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The Causal Role of Mitochondrial Dynamics in Regulating Insulin Resistance in Diabetes: Link through Mitochondrial Reactive Oxygen Species

https://doi.org/10.1155/2018/7514383
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Mitochondrial fission – a drug target for cytoprotection or cytodestruction?
inferredcites →https://doi.org/10.1007/164_2016_7openalex-snapshot
Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases
inferredcites →https://doi.org/10.1007/s00125-009-1553-yopenalex-snapshot
Diabetes regulates mitochondrial biogenesis and fission in mouse neurons
inferredcites →https://doi.org/10.1007/s00125-015-3704-7openalex-snapshot
Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration
inferredcites →https://doi.org/10.1007/s00401-010-0697-7openalex-snapshot
Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy
inferredcites →https://doi.org/10.1016/j.beem.2012.05.004openalex-snapshot
Mitochondrial dynamics and morphology in beta-cells
inferredcites →https://doi.org/10.1016/j.biocel.2008.08.031openalex-snapshot
Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis
inferredcites →https://doi.org/10.1016/j.celrep.2017.02.035openalex-snapshot
Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action
inferredcites →https://doi.org/10.1016/j.cmet.2013.03.002openalex-snapshot
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
inferredcites →https://doi.org/10.1016/j.devcel.2007.11.019openalex-snapshot
Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2016.04.019openalex-snapshot
Altered mitochondrial dynamics and response to insulin in cybrid cells harboring a diabetes-susceptible mitochondrial DNA haplogroup
inferredcites →https://doi.org/10.1016/j.mito.2013.08.001openalex-snapshot
Study of insulin resistance in cybrid cells harboring diabetes-susceptible and diabetes-protective mitochondrial haplogroups
inferredcites →https://doi.org/10.1016/j.redox.2014.11.006openalex-snapshot
Mitochondrial dynamics and mitochondrial quality control
inferredcites →https://doi.org/10.1038/414813aopenalex-snapshot
Biochemistry and molecular cell biology of diabetic complications
inferredcites →https://doi.org/10.1038/nature11707openalex-snapshot
Mitochondrial disorders as windows into an ancient organelle
inferredcites →https://doi.org/10.1038/ni.3704openalex-snapshot
Mitochondria are the powerhouses of immunity
inferredcites →https://doi.org/10.1073/pnas.1108220109openalex-snapshot
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
inferredcites →https://doi.org/10.1074/jbc.m212754200openalex-snapshot
Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism
inferredcites →https://doi.org/10.1080/13813450802676335openalex-snapshot
Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance
inferredcites →https://doi.org/10.1083/jcb.201511036openalex-snapshot
Metabolic regulation of mitochondrial dynamics
inferredcites →https://doi.org/10.1089/ars.2016.6707openalex-snapshot
Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?
inferredcites →https://doi.org/10.1091/mbc.e10-12-0933openalex-snapshot
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells
inferredcites →https://doi.org/10.1101/cshperspect.a011072openalex-snapshot
Mechanisms of Mitochondrial Fission and Fusion
inferredcites →https://doi.org/10.1111/febs.12940openalex-snapshot
Mitochondrial dynamics and the innate antiviral immune response
inferredcites →https://doi.org/10.1126/science.1104343openalex-snapshot
Mitochondrial Dysfunction and Type 2 Diabetes
inferredcites →https://doi.org/10.1128/mcb.05603-11openalex-snapshot
Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle
inferredcites →https://doi.org/10.1146/annurev-genet-110410-132529openalex-snapshot
Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
inferredcites →https://doi.org/10.1152/japplphysiol.01064.2013openalex-snapshot
Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle
inferredcites →https://doi.org/10.1155/2012/824275openalex-snapshot
The Creation of Cybrids Harboring Mitochondrial Haplogroups in the Taiwanese Population of Ethnic Chinese Background: An ExtensiveIn VitroTool for the Study of Mitochondrial Genomic Variations
inferredcites →https://doi.org/10.1160/th14-07-0592openalex-snapshot
Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology
inferredcites →https://doi.org/10.1161/circulationaha.109.906610openalex-snapshot
Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury
inferredcites →https://doi.org/10.1172/jci37829openalex-snapshot
Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
inferredcites →https://doi.org/10.1371/journal.pone.0092810openalex-snapshot
