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Effect of QSKL on MAPK and RhoA Pathways in a Rat Model of Heart Failure

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1 of the 42 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1073/pnas.1321510111 (notice 2022-09-02).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcb.20698openalex-snapshot
Curcumin blocks activation of pancreatic stellate cells
inferredcites →https://doi.org/10.1002/jcb.23361openalex-snapshot
CCN2 promotes cigarette smoke‐induced proliferation of rat pulmonary artery smooth muscle cells through upregulating cyclin D1 expression
inferredcites →https://doi.org/10.1007/s00441-016-2454-2openalex-snapshot
Syndecans in heart fibrosis
inferredcites →https://doi.org/10.1007/s10753-015-0272-4openalex-snapshot
Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho Signaling
inferredcites →https://doi.org/10.1007/s11655-013-1380-3openalex-snapshot
Tanshinone II a protects against lipopolysaccharides-induced endothelial cell injury via Rho/Rho kinase pathway
inferredcites →https://doi.org/10.1016/j.biopha.2016.10.036openalex-snapshot
The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway
inferredcites →https://doi.org/10.1016/j.cellsig.2005.05.001openalex-snapshot
Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK
inferredcites →https://doi.org/10.1016/j.devcel.2008.07.005openalex-snapshot
Polar Body Emission Requires a RhoA Contractile Ring and Cdc42-Mediated Membrane Protrusion
inferredcites →https://doi.org/10.1016/j.ejphar.2008.12.049openalex-snapshot
Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts
inferredcites →https://doi.org/10.1016/j.ejphar.2016.07.053openalex-snapshot
Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways
inferredcites →https://doi.org/10.1016/j.jep.2010.05.026openalex-snapshot
Effect of Salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells
inferredcites →https://doi.org/10.1016/j.toxlet.2005.07.009openalex-snapshot
Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway
inferredcites →https://doi.org/10.1016/j.trsl.2013.09.013openalex-snapshot
Inhibitory effect of ethyl acetate extract of Aristolochia yunnanensis on cardiac fibrosis through extracellular signal-regulated kinases 1/2 and transforming growth factor β/small mother against decapentaplegic signaling pathways
inferredcites →https://doi.org/10.1038/labinvest.2012.113openalex-snapshot
Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway
inferredcites →https://doi.org/10.1038/nsmb1208openalex-snapshot
Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility
inferredcites →https://doi.org/10.1038/srep36949openalex-snapshot
Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism
inferredcites →https://doi.org/10.1073/pnas.1321510111openalex-snapshot
RETRACTED: Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells
inferredcites →https://doi.org/10.1074/jbc.m111.304006openalex-snapshot
Oncogenic Ras and B-Raf Proteins Positively Regulate Death Receptor 5 Expression through Co-activation of ERK and JNK Signaling
inferredcites →https://doi.org/10.1093/cvr/27.11.1933openalex-snapshot
Selective and time related activation of the cardiac renin-angiotensin system after experimental heart failure: relation to ventricular function and morphology
inferredcites →https://doi.org/10.1097/00001573-200007000-00010openalex-snapshot
Fibrosis and hypertensive heart disease
inferredcites →https://doi.org/10.1139/y09-105openalex-snapshot
Emerging concepts in cardiac matrix biologyThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.
inferredcites →https://doi.org/10.1152/ajpcell.00518.2010openalex-snapshot
Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells
inferredcites →https://doi.org/10.1152/ajpheart.00937.2006openalex-snapshot
Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1–7)
inferredcites →https://doi.org/10.1155/2012/698531openalex-snapshot
Drug Target Prediction Based on the Herbs Components: The Study on the Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease
inferredcites →https://doi.org/10.1155/2012/960128openalex-snapshot
Salvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF- β 1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct Pathways
inferredcites →https://doi.org/10.1155/2012/978127openalex-snapshot
Cardioprotective Effects of Qishenyiqi Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin-Converting Enzyme 2
inferredcites →https://doi.org/10.1155/2013/459467openalex-snapshot
PI3K/Akt Pathway Contributes to Neurovascular Unit Protection ofXiao-Xu-MingDecoction against Focal Cerebral Ischemia and Reperfusion Injury in Rats
inferredcites →https://doi.org/10.1155/2019/9791436openalex-snapshot
Corrigendum to “Cardioprotective Effects of Qishenyiqi Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin-Converting Enzyme 2”
inferredcites →https://doi.org/10.1158/1538-7445.am2015-5102openalex-snapshot
Abstract 5102: Differential levels of mutated Kras drive lung cancer cell motility and morphology via a hypoxia-sensitive FAK/Erk/Myosin II signaling pathway
inferredcites →https://doi.org/10.1161/01.hyp.0000144400.49062.6bopenalex-snapshot
Angiotensin II Regulation of Collagen Type I Expression in Cardiac Fibroblasts
inferredcites →https://doi.org/10.1161/circresaha.109.209809openalex-snapshot
Cardiac Fibroblast
inferredcites →https://doi.org/10.1161/circresaha.115.306565openalex-snapshot
Cardiac Fibrosis
inferredcites →https://doi.org/10.1161/jaha.116.003474openalex-snapshot
Local Application of Leptin Antagonist Attenuates Angiotensin II–Induced Ascending Aortic Aneurysm and Cardiac Remodeling
inferredcites →https://doi.org/10.1183/09031936.00112209openalex-snapshot
Mechanisms of bradykinin-induced contraction in human fetal lung fibroblasts
inferredcites →https://doi.org/10.1371/journal.pone.0001321openalex-snapshot
Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling
inferredcites →https://doi.org/10.1371/journal.pone.0104255openalex-snapshot
Qishenyiqi Protects Ligation-Induced Left Ventricular Remodeling by Attenuating Inflammation and Fibrosis via STAT3 and NF-κB Signaling Pathway
inferredcites →https://doi.org/10.1371/journal.pone.0109208openalex-snapshot
The Polyphenols (−)-Epigallocatechin-3-Gallate and Luteolin Synergistically Inhibit TGF-β-Induced Myofibroblast Phenotypes through RhoA and ERK Inhibition
inferredcites →https://doi.org/10.1371/journal.pone.0146094openalex-snapshot
Urotensin-ⅡReceptor Antagonist SB-710411 Protects Rat Heart against Ischemia-Reperfusion Injury via RhoA/ROCK Pathway
inferredcites →https://doi.org/10.14670/hh-27.919openalex-snapshot
Angiotensin AT(1) receptor inhibition-induced apoptosis by RhoA GTPase activation and pERK1/2 signaling pathways in neonatal obstructive nephropathy.
