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CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

https://doi.org/10.1172/jci41649
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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WHIM syndrome, an autosomal dominant disorder: Clinical, hematological, and molecular studies
inferredcites →https://doi.org/10.1002/ar.1166openalex-snapshot
Basement membrane of mouse bone marrow sinusoids shows distinctive structure and proteoglycan composition: A high resolution ultrastructural study
inferredcites →https://doi.org/10.1006/geno.1995.1180openalex-snapshot
Structure and Chromosomal Localization of the Human Stromal Cell-Derived Factor 1 (SDF1) Gene
inferredcites →https://doi.org/10.1007/bf01026389openalex-snapshot
Myelokathexis: Chronic neutropenia with hyperplastic bone marrow and hypersegmented neutrophils in two siblings
inferredcites →https://doi.org/10.1007/bf01739426openalex-snapshot
How do normal and leukemic white blood cells egress from the bone marrow?
inferredcites →https://doi.org/10.1016/j.cell.2005.10.041openalex-snapshot
Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
inferredcites →https://doi.org/10.1016/j.cyto.2008.03.002openalex-snapshot
Granulocyte colony-stimulating factor: Molecular mechanisms of action during steady state and ‘emergency’ hematopoiesis
inferredcites →https://doi.org/10.1016/j.exphem.2005.01.001openalex-snapshot
Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome
inferredcites →https://doi.org/10.1016/j.immuni.2005.01.011openalex-snapshot
Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17
inferredcites →https://doi.org/10.1016/j.immuni.2006.10.016openalex-snapshot
Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches
inferredcites →https://doi.org/10.1016/s0031-6997(24)01439-xopenalex-snapshot
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
inferredcites →https://doi.org/10.1016/s0167-5699(97)01243-7openalex-snapshot
The molecular basis of leukocytosis
inferredcites →https://doi.org/10.1016/s1074-7613(00)80046-1openalex-snapshot
The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment
inferredcites →https://doi.org/10.1016/s1074-7613(02)00424-7openalex-snapshot
G-CSF Is an Essential Regulator of Neutrophil Trafficking from the Bone Marrow to the Blood
inferredcites →https://doi.org/10.1016/s1074-7613(03)00201-2openalex-snapshot
Long-Term Hematopoietic Stem Cells Require Stromal Cell-Derived Factor-1 for Colonizing Bone Marrow during Ontogeny
inferredcites →https://doi.org/10.1016/s1074-7613(03)00263-2openalex-snapshot
Chemokines Acting via CXCR2 and CXCR4 Control the Release of Neutrophils from the Bone Marrow and Their Return following Senescence
inferredcites →https://doi.org/10.1016/s8756-3282(02)00912-2openalex-snapshot
Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters
inferredcites →https://doi.org/10.1038/31261openalex-snapshot
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
inferredcites →https://doi.org/10.1038/31269openalex-snapshot
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
inferredcites →https://doi.org/10.1038/382635a0openalex-snapshot
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
inferredcites →https://doi.org/10.1038/ng1149openalex-snapshot
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
inferredcites →https://doi.org/10.1038/nm1567openalex-snapshot
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
inferredcites →https://doi.org/10.1056/nejm196404022701402openalex-snapshot
Myelokathexis — A New Form of Chronic Granulocytopenia
inferredcites →https://doi.org/10.1056/nejm196405072701902openalex-snapshot
Chronic Idiopathic Granulocytopenia
inferredcites →https://doi.org/10.1073/pnas.95.16.9448openalex-snapshot
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice
inferredcites →https://doi.org/10.1073/pnas.96.10.5663openalex-snapshot
A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution
inferredcites →https://doi.org/10.1074/jbc.m211745200openalex-snapshot
Interleukin-8-mediated Heterologous Receptor Internalization Provides Resistance to HIV-1 Infectivity
inferredcites →https://doi.org/10.1084/jem.184.5.1825openalex-snapshot
Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue.
inferredcites →https://doi.org/10.1084/jem.188.1.119openalex-snapshot
Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice
inferredcites →https://doi.org/10.1084/jem.20041385openalex-snapshot
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
inferredcites →https://doi.org/10.1097/00062752-200701000-00003openalex-snapshot
Regulation of neutrophil homeostasis
inferredcites →https://doi.org/10.1111/j.0105-2896.2005.00226.xopenalex-snapshot
CXCR4 mutations in WHIM syndrome: a misguided immune system?
