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Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/archneur.59.2.321openalex-snapshot
Archives of Neurology Reader's Choice: Continuing Medical Education
inferredcites →https://doi.org/10.1001/archneur.62.7.1091openalex-snapshot
Spectrum of Mutations in Biopsy-Proven CADASIL
inferredcites →https://doi.org/10.1002/ana.410440506openalex-snapshot
The phenotypic spectrum of CADASIL: Clinical findings in 102 cases
inferredcites →https://doi.org/10.1002/gene.20091openalex-snapshot
Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype
inferredcites →https://doi.org/10.1002/jnr.21925openalex-snapshot
Intensity of chronic cerebral hypoperfusion determines white/gray matter injury and cognitive/motor dysfunction in mice
inferredcites →https://doi.org/10.1006/geno.1998.5319openalex-snapshot
Construction and Characterization of a 10-fold Genome Equivalent Rat P1-Derived Artificial Chromosome Library
inferredcites →https://doi.org/10.1006/geno.2000.6286openalex-snapshot
Modular Bacterial Artificial Chromosome Vectors for Transfer of Large Inserts into Mammalian Cells
inferredcites →https://doi.org/10.1007/bf00571504openalex-snapshot
Systemic vascular smooth muscle cell impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
inferredcites →https://doi.org/10.1007/s00401-006-0116-2openalex-snapshot
Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL
inferredcites →https://doi.org/10.1007/s00401-006-0185-2openalex-snapshot
The enigma of vascular cognitive disorder and vascular dementia
inferredcites →https://doi.org/10.1016/0168-9525(93)90208-yopenalex-snapshot
Transcriptional regulation of multigene loci: multilevel control
inferredcites →https://doi.org/10.1016/j.nbd.2004.11.008openalex-snapshot
Reduced brain tissue perfusion in TGF-β1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities
inferredcites →https://doi.org/10.1016/j.neuron.2008.01.003openalex-snapshot
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
inferredcites →https://doi.org/10.1016/j.yexcr.2004.06.004openalex-snapshot
CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk
inferredcites →https://doi.org/10.1016/s0002-9440(10)63824-2openalex-snapshot
Transgenic Mice Expressing Mutant Notch3 Develop Vascular Alterations Characteristic of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
inferredcites →https://doi.org/10.1016/s0006-8993(99)01854-5openalex-snapshot
Postmortem diffusion of autoradiographic blood flow tracers
inferredcites →https://doi.org/10.1016/s0140-6736(01)07142-2openalex-snapshot
Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis
inferredcites →https://doi.org/10.1016/s0140-6736(97)08083-5openalex-snapshot
Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients
inferredcites →https://doi.org/10.1016/s1474-4422(07)70028-5openalex-snapshot
Genetics of ischaemic stroke
inferredcites →https://doi.org/10.1038/383707a0openalex-snapshot
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
inferredcites →https://doi.org/10.1038/jcbfm.1988.16openalex-snapshot
Measurement of Local Cerebral Blood Flow with [ 14 C]Iodoantipyrine in the Mouse
inferredcites →https://doi.org/10.1038/jcbfm.2008.91openalex-snapshot
Do in vivo Experimental Models Reflect Human Cerebral Small Vessel Disease? a Systematic Review
inferredcites →https://doi.org/10.1038/nbt0997-859openalex-snapshot
Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome
inferredcites →https://doi.org/10.1038/nn1492openalex-snapshot
DNER acts as a neuron-specific Notch ligand during Bergmann glial development
inferredcites →https://doi.org/10.1038/nrn1387openalex-snapshot
Neurovascular regulation in the normal brain and in Alzheimer's disease
inferredcites →https://doi.org/10.1046/j.1365-2990.1999.00198.xopenalex-snapshot
CADASIL: hereditary disease of arteries causing brain infarcts and dementia
inferredcites →https://doi.org/10.1046/j.1440-1681.2003.03825.xopenalex-snapshot
Long‐term measurement of cerebral blood flow and metabolism in a rat chronic hypoperfusion model
inferredcites →https://doi.org/10.1073/pnas.252624099openalex-snapshot
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling
inferredcites →https://doi.org/10.1074/jbc.272.47.29752openalex-snapshot
Human Apolipoprotein B Transgenic Mice Generated with 207- and 145-Kilobase Pair Bacterial Artificial Chromosomes
inferredcites →https://doi.org/10.1086/381506openalex-snapshot
Pathogenic Mutations Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Differently Affect Jagged1 Binding and Notch3 Activity via the RBP/JK Signaling Pathway
inferredcites →https://doi.org/10.1093/brain/awh282openalex-snapshot
Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients
inferredcites →https://doi.org/10.1093/brain/awn364openalex-snapshot
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients
inferredcites →https://doi.org/10.1093/brain/awp049openalex-snapshot
Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain
inferredcites →https://doi.org/10.1093/hmg/ddm042openalex-snapshot
The archetypal R90C CADASIL–NOTCH3 mutation retains NOTCH3 function in vivo
inferredcites →https://doi.org/10.1097/01.wco.0000162861.26971.03openalex-snapshot
Cerebral small vessel diseases: cerebral microangiopathies
inferredcites →https://doi.org/10.1101/gad.308904openalex-snapshot
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
inferredcites →https://doi.org/10.1111/j.1600-0404.1997.tb00224.xopenalex-snapshot
CADASIL: skin biopsy allows diagnosis in early stages
inferredcites →https://doi.org/10.1111/j.1750-3639.2004.tb00078.xopenalex-snapshot
Fibrosis and Stenosis of the Long Penetrating Cerebral Arteries: the Cause of the White Matter Pathology in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
inferredcites →https://doi.org/10.1113/expphysiol.2007.038752openalex-snapshot
Genes, endothelial function and cerebral small vessel disease in man
inferredcites →https://doi.org/10.1161/01.str.0000124124.69842.2dopenalex-snapshot
Positron Emission Tomography Examination of Cerebral Blood Flow and Glucose Metabolism in Young CADASIL Patients
inferredcites →https://doi.org/10.1161/01.str.0000143725.19053.60openalex-snapshot
White Matter Lesions and Glial Activation in a Novel Mouse Model of Chronic Cerebral Hypoperfusion
inferredcites →https://doi.org/10.1161/01.str.0000163080.82766.ebopenalex-snapshot
Impaired Cerebral Vasoreactivity in a Transgenic Mouse Model of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Arteriopathy
inferredcites →https://doi.org/10.1161/01.str.28.3.652openalex-snapshot
Pathogenesis of Leukoaraiosis
inferredcites →https://doi.org/10.1161/01.str.31.8.1904openalex-snapshot
Cerebral Hemodynamics in CADASIL Before and After Acetazolamide Challenge Assessed With MRI Bolus Tracking
inferredcites →https://doi.org/10.1161/atvbaha.108.171751openalex-snapshot
Notch3 Is a Major Regulator of Vascular Tone in Cerebral and Tail Resistance Arteries
inferredcites →https://doi.org/10.1172/jci8047openalex-snapshot
The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients
inferredcites →https://doi.org/10.1212/wnl.50.6.1715openalex-snapshot
SPECT study of a German CADASIL family
inferredcites →https://doi.org/10.1212/wnl.51.2.452openalex-snapshot
Patterns of MRI lesions in CADASIL
inferredcites →https://doi.org/10.1212/wnl.59.3.321openalex-snapshot
Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis
inferredcites →https://doi.org/10.1242/dev.122.8.2415openalex-snapshot
The SM 22 promoter directs tissue-specific expression in arterial but not in venous or visceral smooth muscle cells in transgenic mice
inferredcites →https://doi.org/10.1385/1-59259-340-2:105openalex-snapshot
Manipulating Large Insert Clones for Transgenesis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4606226openalex-extracted
Angptl4 May Serve as a Marker of Cognitive Impairment in Patients with Cerebral Small Vessel Disease
inferred← citeshttps://doi.org/10.1001/archneurol.2011.99openalex-snapshot
Stroke-Related Translational Research
inferred← citeshttps://doi.org/10.1002/acn3.574openalex-snapshot
Altered dynamics of neurovascular coupling in CADASIL
inferred← citeshttps://doi.org/10.1002/adbi.202300439openalex-snapshot
Treatment with Cerebrolysin Prolongs Lifespan in a Mouse Model of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
inferred← citeshttps://doi.org/10.1002/alz.14455openalex-snapshot
Non‐ APOE variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer's disease genetic risk on white matter hyperintensities
inferred← citeshttps://doi.org/10.1002/ame2.12005openalex-snapshot
Evaluation of an ischemic model in ischemia prone and general Mongolian gerbils by neurological symptom, injury, and sex difference
inferred← citeshttps://doi.org/10.1002/ana.22281openalex-snapshot
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome mutations increase susceptibility to spreading depression
inferred← citeshttps://doi.org/10.1002/ana.24512openalex-snapshot
Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
inferred← citeshttps://doi.org/10.1002/ana.24573openalex-snapshot
Reducing T imp3 or vitronectin ameliorates disease manifestations in CADASIL mice
inferred← citeshttps://doi.org/10.1002/ana.25284openalex-snapshot
