/activator protein‐1 pathway
inferredcites →https://doi.org/10.1002/cncr.27910openalex-snapshotInhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts
inferredcites →https://doi.org/10.1002/hep.22627openalex-snapshotBile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α‐hydroxylase gene expression†
inferredcites →https://doi.org/10.1002/hep.26333openalex-snapshotTaurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cε in HUH-NTCP Cells
inferredcites →https://doi.org/10.1002/hep.27240openalex-snapshotSodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype
inferredcites →https://doi.org/10.1002/hep.27677openalex-snapshotFarnesoid X receptor–induced lysine‐specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity
inferredcites →https://doi.org/10.1002/ijc.26293openalex-snapshotExpression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis
inferredcites →https://doi.org/10.1002/ijc.2910600322openalex-snapshotApoptosis in colorectal tumour cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate
inferredcites →https://doi.org/10.1002/jcb.24172openalex-snapshotInhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells
inferredcites →https://doi.org/10.1006/bbrc.2000.2899openalex-snapshotBile Acids Reduce the Apoptosis-Inducing Effects of Sodium Butyrate on Human Colon Adenoma (AA/C1) Cells: Implications for Colon Carcinogenesis
inferredcites →https://doi.org/10.1007/978-3-319-20215-0_5openalex-snapshotInteractions Between Bacteria and the Gut Mucosa: Do Enteric Neurotransmitters Acting on the Mucosal Epithelium Influence Intestinal Colonization or Infection?
inferredcites →https://doi.org/10.1007/bf00580794openalex-snapshotInfluence of osmolality, short chain fatty acids and deoxycholic acid on mucus secretion in the rat colon
inferredcites →https://doi.org/10.1007/s00384-004-0616-2openalex-snapshotBile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor
inferredcites →https://doi.org/10.1007/s00424-014-1560-9openalex-snapshotBile acids inhibit Na+/H+ exchanger and Cl−/HCO3 − exchanger activities via cellular energy breakdown and Ca2+ overload in human colonic crypts
inferredcites →https://doi.org/10.1007/s10620-013-2975-4openalex-snapshotCyclooxygenase-2 and Inflammation Mediators Have a Crucial Role in Reflux-Related Esophageal Histological Changes and Barrett’s Esophagus
inferredcites →https://doi.org/10.1007/s10620-015-3634-8openalex-snapshotTransgenic Expression of Vitamin D Receptor in Gut Epithelial Cells Ameliorates Spontaneous Colitis Caused by Interleukin-10 Deficiency
inferredcites →https://doi.org/10.1007/s11605-008-0720-7openalex-snapshotBile Acid Alone, or in Combination with Acid, Induces CDX2 Expression Through Activation of the Epidermal Growth Factor Receptor (EGFR)
inferredcites →https://doi.org/10.1007/s11605-015-3062-2openalex-snapshotBile Salts at Low pH Cause Dilation of Intercellular Spaces in In Vitro Stratified Primary Esophageal Cells, Possibly by Modulating Wnt Signaling
inferredcites →https://doi.org/10.1007/s11894-016-0527-8openalex-snapshotNutritional Strategies in the Management of Adult Patients with Inflammatory Bowel Disease: Dietary Considerations from Active Disease to Disease Remission
inferredcites →https://doi.org/10.1016/j.bbrc.2006.12.168openalex-snapshotInvolvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells
inferredcites →https://doi.org/10.1016/j.bcp.2005.07.023openalex-snapshotBile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors
inferredcites →https://doi.org/10.1016/j.bcp.2006.11.028openalex-snapshotMatrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line
inferredcites →https://doi.org/10.1016/j.cgh.2016.11.012openalex-snapshotColonic Transit and Bile Acid Synthesis or Excretion in Patients With Irritable Bowel Syndrome–Diarrhea Without Bile Acid Malabsorption
inferredcites →https://doi.org/10.1016/j.cgh.2016.11.025openalex-snapshotIncidence, Risk Factors, and Outcomes of Colorectal Cancer in Patients With Ulcerative Colitis With Low-Grade Dysplasia: A Systematic Review and Meta-analysis
inferredcites →https://doi.org/10.1016/j.cgh.2017.06.039openalex-snapshotBile Acid Deficiency in a Subgroup of Patients With Irritable Bowel Syndrome With Constipation Based on Biomarkers in Serum and Fecal Samples
inferredcites →https://doi.org/10.1016/j.crohns.2014.02.027openalex-snapshotBile acid malabsorption assessed by 7 alpha-hydroxy-4-cholesten-3-one in pediatric inflammatory bowel disease: Correlation to clinical and laboratory findings
inferredcites →https://doi.org/10.1016/j.ejphar.2011.06.058openalex-snapshotInhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells
