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Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/glia.20072openalex-snapshot
Evidence that the branched‐chain α‐keto acids accumulating in maple syrup urine disease induce morphological alterations and death in cultured astrocytes from rat cerebral cortex
inferredcites →https://doi.org/10.1007/s10545-006-0276-1openalex-snapshot
Variant maple syrup urine disease (MSUD)—The entire spectrum
inferredcites →https://doi.org/10.1007/s11011-006-9030-5openalex-snapshot
Evidence that oxidative stress is increased in plasma from patients with maple syrup urine disease
inferredcites →https://doi.org/10.1007/s11011-007-9077-yopenalex-snapshot
Oxidative stress in plasma from maple syrup urine disease patients during treatment
inferredcites →https://doi.org/10.1016/0003-9861(90)90645-fopenalex-snapshot
Purification and partial characterization of branched-chain α-ketoacid dehydrogenase kinase from rat liver and rat heart
inferredcites →https://doi.org/10.1016/0065-2571(94)00020-4openalex-snapshot
A new family of protein kinases— The mitochondrial protein kinases
inferredcites →https://doi.org/10.1016/j.bbrc.2007.02.108openalex-snapshot
Identification of a novel PP2C-type mitochondrial phosphatase
inferredcites →https://doi.org/10.1016/j.clinbiochem.2007.11.015openalex-snapshot
Maple syrup urine disease in treated patients: Biochemical and oxidative stress profiles
inferredcites →https://doi.org/10.1016/j.metabol.2005.03.016openalex-snapshot
Ornithine α-ketoglutarate metabolism in the healthy rat in the postabsorptive state
inferredcites →https://doi.org/10.1016/j.neuint.2006.05.007openalex-snapshot
Morphological alterations and induction of oxidative stress in glial cells caused by the branched-chain α-keto acids accumulating in maple syrup urine disease
inferredcites →https://doi.org/10.1016/j.nut.2005.12.008openalex-snapshot
Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction
inferredcites →https://doi.org/10.1016/j.str.2005.10.009openalex-snapshot
A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain α-Ketoacid Dehydrogenase
inferredcites →https://doi.org/10.1016/s0014-5793(01)02149-4openalex-snapshot
Regulation of the activity of branched‐chain 2‐oxo acid dehydrogenase (BCODH) complex by binding BCODH kinase
inferredcites →https://doi.org/10.1016/s0021-9258(18)53663-2openalex-snapshot
Branched chain aminotransferase isoenzymes. Purification and characterization of the rat brain isoenzyme.
inferredcites →https://doi.org/10.1016/s0021-9258(19)49589-6openalex-snapshot
Identification of mitochondrial branched chain aminotransferase and its isoforms in rat tissues.
inferredcites →https://doi.org/10.1016/s0065-2571(96)00009-xopenalex-snapshot
Studies on the regulation of the mitochondrial α-ketoacid dehydrogenase complexes and their kinases
inferredcites →https://doi.org/10.1016/s0076-6879(00)24217-1openalex-snapshot
Spectrophotometric Assay for Measuring Branched-Chain Amino Acids
inferredcites →https://doi.org/10.1016/s0076-6879(88)66044-7openalex-snapshot
[42] Branched-chain α-keto acid dehydrogenase phosphatase and its inhibitor protein from bovine kidney
inferredcites →https://doi.org/10.1021/ac950914hopenalex-snapshot
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels
inferredcites →https://doi.org/10.1042/bj20060869openalex-snapshot
Impaired growth and neurological abnormalities in branched-chain α-keto acid dehydrogenase kinase-deficient mice
inferredcites →https://doi.org/10.1042/bj2570625openalex-snapshot
The 2-oxo acid dehydrogenase complexes: recent advances
inferredcites →https://doi.org/10.1073/pnas.75.10.4881openalex-snapshot
Purification and characterization of branched chain α-keto acid dehydrogenase complex of bovine kidney
inferredcites →https://doi.org/10.1073/pnas.81.14.4335openalex-snapshot
Purification and properties of branched-chain alpha-keto acid dehydrogenase phosphatase from bovine kidney.