Notch3ECD immunotherapy improves cerebrovascular responses in CADASIL mice
inferred← citeshttps://doi.org/10.1002/ana.26527openalex-snapshot
CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T‐MRI
inferred← citeshttps://doi.org/10.1002/glia.23815openalex-snapshot
Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia
inferred← citeshttps://doi.org/10.1002/hbm.24844openalex-snapshot
Metabolic and vascular risk factors are associated with reduced cerebral blood flow and poorer midlife memory performance
inferred← citeshttps://doi.org/10.1002/jmri.70096openalex-snapshot
Assessment of Small Vessel Density Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalophy ( CADASIL ) by High‐Resolution Black‐Blood MRI
inferred← citeshttps://doi.org/10.1002/mds.28171openalex-snapshot
Parkinson's Disease, NOTCH3 Genetic Variants, and White Matter Hyperintensities
inferred← citeshttps://doi.org/10.1002/mrm.26840openalex-snapshot
Simultaneous magnetic resonance diffusion and pseudo‐diffusion tensor imaging
inferred← citeshttps://doi.org/10.1002/trc2.70308openalex-snapshot
Differential presence of cerebral microbleeds in an amyloid mouse model compared with a CADASIL mouse model
inferred← citeshttps://doi.org/10.1007/978-1-4471-2428-3_10openalex-snapshot
Neuropsychiatric Symptoms of CADASIL
inferred← citeshttps://doi.org/10.1007/978-1-4614-9123-1_3openalex-snapshot
CADASIL and Animal Models
inferred← citeshttps://doi.org/10.1007/978-3-319-25616-0_6openalex-snapshot
The Effects of Hypertension on Cerebral Artery Structure and Function, and Cerebral Blood Flow
inferred← citeshttps://doi.org/10.1007/978-3-319-56210-0_14openalex-snapshot
Genetics of Small Vessel Disease
inferred← citeshttps://doi.org/10.1007/978-3-319-89512-3_16openalex-snapshot
Control of Blood Vessel Formation by Notch Signaling
inferred← citeshttps://doi.org/10.1007/978-3-319-90194-7_12openalex-snapshot
Current Understanding of Pathology and Therapeutic Status for CADASIL
inferred← citeshttps://doi.org/10.1007/s00018-018-2934-5openalex-snapshot
Cerebrovascular disorders associated with genetic lesions
inferred← citeshttps://doi.org/10.1007/s00221-010-2447-4openalex-snapshot
What is the optimal anesthetic protocol for measurements of cerebral autoregulation in spontaneously breathing mice?
inferred← citeshttps://doi.org/10.1007/s00277-012-1435-0openalex-snapshot
Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway
inferred← citeshttps://doi.org/10.1007/s00401-018-1853-8openalex-snapshot
CADASIL brain vessels show a HTRA1 loss-of-function profile
inferred← citeshttps://doi.org/10.1007/s00415-019-09331-yopenalex-snapshot
Primary involvement of neurovascular coupling in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy
inferred← citeshttps://doi.org/10.1007/s00415-020-10308-5openalex-snapshot
SQSTM1 gene as a potential genetic modifier of CADASIL phenotype
inferred← citeshttps://doi.org/10.1007/s10048-021-00679-wopenalex-snapshot
NOTCH3 mutations in a cohort of Portuguese patients within CADASIL spectrum phenotype
inferred← citeshttps://doi.org/10.1007/s10237-016-0762-9openalex-snapshot
Analysis of mechanical parameters on the thromboembolism using a patient-specific computational model
inferred← citeshttps://doi.org/10.1007/s10571-015-0286-3openalex-snapshot
Animal Models of Vascular Cognitive Impairment and Dementia (VCID)
inferred← citeshttps://doi.org/10.1007/s10571-015-0308-1openalex-snapshot
Microvascular Dysfunction and Cognitive Impairment
inferred← citeshttps://doi.org/10.1007/s11033-026-12401-wopenalex-snapshot
A review of animal models of vascular dementia
inferred← citeshttps://doi.org/10.1007/s11064-026-04866-9openalex-snapshot
NOTCH3 Mutations in CADASIL Alter Lipid Metabolism: Insights from Patient Plasma and In Vitro Models
inferred← citeshttps://doi.org/10.1007/s11357-019-00139-2openalex-snapshot
The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension
inferred← citeshttps://doi.org/10.1007/s11357-023-00735-3openalex-snapshot
Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter
inferred← citeshttps://doi.org/10.1007/s11357-024-01194-0openalex-snapshot
Linking peripheral atherosclerosis to blood–brain barrier disruption: elucidating its role as a manifestation of cerebral small vessel disease in vascular cognitive impairment
inferred← citeshttps://doi.org/10.1007/s11357-025-01657-yopenalex-snapshot
Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments
inferred← citeshttps://doi.org/10.1007/s11940-017-0468-zopenalex-snapshot
CADASIL: Treatment and Management Options
inferred← citeshttps://doi.org/10.1007/s12031-011-9605-4openalex-snapshot
Is the SHRPS Strain a Suitable Model of Spontaneous CADASIL?
