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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hep.510230204openalex-snapshot
Bile acids suppress the secretion of very-low-density lipoprotein by human hepatocytes in primary culture
inferredcites →https://doi.org/10.1002/j.1552-4604.1981.tb01746.xopenalex-snapshot
Chenodeoxycholic Acid and Ursodeoxycholic Acid Effects in Endogenous Hypertriglyceridemias. A Controlled Double‐Blind Trial
inferredcites →https://doi.org/10.1016/0002-9343(87)90692-9openalex-snapshot
Hypertriglyceridemia: A contraindication to the use of bile acid binding resins
inferredcites →https://doi.org/10.1016/0026-0495(82)90231-1openalex-snapshot
Effects of interruption of the enterohepatic circulation of bile acids on the transport of very low density-lipoprotein triglycerides
inferredcites →https://doi.org/10.1016/s0002-9149(00)01127-9openalex-snapshot
Evidence that triglycerides are an independent coronary heart disease risk factor
inferredcites →https://doi.org/10.1016/s0002-9149(01)01489-8openalex-snapshot
Hypertriglyceridemia: new insights and new approaches to pharmacologic therapy
inferredcites →https://doi.org/10.1016/s0022-2275(20)31533-9openalex-snapshot
Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR:LA-cp rat
inferredcites →https://doi.org/10.1016/s0022-2275(20)33450-7openalex-snapshot
Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia
inferredcites →https://doi.org/10.1016/s0022-2275(20)40685-6openalex-snapshot
Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia.
inferredcites →https://doi.org/10.1016/s0022-2275(20)42003-6openalex-snapshot
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
inferredcites →https://doi.org/10.1016/s0092-8674(00)00062-3openalex-snapshot
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
inferredcites →https://doi.org/10.1016/s0092-8674(00)80213-5openalex-snapshot
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
inferredcites →https://doi.org/10.1016/s0092-8674(02)01169-8openalex-snapshot
SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues
inferredcites →https://doi.org/10.1016/s1097-2765(00)00050-2openalex-snapshot
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
inferredcites →https://doi.org/10.1016/s1097-2765(00)00051-4openalex-snapshot
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
inferredcites →https://doi.org/10.1016/s1097-2765(01)00353-7openalex-snapshot
A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity
inferredcites →https://doi.org/10.1016/s1097-2765(05)00010-9openalex-snapshot
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
inferredcites →https://doi.org/10.1016/s1534-5807(02)00154-5openalex-snapshot
Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis
inferredcites →https://doi.org/10.1016/s1534-5807(02)00187-9openalex-snapshot
Redundant Pathways for Negative Feedback Regulation of Bile Acid Production
inferredcites →https://doi.org/10.1021/jm0002127openalex-snapshot
Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR
inferredcites →https://doi.org/10.1042/bj3160531openalex-snapshot
Characterization of the inhibitory effects of bile acids on very-low-density lipoprotein secretion by rat hepatocytes in primary culture
inferredcites →https://doi.org/10.1046/j.1432-1033.2000.01473.xopenalex-snapshot
Dietary cholic acid lowers plasma levels of mouse and human apolipoprotein A-I primarily via a transcriptional mechanism
inferredcites →https://doi.org/10.1073/pnas.021544398openalex-snapshot
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects
inferredcites →https://doi.org/10.1073/pnas.201524598openalex-snapshot
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene
inferredcites →https://doi.org/10.1073/pnas.96.24.13656openalex-snapshot
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
inferredcites →https://doi.org/10.1073/pnas.98.2.575openalex-snapshot
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects
inferredcites →https://doi.org/10.1074/jbc.271.30.18024openalex-snapshot
Disruption of Cholesterol 7α-Hydroxylase Gene in Mice
inferredcites →https://doi.org/10.1074/jbc.274.17.11564openalex-snapshot
Overexpression of Human Apolipoprotein A-II in Mice Induces Hypertriglyceridemia Due to Defective Very Low Density Lipoprotein Hydrolysis
inferredcites →https://doi.org/10.1074/jbc.274.42.30028openalex-snapshot
Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus
inferredcites →https://doi.org/10.1074/jbc.c100160200openalex-snapshot
Increased Expression of the Sterol Regulatory Element-binding Protein-1 Gene in Insulin Receptor Substrate-2−/−Mouse Liver
inferredcites →https://doi.org/10.1074/jbc.m001811200openalex-snapshot
Disruption of the Oxysterol 7α-Hydroxylase Gene in Mice
inferredcites →https://doi.org/10.1074/jbc.m007653200openalex-snapshot
Disruption of the Sterol 27-Hydroxylase Gene in Mice Results in Hepatomegaly and Hypertriglyceridemia
inferredcites →https://doi.org/10.1074/jbc.m007998200openalex-snapshot
The Farnesoid X-activated Receptor Mediates Bile Acid Activation of Phospholipid Transfer Protein Gene Expression
inferredcites →https://doi.org/10.1074/jbc.m100912200openalex-snapshot
The Orphan Nuclear Receptor LRH-1 Potentiates the Sterol-mediated Induction of the Human CETP Gene by Liver X Receptor
inferredcites →https://doi.org/10.1074/jbc.m107000200openalex-snapshot
Antagonism of the Actions of Peroxisome Proliferator-activated Receptor-α by Bile Acids
inferredcites →https://doi.org/10.1074/jbc.m111421200openalex-snapshot
Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c
inferredcites →https://doi.org/10.1074/jbc.m213202200openalex-snapshot
Angiopoietin-like Protein 3 Mediates Hypertriglyceridemia Induced by the Liver X Receptor
inferredcites →https://doi.org/10.1096/fasebj.8.8.8181666openalex-snapshot
Obesity, diabetes, and neoplasia in yellow A vy /‐ mice: ectopic expression of the agouti gene
inferredcites →https://doi.org/10.1101/gad.1138104openalex-snapshot
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR
inferredcites →https://doi.org/10.1101/gad.844900openalex-snapshot
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
inferredcites →https://doi.org/10.1101/gad.850400openalex-snapshot
Role of LXRs in control of lipogenesis
inferredcites →https://doi.org/10.1101/gad.891301openalex-snapshot
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
inferredcites →https://doi.org/10.1111/j.1365-2125.1978.tb01632.xopenalex-snapshot
Chenodeoxycholic acid therapy for hypertriglyceridaemia in men.