inferredcites →https://doi.org/10.1016/j.ejphar.2013.06.036openalex-snapshotIleal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids
inferredcites →https://doi.org/10.1016/j.ejps.2014.01.007openalex-snapshotPregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
inferredcites →https://doi.org/10.1016/j.ijcard.2016.10.011openalex-snapshotThe effects of bile acid sequestrants on lipid profile and blood glucose concentrations: A systematic review and meta-analysis of randomized controlled trials
inferredcites →https://doi.org/10.1016/j.jsbmb.2017.01.010openalex-snapshotAnti-fibrotic effects of chronic treatment with the selective FXR agonist obeticholic acid in the bleomycin-induced rat model of pulmonary fibrosis
inferredcites →https://doi.org/10.1017/s0007114511004703openalex-snapshotCholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-activeLactobacillus reuteriNCIMB 30242 yoghurt formulation in hypercholesterolaemic adults
inferredcites →https://doi.org/10.1021/jm901390popenalex-snapshotDiscovery of 6α-Ethyl-23( S )-methylcholic Acid ( S -EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity
inferredcites →https://doi.org/10.1038/ajg.2011.156openalex-snapshotHigh-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis
inferredcites →https://doi.org/10.1038/ajg.2011.162openalex-snapshotA Randomized Placebo-Controlled Phase IIb Trial of A3309, A Bile Acid Transporter Inhibitor, for Chronic Idiopathic Constipation
inferredcites →https://doi.org/10.1038/ajg.2011.285openalex-snapshotEffects of A3309, an Ileal Bile Acid Transporter Inhibitor, on Colonic Transit and Symptoms in Females With Functional Constipation
inferredcites →https://doi.org/10.1038/ajg.2015.233openalex-snapshotSelecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target
inferredcites →https://doi.org/10.1038/ajg.2015.424openalex-snapshotCharacterizing Factors Associated With Differences in FGF19 Blood Levels and Synthesis in Patients With Primary Bile Acid Diarrhea
inferredcites →https://doi.org/10.1038/bjc.2011.37openalex-snapshotFarnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion
inferredcites →https://doi.org/10.1038/onc.2011.124openalex-snapshotFarnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression
inferredcites →https://doi.org/10.1038/srep31538openalex-snapshotBile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett’s Esophageal Adenocarcinoma Cells
inferredcites →https://doi.org/10.1039/c6fo01207hopenalex-snapshotMedium-chain fatty acids reduce serum cholesterol by regulating the metabolism of bile acid in C57BL/6J mice
inferredcites →https://doi.org/10.1042/bsr20160124openalex-snapshotControlled bile acid exposure to oesophageal mucosa causes up-regulation of nuclear γ-H2AX possibly via iNOS induction
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4680367openalex-extractedHigh Soybean Meal Diet Inclusion of Lithospermum Erythrorhizon Mitigates Soybean-Induced Enteritis in Pearl Gentian Grouper (Epinephelus Fuscoguttatus ♀ × E. Lanceolatus ♂)
inferred← citeshttps://doi.org/10.1002/bcp.70277openalex-snapshotIleal bile acid transporter inhibitors in Alagille syndrome and Progressive Familial Intrahepatic Cholestasis: A systematic review into dose–response
inferred← citeshttps://doi.org/10.1002/bit.28730openalex-snapshotA perfusion host‐microbe bioreactor (HMB) system that captures dynamic interactions of secreted metabolites between epithelial cells cocultured with a human gut anaerobe
inferred← citeshttps://doi.org/10.1002/cam4.5973openalex-snapshotPhosphatidylcholine in bile‐derived small extracellular vesicles as a novel biomarker of cholangiocarcinoma
inferred← citeshttps://doi.org/10.1002/hep.31651openalex-snapshotTargeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology
inferred← citeshttps://doi.org/10.1002/jgh3.12528openalex-snapshotGut microbiota dysbiosis in functional gastrointestinal disorders: Underpinning the symptoms and pathophysiology
inferred← citeshttps://doi.org/10.1002/jsfa.70884openalex-snapshotHaematococcus pluvialis peptides ameliorated cyclophosphamide‐induced immunodeficiency in mice by regulating intestinal barrier function
inferred← citeshttps://doi.org/10.1002/ptr.6915openalex-snapshotResveratrol inhibits bile acid‐induced gastric intestinal metaplasia via the PI3K / AKT / p‐FoxO4 signalling pathway
inferred← citeshttps://doi.org/10.1007/s00011-024-01884-7openalex-snapshotImpacts of liver macrophages, gut microbiota, and bile acid metabolism on the differences in iHFC diet-induced MASH progression between TSNO and TSOD mice