Impaired Mitochondrial Dynamics and Bioenergetics in Diabetic Skeletal Muscle
inferredcites →https://doi.org/10.15252/embj.201593084openalex-snapshot
Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
inferredcites →https://doi.org/10.2337/db07-1781openalex-snapshot
Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis
inferredcites →https://doi.org/10.2337/db11-1369openalex-snapshot
Mitochondrial DNA Coding and Control Region Variants as Genetic Risk Factors for Type 2 Diabetes
inferredcites →https://doi.org/10.4161/cc.10.16.17002openalex-snapshot
Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Dual GLP-1/GIP agonist tirzepatide modulates hepatic mitochondrial fusion–fission gene expression and oxidative stress in diabetic rats
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Salidroside in the Treatment of NAFLD/NASH
inferred← citeshttps://doi.org/10.1002/jbio.201960140openalex-snapshot
Insulin resistance is improved in high‐fat fed mice by photobiomodulation therapy at 630 nm
inferred← citeshttps://doi.org/10.1002/jcp.31317openalex-snapshot
Ethnicity‐related differences in mitochondrial regulation by insulin stimulation in diabetes
inferred← citeshttps://doi.org/10.1002/mef2.70026openalex-snapshot
Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches
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Chemical inhibition of mitochondrial fission improves insulin signaling and subdues hyperglycemia induced stress in placental trophoblast cells
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Skeletal muscle atrophy and dysfunction in obesity and type-2 diabetes mellitus: Myocellular mechanisms involved
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Impact of sarcopenia and obesity on skeletal muscle size, gene expression, and mitochondrial function
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Silane-coupled chitosan-cyclodextrin/rosmarinic acid-zinc complex coating improves the osseointegration of titanium implants in high-glucose environments
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High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system
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PKA-mediated Drp1 Ser637 phosphorylation modulates mitochondrial function in the placenta of gestational diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.bcp.2020.114295openalex-snapshot
Pharmacological inhibition of mitochondrial fission attenuates cardiac ischemia-reperfusion injury in pre-diabetic rats
inferred← citeshttps://doi.org/10.1016/j.biocel.2022.106158openalex-snapshot
MITOCHONDRIA: Mitochondrial dynamics in the regulation of stem cells
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Is insulin resistance tissue-dependent and substrate-specific? The role of white adipose tissue and skeletal muscle
inferred← citeshttps://doi.org/10.1016/j.cmet.2021.02.017openalex-snapshot
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.02.029openalex-snapshot
Mitochondrial superoxide/hydrogen peroxide: An emerging therapeutic target for metabolic diseases
inferred← citeshttps://doi.org/10.1016/j.jff.2022.105296openalex-snapshot
Biomedical aspects of beta-glucan on glucose metabolism and its role on primary gene PIK3R1
inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101802openalex-snapshot
Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105783openalex-snapshot
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease
inferred← citeshttps://doi.org/10.1038/s41392-023-01547-9openalex-snapshot
Mitochondrial dynamics in health and disease: mechanisms and potential targets
inferred← citeshttps://doi.org/10.1038/s41419-025-07936-yopenalex-snapshot
Mitochondrial quality control in diabetes mellitus and complications: molecular mechanisms and therapeutic strategies
inferred← citeshttps://doi.org/10.1080/10408398.2020.1809344openalex-snapshot
Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome
inferred← citeshttps://doi.org/10.1080/17435390.2019.1663288openalex-snapshot
Molecular mechanisms underlying zinc oxide nanoparticle induced insulin resistance in mice
inferred← citeshttps://doi.org/10.1089/ars.2022.0016openalex-snapshot
Mitochondrial Dysfunction and Mitophagy in Type 2 Diabetes: Pathophysiology and Therapeutic Targets
inferred← citeshttps://doi.org/10.1089/dna.2019.5326openalex-snapshot
Mitochondrial DNA Copy Number in Peripheral Blood Is Reduced in Type 2 Diabetes Patients with Polyneuropathy and Associated with a MIR499A Gene Polymorphism
inferred← citeshttps://doi.org/10.1096/fj.202002394ropenalex-snapshot
Moderate aerobic exercise training ameliorates impairment of mitochondrial function and dynamics in skeletal muscle of high‐fat diet‐induced obese mice