inferred← citeshttps://doi.org/10.1007/s12031-020-01733-2openalex-snapshot
Rodent Models of Vascular Cognitive Impairment
inferred← citeshttps://doi.org/10.1007/s12035-021-02282-4openalex-snapshot
CADASIL from Bench to Bedside: Disease Models and Novel Therapeutic Approaches
inferred← citeshttps://doi.org/10.1007/s12272-012-0116-9openalex-snapshot
Protective effects of acetyl-L-carnitine on neurodegenarative changes in chronic cerebral ischemia models and learning-memory impairment in aged rats
inferred← citeshttps://doi.org/10.1007/s12975-011-0112-2openalex-snapshot
von Willebrand Factor Permeates Small Vessels in CADASIL and Inhibits Smooth Muscle Gene Expression
inferred← citeshttps://doi.org/10.1007/s12975-019-00742-7openalex-snapshot
Progression and Classification of Granular Osmiophilic Material (GOM) Deposits in Functionally Characterized Human NOTCH3 Transgenic Mice
inferred← citeshttps://doi.org/10.1007/s12975-019-00778-9openalex-snapshot
Adenosine A2A Receptors in Bone Marrow-Derived Cells Attenuate Cognitive Impairment in Mice After Chronic Hypoperfusion White Matter Injury
inferred← citeshttps://doi.org/10.1007/s12975-020-00843-8openalex-snapshot
A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease
inferred← citeshttps://doi.org/10.1007/s12975-023-01142-8openalex-snapshot
MYPT1SMKO Mice Function as a Novel Spontaneous Age- and Hypertension-Dependent Animal Model of CSVD
inferred← citeshttps://doi.org/10.1007/s13238-019-0608-1openalex-snapshot
Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1007/s13577-026-01391-3openalex-snapshot
NOTCH3 signal activation by its extracellular domain accumulation in an iPSC line newly established from a CADASIL patient
inferred← citeshttps://doi.org/10.1016/b978-0-12-378638-8.00019-1openalex-snapshot
Cerebral Vascular Dysfunction with Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-394596-9.00002-0openalex-snapshot
Genetic Animal Models of Cerebral Vasculopathies
inferred← citeshttps://doi.org/10.1016/b978-0-12-397025-1.00139-1openalex-snapshot
Imaging as Means to Study Cerebrovascular Pathophysiology
inferred← citeshttps://doi.org/10.1016/b978-0-12-410529-4.00100-5openalex-snapshot
Cerebral Vasculopathies
inferred← citeshttps://doi.org/10.1016/b978-0-12-801387-8.00019-3openalex-snapshot
Impact of Arterial Aging on Early and Late Stages of Brain Damage
inferred← citeshttps://doi.org/10.1016/b978-0-12-802851-3.00011-5openalex-snapshot
Stroke, Cognitive Function, and Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-811353-0.00043-9openalex-snapshot
Animal Models of Vascular Cognitive Impairment and Dementia
inferred← citeshttps://doi.org/10.1016/b978-0-12-813866-3.00033-3openalex-snapshot
Cerebral vasculopathies
inferred← citeshttps://doi.org/10.1016/b978-0-443-15512-3.00030-1openalex-snapshot
Arterial Aging, Blood Pressure, and Brain Damage
inferred← citeshttps://doi.org/10.1016/b978-0-443-19176-3.00040-6openalex-snapshot
Cerebral vasculopathies
inferred← citeshttps://doi.org/10.1016/bs.apha.2016.07.002openalex-snapshot
Notch Signaling in Vascular Smooth Muscle Cells
inferred← citeshttps://doi.org/10.1016/j.ajpath.2020.11.015openalex-snapshot
Overlapping Protein Accumulation Profiles of CADASIL and CAA
inferred← citeshttps://doi.org/10.1016/j.ajpath.2021.03.015openalex-snapshot
Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases
inferred← citeshttps://doi.org/10.1016/j.bbrc.2014.09.093openalex-snapshot
Blood–brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone
inferred← citeshttps://doi.org/10.1016/j.brainres.2016.05.008openalex-snapshot
Blood biomarkers in a mouse model of CADASIL
inferred← citeshttps://doi.org/10.1016/j.cccb.2021.100013openalex-snapshot
Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs” study
inferred← citeshttps://doi.org/10.1016/j.cccb.2021.100030openalex-snapshot
Pathologic sequelae of vascular cognitive impairment and dementia sheds light on potential targets for intervention
inferred← citeshttps://doi.org/10.1016/j.cccb.2021.100031openalex-snapshot
The pericyte: A critical cell in the pathogenesis of CADASIL
inferred← citeshttps://doi.org/10.1016/j.cccb.2022.100043openalex-snapshot
Cognition, mood and behavior in CADASIL
inferred← citeshttps://doi.org/10.1016/j.cccb.2023.100189openalex-snapshot