inferred← citeshttps://doi.org/10.1007/s00210-023-02455-zopenalex-snapshotAlleviation of cholestatic liver injury and intestinal permeability by lubiprostone treatment in bile duct ligated rats: role of intestinal FXR and tight junction proteins claudin-1, claudin-2, and occludin
inferred← citeshttps://doi.org/10.1007/s00394-023-03126-8openalex-snapshotDefecation status, intestinal microbiota, and habitual diet are associated with the fecal bile acid composition: a cross-sectional study in community-dwelling young participants
inferred← citeshttps://doi.org/10.1007/s00604-025-07120-1openalex-snapshotDesign and application of graphene oxide-based molecularly imprinted covalent organic framework for simultaneous and precise recognition of bile acid metabolites
inferred← citeshttps://doi.org/10.1007/s10863-021-09927-yopenalex-snapshotGualou Xiebai Decoction ameliorates increased Caco-2 monolayer permeability induced by bile acids via tight junction regulation, oxidative stress suppression and apoptosis reduction
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2026.743957openalex-snapshotDietary bile acids supplementation improves the growth performance, glycolipid metabolism and bile acids homeostasis of blunt snout bream (Megalobrama amblycephala) fed a high-carbohydrate diet
inferred← citeshttps://doi.org/10.1016/j.bbi.2022.08.007openalex-snapshotThe live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism
inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114590openalex-snapshotA comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.117313openalex-snapshotBile acids supplementation improves colonic mucosal barrier via alteration of bile acids metabolism and gut microbiota composition in goats with subacute ruminal acidosis (SARA)
inferred← citeshttps://doi.org/10.1016/j.foodres.2024.114317openalex-snapshotExploring lipid digestion discrepancies between preterm formula and human milk: Insights from in vitro gastrointestinal digestion and the impact of added milk fat
inferred← citeshttps://doi.org/10.1016/j.foodres.2026.118599openalex-snapshotModulation of intestinal microbiota and metabolites mediates the improvement of cyclophosphamide-induced immunodeficiency in mice by Monopterus albus slime protein
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2019.01.209openalex-snapshotDisorder-to-helix conformational conversion of the human immunomodulatory peptide LL-37 induced by antiinflammatory drugs, food dyes and some metabolites
inferred← citeshttps://doi.org/10.1016/j.jad.2024.09.058openalex-snapshotProbiotic Lactobacillus plantarum 299v supplementation in patients with major depression in a double-blind, randomized, placebo-controlled trial: A metabolomics study
inferred← citeshttps://doi.org/10.1016/j.japr.2026.100674openalex-snapshotEffects of dietary Rhus coriaria L. powder on growth performance, antioxidant status, and immune competence of broiler chickens under high-density rearing conditions
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.102569openalex-snapshotPentacyclic triterpenes modulate farnesoid X receptor expression in colonic epithelial cells: Implications for colonic secretory function
inferred← citeshttps://doi.org/10.1016/j.jep.2026.121486openalex-snapshotYanxiao Di’naer decoction attenuates metabolic dysfunction-associated steatohepatitis through the regulation of gut microbiota and the metabolism of bile acid
inferred← citeshttps://doi.org/10.1016/j.jhip.2026.02.002openalex-snapshotMechanistic insights into the preventive efficacy of 21-day prefeeding with β-galactosidase hydrolyzed milk in DSS-induced ulcerative colitis mice
inferred← citeshttps://doi.org/10.1016/j.jlr.2023.100340openalex-snapshotCombining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2022.08.007openalex-snapshotN-(4-[18F]fluorobenzyl)cholylglycine, a potential tracer for positron emission tomography of enterohepatic circulation and drug-induced inhibition of ileal bile acid transport. A proof-of-concept PET/CT study in pigs
inferred← citeshttps://doi.org/10.1016/j.stem.2022.08.008openalex-snapshotHepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
inferred← citeshttps://doi.org/10.1016/j.yexcr.2023.113670openalex-snapshotBile salts and proinflammatory cytokines inhibit MCT1-mediated cellular uptake of butyrate and interfere with its antiproliferative properties
inferred← citeshttps://doi.org/10.1021/acs.jafc.9b03173openalex-snapshotChenodeoxycholic Acid (CDCA) Protects against the Lipopolysaccharide-Induced Impairment of the Intestinal Epithelial Barrier Function via the FXR-MLCK Pathway