inferred← citeshttps://doi.org/10.1097/md.0000000000042748openalex-snapshot
Mitochondrial dynamics in diabetic peripheral neuropathy: Pathogenesis, progression, and therapeutic approaches
inferred← citeshttps://doi.org/10.1111/febs.17214openalex-snapshot
MitoNEET preserves muscle insulin sensitivity during iron overload by regulating mitochondrial iron, reactive oxygen species and fission
inferred← citeshttps://doi.org/10.1111/jdi.13629openalex-snapshot
Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals
inferred← citeshttps://doi.org/10.1111/jfbc.13125openalex-snapshot
The effect of endurance training with crocin consumption on the levels of MFN2 and DRP1 gene expression and glucose and insulin indices in the muscle tissue of diabetic rats
inferred← citeshttps://doi.org/10.1111/jphp.13359openalex-snapshot
C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage
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The role of mitochondrial dysfunction in periodontitis: From mechanisms to therapeutic strategy
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Mitochondrial Transfer of Wharton’s Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts
inferred← citeshttps://doi.org/10.1155/2021/6655685openalex-snapshot
Uterine Insulin Sensitivity Defects Induced Embryo Implantation Loss Associated with Mitochondrial Dysfunction‐Triggered Oxidative Stress
inferred← citeshttps://doi.org/10.1186/s13098-022-00888-9openalex-snapshot
The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus: a double-blind controlled randomized clinical trial
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Mitochondrial Dynamics and Research Status of Hypoglycemic Drugs and Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.14814/phy2.14607openalex-snapshot
Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue
inferred← citeshttps://doi.org/10.14814/phy2.14808openalex-snapshot
Pharmacological inhibition of dynamin‐related protein 1 attenuates skeletal muscle insulin resistance in obesity
inferred← citeshttps://doi.org/10.14814/phy2.15898openalex-snapshot
Extracellular vesicles from obese and diabetic mouse plasma alter C2C12 myotube glucose uptake and gene expression
inferred← citeshttps://doi.org/10.15252/embr.201948395openalex-snapshot
Causal roles of mitochondrial dynamics in longevity and healthy aging
inferred← citeshttps://doi.org/10.1530/joe-19-0393openalex-snapshot
Anti-insulin resistance effects of salidroside through mitochondrial quality control
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Targeting mitochondria: a great boon to fight type 2 diabetes
inferred← citeshttps://doi.org/10.20381/ruor-25234openalex-snapshot
The Effects of BPA and BPS on Skeletal Muscle and Adipose Tissue Metabolism
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1706968/v1openalex-snapshot
Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast Cells
inferred← citeshttps://doi.org/10.2147/dmso.s299570openalex-snapshot
Hepatic Knockdown of Endothelin Type A Receptor (ETAR) Ameliorates Hepatic Insulin Resistance and Hyperglycemia Through Suppressing p66Shc-Mediated Mitochondrial Fragmentation in High-Fat Diet-Fed Mice
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The Role of Placental MFF-Mediated Mitochondrial Fission in Gestational Diabetes Mellitus
inferred← citeshttps://doi.org/10.2174/1573399820666230817102053openalex-snapshot
Study of the Relationship Between Insulin Resistance, Iron Status Markers, and Body Weight in a Sample of Egyptian Population
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Ginger Supplementation Attenuated Mitochondrial Fusion and Improved Skeletal Muscle Size in Type 2 Diabetic Rats
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Potencial terapêutico das células-tronco mesenquimais na doença renal diabética é mediado pelo efeito antioxidante e modulador no programa de controle de qualidade mitocondrial
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Cuban Policosanol Prevents the Apoptosis and the Mitochondrial Dysfunction Induced by Lipopolysaccharide in C2C12 Myoblast via Activation of Akt and Erk Pathways
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Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer
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The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes
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Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes
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Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease
inferred← citeshttps://doi.org/10.3389/fendo.2023.1230168openalex-snapshot