inferredcites →https://doi.org/10.1128/mcb.19.5.3760openalex-snapshot
ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose
inferredcites →https://doi.org/10.1128/mcb.21.9.2991-3000.2001openalex-snapshot
Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
inferredcites →https://doi.org/10.1152/ajpcell.1997.273.1.c37openalex-snapshot
Measurement of mitochondrial calcium in single living cardiomyocytes by selective removal of cytosolic indo 1
inferredcites →https://doi.org/10.1152/ajpendo.1997.273.1.e37openalex-snapshot
Cholate inhibits high-fat diet-induced hyperglycemia and obesity with acyl-CoA synthetase mRNA decrease
inferredcites →https://doi.org/10.1152/ajpendo.2002.282.1.e46openalex-snapshot
Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity
inferredcites →https://doi.org/10.1172/jci0214505openalex-snapshot
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element
inferredcites →https://doi.org/10.1172/jci0215387openalex-snapshot
Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
inferredcites →https://doi.org/10.1172/jci0215593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1172/jci0216076openalex-snapshot
Human CYP7A1 deficiency: progress and enigmas
inferredcites →https://doi.org/10.1172/jci118951openalex-snapshot
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
inferredcites →https://doi.org/10.1172/jci119248openalex-snapshot
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
inferredcites →https://doi.org/10.1172/jci14505openalex-snapshot
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element
inferredcites →https://doi.org/10.1172/jci15387openalex-snapshot
Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
inferredcites →https://doi.org/10.1172/jci15593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1172/jci16076openalex-snapshot
Human CYP7A1 deficiency: progress and enigmas
inferredcites →https://doi.org/10.1210/me.15.10.1720openalex-snapshot
Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids
inferredcites →https://doi.org/10.1210/me.2001-0194openalex-snapshot
The Small Heterodimer Partner Interacts with the Liver X Receptor α and Represses Its Transcriptional Activity
inferredcites →https://doi.org/10.1210/me.2002-0120openalex-snapshot
Bile Acids Induce the Expression of the Human Peroxisome Proliferator-Activated Receptor α Gene via Activation of the Farnesoid X Receptor
inferredcites →https://doi.org/10.1210/me.2002-0246openalex-snapshot
Differential Regulation of Rat and HumanCYP7A1by the Nuclear Oxysterol Receptor Liver X Receptor-α
inferredcites →https://doi.org/10.1210/mend.15.10.0712openalex-snapshot
Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids
inferredcites →https://doi.org/10.1515/bchm3.1987.368.2.887openalex-snapshot
Bile Acids Inhibit Secretion of Very Low Density Lipoprotein by Rat Hepatocytes
inferredcites →https://doi.org/10.1538/expanim1957.18.4_147openalex-snapshot
Breeding of Mice Strains for Diabetes Mellitus
inferredcites →https://doi.org/10.2165/00003495-198121020-00002openalex-snapshot
Chenodeoxycholic Acid
inferredcites →https://doi.org/10.2183/pjab1945.38.348openalex-snapshot
A Diabetic Strain of the Mouse
inferredcites →https://doi.org/10.7326/0003-4819-95-3-257openalex-snapshot
Chenodiol (Chenodeoxycholic Acid) for Dissolution of Gallstones: The National Cooperative Gallstone Study
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.3736702openalex-extracted
NR1H4 rs35724 G>C Variant Modulates Liver Damage in Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.2139/ssrn.4189786openalex-extracted
Design, Synthesis and Biological Evaluations of Novel Farnesoid X Receptor (FXR) Agonists
inferred← citeshttps://doi.org/10.2139/ssrn.4533760openalex-extracted
Dietary Berberine Improves Growth Performance, Alleviates Hepatic Lipid Accumulation, and Modulates Bile Acids and Intestinal Bacteria in Yellow Catfish (Pelteobagrus Fulvidraco)
inferred← citeshttps://doi.org/10.1002/0471266949.bmc191openalex-snapshot
Nuclear Hormone Receptor Medicinal Chemistry
inferred← citeshttps://doi.org/10.1002/0471266949.bmc191.pub2openalex-snapshot
Nuclear Hormone Receptor Medicinal Chemistry
inferred← citeshttps://doi.org/10.1002/1873-3468.12845openalex-snapshot
FXR controls CHOP expression in steatohepatitis
inferred← citeshttps://doi.org/10.1002/2211-5463.12123openalex-snapshot
Hepatic caveolin‐1 is enhanced in Cyp27a1/ApoE double knockout mice
inferred← citeshttps://doi.org/10.1002/9780470409107.ch10openalex-snapshot
Beyond PXR and CAR, Regulation of Xenobiotic Metabolism by other Nuclear Receptors
inferred← citeshttps://doi.org/10.1002/9780470747919.ch19openalex-snapshot
Lipoprotein Metabolism and Cholesterol Balance
inferred← citeshttps://doi.org/10.1002/9780470747919.ch45openalex-snapshot
