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Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice

https://doi.org/10.1165/rcmb.2015-0147le
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.clim.2010.06.017openalex-snapshot
Alternatively activated alveolar macrophages in pulmonary fibrosis—mediator production and intracellular signal transduction
inferredcites →https://doi.org/10.1016/j.immuni.2013.08.007openalex-snapshot
Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes
inferredcites →https://doi.org/10.1016/j.immuni.2015.03.011openalex-snapshot
C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages
inferredcites →https://doi.org/10.1016/j.molimm.2010.02.008openalex-snapshot
Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy
inferredcites →https://doi.org/10.1038/ni.2419openalex-snapshot
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
inferredcites →https://doi.org/10.1038/nri3600openalex-snapshot
Alveolar macrophages: plasticity in a tissue-specific context
inferredcites →https://doi.org/10.1084/jem.20131199openalex-snapshot
Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
inferredcites →https://doi.org/10.1111/imr.12220openalex-snapshot
Mononuclear phagocytes of the intestine, the skin, and the lung
inferredcites →https://doi.org/10.1155/2013/780502openalex-snapshot
Evolution of the Macrophage CD163 Phenotype and Cytokine Profiles in a Human Model of Resolving Inflammation
inferredcites →https://doi.org/10.1165/rcmb.2012-0366maopenalex-snapshot
Identification of Myeloid Cell Subsets in Murine Lungs Using Flow Cytometry
inferredcites →https://doi.org/10.1165/rcmb.2013-0086maopenalex-snapshot
Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung
inferredcites →https://doi.org/10.1165/rcmb.2015-0146ocopenalex-snapshot
Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues
inferredcites →https://doi.org/10.1542/peds.74.2.221openalex-snapshot
Alveolar Macrophages in Perinatal Infants
inferredcites →https://doi.org/10.4049/jimmunol.179.6.3488openalex-snapshot
Lung Macrophages Serve as Obligatory Intermediate between Blood Monocytes and Alveolar Macrophages

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Human and Mouse Transcriptome Profiling Identifies Cross-Species Homology in Pulmonary and Lymph Node Mononuclear Phagocytes
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T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques
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IL-9R/Arg1 pathway promotes polyamine metabolism in human airway macrophages
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Phosphate bacterial solubilization: A key rhizosphere driving force enabling higher P use efficiency and crop productivity
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Cord Blood Biomarkers of Placental Maternal Vascular Underperfusion Predict Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension
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Monocytes promote pyroptosis of endothelial cells during lung ischemia-reperfusion via IL-1R/NF-κB/NLRP3 signaling
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Expansion of PMN-myeloid derived suppressor cells and their clinical relevance in patients with oral squamous cell carcinoma
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Pulmonary fibroblasts-secreted CXCL10 polarizes alveolar macrophages under pro-inflammatory stimuli
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Ectonucleotidase CD39 and Checkpoint Signalling Receptor Programmed Death 1 are Highly Elevated in Intratumoral Immune Cells in Non–small-cell Lung Cancer
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Non-neuronal neuropeptide Y and its receptors during acute rejection of rat pulmonary allografts
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IL-27 Inhibits Anti-Mycobacterium Tuberculosis Innate Immune Activity of Primary Human Macrophages
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Targeting Pro-Tumoral Macrophages in Early Primary and Metastatic Breast Tumors with the CD206-Binding mUNO Peptide
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High-parametric protein maps reveal the spatial organization in early-developing human lung
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An immune-competent lung-on-a-chip for modelling the human severe influenza infection response
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Phenotypic characterisation of bovine alveolar macrophages reveals two major subsets with differential expression of CD163
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Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
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CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages
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Fluoroquinolones directly drive mitochondrial hyperpolarization and modulate iNOS expression in monocyte-derived macrophage populations
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A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection
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Role of monocytes and macrophages in regulating immune response following lung transplantation
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Neuroimmune interactions and osteoarthritis pain: focus on macrophages
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Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease
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Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis
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Chronic ethanol drinking in non-human primates induces inflammatory cathepsin gene expression in alveolar macrophages accompanied by functional defects
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In vivo single cell transcriptomics reveals Klebsiella pneumoniae rewiring of lung macrophages to promote infection
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T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis -infected cynomolgus macaques
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Mapping fetal myeloid differentiation in airway samples from premature neonates with single-cell profiling
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Early human lung immune cell development and its role in epithelial cell fate
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Humanized Bone Marrow-Liver-Thymus Mice for Studying HIV-1 Persistence in Liver and Lung CD4+ T and Myeloid Cell Subsets during Antiretroviral Therapy
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Hallmarks and metabolic regulation of type 2 activated human lung macrophages
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Profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in systemic sclerosis-associated interstitial lung disease
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Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung
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Long-Term Persistence of Donor Alveolar Macrophages in Human Lung Transplant Recipients That Influences Donor-Specific Immune Responses
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Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia
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Immediate myeloid depot for SARS-CoV-2 in the human lung
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High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways
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Itaconate controls the severity of pulmonary fibrosis
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Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection
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Early human lung immune cell development and its role in epithelial cell fate
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Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction
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Bystander monocytic cells drive infection-independent NLRP3 inflammasome response to SARS-CoV-2
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Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies
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Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease
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Tissue-Resident Immune Cells in Humans
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Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis
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Alveolar macrophages drive lung fibroblast function in cocultures of IPF and normal patient samples
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Cigarette smoke depletes alveolar macrophages and delays clearance of Legionella pneumophila
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Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells
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Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways
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Dysregulated Functions of Lung Macrophage Populations in COPD
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Lung Interstitial Macrophages: Past, Present, and Future
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Proteína de transferência de colesterol esterificado (CETP) altera a polarização de macrófagos M1 e M2 agravando o enfisema pulmonar experimental induzido por elastase
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Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes
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Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis
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Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia
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The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis
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Localization of Macrophages in the Human Lung via Design-based Stereology
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Know Where You Are: Pulmonary Macrophage Locations in the Human Lung
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Airspace Macrophages and Monocytes Exist in Transcriptionally Distinct Subsets in Healthy Adults
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Human Lung-Resident Macrophages Colocalize with and Provide Costimulation to PD1hi Tissue-Resident Memory T Cells
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Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues
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Pulmonary Macrophages: Overlooked and Underappreciated
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Diversity of Human and Macaque Airway Immune Cells at Baseline and during Tuberculosis Infection
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Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report
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Lower PDL1, PDL2, and AXL Expression on Lung Myeloid Cells Suggests Inflammatory Bias in Smoking and Chronic Obstructive Pulmonary Disease
inferred← citeshttps://doi.org/10.1165/rcmb.2020-0137leopenalex-snapshot
Nonclassical Monocytes Promote Edema in Lung Allografts from Traumatic Brain Injury Donors
inferred← citeshttps://doi.org/10.1165/rcmb.2021-0346ocopenalex-snapshot
Ethanol Consumption Induces Nonspecific Inflammation and Functional Defects in Alveolar Macrophages
inferred← citeshttps://doi.org/10.1165/rcmb.2021-0563ocopenalex-snapshot
Airway Macrophages Encompass Transcriptionally and Functionally Distinct Subsets Altered by Smoking
inferred← citeshttps://doi.org/10.1165/rcmb.2022-0282ocopenalex-snapshot
AMPK-driven Macrophage Responses Are Autophagy Dependent in Experimental Bronchopulmonary Dysplasia
inferred← citeshttps://doi.org/10.1165/rcmb.2022-0293ocopenalex-snapshot
Single-Cell Profiling of Premature Neonate Airways Reveals a Continuum of Myeloid Differentiation
inferred← citeshttps://doi.org/10.1172/jci.insight.147282openalex-snapshot
Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment
inferred← citeshttps://doi.org/10.1172/jci135838openalex-snapshot
Residual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages
inferred← citeshttps://doi.org/10.1172/jci98436openalex-snapshot
Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β
inferred← citeshttps://doi.org/10.1183/13993003.00075-2025openalex-snapshot
Yapping about macrophages in fibrotic lung disease
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The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension
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The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis
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A comprehensive evaluation of murine and humanex vivocultured alveolar macrophages
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Inhaled granulocyte–macrophage colony-stimulating factor (molgramostim) as host-directed therapy for pneumonia-related acute respiratory distress syndrome: a multicentre, randomised, placebo-controlled phase 2a trial (GI-HOPE)
inferred← citeshttps://doi.org/10.1186/s12931-020-1297-2openalex-snapshot
Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease
inferred← citeshttps://doi.org/10.1186/s12964-026-02658-wopenalex-snapshot
Recent perspectives on macrophage memory: types, mechanisms, and characteristics in pulmonary diseases
inferred← citeshttps://doi.org/10.1186/s12967-020-02595-3openalex-snapshot
Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome
inferred← citeshttps://doi.org/10.1186/s13075-017-1504-9openalex-snapshot
Thinking BIG rheumatology: how to make functional genomics data work for you
inferred← citeshttps://doi.org/10.1371/journal.pone.0241323openalex-snapshot
Technical advance: The use of tree shrews as a model of pulmonary fibrosis
inferred← citeshttps://doi.org/10.1371/journal.pone.0272069openalex-snapshot
Sputum analysis by flow cytometry; an effective platform to analyze the lung environment
inferred← citeshttps://doi.org/10.1371/journal.pone.0279037openalex-snapshot
Expanded characterization of in vitro polarized M0, M1, and M2 human monocyte-derived macrophages: Bioenergetic and secreted mediator profiles
inferred← citeshttps://doi.org/10.1371/journal.ppat.1010395openalex-snapshot
Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates
inferred← citeshttps://doi.org/10.14800/macrophage.1262openalex-snapshot
Macrophages, Corticosteroids and COPD: What do we know?