A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia
inferred← citeshttps://doi.org/10.1016/j.cccb.2024.100211openalex-snapshot
A multicenter, single-arm, phase II clinical trial of adrenomedullin in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
inferred← citeshttps://doi.org/10.1016/j.cccb.2026.100547openalex-snapshot
Determinants of cerebral microbleed presence and burden in CADASIL
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117285openalex-snapshot
Multi-omic profiling reveals pericyte and smooth muscle cell contributions to CADASIL pathology in cell-specific Notch3 mutant mice
inferred← citeshttps://doi.org/10.1016/j.exger.2014.12.016openalex-snapshot
Yerba mate (Ilex paraguariensis) improves microcirculation of volunteers with high blood viscosity: A randomized, double-blind, placebo-controlled trial
inferred← citeshttps://doi.org/10.1016/j.expneurol.2021.113765openalex-snapshot
Mild traumatic brain injury increases vulnerability to cerebral ischemia in mice
inferred← citeshttps://doi.org/10.1016/j.expneurol.2026.115947openalex-snapshot
Animal models of ischemic cerebral small vessel disease: A narrative review of pathological phenotypes, challenges, and future directions
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e30443openalex-snapshot
In silico analysis of embolism in cerebral arteries using fluid-structure interaction method
inferred← citeshttps://doi.org/10.1016/j.ijcard.2013.09.009openalex-snapshot
Aortic stiffness and hypotension episodes are associated with impaired cognitive function in older subjects with subjective complaints of memory loss
inferred← citeshttps://doi.org/10.1016/j.ijcard.2017.01.096openalex-snapshot
Notch3 deficiency impairs coronary microvascular maturation and reduces cardiac recovery after myocardial ischemia
inferred← citeshttps://doi.org/10.1016/j.jacc.2012.04.045openalex-snapshot
The Year in Atherothrombosis
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107787openalex-snapshot
The N-acetylglucosaminyltransferase Radical fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants
inferred← citeshttps://doi.org/10.1016/j.jns.2012.05.046openalex-snapshot
Pre-clinical models of human cerebral small vessel disease: Utility for clinical application
inferred← citeshttps://doi.org/10.1016/j.jns.2015.01.018openalex-snapshot
New mutations in the Notch3 gene in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
inferred← citeshttps://doi.org/10.1016/j.jns.2016.05.061openalex-snapshot
Phenotypic comparison of individuals with homozygous or heterozygous mutation of NOTCH3 in a large CADASIL family
inferred← citeshttps://doi.org/10.1016/j.jns.2024.123227openalex-snapshot
Individual analysis of fMRI data reveals incongruency in a potential CADASIL biomarker
inferred← citeshttps://doi.org/10.1016/j.mad.2020.111389openalex-snapshot
HB-EGF depolarizes hippocampal arterioles to restore myogenic tone in a genetic model of small vessel disease
inferred← citeshttps://doi.org/10.1016/j.media.2025.103465openalex-snapshot
Topology-oriented foreground focusing network for semi-supervised coronary artery segmentation
inferred← citeshttps://doi.org/10.1016/j.mvr.2021.104300openalex-snapshot
Microvascular rarefaction in patients with cerebrovascular events
inferred← citeshttps://doi.org/10.1016/j.nbd.2014.09.006openalex-snapshot
Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL
inferred← citeshttps://doi.org/10.1016/j.nbd.2014.12.018openalex-snapshot
Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis
inferred← citeshttps://doi.org/10.1016/j.nbd.2019.104561openalex-snapshot
Stem cell factor and granulocyte colony-stimulating factor promote brain repair and improve cognitive function through VEGF-A in a mouse model of CADASIL
inferred← citeshttps://doi.org/10.1016/j.nbd.2020.105022openalex-snapshot
Structure and function of the perivascular fluid compartment and vertebral venous plexus: Illumining a novel theory on mechanisms underlying the pathogenesis of Alzheimer's, cerebral small vessel, and neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.nbd.2026.107404openalex-snapshot
NOTCH3 R545C mutation drives vascular-neuronal dysfunction and cognitive impairment in CADASIL pathogenesis