inferredcites →https://doi.org/10.1074/jbc.270.34.19861openalex-snapshot
Expression and Characterization of Branched-chain α-Ketoacid Dehydrogenase Kinase from the Rat
inferredcites →https://doi.org/10.1093/ajcn/68.1.72openalex-snapshot
A molecular model of human branched-chain amino acid metabolism
inferredcites →https://doi.org/10.1093/jn/135.6.1557sopenalex-snapshot
Branched-Chain Amino Acid Metabolism: Implications for Establishing Safe Intakes
inferredcites →https://doi.org/10.1093/jn/136.1.243sopenalex-snapshot
Lessons from Genetic Disorders of Branched-Chain Amino Acid Metabolism
inferredcites →https://doi.org/10.1093/jn/136.1.319sopenalex-snapshot
Potential Importance of Leucine in Treatment of Obesity and the Metabolic Syndrome
inferredcites →https://doi.org/10.1101/gad.1499107openalex-snapshot
A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development
inferredcites →https://doi.org/10.1146/annurev.nu.04.070184.002205openalex-snapshot
Branched-Chain Amino Acid Metabolism
inferredcites →https://doi.org/10.1152/ajpendo.00153.2003openalex-snapshot
Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR
inferredcites →https://doi.org/10.1152/ajpendo.00276.2003openalex-snapshot
Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves
inferredcites →https://doi.org/10.1172/jci117804openalex-snapshot
Molecular and biochemical basis of intermediate maple syrup urine disease. Occurrence of homozygous G245R and F364C mutations at the E1 alpha locus of Hispanic-Mexican patients.
inferredcites →https://doi.org/10.1186/1471-2350-7-33openalex-snapshot
Production and characterization of murine models of classic and intermediate maple syrup urine disease
inferredcites →https://doi.org/10.1542/peds.25.1.72openalex-snapshot
MAPLE SYRUP URINE DISEASE: BRANCHED-CHAIN KETO-ACIDURIA
inferredcites →https://doi.org/10.2337/db07-0123openalex-snapshot
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
inferredcites →https://doi.org/10.3177/jnsv.51.48openalex-snapshot
Dissociation of Branched-Chain .ALPHA.-Keto Acid Dehydrogenase Kinase (BDK) from Branched-Chain .ALPHA.-Keto Acid Dehydrogenase Complex (BCKDC) by BDK Inhibitors
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4022706openalex-extracted
Branched-Chain Keto Acid Inhibits Mitochondrial Pyruvate Carrier and Suppresses Gluconeogenesis
inferred← citeshttps://doi.org/10.1002/ajmg.a.63129openalex-snapshot
PPM1K defects cause mild maple syrup urine disease: The second case in the literature
inferred← citeshttps://doi.org/10.1002/ajmg.a.64037openalex-snapshot
Expanding the Genetic Spectrum of PPM1K ‐Related Maple Syrup Urine Disease: A Novel Mutation
inferred← citeshttps://doi.org/10.1002/dvdy.23990openalex-snapshot
Nuclear phosphatase PPM1G in cellular survival and neural development
inferred← citeshttps://doi.org/10.1002/humu.22242openalex-snapshot
A Novel Regulatory Defect in the Branched-Chain α-Keto Acid Dehydrogenase Complex Due to a Mutation in thePPM1KGene Causes a Mild Variant Phenotype of Maple Syrup Urine Disease
inferred← citeshttps://doi.org/10.1002/humu.22513openalex-snapshot
Two Novel Mutations in theBCKDK(Branched-Chain Keto-Acid Dehydrogenase Kinase) Gene Are Responsible for a Neurobehavioral Deficit in Two Pediatric Unrelated Patients
inferred← citeshttps://doi.org/10.1002/jimd.70242openalex-snapshot
Treating a Disorder Caused by an Overactive Enzyme: BCKD‐Kinase Deficiency
inferred← citeshttps://doi.org/10.1002/oby.23240openalex-snapshot
Association of plasma branched‐chain amino acids with overweight: A Mendelian randomization analysis
inferred← citeshttps://doi.org/10.1002/psp4.70328openalex-snapshot
A Quantitative Systems Pharmacology Model of Human Leucine Metabolism
inferred← citeshttps://doi.org/10.1007/978-1-4939-1914-7_6openalex-snapshot
Branched Chain Amino Acids in Heart Failure
inferred← citeshttps://doi.org/10.1007/978-3-030-54462-1_3openalex-snapshot
Amino Acids in Beef Cattle Nutrition and Production
inferred← citeshttps://doi.org/10.1007/978-3-319-31251-4_4openalex-snapshot
Cardiac Metabolism and Energetic Control
inferred← citeshttps://doi.org/10.1007/s00246-010-9856-9openalex-snapshot
Catabolism of Branched-Chain Amino Acids in Heart Failure: Insights from Genetic Models
inferred← citeshttps://doi.org/10.1007/s00592-018-1165-4openalex-snapshot
Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese
inferred← citeshttps://doi.org/10.1007/s00726-011-1088-7openalex-snapshot
Insulin resistance and the metabolism of branched-chain amino acids in humans
inferred← citeshttps://doi.org/10.1007/s00726-024-03417-2openalex-snapshot
Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production
inferred← citeshttps://doi.org/10.1007/s10545-017-0091-xopenalex-snapshot
Metabolic pathways at the crossroads of diabetes and inborn errors
inferred← citeshttps://doi.org/10.1007/s10555-021-10016-0openalex-snapshot
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
inferred← citeshttps://doi.org/10.1007/s10557-022-07320-4openalex-snapshot
Branched-Chain Amino Acid Metabolism in the Failing Heart