inferred← citeshttps://doi.org/10.1615/critrevimmunol.2018026459openalex-snapshot
Airway Macrophage and Dendritic Cell Subsets in the Resting Human Lung
inferred← citeshttps://doi.org/10.18632/oncotarget.22584openalex-snapshot
Non-classical monocytes in tissue injury and cancer
inferred← citeshttps://doi.org/10.21037/tlcr-20-1103openalex-snapshot
Identification of PD-1 ligands: PD-L1 and PD-L2 on macrophages in lung cancer milieu by flow cytometry
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1639631/v1openalex-snapshot
Immediate myeloid depot for SARS-CoV-2 in the human lung
inferred← citeshttps://doi.org/10.2147/copd.s337354openalex-snapshot
Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis
inferred← citeshttps://doi.org/10.21873/invivo.12601openalex-snapshot
Silica Induced Lung Fibrosis Is Associated With Senescence, Fgr, and Recruitment of Bone Marrow Monocyte/Macrophages
inferred← citeshttps://doi.org/10.26508/lsa.202201458openalex-snapshot
ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF
inferred← citeshttps://doi.org/10.33029/1816-2134-2024-45-2-235-244openalex-snapshot
Role of macrophages in the pathogenesis of pulmonary fibrosis
inferred← citeshttps://doi.org/10.33549/physiolres.935058openalex-snapshot
Mechanisms and Effects of Macrophage Polarization and Its Specifics in Pulmonary Environment
inferred← citeshttps://doi.org/10.3389/fcimb.2022.826738openalex-snapshot
Macrophage Meets the Circadian Clock: Implication of the Circadian Clock in the Role of Macrophages in Acute Lower Respiratory Tract Infection
inferred← citeshttps://doi.org/10.3389/fimmu.2017.00499openalex-snapshot
Human Lung Mononuclear Phagocytes in Health and Disease
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02733openalex-snapshot
Origin, Differentiation, and Function of Intestinal Macrophages
inferred← citeshttps://doi.org/10.3389/fimmu.2019.02035openalex-snapshot
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
inferred← citeshttps://doi.org/10.3389/fimmu.2020.01698openalex-snapshot
Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung
inferred← citeshttps://doi.org/10.3389/fimmu.2021.667834openalex-snapshot
The Impact of Inflammation on the Immune Responses to Transplantation: Tolerance or Rejection?
inferred← citeshttps://doi.org/10.3389/fimmu.2022.827719openalex-snapshot
Picturing of the Lung Tumor Cellular Composition by Multispectral Flow Cytometry
inferred← citeshttps://doi.org/10.3389/fimmu.2022.958098openalex-snapshot
Resting time after phorbol 12-myristate 13-acetate in THP-1 derived macrophages provides a non-biased model for the study of NLRP3 inflammasome
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1149015openalex-snapshot
Shaping of the alveolar landscape by respiratory infections and long-term consequences for lung immunity
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1654717openalex-snapshot
The chemokines CCL22 and CCL17 are a defining feature of type 2 stimulated human lung macrophages and exhibit different metabolic dependencies
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1708716openalex-snapshot
Immunobiology of pulmonary fibrosis
inferred← citeshttps://doi.org/10.3389/fmed.2020.606462openalex-snapshot
Senescence in Pulmonary Fibrosis: Between Aging and Exposure
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1922948openalex-snapshot
Integrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infection
inferred← citeshttps://doi.org/10.3389/fped.2023.1146014openalex-snapshot
Development of a novel humanized mouse model to study bronchopulmonary dysplasia
inferred← citeshttps://doi.org/10.3390/cancers13081788openalex-snapshot
Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions
inferred← citeshttps://doi.org/10.3390/cells12172193openalex-snapshot
Macrophage Implication in IPF: Updates on Immune, Epigenetic, and Metabolic Pathways
inferred← citeshttps://doi.org/10.3390/diagnostics12123033openalex-snapshot
Biomarkers in Pulmonary Arterial Hypertension
inferred← citeshttps://doi.org/10.3390/ijms232113328openalex-snapshot
Mucosal Immunity and the Gut-Microbiota-Brain-Axis in Neuroimmune Disease
inferred← citeshttps://doi.org/10.3390/ijms25115631openalex-snapshot
Macrophage Polarization and Functions in Pathogenesis of Chronic Obstructive Pulmonary Disease
inferred← citeshttps://doi.org/10.3390/ijms27177787openalex-snapshot
Integrated Cytokine and Immune Cell Profiling Reveals a Distinct Immune Signature Associated with High-Altitude Pulmonary Edema
inferred← citeshttps://doi.org/10.4049/jimmunol.1600777openalex-snapshot
Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets
inferred← citeshttps://doi.org/10.4049/jimmunol.2000361openalex-snapshot
HIV Infection Is Associated with Loss of Anti-Inflammatory Alveolar Macrophages
inferred← citeshttps://doi.org/10.5772/intechopen.110509openalex-snapshot
Physiological Role of Alveolar Macrophage in Acute Lower Respiratory Tract Infection: Phagocytosis and Aging
inferred← citeshttps://doi.org/10.6084/m9.figshare.13225807openalex-snapshot
Additional file 1 of Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome
inferred← citeshttps://doi.org/10.70675/afce218czd47fz4e81za3d3z2d2a848304d4openalex-snapshot
Jun regulates monocyte-derived macrophage accumulation and tumour progression
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