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The RhoA/Rho Kinase Pathway Regulates Nuclear Localization of Serum Response Factor

https://doi.org/10.1165/rcmb.2002-0206oc

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/j.1460-2075.1994.tb06877.xopenalex-snapshot

Serum‐regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain.

inferredcites →https://doi.org/10.1006/bbrc.1998.8525openalex-snapshot

Rho Protein Inhibition Blocks Protein Kinase C Translocation and Activation

inferredcites →https://doi.org/10.1006/dbio.1997.8621openalex-snapshot

Evidence for Serum Response Factor-Mediated Regulatory Networks GoverningSM22αTranscription in Smooth, Skeletal, and Cardiac Muscle Cells

inferredcites →https://doi.org/10.1006/dbio.2001.0403openalex-snapshot

Coronary Smooth Muscle Differentiation from Proepicardial Cells Requires RhoA-Mediated Actin Reorganization and p160 Rho-Kinase Activity

inferredcites →https://doi.org/10.1006/excr.1999.4565openalex-snapshot

Cellular Redistribution of PKCα, rhoA, and ROKα Following Smooth Muscle Agonist Stimulation

inferredcites →https://doi.org/10.1006/geno.1998.5267openalex-snapshot

Expression and Cytogenetic Localization of the Human SM22 Gene (TAGLN)

inferredcites →https://doi.org/10.1016/0092-8674(95)90370-4openalex-snapshot

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

inferredcites →https://doi.org/10.1016/s0014-5793(97)00107-5openalex-snapshot

p160ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

inferredcites →https://doi.org/10.1016/s0021-9258(18)43847-1openalex-snapshot

Identification of functional promoter elements in the rabbit smooth muscle myosin heavy chain gene.

inferredcites →https://doi.org/10.1016/s0026-895x(24)26508-1openalex-snapshot

Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases

inferredcites →https://doi.org/10.1016/s0092-8674(00)80941-1openalex-snapshot

Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation

inferredcites →https://doi.org/10.1016/s0092-8674(00)81011-9openalex-snapshot

Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics

inferredcites →https://doi.org/10.1016/s0092-8674(00)81371-9openalex-snapshot

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

inferredcites →https://doi.org/10.1016/s0092-8674(05)80020-0openalex-snapshot

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

inferredcites →https://doi.org/10.1038/35010550openalex-snapshot

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

inferredcites →https://doi.org/10.1038/40187openalex-snapshot

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

inferredcites →https://doi.org/10.1038/sj.onc.1202022openalex-snapshot

Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation

inferredcites →https://doi.org/10.1038/sj.onc.1203121openalex-snapshot

Expression of the SRF gene occurs through a Ras/Sp/SRF-mediated-mechanism in response to serum growth signals

inferredcites →https://doi.org/10.1073/pnas.95.5.2061openalex-snapshot

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

inferredcites →https://doi.org/10.1074/jbc.270.22.13460openalex-snapshot

Structure and Expression of a Smooth Muscle Cell-specific Gene, SM22α

inferredcites →https://doi.org/10.1074/jbc.271.28.16535openalex-snapshot

Expression of the Serum Response Factor Gene Is Regulated by Serum Response Factor Binding Sites

inferredcites →https://doi.org/10.1074/jbc.271.49.31666openalex-snapshot

Specific Triggering of the Fas Signal Transduction Pathway in Normal Human Keratinocytes

inferredcites →https://doi.org/10.1074/jbc.272.10.6332openalex-snapshot

Expression of the Smooth Muscle Myosin Heavy Chain Gene Is Regulated by a Negative-acting GC-rich Element Located between Two Positive-acting Serum Response Factor-binding Elements

inferredcites →https://doi.org/10.1074/jbc.272.40.25121openalex-snapshot

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

inferredcites →https://doi.org/10.1074/jbc.272.47.29842openalex-snapshot

Interaction of CArG Elements and a GC-rich Repressor Element in Transcriptional Regulation of the Smooth Muscle Myosin Heavy Chain Gene in Vascular Smooth Muscle Cells

inferredcites →https://doi.org/10.1074/jbc.272.49.31016openalex-snapshot

The CREB-binding Protein (CBP) Cooperates with the Serum Response Factor for Transactivation of the c-fos Serum Response Element

inferredcites →https://doi.org/10.1074/jbc.273.30.18943openalex-snapshot

Different Regions of Rho Determine Rho-selective Binding of Different Classes of Rho Target Molecules

