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Drug Target Prediction Based on the Herbs Components: The Study on the Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamsters
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Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats
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Chinese medicine pattern differentiation and its implications for clinical practice
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Progression of left ventricular dysfunction secondary to coronary artery disease, sustained neurohormonal activation and effects of ibopamine therapy during long-term therapy with angiotensin-converting enzyme inhibitor
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Molecular Similarity Searching Using Atom Environments, Information-Based Feature Selection, and a Naïve Bayesian Classifier
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Prediction of Biological Targets for Compounds Using Multiple-Category Bayesian Models Trained on Chemogenomics Databases
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Major Causes of Death among Men and Women in China
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Supervised prediction of drug–target interactions using bipartite local models
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Selective and time related activation of the cardiac renin-angiotensin system after experimental heart failure: relation to ventricular function and morphology
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DrugBank: a knowledgebase for drugs, drug actions and drug targets
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The IntAct molecular interaction database in 2010
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MINT, the molecular interaction database: 2009 update
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Angiotensin Receptor Blockers: Role in Hypertension Management, Cardiovascular Risk Reduction, and Nephropathy
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The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
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Bradykinin pathway is involved in acute hemodynamic effects of enalaprilat in dogs with heart failure
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The role of calcium in the regulation of renin secretion
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Endothelin-1–Induced Enhancement of Coronary Smooth Muscle Contraction via MAPK-Dependent and MAPK-Independent [Ca 2+ ] i Sensitization Pathways
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Regulation of myocardial amino acid balance in the conscious dog.
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Review: Renal protection by inhibition of the renin-angiotensin-aldosterone system
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Choosing among renin-angiotensin system blockers for the management of hypertension: from pharmacology to clinical efficacy
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Questioning the Ubiquity of Neofunctionalization
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Structure of Protein Interaction Networks and Their Implications on Drug Design
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Network-Based Relating Pharmacological and Genomic Spaces for Drug Target Identification
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Aldosterone Receptor Antagonists in the Medical Management of Chronic Heart Failure
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Quantitative analysis and pharmacokinetic comparison of multiple bioactive components in rat plasma after oral administration of Qi‐Shen‐Ke‐Li formula and its single‐herb extracts using ultra‐high‐performance liquid chromatography–tandem mass spectrometry
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Pseudotargeted screening and determination of constituents in Qishen granule based on compound biosynthetic correlation using UHPLC coupled with high‐resolution MS
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Pharmacokinetics and tissue distribution study of 18 bioactive components in healthy and chronic heart failure rats after oral administration of Qi‐Shen‐Ke‐Li formula using ultra‐high‐performance liquid chromatography/triple quadrupole mass spectrometry
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Cardioprotective effects of Qishen Granule (芪参颗粒) on sarcoplasmic reticulum Ca2+ handling in heart failure rats
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Qishen granule (QSG) exerts cardioprotective effects by inhibiting NLRP3 inflammasome and pyroptosis in myocardial infarction rats
inferred← citeshttps://doi.org/10.1016/j.jtcms.2020.03.001openalex-snapshot
Use of Qishen granule for the treatment of heart failure: A systematic review and meta-analysis of animal studies
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Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia
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Qishen granule attenuates cardiac fibrosis by regulating TGF-β /Smad3 and GSK-3β pathway
inferred← citeshttps://doi.org/10.1016/s1674-6384(16)60018-7openalex-snapshot
Network Pharmacology-based Approaches Capture Essence of Chinese Herbal Medicines
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Traditional Chinese medicine network pharmacology: theory, methodology and application
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Systematic Investigation of Ginkgo Biloba Leaves for Treating Cardio-cerebrovascular Diseases in an Animal Model
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Different network pharmacology mechanisms of Danshen-based Fangjis in the treatment of stable angina
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A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi
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Qishen Yiqi Drop Pill improves cardiac function after myocardial ischemia
inferred← citeshttps://doi.org/10.1038/srep29823openalex-snapshot
Systematic investigation of transcription factors critical in the protection against cerebral ischemia by Danhong injection
inferred← citeshttps://doi.org/10.1038/srep36949openalex-snapshot
Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism
inferred← citeshttps://doi.org/10.1039/c3mb70263dopenalex-snapshot
Integrated proteomic and metabolomic analysis reveals the NADH-mediated TCA cycle and energy metabolism disorders based on a new model of chronic progressive heart failure
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Integrated gene expression profiling and functional enrichment analyses to discover biomarkers and pathways associated with Guillain-Barré syndrome and autism spectrum disorder to identify new therapeutic targets
inferred← citeshttps://doi.org/10.1093/bioinformatics/btv055openalex-snapshot
Similarity-based prediction for Anatomical Therapeutic Chemical classification of drugs by integrating multiple data sources
inferred← citeshttps://doi.org/10.1097/md.0000000000023901openalex-snapshot
Efficacy and safety of Qishen granules for chronic heart failure
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Systems Pharmacology-Based Strategy to Explore the Pharmacological Mechanisms of Citrus Peel (Chenpi) for Treating Complicated Diseases
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Danqi Pill regulates lipid metabolism disorder induced by myocardial ischemia through FATP-CPTI pathway
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Qishen Granules attenuate adverse ventricular remodeling in chronic heart failure by promoting Legumain/Arg1/Rac1-mediated efferocytosis of resident cardiac macrophages
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inferred← citeshttps://doi.org/10.3389/fphar.2017.00098openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fphar.2021.752926openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fphar.2022.850187openalex-snapshot
Qishen Granule (QSG) Inhibits Monocytes Released From the Spleen and Protect Myocardial Function via the TLR4-MyD88-NF-κB p65 Pathway in Heart Failure Mice
inferred← citeshttps://doi.org/10.3389/fphys.2019.00607openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms17122114openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/molecules23071829openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/molecules26196032openalex-snapshot
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inferred← citeshttps://doi.org/10.5897/ajpp12.963openalex-snapshot
The study on therapy effect of Danqi pill to renin-angiotensin-aldosterone system (RAAS) and lipid metabolism disorder in coronary heart disease
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