inferred← citeshttps://doi.org/10.1016/j.neuint.2016.02.012openalex-snapshot
Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions
inferred← citeshttps://doi.org/10.1016/j.neuint.2021.105073openalex-snapshot
Cerebral microbleeds in vascular dementia from clinical aspects to host-microbial interaction
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2014.08.021openalex-snapshot
Hypomorphic NOTCH3 mutation in an Italian family with CADASIL features
inferred← citeshttps://doi.org/10.1016/j.neuroimage.2019.03.059openalex-snapshot
Quantitative phase contrast MRI of penetrating arteries in centrum semiovale at 7T
inferred← citeshttps://doi.org/10.1016/j.neuron.2025.10.001openalex-snapshot
The brain neurovascular epigenome and its association with dementia
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2019.07.048openalex-snapshot
Altered Brain Glucose Metabolism Assessed by 18F-FDG PET Imaging Is Associated with the Cognitive Impairment of CADASIL
inferred← citeshttps://doi.org/10.1016/j.semcdb.2012.02.005openalex-snapshot
Notch and disease: A growing field
inferred← citeshttps://doi.org/10.1016/j.stemcr.2019.10.004openalex-snapshot
Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures
inferred← citeshttps://doi.org/10.1016/j.tins.2020.11.003openalex-snapshot
A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease
inferred← citeshttps://doi.org/10.1016/s0070-2153(10)92009-7openalex-snapshot
Notch Signaling in the Vasculature
inferred← citeshttps://doi.org/10.1016/s0246-0378(16)79762-4openalex-snapshot
10.1016/s0246-0378(16)79762-4
inferred← citeshttps://doi.org/10.1016/s1474-4422(13)70060-7openalex-snapshot
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging
inferred← citeshttps://doi.org/10.1017/cbo9781139382694.002openalex-snapshot
Classification, pathology, and basic aspects
inferred← citeshttps://doi.org/10.1017/cbo9781139382694.006openalex-snapshot
Experimental animal models of cerebral small vessel disease
inferred← citeshttps://doi.org/10.1017/cbo9781139382694.008openalex-snapshot
Pathogenic aspects of hereditary small vessel disease of the brain
inferred← citeshttps://doi.org/10.1017/cbo9781139382694.010openalex-snapshot
The link between large artery aging and cerebral small vessel disease
inferred← citeshttps://doi.org/10.1017/cbo9781139382694.012openalex-snapshot
Neuroimaging and laboratory aspects
inferred← citeshttps://doi.org/10.1017/cbo9781139382694.016openalex-snapshot
Cerebral hemodynamics in cerebral small vessel disease
inferred← citeshttps://doi.org/10.1038/jcbfm.2012.123openalex-snapshot
CADASIL Mutations and shRNA Silencing of NOTCH3 Affect Actin Organization in Cultured Vascular Smooth Muscle Cells
inferred← citeshttps://doi.org/10.1038/jcbfm.2012.147openalex-snapshot
Dynamic Spatio-Temporal Imaging of Early Reflow in a Neonatal Rat Stroke Model
inferred← citeshttps://doi.org/10.1038/jcbfm.2013.14openalex-snapshot
An MRI-Histological Study of White Matter in Stroke-Free SHRSP
inferred← citeshttps://doi.org/10.1038/jcbfm.2013.140openalex-snapshot
Mouse Models to Study the Effect of Cardiovascular Risk Factors on Brain Structure and Cognition
inferred← citeshttps://doi.org/10.1038/jcbfm.2013.180openalex-snapshot
Impaired Cerebrovascular Hemodynamics are Associated with Cerebral White Matter Damage
inferred← citeshttps://doi.org/10.1038/jcbfm.2015.107openalex-snapshot
Dysfunction of Mouse Cerebral Arteries during Early Aging
inferred← citeshttps://doi.org/10.1038/jcbfm.2015.172openalex-snapshot
Consensus statement for diagnosis of subcortical small vessel disease
inferred← citeshttps://doi.org/10.1038/jcbfm.2015.62openalex-snapshot
Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?
inferred← citeshttps://doi.org/10.1038/jcbfm.2015.71openalex-snapshot
Genetic factors in cerebral small vessel disease and their impact on stroke and dementia
inferred← citeshttps://doi.org/10.1038/nn.2947openalex-snapshot
Cerebrovascular disorders: molecular insights and therapeutic opportunities
inferred← citeshttps://doi.org/10.1038/nprot.2018.034openalex-snapshot
In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain
inferred← citeshttps://doi.org/10.1038/nrd4252openalex-snapshot
Therapeutic modulation of Notch signalling — are we there yet?