inferredcites →https://doi.org/10.1074/jbc.273.44.28564openalex-snapshot

Steroid Receptor Coactivator-1 Interacts with Serum Response Factor and Coactivates Serum Response Element-mediated Transactivations

inferredcites →https://doi.org/10.1074/jbc.273.46.30287openalex-snapshot

RhoA Signaling via Serum Response Factor Plays an Obligatory Role in Myogenic Differentiation

inferredcites →https://doi.org/10.1074/jbc.274.26.18675openalex-snapshot

M3 Muscarinic Acetylcholine Receptors Regulate Cytoplasmic Myosin by a Process Involving RhoA and Requiring Conventional Protein Kinase C Isoforms

inferredcites →https://doi.org/10.1074/jbc.274.48.34096openalex-snapshot

p300 Protein as a Coactivator of GATA-5 in the Transcription of Cardiac-restricted Atrial Natriuretic Factor Gene

inferredcites →https://doi.org/10.1074/jbc.m000828200openalex-snapshot

A p300 Protein as a Coactivator of GATA-6 in the Transcription of the Smooth Muscle-Myosin Heavy Chain Gene

inferredcites →https://doi.org/10.1074/jbc.m000840200openalex-snapshot

Physiological Control of Smooth Muscle-specific Gene Expression through Regulated Nuclear Translocation of Serum Response Factor

inferredcites →https://doi.org/10.1074/jbc.m005505200openalex-snapshot

Smooth Muscle Differentiation Marker Gene Expression Is Regulated by RhoA-mediated Actin Polymerization

inferredcites →https://doi.org/10.1083/jcb.131.6.1857openalex-snapshot

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

inferredcites →https://doi.org/10.1083/jcb.132.5.849openalex-snapshot

Expression of the SM22alpha promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells.

inferredcites →https://doi.org/10.1083/jcb.144.6.1235openalex-snapshot

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

inferredcites →https://doi.org/10.1083/jcb.200107049openalex-snapshot

High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis

inferredcites →https://doi.org/10.1083/jcb.200203126openalex-snapshot

LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics

inferredcites →https://doi.org/10.1091/mbc.10.8.2481openalex-snapshot

Distinct Actions and Cooperative Roles of ROCK and mDia in Rho Small G Protein-induced Reorganization of the Actin Cytoskeleton in Madin–Darby Canine Kidney Cells

inferredcites →https://doi.org/10.1093/emboj/17.22.6573openalex-snapshot

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of theCBP/p300 coactivator by the hypoxia‐induciblefactor‐1α

inferredcites →https://doi.org/10.1093/emboj/17.5.1350openalex-snapshot

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation

inferredcites →https://doi.org/10.1093/nar/11.5.1475openalex-snapshot

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

inferredcites →https://doi.org/10.1098/rstb.1996.0054openalex-snapshot

Integration of growth factor signals at the c-fos serum response element

inferredcites →https://doi.org/10.1101/gad.11.18.2295openalex-snapshot

Rho GTPases and signaling networks

inferredcites →https://doi.org/10.1101/sqb.1998.63.643openalex-snapshot

Regulation of SRF Activity by Rho Family GTPases

inferredcites →https://doi.org/10.1126/science.279.5350.509openalex-snapshot

Rho GTPases and the Actin Cytoskeleton

inferredcites →https://doi.org/10.1128/mcb.15.1.433openalex-snapshot

The Serum Response Factor Nuclear Localization Signal: General Implications for Cyclic AMP-Dependent Protein Kinase Activity in Control of Nuclear Translocation

inferredcites →https://doi.org/10.1128/mcb.17.4.2266openalex-snapshot

A Serum Response Factor-Dependent Transcriptional Regulatory Program Identifies Distinct Smooth Muscle Cell Sublineages

inferredcites →https://doi.org/10.1128/mcb.19.2.1313openalex-snapshot

Novel Roles of Specific Isoforms of Protein Kinase C in Activation of the c-fosSerum Response Element

inferredcites →https://doi.org/10.1128/mcb.20.11.4159-4168.2000openalex-snapshot

Regulated Nuclear-Cytoplasmic Localization of Interferon Regulatory Factor 3, a Subunit of Double-Stranded RNA-Activated Factor 1

inferredcites →https://doi.org/10.1152/ajpcell.1999.276.4.c915openalex-snapshot

Caffeine does not inhibit substance P-evoked intracellular Ca2+mobilization in rat salivary acinar cells