Non‐Alcoholic Fatty Liver Disease: A Pathophysiological Perspective
inferred← citeshttps://doi.org/10.1002/9780470942390.mo100226openalex-snapshot
Characterizing Bile Acid and Lipid Metabolism in the Liver and Gastrointestinal Tract of Mice
inferred← citeshttps://doi.org/10.1002/9781118663387.ch28openalex-snapshot
Bile acids and their receptors
inferred← citeshttps://doi.org/10.1002/9781119436812.ch24openalex-snapshot
TGR5 (GPBAR1) in the Liver
inferred← citeshttps://doi.org/10.1002/9781119436812.ch25openalex-snapshot
Bile Acids as Signaling Molecules
inferred← citeshttps://doi.org/10.1002/9783527611942.ch5openalex-snapshot
Exploration of Metabolic and Endocrine Function in the Mouse
inferred← citeshttps://doi.org/10.1002/9783527679430.ch9openalex-snapshot
The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR)
inferred← citeshttps://doi.org/10.1002/9783527808694.ch8openalex-snapshot
The Discovery of Obeticholic Acid ( Ocaliva™ ): First‐in‐Class FXR Agonist
inferred← citeshttps://doi.org/10.1002/adbi.202200150openalex-snapshot
Alleviation of Hepatic Steatosis by 4‐azidophlorizin via the Degradation of Geranylgeranyl Diphosphate Synthase by the Ubiquitin‐Proteasome Pathway in Vivo and in Vitro
inferred← citeshttps://doi.org/10.1002/cbf.2842openalex-snapshot
Dietary modification of metabolic pathways via nuclear hormone receptors
inferred← citeshttps://doi.org/10.1002/cbf.3247openalex-snapshot
Mechanistic insight into nuclear receptor‐mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE)
inferred← citeshttps://doi.org/10.1002/cphy.c120023openalex-snapshot
Bile Acid Metabolism and Signaling
inferred← citeshttps://doi.org/10.1002/cphy.c190007openalex-snapshot
Intestinal Absorption of Bile Acids in Health and Disease
inferred← citeshttps://doi.org/10.1002/edm2.105openalex-snapshot
Drug discovery and treatment paradigms in nonalcoholic steatohepatitis
inferred← citeshttps://doi.org/10.1002/elps.201300017openalex-snapshot
Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes
inferred← citeshttps://doi.org/10.1002/hep.21616openalex-snapshot
Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease†
inferred← citeshttps://doi.org/10.1002/hep.21632openalex-snapshot
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver
inferred← citeshttps://doi.org/10.1002/hep.22196openalex-snapshot
Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis
inferred← citeshttps://doi.org/10.1002/hep.23408openalex-snapshot
Bile Salt Sequestration Induces Hepatic De Novo Lipogenesis Through Farnesoid X Receptor– and Liver X Receptorα–Controlled Metabolic Pathways in Mice
inferred← citeshttps://doi.org/10.1002/hep.23721openalex-snapshot
Transgenic expression of cholesterol 7α‐hydroxylase in the liver prevents high‐fat diet–induced obesity and insulin resistance in mice†
inferred← citeshttps://doi.org/10.1002/hep.24697openalex-snapshot
Phosphatidylcholines as regulators of glucose and lipid homeostasis: Promises and potential risks
inferred← citeshttps://doi.org/10.1002/hep.25609openalex-snapshot
Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice
inferred← citeshttps://doi.org/10.1002/hep.25797openalex-snapshot
Specific bile acids inhibit hepatic fatty acid uptake in mice
inferred← citeshttps://doi.org/10.1002/hep.25812openalex-snapshot
Bile acids in nonalcoholic steatohepatitis: Inserting nuclear receptors into the circle
inferred← citeshttps://doi.org/10.1002/hep.25996openalex-snapshot
RE: Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males
inferred← citeshttps://doi.org/10.1002/hep.26427openalex-snapshot
Regulation of Cholesterol And Bile Acid Homeostasis by the Cholesterol 7α-Hydroxylase/Steroid Response Element-Binding Protein 2/Microrna-33A Axis in Mice
inferred← citeshttps://doi.org/10.1002/hep.26714openalex-snapshot
Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor-Controlled Lipid Homeostasis
inferred← citeshttps://doi.org/10.1002/hep.27437openalex-snapshot
Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism
inferred← citeshttps://doi.org/10.1002/hep.27963openalex-snapshot
Bile acids and nonalcoholic fatty liver disease: An intriguing relationship
inferred← citeshttps://doi.org/10.1002/hep.28709openalex-snapshot
Bile acids and nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1002/hep.29305openalex-snapshot
Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice
inferred← citeshttps://doi.org/10.1002/hep.29654openalex-snapshot
Long noncoding RNA H19 interacts with polypyrimidine tract‐binding protein 1 to reprogram hepatic lipid homeostasis
inferred← citeshttps://doi.org/10.1002/hep.30513openalex-snapshot
Deficiency of Both Farnesoid X Receptor and Takeda G Protein–Coupled Receptor 5 Exacerbated Liver Fibrosis in Mice
inferred← citeshttps://doi.org/10.1002/hep.32153openalex-snapshot