inferred← citeshttps://doi.org/10.1038/nrn.2017.48openalex-snapshot
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
inferred← citeshttps://doi.org/10.1038/s41392-022-00934-yopenalex-snapshot
Notch signaling pathway: architecture, disease, and therapeutics
inferred← citeshttps://doi.org/10.1038/s41401-020-00568-2openalex-snapshot
Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway
inferred← citeshttps://doi.org/10.1038/s41419-025-07893-6openalex-snapshot
Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases
inferred← citeshttps://doi.org/10.1038/s41467-022-34293-7openalex-snapshot
Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice
inferred← citeshttps://doi.org/10.1038/s41467-024-51819-3openalex-snapshot
NOTCH3 p.Arg1231Cys is markedly enriched in South Asians and associated with stroke
inferred← citeshttps://doi.org/10.1038/s41583-025-00950-1openalex-snapshot
The vascular contribution to cognitive decline in ageing and dementia
inferred← citeshttps://doi.org/10.1038/s41593-025-02136-5openalex-snapshot
The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling
inferred← citeshttps://doi.org/10.1038/s41598-019-54807-6openalex-snapshot
Loss of the serine protease HTRA1 impairs smooth muscle cells maturation
inferred← citeshttps://doi.org/10.1038/s41598-022-15710-9openalex-snapshot
Reduced cerebral vascular fractal dimension among asymptomatic individuals as a potential biomarker for cerebral small vessel disease
inferred← citeshttps://doi.org/10.1038/s44161-026-00844-0openalex-snapshot
Pericyte KATP channel hyperactivity redistributes cortical blood flow in a CADASIL mouse model
inferred← citeshttps://doi.org/10.1038/s44161-026-00847-xopenalex-snapshot
A balancing act keeps the brain fed
inferred← citeshttps://doi.org/10.1038/srep16449openalex-snapshot
Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL and results in arteriovenous malformations
inferred← citeshttps://doi.org/10.1038/srep45372openalex-snapshot
Stimulation of adult hippocampal neurogenesis by physical exercise and enriched environment is disturbed in a CADASIL mouse model
inferred← citeshttps://doi.org/10.1042/cs20160380openalex-snapshot
Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms
inferred← citeshttps://doi.org/10.1042/cs20160381openalex-snapshot
Perivascular spaces, glymphatic dysfunction, and small vessel disease
inferred← citeshttps://doi.org/10.1042/cs20160618openalex-snapshot
Endothelial cell–oligodendrocyte interactions in small vessel disease and aging
inferred← citeshttps://doi.org/10.1042/cs20160720openalex-snapshot
Neurovascular dysfunction in dementia – human cellular models and molecular mechanisms
inferred← citeshttps://doi.org/10.1042/cs20160825openalex-snapshot
New insights into mechanisms of small vessel disease stroke from genetics
inferred← citeshttps://doi.org/10.1042/cs20210288openalex-snapshot
Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease
inferred← citeshttps://doi.org/10.1073/pnas.1101964108openalex-snapshot
Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease
inferred← citeshttps://doi.org/10.1073/pnas.1420765112openalex-snapshot
Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease
inferred← citeshttps://doi.org/10.1073/pnas.2025998118openalex-snapshot
PIP 2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity
inferred← citeshttps://doi.org/10.1073/pnas.2106308118openalex-snapshot
PIP 2 as the “coin of the realm” for neurovascular coupling
inferred← citeshttps://doi.org/10.1080/02688697.2025.2602629openalex-snapshot
Cerebral blood flow and modern approaches for clinical assessment & monitoring: a view to the future
inferred← citeshttps://doi.org/10.1080/17460441.2019.1573984openalex-snapshot
Animal models of ischemic stroke and their impact on drug discovery
inferred← citeshttps://doi.org/10.1084/jem.20161715openalex-snapshot
Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL
inferred← citeshttps://doi.org/10.1089/ten.tec.2020.0327openalex-snapshot
Ex Vivo Models to Decipher the Molecular Mechanisms of Genetic Notch Cardiovascular Disorders
inferred← citeshttps://doi.org/10.1089/ther.2019.0015openalex-snapshot
Interaction Effects Between Targeted Temperature Management and Hypertension on Survival Outcomes After Out-of-Hospital Cardiac Arrest: A National Observational Study from 2009 to 2016
inferred← citeshttps://doi.org/10.1093/brain/awab003openalex-snapshot
Microglial activation and blood–brain barrier permeability in cerebral small vessel disease
inferred← citeshttps://doi.org/10.1093/brain/awr252openalex-snapshot
Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease
inferred← citeshttps://doi.org/10.1093/brain/awt092openalex-snapshot
Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL
inferred← citeshttps://doi.org/10.1093/brain/aww259openalex-snapshot
Stroke outcomes are worse with larger leukoaraiosis volumes
inferred← citeshttps://doi.org/10.1093/cvr/cvs019openalex-snapshot
Notch signalling in smooth muscle cells during development and disease
inferred← citeshttps://doi.org/10.1093/cvr/cvy113openalex-snapshot
Understanding the role of the perivascular space in cerebral small vessel disease
inferred← citeshttps://doi.org/10.1093/gerona/glae083openalex-snapshot
Exercise to Mitigate Cerebrovascular Aging: A Geroscience Perspective
inferred← citeshttps://doi.org/10.1093/hmg/ddr237openalex-snapshot
Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis
inferred← citeshttps://doi.org/10.1093/hmg/ddz285openalex-snapshot
Naturally occurring NOTCH3 exon skipping attenuates NOTCH3 protein aggregation and disease severity in CADASIL patients
inferred← citeshttps://doi.org/10.1096/fj.202504022ropenalex-snapshot
NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process
inferred← citeshttps://doi.org/10.1097/jbr.0000000000000014openalex-snapshot
The role of the Notch signaling pathway in liver injury and repair
inferred← citeshttps://doi.org/10.1097/moh.0b013e3283386750openalex-snapshot
Mechanisms of vascular stability and the relationship to human disease
inferred← citeshttps://doi.org/10.1097/yco.0000000000000978openalex-snapshot
Monogenic causes of cerebral small vessel disease- models for vascular cognitive impairment and dementia?