inferredcites →https://doi.org/10.1152/ajpgi.1999.276.4.g915openalex-snapshot

Involvement of RhoA and its interaction with protein kinase C and Src in CCK-stimulated pancreatic acini

inferredcites →https://doi.org/10.1152/ajplung.1998.274.5.l803openalex-snapshot

Carbachol-induced actin reorganization involves Giactivation of Rho in human airway smooth muscle cells

inferredcites →https://doi.org/10.1152/ajplung.1999.276.1.l197openalex-snapshot

Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes

inferredcites →https://doi.org/10.1152/ajplung.2000.278.5.l1091openalex-snapshot

Selective restoration of calcium coupling to muscarinic M3 receptors in contractile cultured airway myocytes

inferredcites →https://doi.org/10.1161/01.res.78.2.188openalex-snapshot

SM22α, a Marker of Adult Smooth Muscle, Is Expressed in Multiple Myogenic Lineages During Embryogenesis

inferredcites →https://doi.org/10.1161/01.res.82.5.566openalex-snapshot

Evolutionarily Conserved Promoter Region Containing CArG*-Like Elements Is Crucial for Smooth Muscle Myosin Heavy Chain Gene Expression

inferredcites →https://doi.org/10.1242/jcs.107.11.3029openalex-snapshot

Nuclear import of serum response factor (SRF) requires a short aminoterminal nuclear localization sequence and is independent of the casein kinase II phosphorylation site

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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General discussion summary

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Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle

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Motile cilia harbor serum response factor as a mechanism of environment sensing and injury response in the airway

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Statins in Asthma: Potential Beneficial Effects and Limitations

inferred← citeshttps://doi.org/10.1161/01.res.0000125622.46280.95openalex-snapshot

Myocardin and Prx1 Contribute to Angiotensin II-Induced Expression of Smooth Muscle α-Actin

inferred← citeshttps://doi.org/10.1161/01.res.0000128405.83582.2eopenalex-snapshot

RhoA Activation by Hypoxia in Pulmonary Arterial Smooth Muscle Cells Is Age and Site Specific

inferred← citeshttps://doi.org/10.1161/01.res.0000138582.36921.9eopenalex-snapshot

L-type Voltage-Gated Ca 2+ Channels Modulate Expression of Smooth Muscle Differentiation Marker Genes via a Rho Kinase/Myocardin/SRF–Dependent Mechanism

inferred← citeshttps://doi.org/10.1161/01.res.0000141428.53262.a4openalex-snapshot

Rho Kinase–Induced Nuclear Translocation of ERK1/ERK2 in Smooth Muscle Cell Mitogenesis Caused by Serotonin

inferred← citeshttps://doi.org/10.1161/01.res.0000147961.09840.fbopenalex-snapshot

A G/C Element Mediates Repression of the SM22α Promoter Within Phenotypically Modulated Smooth Muscle Cells in Experimental Atherosclerosis

inferred← citeshttps://doi.org/10.1161/01.res.0000176025.57706.1eopenalex-snapshot

Interdependent Serotonin Transporter and Receptor Pathways Regulate S100A4/Mts1, a Gene Associated With Pulmonary Vascular Disease

inferred← citeshttps://doi.org/10.1161/01.res.0000179776.40216.a9openalex-snapshot

Depletion of Serum Response Factor by RNA Interference Mimics the Mitogenic Effects of Platelet Derived Growth Factor-BB in Vascular Smooth Muscle Cells

inferred← citeshttps://doi.org/10.1161/01.res.0000201960.04223.3copenalex-snapshot

Rho Kinases in Cardiovascular Physiology and Pathophysiology

inferred← citeshttps://doi.org/10.1161/01.res.0000202802.34727.fdopenalex-snapshot

LPP Expression During In Vitro Smooth Muscle Differentiation and Stent-Induced Vascular Injury

inferred← citeshttps://doi.org/10.1161/01.res.0000210579.35304.d3openalex-snapshot

Rho GTPases and Leukocyte Adhesion Receptor Expression and Function in Endothelial Cells

inferred← citeshttps://doi.org/10.1161/01.res.0000216039.75913.9eopenalex-snapshot

The Rac and Rho Hall of Fame

inferred← citeshttps://doi.org/10.1161/01.res.0000216596.73005.3copenalex-snapshot

Excitation–Transcription Coupling in Arterial Smooth Muscle

inferred← citeshttps://doi.org/10.1161/atvbaha.110.221135openalex-snapshot

Signaling Mechanisms That Regulate Smooth Muscle Cell Differentiation

inferred← citeshttps://doi.org/10.1161/circresaha.107.162511openalex-snapshot

Phosphodiesterase Type 5

inferred← citeshttps://doi.org/10.1161/circulationaha.105.534024openalex-snapshot

