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Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium
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1 of the 168 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1074/jbc.m404421200 (notice 2019-09-06).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jama.265.24.3255openalex-snapshotPrevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group
inferredcites →https://doi.org/10.1002/jcp.21063openalex-snapshotOxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells
inferredcites →https://doi.org/10.1002/jcp.21986openalex-snapshotHigh glucose increases expression of cyclooxygenase‐2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells
inferredcites →https://doi.org/10.1007/bf00281116openalex-snapshotPhotocoagulation for proliferative diabetic retinopathy: a randomised controlled clinical trial using the xenon-arc
inferredcites →https://doi.org/10.1007/s00210-005-1083-1openalex-snapshotMetformin prevents the impairment of endothelium-dependent vascular relaxation induced by high glucose challenge in rabbit isolated perfused kidneys
inferredcites →https://doi.org/10.1016/0091-7435(85)90059-3openalex-snapshotMortality findings for stepped-care and referred-care participants in the hypertension detection and follow-up program, stratified by other risk factors
inferredcites →https://doi.org/10.1016/j.bcp.2004.04.003openalex-snapshotMetformin-induced stimulation of AMP-activated protein kinase in β-cells impairs their glucose responsiveness and can lead to apoptosis
inferredcites →https://doi.org/10.1016/j.cellsig.2012.04.017openalex-snapshotA potential mechanism of metformin-mediated regulation of glucose homeostasis: Inhibition of Thioredoxin-interacting protein (Txnip) gene expression
inferredcites →https://doi.org/10.1016/s0022-3476(94)70190-3openalex-snapshotEffect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial
inferredcites →https://doi.org/10.1016/s0140-6736(98)04311-6openalex-snapshotEffects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
inferredcites →https://doi.org/10.1038/nm.3372openalex-snapshotSingle phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
inferredcites →https://doi.org/10.1038/sj.bjp.0707189openalex-snapshotMethyl succinate antagonises biguanide‐induced AMPK‐activation and death of pancreatic β‐cells through restoration of mitochondrial electron transfer
inferredcites →https://doi.org/10.1042/bj3480607openalex-snapshotEvidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
inferredcites →https://doi.org/10.1056/nejm199309303291401openalex-snapshotThe Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
inferredcites →https://doi.org/10.1074/jbc.m111.330746openalex-snapshotDefining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells
inferredcites →https://doi.org/10.1093/cvr/cvp131openalex-snapshotMetformin decreases angiogenesis via NF-κB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1
inferredcites →https://doi.org/10.1096/fj.10-173492openalex-snapshotHepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
inferredcites →https://doi.org/10.1097/00004872-199303000-00012openalex-snapshotHypertension in Diabetes Study (HDS): I. Prevalence of hypertension in newly presenting type 2 diabetic patients and the association with risk factors for cardiovascular and diabetic complications
inferredcites →https://doi.org/10.1124/dmd.107.015495openalex-snapshotMetformin Transport by a Newly Cloned Proton-Stimulated Organic Cation Transporter (Plasma Membrane Monoamine Transporter) Expressed in Human Intestine
inferredcites →https://doi.org/10.1136/bmj.316.7134.823openalex-snapshotRisk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23)
inferredcites →https://doi.org/10.1136/bmj.317.7160.713openalex-snapshotEfficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39
inferredcites →https://doi.org/10.1159/000341770openalex-snapshotPioglitazone Ameliorates Endothelial Dysfunction in Those with Impaired Glucose Regulation among the First-Degree Relatives of Type 2 Diabetes Mellitus Patients
inferredcites →https://doi.org/10.1159/000381643openalex-snapshotMetformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium
inferredcites →https://doi.org/10.1159/000444053openalex-snapshotDietary Advanced Glycation End Products and Their Potential Role in Cardiometabolic Disease in Children
inferredcites →https://doi.org/10.1172/jci118709openalex-snapshotObesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance.