inferred← citeshttps://doi.org/10.1039/d3fo01044aopenalex-snapshotDietary berberine supplementation improves growth performance and alleviates gut injury in weaned piglets by modulating ileal microbiota and metabolites
inferred← citeshttps://doi.org/10.1039/d5lc00937eopenalex-snapshotA microfluidic chip recapitulating the human neurovascular unit with a functional blood–brain barrier for modeling gut–brain interactions
inferred← citeshttps://doi.org/10.1093/bbb/zbad030openalex-snapshotSkatole-induced p38 and JNK activation coordinately upregulates, whereas AhR activation partially attenuates TNFα expression in intestinal epithelial cells
inferred← citeshttps://doi.org/10.1093/jn/nxac161openalex-snapshotThe Fecal Metabolome Links Diet Composition, Foacidic positive ion conditions, chromatographicallyod Processing, and the Gut Microbiota to Gastrointestinal Health in a Randomized Trial of Adults Consuming a Processed Diet
inferred← citeshttps://doi.org/10.1097/hep.0000000000001430openalex-snapshotPretreatment serum bile acid composition and predictability of subsequent response to odevixibat in patients with bile salt export pump (BSEP) deficiency
inferred← citeshttps://doi.org/10.1111/apt.70666openalex-snapshotReview Article: Ileal Bile Acid Transport ( IBAT ) Inhibitors as an Emerging Treatment for Cholestatic Liver Disease
inferred← citeshttps://doi.org/10.1111/gtc.13134openalex-snapshotAntibiotic effects on gut microbiota modulate diet‐induced metabolic dysfunction‐associated steatohepatitis development in C57BL/6 mice
inferred← citeshttps://doi.org/10.1111/jgh.15032openalex-snapshotMarshall and Warren Lecture 2019: A paradigm shift in pathophysiological basis of irritable bowel syndrome and its implication on treatment
inferred← citeshttps://doi.org/10.1111/jgh.15676openalex-snapshotDeoxycholic acid delays the wound healing of colonic epithelial cells via transmembrane G‐protein‐coupled receptor 5
inferred← citeshttps://doi.org/10.1111/liv.14553openalex-snapshotPotential of ileal bile acid transporter inhibition as a therapeutic target in Alagille syndrome and progressive familial intrahepatic cholestasis
inferred← citeshttps://doi.org/10.1111/nmo.13943openalex-snapshotSynthetic G protein‐coupled bile acid receptor agonists and bile acids act via basolateral receptors in ileal and colonic mucosa
inferred← citeshttps://doi.org/10.1113/ep092451openalex-snapshotThe mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat
inferred← citeshttps://doi.org/10.1113/jp291470openalex-snapshotIncreasing gut short‐chain fatty acids protects intestinal barrier function but does not spare muscle glycogen or impact aerobic performance
inferred← citeshttps://doi.org/10.1128/aem.00724-21openalex-snapshotExtreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12
inferred← citeshttps://doi.org/10.1128/msphere.00669-21openalex-snapshotFecal Microbiota Transplantation Increases Colonic IL-25 and Dampens Tissue Inflammation in Patients with Recurrent Clostridioides difficile
inferred← citeshttps://doi.org/10.1152/ajpgi.00086.2025openalex-snapshotFarnesoid X receptor inhibits proinflammatory cytokine-induced epithelial necroptosis in vitro: implications for preservation of intestinal barrier function
inferred← citeshttps://doi.org/10.1155/2020/1805418openalex-snapshotAn Integrated Fecal Microbiome and Metabolomics in T2DM Rats Reveal Antidiabetes Effects from Host-Microbial Metabolic Axis of EtOAc Extract from Sophora flavescens
inferred← citeshttps://doi.org/10.1155/2020/2389312openalex-snapshotAn Inverse Correlation of Serum Fibroblast Growth Factor 19 with Abdominal Pain and Inflammatory Markers in Patients with Ulcerative Colitis
inferred← citeshttps://doi.org/10.1155/2022/3589525openalex-snapshotFarnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4
inferred← citeshttps://doi.org/10.1172/jci.insight.132055openalex-snapshotA human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis
inferred← citeshttps://doi.org/10.1186/s12889-020-09124-3openalex-snapshotThe study protocol for a pseudo-randomised pre-post designed controlled intervention trial to study the effects of a 7-week cooking program on self-efficacy and biomarkers of health: the ECU lifestyle and biomarkers get connected study (ECULABJMOF) including the Jamie’s Ministry of Food WA…
inferred← citeshttps://doi.org/10.1194/jlr.m094508openalex-snapshotFXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements
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