Rho-Kinase Mediates Hyperglycemia-Induced Plasminogen Activator Inhibitor-1 Expression in Vascular Endothelial Cells

inferred← citeshttps://doi.org/10.1161/circulationaha.106.649566openalex-snapshot

Oxygen Activates the Rho/Rho-Kinase Pathway and Induces RhoB and ROCK-1 Expression in Human and Rabbit Ductus Arteriosus by Increasing Mitochondria-Derived Reactive Oxygen Species

inferred← citeshttps://doi.org/10.1161/jaha.115.002113openalex-snapshot

Rho‐GTPase and Atherosclerosis: Pleiotropic Effects of Statins

inferred← citeshttps://doi.org/10.1164/rccm.200409-1249ocopenalex-snapshot

Protective Effects of Tiotropium Bromide in the Progression of Airway Smooth Muscle Remodeling

inferred← citeshttps://doi.org/10.1165/rcmb.2003-0240ocopenalex-snapshot

Mechanical Strain Inhibits Airway Smooth Muscle Gene Transcription via Protein Kinase C Signaling

inferred← citeshttps://doi.org/10.1165/rcmb.2003-0272ocopenalex-snapshot

Phophatidylinositol-3 Kinase/Mammalian Target of Rapamycin/p70 S6K Regulates Contractile Protein Accumulation in Airway Myocyte Differentiation

inferred← citeshttps://doi.org/10.1165/rcmb.2007-0165ocopenalex-snapshot

Laminin-Binding Integrin α7 Is Required for Contractile Phenotype Expression by Human Airway Myocytes

inferred← citeshttps://doi.org/10.1165/rcmb.2008-0251ocopenalex-snapshot

Insulin-Induced Laminin Expression Promotes a Hypercontractile Airway Smooth Muscle Phenotype

inferred← citeshttps://doi.org/10.1165/rcmb.2008-0393ocopenalex-snapshot

Nuclear Import of Serum Response Factor in Airway Smooth Muscle

inferred← citeshttps://doi.org/10.1165/rcmb.2017-0088ocopenalex-snapshot

Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148

inferred← citeshttps://doi.org/10.1165/rcmb.2024-0081ocopenalex-snapshot

Serum Response Factor Expression in Excess Permits a Dual Contractile–Proliferative Phenotype of Airway Smooth Muscle

inferred← citeshttps://doi.org/10.1165/rcmb.f267openalex-snapshot

Lymphangioleiomyomatosis

inferred← citeshttps://doi.org/10.1172/jci200522648openalex-snapshot

5′ CArG degeneracy in smooth muscle α-actin is required for injury-induced gene suppression in vivo

inferred← citeshttps://doi.org/10.1186/1465-9921-14-51openalex-snapshot

Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust

inferred← citeshttps://doi.org/10.1186/1465-9921-15-55openalex-snapshot

Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1

inferred← citeshttps://doi.org/10.1186/1465-9921-7-73openalex-snapshot

Muscarinic receptor signaling in the pathophysiology of asthma and COPD

inferred← citeshttps://doi.org/10.1186/1476-4598-8-9openalex-snapshot

Protein kinase Cε: an oncogene and emerging tumor biomarker

inferred← citeshttps://doi.org/10.1186/s12929-022-00820-3openalex-snapshot

SRF: a seriously responsible factor in cardiac development and disease

inferred← citeshttps://doi.org/10.1186/s12935-025-04166-2openalex-snapshot

Rho-related GTP-binding protein RhoE (RND3) regulates multiple myeloma bone disease

inferred← citeshttps://doi.org/10.1242/dev.204965openalex-snapshot

Mouse scalp development requires Rac1 and SRF for the maintenance of mechanoresponsive mesenchyme

inferred← citeshttps://doi.org/10.1371/journal.pone.0110453openalex-snapshot

A Novel 2.5D Culture Platform to Investigate the Role of Stiffness Gradients on Adhesion-Independent Cell Migration

inferred← citeshttps://doi.org/10.1371/journal.pone.0190191openalex-snapshot

SM22α suppresses cytokine-induced inflammation and the transcription of NF-κB inducing kinase (Nik) by modulating SRF transcriptional activity in vascular smooth muscle cells