The RNA binding protein human antigen R is a gatekeeper of liver homeostasis
inferred← citeshttps://doi.org/10.1002/hep.32577openalex-snapshot
Hepatocellular cystathionine γ lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor
inferred← citeshttps://doi.org/10.1002/hep4.1203openalex-snapshot
Nuclear receptors and liver disease: Summary of the 2017 basic research symposium
inferred← citeshttps://doi.org/10.1002/hep4.1256openalex-snapshot
FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inflammation After Binge or Prolonged Alcohol Feeding in Mice
inferred← citeshttps://doi.org/10.1002/hep4.1368openalex-snapshot
Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents
inferred← citeshttps://doi.org/10.1002/hep4.1443openalex-snapshot
Farnesoid X Receptor Agonism, Acetyl‐Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model
inferred← citeshttps://doi.org/10.1002/hep4.1479openalex-snapshot
Pathogenesis of Nonalcoholic Steatohepatitis: An Overview
inferred← citeshttps://doi.org/10.1002/iub.1409openalex-snapshot
Curcumin attenuates ethanol‐induced hepatic steatosis through modulating N rf2/ FXR signaling in hepatocytes
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2013.tb00517.xopenalex-snapshot
Bile Acid Metabolism and Signaling
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2013.tb00530.xopenalex-snapshot
Steatosis in the Liver
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2014.tb00548.xopenalex-snapshot
Energy Metabolism in the Liver
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2020.tb00108.xopenalex-snapshot
Intestinal Absorption of Bile Acids in Health and Disease
inferred← citeshttps://doi.org/10.1002/jimd.70129openalex-snapshot
Lipid Metabolism Alterations in Hereditary Inorganic Pyrophosphate Deficiency Syndromes: A Narrative Review of Insights and Controversies
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The hypolipidemic effects of peptides prepared from Cicer arietinum in ovariectomized rats and HepG2 cells
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Exogenous oxidized phytosterol may modulate linoleic acid metabolism through upregulation of fatty acid desaturase in rats
inferred← citeshttps://doi.org/10.1002/mco2.70442openalex-snapshot
Benzoxazole Derivatives as Potent FXR and PPARα Dual Agonists With Anti‐Fibrotic and Metabolic Regulatory Effects
inferred← citeshttps://doi.org/10.1002/mnfr.200800054openalex-snapshot
Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner
inferred← citeshttps://doi.org/10.1002/mnfr.200800364openalex-snapshot
Dietary procyanidins enhance transcriptional activity of bile acid‐activated FXR in vitro and reduce triglyceridemia in vivo in a FXR‐dependent manner
inferred← citeshttps://doi.org/10.1002/mnfr.200900476openalex-snapshot
Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms
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9‐oxo‐10(E),12(E)‐octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes
inferred← citeshttps://doi.org/10.1002/mnfr.201000489openalex-snapshot
Stabilization of small heterodimer partner mRNA by grape seed procyanidins extract in cultured hepatocytes
inferred← citeshttps://doi.org/10.1002/mnfr.201200522openalex-snapshot
Natural compounds regulate energy metabolism by the modulating the activity of lipid‐sensing nuclear receptors
inferred← citeshttps://doi.org/10.1002/mnfr.201200808openalex-snapshot
Nutritional lipidomics: Molecular metabolism, analytics, and diagnostics
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Trimethylamine N ‐Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease
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Extension Region Domain of Soybean 7S Globulin Contributes to Serum Triglyceride‐Lowering Effect via Modulation of Bile Acids Homeostasis
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Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol‐Induced Liver Injury by Regulating the FXR/SHP/SREBP‐1c Axis
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Inverted U‐Shaped Dose‐Response Curve of the Anti‐Atherosclerotic Effect of Protocatechuic Acid in Both Male and Female C57BL/6J Mice
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Mitochondria of trained skeletal muscle are protected from deleterious effects of statins
inferred← citeshttps://doi.org/10.1002/nbm.1672openalex-snapshot
Ursodeoxycholic acid treatment of hepatic steatosis: a 13C NMR metabolic study
inferred← citeshttps://doi.org/10.1002/nbm.3583openalex-snapshot
The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissue in vitro: insight into how bile acids decrease obesity
inferred← citeshttps://doi.org/10.1002/oby.20548openalex-snapshot
Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner
inferred← citeshttps://doi.org/10.1002/oby.20890openalex-snapshot
The role of small heterodimer partner in nonalcoholic fatty liver disease improvement after sleeve gastrectomy in mice
inferred← citeshttps://doi.org/10.1002/oby.21658openalex-snapshot
Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents
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Changes in liver lipidomics associated with sodium cholate-induced liver injury and its prevention by boiogito, a Japanese herbal medicine, in mice
inferred← citeshttps://doi.org/10.1002/tkm2.1254openalex-snapshot
Boiogito extract alters fecal bile acid profile in mice: Possible roles in changes in fecal and liver lipid levels
inferred← citeshttps://doi.org/10.1002/wsbm.137openalex-snapshot
Lipid‐sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome
inferred← citeshttps://doi.org/10.1007/0-387-36279-3_10openalex-snapshot
Bile Acids: At the Crossroads of Sterol, Fat and Carbohydrate Metabolism
inferred← citeshttps://doi.org/10.1007/164_2019_228openalex-snapshot
Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis
inferred← citeshttps://doi.org/10.1007/164_2019_232openalex-snapshot
Nonsteroidal FXR Ligands: Current Status and Clinical Applications
inferred← citeshttps://doi.org/10.1007/164_2019_236openalex-snapshot
Bile Acid-Activated Receptors: A Review on FXR and Other Nuclear Receptors
inferred← citeshttps://doi.org/10.1007/164_2019_238openalex-snapshot
The Pharmacology of Bile Acids and Their Receptors
inferred← citeshttps://doi.org/10.1007/3-540-29662-x_1853openalex-snapshot
Mitogen-activated protein kinase pathway
inferred← citeshttps://doi.org/10.1007/978-1-0716-1433-4_12openalex-snapshot
Protocols for Mitochondria as the Target of Pharmacological Therapy in the Context of Nonalcoholic Fatty Liver Disease (NAFLD)
inferred← citeshttps://doi.org/10.1007/978-1-4020-9644-0_18openalex-snapshot
Role of intestinal nuclear bile acid receptor FXR in the gut—liver axis
inferred← citeshttps://doi.org/10.1007/978-1-4020-9644-0_19openalex-snapshot
Linking nutrition and metabolism, a role for the membrane bile acid receptor TGR5
inferred← citeshttps://doi.org/10.1007/978-1-4020-9644-0_20openalex-snapshot
Potential role of ursodeoxycholic acid and its side-chain modified derivatives in the treatment of non-alcoholic fatty liver disease and associated atherosclerosis
inferred← citeshttps://doi.org/10.1007/978-1-59745-309-7_3openalex-snapshot
Analysis of Growth Hormone Effects on Hepatic Gene Expression in Hypophysectomized Rats
inferred← citeshttps://doi.org/10.1007/978-3-030-28803-7_2openalex-snapshot
Gastric Bypass: Mechanisms of Functioning
inferred← citeshttps://doi.org/10.1007/978-3-030-39684-8_6openalex-snapshot
Oxysterols and Bile Acid Act as Signaling Molecules That Regulate Cholesterol Homeostasis: Nuclear Receptors LXR, FXR, and Fibroblast Growth Factor 15/19
inferred← citeshttps://doi.org/10.1007/978-3-030-52215-5_57openalex-snapshot
Dyslipidemia in the Pediatric Population
inferred← citeshttps://doi.org/10.1007/978-3-030-78315-0_13openalex-snapshot
Nuclear Hormone Receptors and Host-Virus Interactions
inferred← citeshttps://doi.org/10.1007/978-3-319-01008-3_3openalex-snapshot
The Liver in Metabolic Syndrome
inferred← citeshttps://doi.org/10.1007/978-3-319-11161-2_9openalex-snapshot
Non-Alcoholic Fatty Liver Disease (NAFLD): The Lipid Disease of the Liver and the Effect of Statins
inferred← citeshttps://doi.org/10.1007/978-3-319-25065-6_11openalex-snapshot
Metabolic Rhythm of Hepatic Lipogenesis: Regulation and Roles in Metabolism
inferred← citeshttps://doi.org/10.1007/978-3-642-00150-5_21openalex-snapshot
Bile Acids and Their Receptors
inferred← citeshttps://doi.org/10.1007/978-3-642-00300-4_4openalex-snapshot
Bile Acids and Their Role in Cholesterol Homeostasis
inferred← citeshttps://doi.org/10.1007/978-4-431-55790-6_6openalex-snapshot
Lipid Metabolism and the Liver
inferred← citeshttps://doi.org/10.1007/978-4-431-56062-3_15openalex-snapshot
Bile Acids and Metabolic Syndrome
inferred← citeshttps://doi.org/10.1007/978-4-431-56062-3_5openalex-snapshot
Bile Acid as Therapeutic Agents
inferred← citeshttps://doi.org/10.1007/978-981-13-7647-4_8openalex-snapshot
Intestinal Transporter-Associated Drug Absorption and Toxicity
inferred← citeshttps://doi.org/10.1007/978-981-19-2615-0_6openalex-snapshot
Ursodeoxycholic Acid in Liver Cirrhosis: A Chinese Perspective
inferred← citeshttps://doi.org/10.1007/s00011-014-0780-yopenalex-snapshot
Role of farnesoid X receptor in inflammation and resolution
inferred← citeshttps://doi.org/10.1007/s00018-007-7280-yopenalex-snapshot
Lipid sensing and lipid sensors
inferred← citeshttps://doi.org/10.1007/s00018-013-1387-0openalex-snapshot
Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?