New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics
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The role of circadian clock-controlled mitochondrial dynamics in diabetic cardiomyopathy
inferred← citeshttps://doi.org/10.3389/fmed.2026.1811028openalex-snapshot
QDPR rs3733570 polymorphism is associated with type 2 diabetes and diabetic kidney disease accompanied by hyperlipidemia in the Chinese Han population
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Dietary bioactive compounds targeting insulin resistance: mechanisms and preventive potential
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Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD
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Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet
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Mitophagy: A potential therapeutic target for insulin resistance
inferred← citeshttps://doi.org/10.3390/antiox12010074openalex-snapshot
Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia
inferred← citeshttps://doi.org/10.3390/antiox12030592openalex-snapshot
Muscle Oxidative Stress Plays a Role in Hyperthyroidism-Linked Insulin Resistance
inferred← citeshttps://doi.org/10.3390/antiox15091193openalex-snapshot
Molecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies
inferred← citeshttps://doi.org/10.3390/biomedicines11030981openalex-snapshot
Single Nucleotide Polymorphisms of the RAC1 Gene as Novel Susceptibility Markers for Neuropathy and Microvascular Complications in Type 2 Diabetes
inferred← citeshttps://doi.org/10.3390/cells12091223openalex-snapshot
The Complex Interplay between Imbalanced Mitochondrial Dynamics and Metabolic Disorders in Type 2 Diabetes
inferred← citeshttps://doi.org/10.3390/cimb48070736openalex-snapshot
Carnosic Acid Attenuates TNF-α-Induced Insulin Resistance by Regulating Mitochondrial Function in 3T3-L1 Adipocytes
inferred← citeshttps://doi.org/10.3390/ijms21176275openalex-snapshot
Pathophysiology of Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.3390/ijms22052668openalex-snapshot
The Role of Mitochondria in Immune-Cell-Mediated Tissue Regeneration and Ageing
inferred← citeshttps://doi.org/10.3390/ijms23169252openalex-snapshot
Macrophage Polarization Mediated by Mitochondrial Dysfunction Induces Adipose Tissue Inflammation in Obesity
inferred← citeshttps://doi.org/10.3390/ijms242417241openalex-snapshot
Hexavalent-Chromium-Induced Disruption of Mitochondrial Dynamics and Apoptosis in the Liver via the AMPK-PGC-1α Pathway in Ducks
inferred← citeshttps://doi.org/10.3390/ijms25010480openalex-snapshot
MitoNEET Provides Cardioprotection via Reducing Oxidative Damage and Conserving Mitochondrial Function
inferred← citeshttps://doi.org/10.3390/jcm9082522openalex-snapshot
Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control
inferred← citeshttps://doi.org/10.3390/nu15071568openalex-snapshot
Low Protein Programming Causes Increased Mitochondrial Fusion and Decreased Oxygen Consumption in the Hepatocytes of Female Rats
inferred← citeshttps://doi.org/10.33915/etd.11325openalex-snapshot
Amelioration of Mitochondrial Bioenergetic Dysfunction in Diabetes Mellitus: Delving into Specialized and Non-specific Therapeutics for the Ailing Heart
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A INFLUÊNCIA DA DIABETES MELLITUS TIPO 2 NA OSSEOINTEGRAÇÃO DE IMPLANTES DENTÁRIOS
inferred← citeshttps://doi.org/10.4055/cios25386openalex-snapshot
Identification of Mitochondrial Dynamics-Related Genes as Diagnostic Biomarkers for Osteoarthritis Using Weighted Gene Co-expression Network Analysis and Machine Learning
inferred← citeshttps://doi.org/10.6084/m9.figshare.20579778openalex-snapshot
Additional file 1 of The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus: a double-blind controlled randomized clinical trial
inferred← citeshttps://doi.org/10.7287/peerj.9741v0.1/reviews/1openalex-snapshot
Peer Review #1 of "Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.9741v0.1/reviews/2openalex-snapshot
Peer Review #2 of "Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.9741v0.2/reviews/1openalex-snapshot
Peer Review #1 of "Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria (v0.2)"
inferred← citeshttps://doi.org/10.7287/peerj.9741v0.2/reviews/2openalex-snapshot
Peer Review #2 of "Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria (v0.2)"
inferred← citeshttps://doi.org/10.7555/jbr.36.20220078openalex-snapshot
SIRT3 regulates mitochondrial biogenesis in aging-related diseases
inferred← citeshttps://doi.org/10.7717/peerj.9741openalex-snapshot
Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria
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