inferred← citeshttps://doi.org/10.1007/s10741-023-10353-yopenalex-snapshot
Metabolic adaptations in pressure overload hypertrophic heart
inferred← citeshttps://doi.org/10.1007/s11010-024-05188-6openalex-snapshot
Phosphatase activity-based PPM1K: a key player in the regulation of mitochondrial function and its multifaceted impact in diseases
inferred← citeshttps://doi.org/10.1007/s11011-016-9867-1openalex-snapshot
In silico analysis of novel mutations in maple syrup urine disease patients from Iran
inferred← citeshttps://doi.org/10.1007/s11011-017-0168-0openalex-snapshot
Clinical characteristics and mutation analysis of five Chinese patients with maple syrup urine disease
inferred← citeshttps://doi.org/10.1007/s11892-018-1048-7openalex-snapshot
Branched Chain Amino Acids in Metabolic Disease
inferred← citeshttps://doi.org/10.1007/s12012-025-10079-3openalex-snapshot
Multimodal Therapeutic Strategies Targeting BCAA Metabolism in Diabetic Cardiomyopathy: A Path to Cardioprotection
inferred← citeshttps://doi.org/10.1007/s12265-023-10432-3openalex-snapshot
Cardiac Metabolism, Reprogramming, and Diseases
inferred← citeshttps://doi.org/10.1016/b978-0-12-378630-2.00072-4openalex-snapshot
Branched-Chain Amino Acids
inferred← citeshttps://doi.org/10.1016/b978-0-12-410529-4.00059-0openalex-snapshot
Maple Syrup Urine Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-809633-8.21436-2openalex-snapshot
Amino Acids | Branched-Chain Amino Metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-12-813955-4.00063-5openalex-snapshot
Maple syrup urine disease: biochemical, clinical and therapeutic considerations
inferred← citeshttps://doi.org/10.1016/b978-0-443-19041-4.00001-7openalex-snapshot
Maple syrup urine disease: biochemical, clinical, and therapeutic considerations
inferred← citeshttps://doi.org/10.1016/j.ab.2013.05.002openalex-snapshot
Quantification of branched-chain keto acids in tissue by ultra fast liquid chromatography–mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.bbadis.2016.01.016openalex-snapshot
Mitochondrial response to the BCKDK-deficiency: Some clues to understand the positive dietary response in this form of autism
inferred← citeshttps://doi.org/10.1016/j.bbadis.2016.09.009openalex-snapshot
Branched chain amino acid metabolic reprogramming in heart failure
inferred← citeshttps://doi.org/10.1016/j.bbrc.2010.02.004openalex-snapshot
Regulation of hepatic branched-chain α-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.09.162openalex-snapshot
BCKA down-regulates mTORC2-Akt signal and enhances apoptosis susceptibility in cardiomyocytes
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.09.038openalex-snapshot
Ca2+-dependent inhibition of branched-chain α-ketoacid dehydrogenase kinase by thiamine pyrophosphate
inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.03.010openalex-snapshot
α-ketoisocaproic acid promotes ER stress through impairment of autophagy, thereby provoking lipid accumulation and insulin resistance in murine preadipocytes
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.151154openalex-snapshot
Dephosphorylation of branched-chain α-keto acid dehydrogenase E1α (BCKDHA) promotes branched-chain amino acid catabolism and renders cancer cells resistant to X-rays by mitigating DNA damage
inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.153200openalex-snapshot
Design-driven optimization of mitochondrial protein phosphatases for in vitro studies
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113222openalex-snapshot
SGLT2 inhibitor-empagliflozin treatment ameliorates diabetic retinopathy manifestations and exerts protective effects associated with augmenting branched chain amino acids catabolism and transportation in db/db mice
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115271openalex-snapshot
Energy metabolism: A critical target of cardiovascular injury
inferred← citeshttps://doi.org/10.1016/j.cellsig.2021.110061openalex-snapshot
Metal dependent protein phosphatase PPM family in cardiac health and diseases
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.03.140openalex-snapshot
PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108239openalex-snapshot
The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112186openalex-snapshot
Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112641openalex-snapshot
Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes
inferred← citeshttps://doi.org/10.1016/j.cmet.2016.11.005openalex-snapshot
Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury
inferred← citeshttps://doi.org/10.1016/j.cmet.2018.04.015openalex-snapshot
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase
inferred← citeshttps://doi.org/10.1016/j.cmet.2018.10.013openalex-snapshot
Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
inferred← citeshttps://doi.org/10.1016/j.cmet.2022.09.008openalex-snapshot
Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure
inferred← citeshttps://doi.org/10.1016/j.ebiom.2016.10.013openalex-snapshot
Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy
inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104492openalex-snapshot
PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome
inferred← citeshttps://doi.org/10.1016/j.ejphar.2019.172796openalex-snapshot
PP2Cm overexpression alleviates MI/R injury mediated by a BCAA catabolism defect and oxidative stress in diabetic mice
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2026.06.041openalex-snapshot
Impaired BCAA catabolism in macrophages exacerbates sepsis-induced lung injury by modulating mitochondrial AGE–RAGE and mtDNA release
inferred← citeshttps://doi.org/10.1016/j.gene.2012.12.097openalex-snapshot
Molecular characterization of maple syrup urine disease patients from Tunisia
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100880openalex-snapshot
The extensive and functionally uncharacterized mitochondrial phosphoproteome
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.105702openalex-snapshot
The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113345openalex-snapshot
Lauric acid engages an O-GlcNAc–sensitive BCKDH regulatory node to modulate branched-chain amino acid oxidation in skeletal myotubes
inferred← citeshttps://doi.org/10.1016/j.jcmg.2011.11.009openalex-snapshot
Targeted Metabolic Imaging to Improve the Management of Heart Disease
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2026.110462openalex-snapshot
Disruption of branched-chain amino acids homeostasis exacerbates MCD-induced steatohepatitis by amplifying a pro-inflammatory positive feedback loop between hepatocytes and macrophages
inferred← citeshttps://doi.org/10.1016/j.jtha.2023.06.039openalex-snapshot
Branched-chain amino acids promote thrombocytopoiesis by activating mTOR signaling
inferred← citeshttps://doi.org/10.1016/j.lfs.2015.06.021openalex-snapshot
Branched-chain amino acids ameliorate heart failure with cardiac cachexia in rats
inferred← citeshttps://doi.org/10.1016/j.metabol.2021.154871openalex-snapshot
Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart
inferred← citeshttps://doi.org/10.1016/j.metabol.2024.156037openalex-snapshot
Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition
inferred← citeshttps://doi.org/10.1016/j.molmet.2013.07.005openalex-snapshot
PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101478openalex-snapshot
An amino acid-defined diet impairs tumour growth in mice by promoting endoplasmic reticulum stress and mTOR inhibition
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101611openalex-snapshot
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice
inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101694openalex-snapshot
Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2016.01.005openalex-snapshot
Identification of six novel mutations in Iranian patients with maple syrup urine disease and their in silico analysis
inferred← citeshttps://doi.org/10.1016/j.nut.2020.110794openalex-snapshot
Energy metabolism profile of the effects of amino acid treatment on skeletal muscle cells: Leucine inhibits glycolysis of myotubes
inferred← citeshttps://doi.org/10.1016/j.phanu.2018.01.003openalex-snapshot
Emerging role of branched chain amino acids in metabolic disorders: A mechanistic review
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107622openalex-snapshot
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors
inferred← citeshttps://doi.org/10.1016/j.phrs.2018.05.014openalex-snapshot
Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.12.019openalex-snapshot
Non-coding RNAs rewire cancer metabolism networks
inferred← citeshttps://doi.org/10.1016/j.tox.2009.10.002openalex-snapshot
Adverse effect of fenofibrate on branched-chain α-ketoacid dehydrogenase complex in rat's liver
inferred← citeshttps://doi.org/10.1016/j.tox.2013.02.011openalex-snapshot
Stimulation of rat liver branched-chain alpha-keto acid dehydrogenase activity by low doses of bezafibrate
inferred← citeshttps://doi.org/10.1016/j.tox.2014.09.001openalex-snapshot
Simvastatin increases liver branched-chain α-ketoacid dehydrogenase activity in rats fed with low protein diet
inferred← citeshttps://doi.org/10.1016/j.tranon.2023.101696openalex-snapshot
Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2016.11.002openalex-snapshot
Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia–reperfusion injury
inferred← citeshttps://doi.org/10.1016/j.ymgme.2010.04.017openalex-snapshot
Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation
inferred← citeshttps://doi.org/10.1016/j.ymgme.2012.05.023openalex-snapshot
Analysis of gene mutations in Chinese patients with maple syrup urine disease
inferred← citeshttps://doi.org/10.1016/j.ymgme.2013.05.010openalex-snapshot
Adipose transplant for inborn errors of branched chain amino acid metabolism in mice
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c09448openalex-snapshot
Bergenin Alleviates Ulcerative Colitis By Decreasing Gut Commensal Bacteroides vulgatus-Mediated Elevated Branched-Chain Amino Acids
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c02230openalex-snapshot
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.4c00362openalex-snapshot
Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity
inferred← citeshttps://doi.org/10.1038/aps.2015.119openalex-snapshot
Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells
inferred← citeshttps://doi.org/10.1038/nm.4179openalex-snapshot
The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy
inferred← citeshttps://doi.org/10.1038/nrendo.2014.171openalex-snapshot
Branched-chain amino acids in metabolic signalling and insulin resistance
inferred← citeshttps://doi.org/10.1038/s12276-024-01263-6openalex-snapshot
The role of BCAA metabolism in metabolic health and disease
inferred← citeshttps://doi.org/10.1038/s41387-022-00213-3openalex-snapshot
Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes
inferred← citeshttps://doi.org/10.1038/s41392-022-00971-7openalex-snapshot
Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction
inferred← citeshttps://doi.org/10.1038/s41401-023-01076-9openalex-snapshot
Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice
inferred← citeshttps://doi.org/10.1038/s41401-024-01417-2openalex-snapshot
Branched-chain amino acids promote hepatic Cyp7a1 expression and bile acid synthesis via suppressing FGF21-ERK pathway
inferred← citeshttps://doi.org/10.1038/s41419-023-06135-xopenalex-snapshot
PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons
inferred← citeshttps://doi.org/10.1038/s41419-024-07071-0openalex-snapshot
BCKDH kinase promotes hepatic gluconeogenesis independent of BCKDHA
inferred← citeshttps://doi.org/10.1038/s41467-018-05362-7openalex-snapshot
Glucose promotes cell growth by suppressing branched-chain amino acid degradation
inferred← citeshttps://doi.org/10.1038/s41467-023-40536-yopenalex-snapshot
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels
inferred← citeshttps://doi.org/10.1038/s41467-024-55036-wopenalex-snapshot
Pantothenate kinase 4 controls skeletal muscle substrate metabolism
inferred← citeshttps://doi.org/10.1038/s41569-022-00760-3openalex-snapshot
Branched-chain amino acids in cardiovascular disease
inferred← citeshttps://doi.org/10.1038/s41598-018-34245-6openalex-snapshot
Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI
inferred← citeshttps://doi.org/10.1038/s41598-020-60536-yopenalex-snapshot
Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase
inferred← citeshttps://doi.org/10.1038/s41598-020-76228-6openalex-snapshot
Dietary casein, egg albumin, and branched-chain amino acids attenuate phosphate-induced renal tubulointerstitial injury in rats
inferred← citeshttps://doi.org/10.1038/s41598-026-47741-xopenalex-snapshot
Branched-chain amino acid catabolism is potentially deficient in pancreatic cancer with high-neural invasion
inferred← citeshttps://doi.org/10.1038/s42255-020-0226-5openalex-snapshot
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours
inferred← citeshttps://doi.org/10.1038/s42255-021-00520-6openalex-snapshot
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16
inferred← citeshttps://doi.org/10.1038/s42255-023-00794-yopenalex-snapshot
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance
inferred← citeshttps://doi.org/10.1038/srep08560openalex-snapshot
The catalytic role of the M2 metal ion in PP2Cα
inferred← citeshttps://doi.org/10.1038/srep28775openalex-snapshot
Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD
inferred← citeshttps://doi.org/10.1042/bcj20160822openalex-snapshot
Amino acid homeostasis and signalling in mammalian cells and organisms
inferred← citeshttps://doi.org/10.1042/bcj20200686openalex-snapshot
Whole-body metabolic fate of branched-chain amino acids
inferred← citeshttps://doi.org/10.1042/cs20260961openalex-snapshot
Impact of impaired branched-chain amino acid metabolism on kidney disease
inferred← citeshttps://doi.org/10.1073/pnas.1303220110openalex-snapshot
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase
inferred← citeshttps://doi.org/10.1074/jbc.m111.314963openalex-snapshot
Structural and Biochemical Characterization of Human Mitochondrial Branched-chain α-Ketoacid Dehydrogenase Phosphatase
inferred← citeshttps://doi.org/10.1074/jbc.m112.351031openalex-snapshot
Tissue-specific and Nutrient Regulation of the Branched-chain α-Keto Acid Dehydrogenase Phosphatase, Protein Phosphatase 2Cm (PP2Cm)
inferred← citeshttps://doi.org/10.1074/jbc.m114.569251openalex-snapshot
Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase
inferred← citeshttps://doi.org/10.1074/jbc.ra119.010371openalex-snapshot
Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet
inferred← citeshttps://doi.org/10.1074/jbc.ra120.013121openalex-snapshot
Branched-chain ketoacid overload inhibits insulin action in the muscle
inferred← citeshttps://doi.org/10.1080/09168451.2018.1440174openalex-snapshot
Branched-chain amino acid (BCAA) supplementation enhances adaptability to exercise training of mice with a muscle-specific defect in the control of BCAA catabolism
inferred← citeshttps://doi.org/10.1080/10408398.2021.1977910openalex-snapshot
Branched chain amino acids—friend or foe in the control of energy substrate turnover and insulin sensitivity?