inferred← citeshttps://doi.org/10.1007/s00018-014-1805-yopenalex-snapshot
Nuclear bile acid signaling through the farnesoid X receptor
inferred← citeshttps://doi.org/10.1007/s00204-013-1078-5openalex-snapshot
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
inferred← citeshttps://doi.org/10.1007/s00204-014-1410-8openalex-snapshot
SEURAT-1 liver gold reference compounds: a mechanism-based review
inferred← citeshttps://doi.org/10.1007/s00210-011-0691-1openalex-snapshot
Rilmenidine improves hepatic steatosis through p38-dependent pathway to higher the expression of farnesoid X receptor
inferred← citeshttps://doi.org/10.1007/s00216-016-0048-1openalex-snapshot
Rapid analysis of bile acids in different biological matrices using LC-ESI-MS/MS for the investigation of bile acid transformation by mammalian gut bacteria
inferred← citeshttps://doi.org/10.1007/s00394-012-0459-5openalex-snapshot
An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training
inferred← citeshttps://doi.org/10.1007/s00394-014-0700-5openalex-snapshot
Hypolipidemic effect of dietary water-soluble protein extract from chicken: impact on genes regulating hepatic lipid and bile acid metabolism
inferred← citeshttps://doi.org/10.1007/s00394-015-0918-xopenalex-snapshot
Modulation of cholesterol-related gene expression by ergosterol and ergosterol-enriched extracts obtained from Agaricus bisporus
inferred← citeshttps://doi.org/10.1007/s00394-017-1445-8openalex-snapshot
Gut microbiota functions: metabolism of nutrients and other food components
inferred← citeshttps://doi.org/10.1007/s00592-025-02488-1openalex-snapshot
Dapagliflozin ameliorates metabolic and hepatic outcomes in a mouse model of metabolic dysfunction-associated steatotic liver disease and diabetes
inferred← citeshttps://doi.org/10.1007/s00726-009-0461-2openalex-snapshot
Methionine limitation results in increased hepatic FAS activity, higher liver 18:1 to 18:0 fatty acid ratio and hepatic TAG accumulation in Atlantic salmon, Salmo salar
inferred← citeshttps://doi.org/10.1007/s00726-018-2652-1openalex-snapshot
PGC1α regulates ACMSD expression through cooperation with HNF4α
inferred← citeshttps://doi.org/10.1007/s10126-026-10622-5openalex-snapshot
White Adipose Tissue as a Functional Target of Secondary Bile Acids in Rainbow Trout (Oncorhynchus mykiss)
inferred← citeshttps://doi.org/10.1007/s10555-023-10156-5openalex-snapshot
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s10565-024-09862-9openalex-snapshot
Activation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s10695-022-01130-zopenalex-snapshot
Farnesoid X receptor regulates PI3K/AKT/mTOR signaling pathway, lipid metabolism, and immune response in hybrid grouper
inferred← citeshttps://doi.org/10.1007/s10753-025-02294-5openalex-snapshot
Critical Role of Cholic Acid in the Development of iHFC Diet-induced MASH in TSNO Mice
inferred← citeshttps://doi.org/10.1007/s10811-025-03721-8openalex-snapshot
Seaweed-based dessert as a nutraceutical for cardiovascular diseases
inferred← citeshttps://doi.org/10.1007/s11010-022-04610-1openalex-snapshot
Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise
inferred← citeshttps://doi.org/10.1007/s11033-010-0140-0openalex-snapshot
Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase
inferred← citeshttps://doi.org/10.1007/s11095-013-0986-7openalex-snapshot
Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance
inferred← citeshttps://doi.org/10.1007/s11095-013-1006-7openalex-snapshot
Hepatocyte Nuclear Factor 4 Alpha and Farnesoid X Receptor Co-regulates Gene Transcription in Mouse Livers on a Genome-Wide Scale
inferred← citeshttps://doi.org/10.1007/s11095-022-03231-zopenalex-snapshot
In Silico Development of Combinatorial Therapeutic Approaches Targeting Key Signaling Pathways in Metabolic Syndrome
inferred← citeshttps://doi.org/10.1007/s11306-021-01774-7openalex-snapshot
Serum metabolomic patterns in young patients with ischemic stroke: a case study
inferred← citeshttps://doi.org/10.1007/s11427-015-4836-1openalex-snapshot
Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation
inferred← citeshttps://doi.org/10.1007/s11428-007-0129-zopenalex-snapshot
Fettleber und Lipidstoffwechsel
inferred← citeshttps://doi.org/10.1007/s11596-026-00190-zopenalex-snapshot
Targeting the Gut-Liver Mitochondria Axis in MASLD: Mechanisms and Therapeutic Perspectives
inferred← citeshttps://doi.org/10.1007/s11695-012-0673-5openalex-snapshot
Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass
inferred← citeshttps://doi.org/10.1007/s11695-014-1308-9openalex-snapshot