inferredcites →https://doi.org/10.1586/14779072.2013.839942openalex-snapshot
Investigational drugs targeting cardiac fibrosis
inferredcites →https://doi.org/10.3892/or.19.3.737openalex-snapshot
AP-1 transcription factor decoy reduces the TGF-β1-induced cell growth in scleroderma fibroblasts through inhibition of cyclin E
inferredcites →https://doi.org/10.7150/ijbs.7.869openalex-snapshot
Dimerumic Acid Inhibits SW620 Cell Invasion by Attenuating H2O2-Mediated MMP-7 Expression via JNK/C-Jun and ERK/C-Fos Activation in an AP-1-Dependent Manner

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4752183openalex-extracted
Yixinjiedu Formula Inhibits Ferroptosis by Regulating PINK1/Parkin-Mediated Mitophagy to Attenuate Pressure Overload-Induced Cardiac Dysfunction
inferred← citeshttps://doi.org/10.1016/j.chmed.2023.12.007openalex-snapshot
Qishen Granule protects against myocardial ischemia by promoting angiogenesis through BMP2-Dll4-Notch1 pathway
inferred← citeshttps://doi.org/10.1016/j.jep.2020.112573openalex-snapshot
Qishen Granule alleviates endoplasmic reticulum stress-induced myocardial apoptosis through IRE-1-CRYAB pathway in myocardial ischemia
inferred← citeshttps://doi.org/10.1016/j.jep.2021.114841openalex-snapshot
Qishen granule (QSG) exerts cardioprotective effects by inhibiting NLRP3 inflammasome and pyroptosis in myocardial infarction rats
inferred← citeshttps://doi.org/10.1016/j.jep.2023.117134openalex-snapshot
Qishen granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3
inferred← citeshttps://doi.org/10.1016/j.jep.2024.118604openalex-snapshot
Qishen granule alleviates doxorubicin-induced cardiotoxicity by suppressing ferroptosis via nuclear erythroid factor 2-related factor 2 (Nrf2) pathway
inferred← citeshttps://doi.org/10.1016/j.jtcms.2020.03.001openalex-snapshot
Use of Qishen granule for the treatment of heart failure: A systematic review and meta-analysis of animal studies
inferred← citeshttps://doi.org/10.1016/j.phymed.2019.152949openalex-snapshot
Qishen granule attenuates cardiac fibrosis by regulating TGF-β /Smad3 and GSK-3β pathway
inferred← citeshttps://doi.org/10.1038/s41467-023-39934-zopenalex-snapshot
Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease
inferred← citeshttps://doi.org/10.1097/md.0000000000008167openalex-snapshot
Huangqi injection in the treatment of chronic heart failure
inferred← citeshttps://doi.org/10.1155/2019/1642575openalex-snapshot
Antiapoptosis and Antifibrosis Effects of Qishen Granules on Heart Failure Rats via Hippo Pathway
inferred← citeshttps://doi.org/10.1155/2020/1868974openalex-snapshot
The Protective Effect of Qishen Granule on Heart Failure after Myocardial Infarction through Regulation of Calcium Homeostasis
inferred← citeshttps://doi.org/10.1155/2021/4963346openalex-snapshot
Chinese Herbal Medicine Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress
inferred← citeshttps://doi.org/10.1155/2021/5779307openalex-snapshot
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats
inferred← citeshttps://doi.org/10.1155/2022/9024394openalex-snapshot
Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure
inferred← citeshttps://doi.org/10.1186/s13020-020-0299-9openalex-snapshot
Qishen granules exerts cardioprotective effects on rats with heart failure via regulating fatty acid and glucose metabolism
inferred← citeshttps://doi.org/10.12659/msm.919768openalex-snapshot
A Network Pharmacology Approach to Explore the Mechanisms of Qishen Granules in Heart Failure
inferred← citeshttps://doi.org/10.3389/fmicb.2023.1202768openalex-snapshot
Qishen granules regulate intestinal microecology to improve cardiac function in rats with heart failure
inferred← citeshttps://doi.org/10.3389/fphar.2022.850187openalex-snapshot
Qishen Granule (QSG) Inhibits Monocytes Released From the Spleen and Protect Myocardial Function via the TLR4-MyD88-NF-κB p65 Pathway in Heart Failure Mice
inferred← citeshttps://doi.org/10.3390/molecules23071829openalex-snapshot
Decomposing the Mechanism of Qishen Granules in the Treatment of Heart Failure by a Quantitative Pathway Analysis Method
inferred← citeshttps://doi.org/10.3390/ph18101584openalex-snapshot
An Efficacy- and In Vivo Exposure-Oriented Integrated Study to Investigate the Effective Components of Qishen Granule
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