inferred← citeshttps://doi.org/10.1080/14728222.2026.2709804openalex-snapshot
BCAA metabolic reprogramming identifies BCKDK as a therapeutic target in cancer
inferred← citeshttps://doi.org/10.1080/14756366.2023.2290458openalex-snapshot
Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation
inferred← citeshttps://doi.org/10.1080/17501911.2024.2435257openalex-snapshot
Multi-omics insights into the pathogenesis of diabetic cardiomyopathy: epigenetic and metabolic profiles
inferred← citeshttps://doi.org/10.1080/27697061.2025.2549893openalex-snapshot
Precision Nutritional Genomics, Gut Microbiota and Artificial Intelligence in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1093/cvr/cvad005openalex-snapshot
Dietary essential amino acids for the treatment of heart failure with reduced ejection fraction
inferred← citeshttps://doi.org/10.1093/cvr/cvr070openalex-snapshot
Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?
inferred← citeshttps://doi.org/10.1093/cvr/cvx017openalex-snapshot
Metabolism in cardiomyopathy: every substrate matters
inferred← citeshttps://doi.org/10.1093/hmg/ddq507openalex-snapshot
Phenylbutyrate therapy for maple syrup urine disease
inferred← citeshttps://doi.org/10.1093/intimm/dxae007openalex-snapshot
Reprogramming T-cell metabolism to enhance adoptive cell therapies
inferred← citeshttps://doi.org/10.1093/nar/gkae226openalex-snapshot
Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH
inferred← citeshttps://doi.org/10.1096/fj.201802842rropenalex-snapshot
Role of branched‐chain amino acid–catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis
inferred← citeshttps://doi.org/10.1101/2020.02.21.960153openalex-snapshot
Silencing branched-chain ketoacid dehydrogenase or treatment with branched-chain ketoacids ex vivo inhibits muscle insulin signaling
inferred← citeshttps://doi.org/10.1101/2022.06.10.495711openalex-snapshot
Nervous system reduction in branched-chain amino acid metabolism disrupts hippocampal neurogenesis and memory
inferred← citeshttps://doi.org/10.1101/2024.12.17.629007openalex-snapshot
ldentify potential feature genes and immune cell infiltration of HIRI based on branched-chain amino acid-related genes by machine learning and experimental validation
inferred← citeshttps://doi.org/10.1101/2025.11.01.685925openalex-snapshot
Differential Branched-Chain Amino Acid Metabolism in Tissues of Tumor-Bearing Mice
inferred← citeshttps://doi.org/10.1111/acel.13626openalex-snapshot
Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism
inferred← citeshttps://doi.org/10.1111/bph.13624openalex-snapshot
Branched‐chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view
inferred← citeshttps://doi.org/10.1111/j.1751-7133.2011.00266.xopenalex-snapshot
Mitochondrial Protein Phosphorylation as a Regulatory Modality: Implications for Mitochondrial Dysfunction in Heart Failure
inferred← citeshttps://doi.org/10.1111/jnc.14631openalex-snapshot
Crystal structure and catalytic activity of the PPM 1K N94K mutant
inferred← citeshttps://doi.org/10.1111/obr.13856openalex-snapshot
Branched‐chain amino acid metabolism: Pathophysiological mechanism and therapeutic intervention in metabolic diseases
inferred← citeshttps://doi.org/10.1111/obr.70092openalex-snapshot
The Complex Relation of Branched‐Chain Amino Acids and Inflammation in the Obesity and Diabetes Context
inferred← citeshttps://doi.org/10.1113/ep090305openalex-snapshot
High doses of rosuvastatin induce impaired branched‐chain amino acid catabolism and lead to insulin resistance
inferred← citeshttps://doi.org/10.1152/ajpendo.00206.2022openalex-snapshot
Defective muscle ketone body oxidation disrupts BCAA catabolism by altering mitochondrial branched-chain aminotransferase
inferred← citeshttps://doi.org/10.1152/ajpendo.00630.2012openalex-snapshot
Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity
inferred← citeshttps://doi.org/10.1152/ajpheart.00077.2012openalex-snapshot
Cardiac mitochondrial matrix and respiratory complex protein phosphorylation
inferred← citeshttps://doi.org/10.1152/ajpheart.00114.2016openalex-snapshot
Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction
inferred← citeshttps://doi.org/10.1152/ajpregu.00320.2025openalex-snapshot
Differential branched-chain amino acid metabolism in tissues of tumor-bearing male mice
inferred← citeshttps://doi.org/10.1152/physiol.00034.2011openalex-snapshot
Novel Ser/Thr Protein Phosphatases in Cell Death Regulation
inferred← citeshttps://doi.org/10.1155/2019/8247019openalex-snapshot
A High Level of Circulating Valine Is a Biomarker for Type 2 Diabetes and Associated with the Hypoglycemic Effect of Sitagliptin
inferred← citeshttps://doi.org/10.1158/0008-5472.can-14-2268openalex-snapshot
Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain
inferred← citeshttps://doi.org/10.11606/d.39.2011.tde-14022012-145955openalex-snapshot
Insuficiência cardíaca por excesso de catecolaminas: influência do treinamento físico aeróbico associado à suplementação com leucina na musculatura esquelética
inferred← citeshttps://doi.org/10.1161/circresaha.112.268128openalex-snapshot
Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy
inferred← citeshttps://doi.org/10.1161/circresaha.113.302095openalex-snapshot
Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes
inferred← citeshttps://doi.org/10.1161/circresaha.118.312017openalex-snapshot
Metabolic Coordination of Physiological and Pathological Cardiac Remodeling
inferred← citeshttps://doi.org/10.1161/circulationaha.115.020226openalex-snapshot
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure
inferred← citeshttps://doi.org/10.1161/circulationaha.119.043581openalex-snapshot
Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets
inferred← citeshttps://doi.org/10.1161/hypertensionaha.118.10919openalex-snapshot
Branched-Chain Amino Acids as Critical Switches in Health and Disease
inferred← citeshttps://doi.org/10.1161/jaha.113.000233openalex-snapshot
Enoyl Coenzyme A Hydratase Domain–Containing 2, a Potential Novel Regulator of Myocardial Ischemia Injury
inferred← citeshttps://doi.org/10.1161/jaha.118.011625openalex-snapshot
Therapeutic Effect of Targeting Branched‐Chain Amino Acid Catabolic Flux in Pressure‐Overload Induced Heart Failure
inferred← citeshttps://doi.org/10.1161/jaha.119.015118openalex-snapshot
Novel Findings From a Metabolomics Study of Left Ventricular Diastolic Function: The Bogalusa Heart Study
inferred← citeshttps://doi.org/10.1177/2047487318797395openalex-snapshot
Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study
inferred← citeshttps://doi.org/10.1186/s12916-022-02688-4openalex-snapshot
Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study
inferred← citeshttps://doi.org/10.1186/s12933-019-0892-3openalex-snapshot
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
inferred← citeshttps://doi.org/10.1186/s12986-025-01053-5openalex-snapshot
Branched-chain amino acids and sepsis: from pathological mechanisms to clinical interventions
inferred← citeshttps://doi.org/10.1242/jcs.256230openalex-snapshot
Interferon regulatory factor 7 impairs cellular metabolism in aging adipose-derived stromal cells
inferred← citeshttps://doi.org/10.1371/journal.pmed.1002179openalex-snapshot
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
inferred← citeshttps://doi.org/10.1371/journal.pone.0059443openalex-snapshot
Leucine and Protein Metabolism in Obese Zucker Rats
inferred← citeshttps://doi.org/10.1371/journal.pone.0134184openalex-snapshot
The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy
inferred← citeshttps://doi.org/10.1371/journal.pone.0166574openalex-snapshot
Transcriptome Dynamics and Potential Roles of Sox6 in the Postnatal Heart
inferred← citeshttps://doi.org/10.1371/journal.pone.0180989openalex-snapshot
Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism
inferred← citeshttps://doi.org/10.14797/mdcvj.1309openalex-snapshot
Metabolic Control of Cardiomyocyte Cell Cycle
inferred← citeshttps://doi.org/10.14814/phy2.14396openalex-snapshot
Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy
inferred← citeshttps://doi.org/10.1515/med-2026-1473openalex-snapshot
Aloe emodin attenuates Aβ 1–42 -Induced neurotoxicity in SH-SY5Y cells via downregulation of PPM1K
inferred← citeshttps://doi.org/10.1530/ec-23-0079openalex-snapshot
A metabolomics-based analysis of the metabolic pathways associated with the regulation of branched-chain amino acids in rats fed a high-fructose diet
inferred← citeshttps://doi.org/10.1590/1806-9282.65.6.786openalex-snapshot
The study of copy number variations in the regions of PRKAB2 and PPM1K among congenital heart defects patients
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4616706/v1openalex-snapshot
PRSS55 Regulates Energy Homeostasis and BCAA Metabolism via Interacting with BCKDK in Mouse Testes and Sperm
inferred← citeshttps://doi.org/10.2147/cia.s376668openalex-snapshot
The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging
inferred← citeshttps://doi.org/10.2337/db13-0570openalex-snapshot
Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach
inferred← citeshttps://doi.org/10.2337/db14-0312openalex-snapshot
Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice
inferred← citeshttps://doi.org/10.2337/db18-0927openalex-snapshot
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
inferred← citeshttps://doi.org/10.31219/osf.io/ps6fqopenalex-snapshot
Down-regulation of protein phosphatases PPM1K and PPP1R3C in high-grade serous ovarian cancers.
inferred← citeshttps://doi.org/10.31274/td-20240617-325openalex-snapshot
The contribution of biological sex to heat stress-mediated outcomes in oxidative skeletal muscle
inferred← citeshttps://doi.org/10.3168/jds.2018-14463openalex-snapshot
Changes in tissue abundance and activity of enzymes related to branched-chain amino acid catabolism in dairy cows during early lactation
inferred← citeshttps://doi.org/10.3168/jds.2019-17147openalex-snapshot
Branched-chain amino acids: Abundance of their transporters and metabolizing enzymes in adipose tissue, skeletal muscle, and liver of dairy cows at high or normal body condition
inferred← citeshttps://doi.org/10.3389/fcell.2021.656604openalex-snapshot
Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand
inferred← citeshttps://doi.org/10.3389/fcimb.2026.1902640openalex-snapshot
Branched-chain amino acid metabolism and macrophage polarization: potential regulatory nodes and therapeutic targets in diabetes-associated metabolic inflammation
inferred← citeshttps://doi.org/10.3389/fcvm.2021.789267openalex-snapshot
Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease
inferred← citeshttps://doi.org/10.3389/fcvm.2021.792350openalex-snapshot
Metabolic Impairment in Coronary Artery Disease: Elevated Serum Acylcarnitines Under the Spotlights
inferred← citeshttps://doi.org/10.3389/fcvm.2023.1105581openalex-snapshot
Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway in a diet induced pre-HFpEF mouse model
inferred← citeshttps://doi.org/10.3389/fnut.2023.1279066openalex-snapshot
Branched chain amino acids metabolism in heart failure
inferred← citeshttps://doi.org/10.3389/fonc.2022.887257openalex-snapshot
Elevated BCAA Suppresses the Development and Metastasis of Breast Cancer
inferred← citeshttps://doi.org/10.3389/fphys.2019.01140openalex-snapshot
BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice
inferred← citeshttps://doi.org/10.3389/fphys.2021.702826openalex-snapshot
Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism
inferred← citeshttps://doi.org/10.3389/fpls.2021.814138openalex-snapshot
Branched-Chain Volatiles in Fruit: A Molecular Perspective
inferred← citeshttps://doi.org/10.3389/fvets.2025.1602363openalex-snapshot
Effects of BCAA supplementation on plasma and mare's milk amino acid contents in Yili mares and growth performance of suckling foals
inferred← citeshttps://doi.org/10.3390/biomedicines13112603openalex-snapshot
Mitochondrial Dynamics in Aging Heart
inferred← citeshttps://doi.org/10.3390/cells11213523openalex-snapshot
Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits
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