Duodenal-Jejunal Bypass Surgery Suppresses Hepatic De Novo Lipogenesis and Alleviates Liver Fat Accumulation in a Diabetic Rat Model
inferred← citeshttps://doi.org/10.1007/s11695-015-1633-7openalex-snapshot
Expedited Biliopancreatic Juice Flow to the Distal Gut Benefits the Diabetes Control After Duodenal-Jejunal Bypass
inferred← citeshttps://doi.org/10.1007/s11695-015-1834-0openalex-snapshot
FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes
inferred← citeshttps://doi.org/10.1007/s11695-015-2031-xopenalex-snapshot
Duodenal-Jejunal Bypass Preferentially Elevates Serum Taurine-Conjugated Bile Acids and Alters Gut Microbiota in a Diabetic Rat Model
inferred← citeshttps://doi.org/10.1007/s11695-016-2272-3openalex-snapshot
The Contributing Role of Bile Acids to Metabolic Improvements After Obesity and Metabolic Surgery
inferred← citeshttps://doi.org/10.1007/s11695-016-2515-3openalex-snapshot
Association Between Subtotal Gastrectomy with Billroth II Anastomosis and Coronary Heart Disease
inferred← citeshttps://doi.org/10.1007/s11695-017-2549-1openalex-snapshot
Mechanisms of Action of Surgical Interventions on Weight-Related Diseases: the Potential Role of Bile Acids
inferred← citeshttps://doi.org/10.1007/s11695-017-3052-4openalex-snapshot
Effects of Sleeve Gastrectomy on Nonalcoholic Fatty Liver Disease in an Obese Rat Model
inferred← citeshttps://doi.org/10.1007/s11695-019-03790-yopenalex-snapshot
Changes in Enterohepatic Circulation after Duodenal–Jejunal Bypass and Reabsorption of Bile Acids in the Bilio-Pancreatic Limb
inferred← citeshttps://doi.org/10.1007/s11695-019-03918-0openalex-snapshot
Roux-en-Y Gastric Bypass Improves Metabolic Conditions in Association with Increased Serum Bile Acids Level and Hepatic Farnesoid X Receptor Expression in a T2DM Rat Model
inferred← citeshttps://doi.org/10.1007/s11745-014-3947-yopenalex-snapshot
Dietary Hyodeoxycholic Acid Exerts Hypolipidemic Effects by Reducing Farnesoid X Receptor Antagonist Bile Acids in Mouse Enterohepatic Tissues
inferred← citeshttps://doi.org/10.1007/s11745-017-4242-5openalex-snapshot
Ursodeoxycholic Acid Suppresses Lipogenesis in Mouse Liver: Possible Role of the Decrease in β‐Muricholic Acid, a Farnesoid X Receptor Antagonist
inferred← citeshttps://doi.org/10.1007/s11802-026-6298-4openalex-snapshot
Bile Acid Supplementation with Degossypolized Cottonseed Oil Improves the Growth Performance, Digestive Enzyme Activity and Reduces Liver Inflammation in Larimichthys crocea Juvenile
inferred← citeshttps://doi.org/10.1007/s11883-010-0151-2openalex-snapshot
Therapies Targeting Exogenous Cholesterol Uptake: New Insights and Controversies
inferred← citeshttps://doi.org/10.1007/s11883-015-0500-2openalex-snapshot
FXR Agonists as Therapeutic Agents for Non-alcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/s11892-009-0087-5openalex-snapshot
Bile Acid Sequestrants for Lipid and Glucose Control
inferred← citeshttps://doi.org/10.1007/s11892-011-0187-xopenalex-snapshot
Bile Acid Metabolism and the Pathogenesis of Type 2 Diabetes
inferred← citeshttps://doi.org/10.1007/s11894-011-0232-6openalex-snapshot
Farnesoid X Receptor Agonists: What They Are and How They Might Be Used in Treating Liver Disease
inferred← citeshttps://doi.org/10.1007/s12038-018-9750-9openalex-snapshot
Gender-divergent expression of lipid and bile acid metabolism-related genes in adult mice offspring of dams fed a high-fat diet
inferred← citeshttps://doi.org/10.1007/s12072-010-9202-6openalex-snapshot
Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1007/s12263-012-0295-5openalex-snapshot
The role of nuclear receptors in the kidney in obesity and metabolic syndrome
inferred← citeshttps://doi.org/10.1007/s12272-016-0812-yopenalex-snapshot
Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function
inferred← citeshttps://doi.org/10.1007/s12272-022-01410-5openalex-snapshot
Mouse models of nonalcoholic steatohepatitis and their application to new drug development
inferred← citeshttps://doi.org/10.1007/s12562-016-0984-xopenalex-snapshot
Hepatic n-3/n-6 polyunsaturated fatty acid shift improves hepatic steatosis in farnesoid X receptor-null mice
inferred← citeshttps://doi.org/10.1007/s13105-014-0336-1openalex-snapshot
Bile acid supplementation improves established liver steatosis in obese mice independently of glucagon-like peptide-1 secretion
inferred← citeshttps://doi.org/10.1007/s13105-023-00954-4openalex-snapshot
Metabolic dysfunction–associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment
inferred← citeshttps://doi.org/10.1007/s13105-025-01118-2openalex-snapshot