inferred← citeshttps://doi.org/10.1378/chest.123.3_suppl.392sopenalex-snapshot

Actin Dynamics

inferred← citeshttps://doi.org/10.1513/pats.200705-057vsopenalex-snapshot

Phenotype and Functional Plasticity of Airway Smooth Muscle: Role of Caveolae and Caveolins

inferred← citeshttps://doi.org/10.1523/jneurosci.3029-13.2013openalex-snapshot

The Transcription Factor Serum Response Factor Stimulates Axon Regeneration through Cytoplasmic Localization and Cofilin Interaction

inferred← citeshttps://doi.org/10.15252/embr.201745253openalex-snapshot

PAR‐3 controls endothelial planar polarity and vascular inflammation under laminar flow

inferred← citeshttps://doi.org/10.1586/14789450.2014.860358openalex-snapshot

Transgelins, cytoskeletal proteins implicated in different aspects of cancer development

inferred← citeshttps://doi.org/10.2147/chc.s5667openalex-snapshot

Pyk2 controls filamentous actin formation in human glomerular mesangial cells via modulation of profilin expression

inferred← citeshttps://doi.org/10.2147/copd.s109243openalex-snapshot

Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of chronic obstructive pulmonary disease

inferred← citeshttps://doi.org/10.2174/138955706776073402openalex-snapshot

Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma

inferred← citeshttps://doi.org/10.2741/1803openalex-snapshot

Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase

inferred← citeshttps://doi.org/10.31083/fbl44589openalex-snapshot

Rho GTPase and Rho Kinase Signaling in Tissue Contractility and Intraocular Pressure Regulation

inferred← citeshttps://doi.org/10.3109/10641963.2015.1081231openalex-snapshot

Polymorphisms and haplotype ofROCK2associate with high altitude essential hypertension in native high altitude Ladakhi Indian population: a preliminary study

inferred← citeshttps://doi.org/10.31857/s0041377124010012openalex-snapshot

The role of the Rho family small GTPases in regulation of normal and pathological processes

inferred← citeshttps://doi.org/10.3389/fphys.2016.00547openalex-snapshot

Mechanosensitive Molecular Networks Involved in Transducing Resistance Exercise-Signals into Muscle Protein Accretion

inferred← citeshttps://doi.org/10.3390/cells12182315openalex-snapshot

Characterisation of Lipoma-Preferred Partner as a Novel Mechanotransducer in Vascular Smooth Muscle Cells

inferred← citeshttps://doi.org/10.3390/cells13232032openalex-snapshot

The p.R66W Variant in RAC3 Causes Severe Fetopathy Through Variant-Specific Mechanisms

inferred← citeshttps://doi.org/10.3390/cells14191499openalex-snapshot

A Pleiotropic and Functionally Divergent RAC3 Variant Disrupts Neurodevelopment and Impacts Organogenesis

inferred← citeshttps://doi.org/10.3390/ijms22094821openalex-snapshot

Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases

inferred← citeshttps://doi.org/10.3390/ijms25115708openalex-snapshot

Translational Relevance of Secondary Intracellular Signaling Cascades Following Traumatic Spinal Cord Injury

inferred← citeshttps://doi.org/10.3390/jcdd8050058openalex-snapshot

The Aging Vasculature: Glucose Tolerance, Hypoglycemia and the Role of the Serum Response Factor

inferred← citeshttps://doi.org/10.3410/f.738877222.793580388openalex-snapshot

Faculty Opinions recommendation of Cell shape regulates subcellular organelle location to control early Ca2+ signal dynamics in vascular smooth muscle cells.

inferred← citeshttps://doi.org/10.3892/mmr.2013.1486openalex-snapshot

Effect of 17β-estradiol in rat bone marrow-derived endothelial progenitor cells

inferred← citeshttps://doi.org/10.3892/mmr.2015.4365openalex-snapshot

Regulatory mechanism of human vascular smooth muscle cell phenotypic transformation induced by NELIN

inferred← citeshttps://doi.org/10.4331/wjbc.v3.i3.41openalex-snapshot

Transforming growth factor-β and smooth muscle differentiation

inferred← citeshttps://doi.org/10.5772/intechopen.69200openalex-snapshot

Rho‐kinase Gene Polymorphisms in Related Disease States

inferred← citeshttps://doi.org/10.70675/01b68e7dzc30cz4316z8270zdf2ab77f39b6openalex-snapshot

Etude de la différenciation des progéniteurs musculaires lisses de l'uretère chez la souris

inferred← citeshttps://doi.org/10.7554/elife.66079openalex-snapshot

In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration

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