inferred← citeshttps://doi.org/10.1098/rstb.2019.0631openalex-snapshot
Separating vascular and neuronal effects of age on fMRI BOLD signals
inferred← citeshttps://doi.org/10.1101/2021.06.30.450101openalex-snapshot
Small Vessel Diseases: 3D Characteristics of the Vasculature and White Matter
inferred← citeshttps://doi.org/10.1101/2022.06.16.495900openalex-snapshot
Axo-vascular coupling mediated by oligodendrocytes
inferred← citeshttps://doi.org/10.1101/2023.02.27.530286openalex-snapshot
Characterization of early white matter changes in CADASIL using microscopic diffusion imaging and relaxometry
inferred← citeshttps://doi.org/10.1101/2023.10.05.23296511openalex-snapshot
NOTCH3 p.Arg1231Cys is Markedly Enriched in South Asians and Associated with Stroke
inferred← citeshttps://doi.org/10.1101/2025.01.10.632391openalex-snapshot
ANGPTL6 variant induces cerebral vascular dysfunction and predisposes to intracranial aneurysm in mice
inferred← citeshttps://doi.org/10.1101/2025.05.30.656914openalex-snapshot
Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor
inferred← citeshttps://doi.org/10.1101/300905openalex-snapshot
Deleterious genetic variants in NOTCH1 are a major contributor to the incidence of non-syndromic Tetralogy of Fallot
inferred← citeshttps://doi.org/10.1101/613257openalex-snapshot
Automated analysis of whole brain vasculature using machine learning
inferred← citeshttps://doi.org/10.1109/cvpr46437.2021.01629openalex-snapshot
clDice - a Novel Topology-Preserving Loss Function for Tubular Structure Segmentation
inferred← citeshttps://doi.org/10.1111/bcpt.70028openalex-snapshot
The Pathobiology of Cerebrovascular Lesions in CADASIL Small Vessel Disease
inferred← citeshttps://doi.org/10.1111/bpa.12218openalex-snapshot
White Matter Changes in Dementia: Role of Impaired Drainage of Interstitial Fluid
inferred← citeshttps://doi.org/10.1111/cge.13382openalex-snapshot
Overlapping but distinct roles for NOTCH receptors in human cardiovascular disease
inferred← citeshttps://doi.org/10.1111/cns.14114openalex-snapshot
Clonal hematopoiesis with DNMT3A mutation is associated with lower white matter hyperintensity volume
inferred← citeshttps://doi.org/10.1111/cns.70205openalex-snapshot
Neural Correlates and Adaptive Mechanisms in Vascular Cognitive Impairment: Exploration of a Structure–Function Coupling Network
inferred← citeshttps://doi.org/10.1111/ene.14293openalex-snapshot
CADASIL: yesterday, today, tomorrow
inferred← citeshttps://doi.org/10.1111/ene.14534openalex-snapshot
Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over 2‐year follow‐up
inferred← citeshttps://doi.org/10.1111/head.13724openalex-snapshot
No Gastrointestinal Dysmotility in Transgenic Mouse Models of Migraine
inferred← citeshttps://doi.org/10.1111/j.1440-1789.2011.01290.xopenalex-snapshot
Pericytes as a new target for pathological processes in CADASIL
inferred← citeshttps://doi.org/10.1111/j.1471-4159.2010.06958.xopenalex-snapshot
Experimental models of vascular dementia and vascular cognitive impairment: a systematic review
inferred← citeshttps://doi.org/10.1111/j.1549-8719.2012.00175.xopenalex-snapshot
Cell‐to‐Cell Communication and Vascular Dementia
inferred← citeshttps://doi.org/10.1111/j.1747-4949.2012.00838.xopenalex-snapshot
Etiology of Stroke and Choice of Models
inferred← citeshttps://doi.org/10.1111/jcmm.16814openalex-snapshot
Elabela gene therapy promotes angiogenesis after myocardial infarction
inferred← citeshttps://doi.org/10.1111/jcpe.70048openalex-snapshot
Characterising the Periodontal Granulation Tissue Using scRNAseq
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