FXR crosstalk with other nuclear receptors
inferred← citeshttps://doi.org/10.1007/s13238-017-0436-0openalex-snapshot
New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD)
inferred← citeshttps://doi.org/10.1007/s13277-014-2342-xopenalex-snapshot
MicroRNA-92 promotes gastric cancer cell proliferation and invasion through targeting FXR
inferred← citeshttps://doi.org/10.1007/s40265-018-1040-1openalex-snapshot
Current and Emerging Therapies for Non-alcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/s40495-017-0085-2openalex-snapshot
Role of FXR in Liver Inflammation During Nonalcoholic Steatohepatitis
inferred← citeshttps://doi.org/10.1007/s43188-026-00387-3openalex-snapshot
Abnormal lipid metabolism in metabolic dysfunction-associated steatohepatitis (MASH)
inferred← citeshttps://doi.org/10.1016/b978-0-12-386456-7.02009-8openalex-snapshot
The Gut Microbiota and Effects on Metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-12-407766-9.00016-xopenalex-snapshot
Sirtuin 1 Deacetylase
inferred← citeshttps://doi.org/10.1016/b978-0-12-407766-9.00018-3openalex-snapshot
Nomilin as an Anti-Obesity and Anti-Hyperglycemic Agent
inferred← citeshttps://doi.org/10.1016/b978-0-12-802241-2.00009-2openalex-snapshot
Rotavirus Replication: the Role of Lipid Droplets
inferred← citeshttps://doi.org/10.1016/b978-0-12-812019-4.00006-4openalex-snapshot
An Overview of the Roles of the Gut Microbiome in Obesity and Diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-12-812293-8.00018-9openalex-snapshot
Influence of the Human Gut Microbiome on the Metabolic Phenotype
inferred← citeshttps://doi.org/10.1016/b978-0-12-814649-1.00003-xopenalex-snapshot
Gut Microbiota Influence Lipid and Glucose Metabolism, Energy Homeostasis and Inflammation Through Effects on Bile Acid Metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-12-816918-6.00004-4openalex-snapshot
Influences of food ingredients on enterohepatic circulation of bile acids
inferred← citeshttps://doi.org/10.1016/b978-0-12-819404-1.00016-6openalex-snapshot
Gut microbiota interaction in host lipid metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-12-821927-0.00002-4openalex-snapshot
The pathophysiology of gut–liver connection
inferred← citeshttps://doi.org/10.1016/b978-0-323-29738-7.00037-xopenalex-snapshot
Disorders of Lipid Metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-323-37591-7.00002-1openalex-snapshot
Bile Acids and Bile Flow
inferred← citeshttps://doi.org/10.1016/b978-0-443-31402-5.00009-8openalex-snapshot
Emerging targets and mechanisms of the host microbiome co-metabolism system (HMMS) in host pathophysiology
inferred← citeshttps://doi.org/10.1016/b978-0-443-40578-5.00008-8openalex-snapshot
Natural products as modulators of bile acid receptor FXR: therapeutic opportunities and challenges in drug discovery
inferred← citeshttps://doi.org/10.1016/b978-1-4160-3258-8.50010-3openalex-snapshot
Mechanisms of Bile Secretion
inferred← citeshttps://doi.org/10.1016/b978-1-4377-0324-5.00037-7openalex-snapshot
Disorders of Lipid Metabolism
inferred← citeshttps://doi.org/10.1016/b978-1-4377-1366-4.00013-5openalex-snapshot
The Role of High-Density Lipoprotein Cholesterol in the Development of Atherosclerotic Cardiovascular Disease
inferred← citeshttps://doi.org/10.1016/bs.vh.2019.09.002openalex-snapshot
Aquaporin regulation in metabolic organs
inferred← citeshttps://doi.org/10.1016/j.aanat.2023.152104openalex-snapshot
SHRSP5/Dmcr rats fed a high-fat and high-cholesterol diet develop disease-induced sarcopenia as nonalcoholic steatohepatitis progresses
inferred← citeshttps://doi.org/10.1016/j.abb.2004.08.030openalex-snapshot
Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR
inferred← citeshttps://doi.org/10.1016/j.abb.2021.109032openalex-snapshot
Beneficial effects of inorganic nitrate in non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.ajcnut.2024.02.019openalex-snapshot
Changes in bile acid subtypes and improvements in lipid metabolism and atherosclerotic cardiovascular disease risk: the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) trial
inferred← citeshttps://doi.org/10.1016/j.ajcnut.2025.09.026openalex-snapshot
Associations between serum bile acid profile and mortality in patients with coronary artery disease: a cohort study
inferred← citeshttps://doi.org/10.1016/j.ajpath.2016.07.014openalex-snapshot
REV-ERBα Activates C/EBP Homologous Protein to Control Small Heterodimer Partner–Mediated Oscillation of Alcoholic Fatty Liver
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