inferredcites →https://doi.org/10.1172/jci40671openalex-snapshotMetformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
inferredcites →https://doi.org/10.2337/dc13-2148openalex-snapshotThe Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Summary and Future Directions
inferredcites →https://doi.org/10.2337/diab.27.7.757openalex-snapshotEnhancement of the Mitochondrial Ca2+ Uptake Rate by Phenethylbiguanide and Other Organic Cations with Hypoglycemic Activity
inferredcites →https://doi.org/10.2337/diabetes.54.4.1123openalex-snapshotMetformin Prevents Glucose-Induced Protein Kinase C-β2 Activation in Human Umbilical Vein Endothelial Cells Through an Antioxidant Mechanism
inferredcites →https://doi.org/10.2337/diabetes.55.02.06.db05-1064openalex-snapshotActivation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase
inferredcites →https://doi.org/10.2337/diacare.16.2.434openalex-snapshotDiabetes, Other Risk Factors, and 12-Yr Cardiovascular Mortality for Men Screened in the Multiple Risk Factor Intervention Trial
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1001/jamainternmed.2015.5110openalex-snapshotRates of Deintensification of Blood Pressure and Glycemic Medication Treatment Based on Levels of Control and Life Expectancy in Older Patients With Diabetes Mellitus
inferred← citeshttps://doi.org/10.1002/clc.4960240210openalex-snapshotOral antidiabetic treatment in patients with coronary disease: Time‐related increased mortality on combined glyburide/metformin therapy over a 7.7‐year follow‐up
inferred← citeshttps://doi.org/10.1002/edm2.404openalex-snapshotTwo‐year trends from the LANDMARC study: A 3‐year, pan‐India, prospective, longitudinal study on the management and real‐world outcome in patients with type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1002/jcp.26085openalex-snapshotConcentration‐dependent metabolic effects of metformin in healthy and Fanconi anemia lymphoblast cells
inferred← citeshttps://doi.org/10.1002/jhm.2321openalex-snapshotAssociation of inpatient and outpatient glucose management with inpatient mortality among patients with and without diabetes at a major academic medical center
inferred← citeshttps://doi.org/10.1002/nbm.4561openalex-snapshotOffset of apparent hyperpolarized 13C lactate flux by the use of adjuvant metformin in ionizing radiation therapy in vivo
inferred← citeshttps://doi.org/10.1002/phar.2083openalex-snapshotPharmacist Intervention for Blood Pressure Control in Patients with Diabetes and/or Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1007/bf02915282openalex-snapshotTarget blood pressure for patients with type 2 diabetes is difficult to achieve in the setting of a busy diabetes clinic
inferred← citeshttps://doi.org/10.1007/bf03259726openalex-snapshotSeated Cuff Blood Pressure-Lowering Efficacy of an Olmesartan Medoxomil-Based Treatment Regimen in Patients with Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1007/bf03404863openalex-snapshotImprovements in Indicators of Diabetes-related Health Status Among First Nations Individuals Enrolled in a Community-driven Diabetes Complications Mobile Screening Program in Alberta, Canada
inferred← citeshttps://doi.org/10.1007/s00125-005-1730-6openalex-snapshotSex differences in cardiovascular and total mortality among diabetic and non-diabetic individuals with or without history of myocardial infarction
inferred← citeshttps://doi.org/10.1007/s00125-006-0297-1openalex-snapshotAdditive effects of glycaemia and blood pressure exposure on risk of complications in type 2 diabetes: a prospective observational study (UKPDS 75)
inferred← citeshttps://doi.org/10.1007/s00125-006-0510-2openalex-snapshotA comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study
inferred← citeshttps://doi.org/10.1007/s00125-007-0792-zopenalex-snapshotMetabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00125-015-3548-1openalex-snapshotBlood pressure level and risk of major cardiovascular events and all-cause of mortality in patients with type 2 diabetes and renal impairment: an observational study from the Swedish National Diabetes Register
inferred← citeshttps://doi.org/10.1007/s00125-015-3804-4openalex-snapshotThe impact of gender on the long-term morbidity and mortality of patients with type 2 diabetes receiving structured personal care: a 13 year follow-up study
inferred← citeshttps://doi.org/10.1007/s00125-024-06287-1openalex-snapshotThe population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice
inferred← citeshttps://doi.org/10.1007/s00228-005-0961-2openalex-snapshotEffect of successful hypertension control by manidipine or lisinopril on albuminuria and left ventricular mass in diabetic hypertensive patients with microalbuminuria
inferred← citeshttps://doi.org/10.1007/s00228-022-03444-6openalex-snapshotEffect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women: a pilot study
inferred← citeshttps://doi.org/10.1007/s00432-015-1909-2openalex-snapshotChanges in [18F]Fluoro-2-deoxy-d-glucose incorporation induced by doxorubicin and anti-HER antibodies by breast cancer cells modulated by co-treatment with metformin and its effects on intracellular signalling
inferred← citeshttps://doi.org/10.1007/s00508-019-1460-2openalex-snapshotIndividualisierung der antihypertensiven Therapie bei Patienten mit Diabetes mellitus. Leitlinie der Österreichischen Diabetes Gesellschaft (Update 2019)
inferred← citeshttps://doi.org/10.1007/s00508-023-02189-1openalex-snapshotIndividualisierung der antihypertensiven Therapie bei Patient:innen mit Diabetes mellitus. Leitlinie der Österreichischen Diabetes Gesellschaft (Update 2023)
inferred← citeshttps://doi.org/10.1007/s10695-024-01386-7openalex-snapshotMetformin attenuates high-carbohydrate diet-induced redox imbalance, inflammation, and mitochondrial dysfunction in Megalobrama amblycephala
inferred← citeshttps://doi.org/10.1007/s10787-022-00980-6openalex-snapshotThe role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases
inferred← citeshttps://doi.org/10.1007/s10943-011-9481-9openalex-snapshotA Methodological Review of Faith-Based Health Promotion Literature: Advancing the Science to Expand Delivery of Diabetes Education to Black Americans
inferred← citeshttps://doi.org/10.1007/s11357-018-0042-yopenalex-snapshotA framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
inferred← citeshttps://doi.org/10.1007/s11605-011-1807-0openalex-snapshotSurgical Treatment of Type 2 Diabetes in Patients with BMI Below 35: Mid-term Outcomes of the Laparoscopic Ileal Interposition Associated with a Sleeve Gastrectomy in 202 Consecutive Cases
inferred← citeshttps://doi.org/10.1007/s11626-017-0136-3openalex-snapshotBiogenic synthesis of Marsilea quadrifolia gold nanoparticles: a study of improved glucose utilization efficiency on 3T3-L1 adipocytes
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