inferredcites →https://doi.org/10.1111/j.1365-2141.2008.07018.xopenalex-snapshot
Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines
inferredcites →https://doi.org/10.1124/pr.55.4.5openalex-snapshot
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
inferredcites →https://doi.org/10.1126/science.269.5230.1591openalex-snapshot
Response : Neutrophilia in Mice that Lack the Murine IL-8 Receptor Homolog
inferredcites →https://doi.org/10.1126/science.7667641openalex-snapshot
Neutrophilia in Mice that Lack the Murine IL-8 Receptor Homolog
inferredcites →https://doi.org/10.1126/science.8036519openalex-snapshot
Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog
inferredcites →https://doi.org/10.1152/ajplegacy.1968.215.2.353openalex-snapshot
Quantitative studies of blood and bone marrow neutrophils in normal mice
inferredcites →https://doi.org/10.1172/jci15994openalex-snapshot
Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
inferredcites →https://doi.org/10.1172/jci33187openalex-snapshot
Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling
inferredcites →https://doi.org/10.1182/blood-2003-02-0663openalex-snapshot
Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
inferredcites →https://doi.org/10.1182/blood-2003-10-3532openalex-snapshot
Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome
inferredcites →https://doi.org/10.1182/blood-2003-10-3638openalex-snapshot
Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis
inferredcites →https://doi.org/10.1182/blood-2004-01-0272openalex-snapshot
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
inferredcites →https://doi.org/10.1182/blood-2004-06-2289openalex-snapshot
WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12
inferredcites →https://doi.org/10.1182/blood-2004-08-3193openalex-snapshot
The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner
inferredcites →https://doi.org/10.1182/blood-2005-01-015081openalex-snapshot
Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection
inferredcites →https://doi.org/10.1182/blood-2005-10-4162openalex-snapshot
G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells
inferredcites →https://doi.org/10.1182/blood-2006-05-025296openalex-snapshot
WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus–truncated CXCR4
inferredcites →https://doi.org/10.1182/blood-2007-07-099648openalex-snapshot
The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation
inferredcites →https://doi.org/10.1182/blood-2008-09-177287openalex-snapshot
CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions
inferredcites →https://doi.org/10.1182/blood-2008-10-184754openalex-snapshot
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
inferredcites →https://doi.org/10.1182/blood.v76.10.1962.1962openalex-snapshot
Levels of serum granulocyte colony-stimulating factor in patients with infections
inferredcites →https://doi.org/10.1182/blood.v85.8.2269.bloodjournal8582269openalex-snapshot
Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability
inferredcites →https://doi.org/10.1182/blood.v97.6.1534openalex-snapshot
Rapid mobilization of murine hematopoietic stem cells with enhanced engraftment properties and evaluation of hematopoietic progenitor cell mobilization in rhesus monkeys by a single injection of SB-251353, a specific truncated form of the human CXC chemokine GROβ
inferredcites →https://doi.org/10.1182/blood.v98.12.3309openalex-snapshot
Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule–deficient mice
inferredcites →https://doi.org/10.1359/jbmr.080612openalex-snapshot
Granulocyte Colony-Stimulating Factor Induces Osteoblast Apoptosis and Inhibits Osteoblast Differentiation
inferredcites →https://doi.org/10.4049/jimmunol.147.1.22openalex-snapshot
Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells
inferredcites →https://doi.org/10.4049/jimmunol.172.5.2853openalex-snapshot
Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer
inferredcites →https://doi.org/10.4049/jimmunol.182.1.604openalex-snapshot
Crosstalk between CXCR4/Stromal Derived Factor-1 and VLA-4/VCAM-1 Pathways Regulates Neutrophil Retention in the Bone Marrow

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/eji.201445245openalex-snapshot
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TCIRG1-Associated Congenital Neutropenia
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inferred← citeshttps://doi.org/10.1002/ijc.29444openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ijc.33552openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/jlb.4mir0220-574rropenalex-snapshot
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The WHIM Syndrome
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The Role of Tumor Associated Neutrophils in Cancer
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Proteolytic inactivation of CXCL12 in the lungs and circulation of COVID-19 patients
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The role of immune cells settled in the bone marrow on adult hematopoietic stem cells
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Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth
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Neuroimaging is the new “spatial omic”: multi-omic approaches to neuro-inflammation and immuno-thrombosis in acute ischemic stroke
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Switch of Steady-State to an Accelerated Granulopoiesis in Response to Androctonus australis hector Venom
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inferred← citeshttps://doi.org/10.1007/s10875-019-00665-wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-394447-4.30080-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-802734-9.00002-0openalex-snapshot
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Chemokines and Chemokine Receptors
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00014-6openalex-snapshot
CXCL12/Stromal Cell-Derived Factor-1 and Hematopoiesis
inferred← citeshttps://doi.org/10.1016/b978-0-12-824465-4.00185-xopenalex-snapshot
Roles of Chemokines in Immune Cell Trafficking to Lymphoid Tissues
inferred← citeshttps://doi.org/10.1016/b978-0-12-824465-4.00212-xopenalex-snapshot
Blood Vascular Endothelial Adhesion Molecules
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Janus-faced role of neutrophils in cancer
inferred← citeshttps://doi.org/10.1016/b978-0-443-18696-7.00009-9openalex-snapshot
Role of Tumor-associated neutrophils in the breast tumor microenvironment
inferred← citeshttps://doi.org/10.1016/b978-1-4557-5414-4.00022-xopenalex-snapshot
10.1016/b978-1-4557-5414-4.00022-x
inferred← citeshttps://doi.org/10.1016/bs.ai.2017.02.001openalex-snapshot
A Chemoattractant-Guided Walk Through Lymphopoiesis
inferred← citeshttps://doi.org/10.1016/bs.apha.2024.04.004openalex-snapshot
IVT-mRNA reprogramming of myeloid cells for cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2023.11.003openalex-snapshot
Chemokine receptors in primary and secondary lymphoid tissues
inferred← citeshttps://doi.org/10.1016/bs.pmbts.2025.02.003openalex-snapshot
Neutrophils and COVID-19
inferred← citeshttps://doi.org/10.1016/j.ajpath.2015.09.008openalex-snapshot
G-CSF and Neutrophils Are Nonredundant Mediators of Murine Experimental Autoimmune Uveoretinitis
inferred← citeshttps://doi.org/10.1016/j.bbcan.2019.01.005openalex-snapshot
Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
inferred← citeshttps://doi.org/10.1016/j.bbi.2014.05.010openalex-snapshot
Acute sleep deprivation in healthy young men: Impact on population diversity and function of circulating neutrophils
inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.07.037openalex-snapshot
The mouse homolog of the mutant WASp responsible for human X-linked neutropenia renders granulopoiesis ineffective
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.151023openalex-snapshot
Single-cell RNA sequencing reveals S100A8/A9hi neutrophils-induced endothelial cell death and lymphocyte infiltration after ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117803openalex-snapshot
Complex gene-dependent and-independent mechanisms control daily rhythms of hematopoietic cells
inferred← citeshttps://doi.org/10.1016/j.bone.2016.06.013openalex-snapshot
The roles of vascular endothelial growth factor in bone repair and regeneration
inferred← citeshttps://doi.org/10.1016/j.bone.2019.07.022openalex-snapshot
Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice
inferred← citeshttps://doi.org/10.1016/j.bpj.2019.08.044openalex-snapshot
Human Neutrophils Will Crawl Upstream on ICAM-1 If Mac-1 Is Blocked
inferred← citeshttps://doi.org/10.1016/j.canlet.2022.01.004openalex-snapshot
Decreased CXCR2 expression on circulating monocytes of colorectal cancer impairs recruitment and induces Re-education of tumor-associated macrophages
inferred← citeshttps://doi.org/10.1016/j.canlet.2026.218527openalex-snapshot
Neutrophil polarization landscapes in HCC: From immunosuppressive niches to antitumor immunity resuscitation
inferred← citeshttps://doi.org/10.1016/j.ccell.2016.04.014openalex-snapshot
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma
inferred← citeshttps://doi.org/10.1016/j.ccell.2023.02.001openalex-snapshot
NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps
inferred← citeshttps://doi.org/10.1016/j.cej.2026.179096openalex-snapshot
Spatiotemporal immune responses and targeted therapeutic strategies in the immune microenvironment of ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.cell.2013.04.040openalex-snapshot
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
inferred← citeshttps://doi.org/10.1016/j.cell.2017.11.003openalex-snapshot
Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell
inferred← citeshttps://doi.org/10.1016/j.cell.2025.11.001openalex-snapshot
The neutrophil collective
inferred← citeshttps://doi.org/10.1016/j.cell.2026.03.006openalex-snapshot
Whole-body molecular and cellular mapping of the laboratory mouse
inferred← citeshttps://doi.org/10.1016/j.cellsig.2020.109816openalex-snapshot
Neutrophil signaling during myocardial infarction wound repair
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.04.042openalex-snapshot
HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108164openalex-snapshot
Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112259openalex-snapshot
METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114911openalex-snapshot
Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115995openalex-snapshot
Sca-1 expression depicts pro-inflammatory murine neutrophils under steady-state and pathological conditions
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117745openalex-snapshot
Circulating memory-phenotype CD4+ T cells rapidly accumulate in the ischemic gut to exacerbate tissue injury in an innate manner
inferred← citeshttps://doi.org/10.1016/j.clicom.2026.05.005openalex-snapshot
Neutrophils in obesity: from expansion to dysfunction
inferred← citeshttps://doi.org/10.1016/j.clim.2023.109317openalex-snapshot
Amelioration of nephritis in receptor for advanced glycation end-products (RAGE)-deficient lupus-prone mice through neutrophil extracellular traps
inferred← citeshttps://doi.org/10.1016/j.clim.2024.110334openalex-snapshot
The role of neutrophils in autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.coi.2018.06.009openalex-snapshot
Regulation of neutrophils in type 2 immune responses
inferred← citeshttps://doi.org/10.1016/j.colsurfa.2024.135519openalex-snapshot
Promotion of bone osteogenic and regeneration by resveratrol-derived carbon dots in inflammatory environments via a one-step hydrothermal method
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2019.01.024openalex-snapshot
Bone marrow sinusoidal endothelium as a facilitator/regulator of cell egress from the bone marrow
inferred← citeshttps://doi.org/10.1016/j.cyto.2015.01.002openalex-snapshot
The effects of the CXCR2 antagonist, MK-7123, on bone marrow functions in healthy subjects
inferred← citeshttps://doi.org/10.1016/j.cyto.2018.01.021openalex-snapshot
Regulation of hematopoiesis by the chemokine system
inferred← citeshttps://doi.org/10.1016/j.cyto.2024.156675openalex-snapshot
The CXCR2 chemokine receptor: A new target for gastric cancer therapy
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2012.04.006openalex-snapshot
The sterile immune response during hepatic ischemia/reperfusion
inferred← citeshttps://doi.org/10.1016/j.exger.2017.12.020openalex-snapshot
Inflammation and neutrophil immunosenescence in health and disease: Targeted treatments to improve clinical outcomes in the elderly
inferred← citeshttps://doi.org/10.1016/j.exphem.2012.05.004openalex-snapshot
Getting blood from bone: An emerging understanding of the role that osteoblasts play in regulating hematopoietic stem cells within their niche
inferred← citeshttps://doi.org/10.1016/j.expneurol.2024.114985openalex-snapshot
CXCR2 mediated trafficking of neutrophils and neutrophil extracellular traps are required for myelin clearance after a peripheral nerve injury
inferred← citeshttps://doi.org/10.1016/j.expneurol.2025.115611openalex-snapshot
From first responders to outcome modulators: The evolving paradigm of neutrophils in ischemic stroke and thrombolysis
inferred← citeshttps://doi.org/10.1016/j.fob.2015.03.001openalex-snapshot
Characterization of G protein coupling mediated by the conserved D1343.49 of DRY motif, M2416.34, and F2516.44 residues on human CXCR1
inferred← citeshttps://doi.org/10.1016/j.fochms.2022.100133openalex-snapshot
New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood
inferred← citeshttps://doi.org/10.1016/j.fsi.2026.111215openalex-snapshot
Construction of a multi-tissue immune atlas for Chinese tongue sole (Cynoglossus semilaevis) reveals granulocyte functional adaptation and underlying regulatory mechanisms
inferred← citeshttps://doi.org/10.1016/j.gimo.2026.104398openalex-snapshot
Mavorixafor (Xolremdi) for individuals with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome: A therapeutics bulletin of the American College of Medical Genetics and Genomics (ACMG)
inferred← citeshttps://doi.org/10.1016/j.healun.2025.11.030openalex-snapshot
Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia–reperfusion
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2022.121684openalex-snapshot
Neutrophils as Emerging Immunotherapeutic Targets: Indirect Treatment of Tumors by Regulating the Tumor Immune Environment Based on a Sialic Acid Derivative-Modified Nanocomplex Platform
inferred← citeshttps://doi.org/10.1016/j.imbio.2019.10.014openalex-snapshot
The emerging role of neutrophils in neurodegeneration
inferred← citeshttps://doi.org/10.1016/j.imlet.2019.06.006openalex-snapshot
Limitations of neutrophil depletion by anti-Ly6G antibodies in two heterogenic immunological models
inferred← citeshttps://doi.org/10.1016/j.imlet.2026.107210openalex-snapshot
Functional reprogramming of bone marrow neutrophils in tumor-driven emergency granulopoiesis
inferred← citeshttps://doi.org/10.1016/j.immuni.2010.11.011openalex-snapshot
Neutrophils, from Marrow to Microbes
inferred← citeshttps://doi.org/10.1016/j.immuni.2011.02.016openalex-snapshot
Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands
inferred← citeshttps://doi.org/10.1016/j.immuni.2016.06.025openalex-snapshot
Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation
inferred← citeshttps://doi.org/10.1016/j.immuni.2019.01.002openalex-snapshot
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection
inferred← citeshttps://doi.org/10.1016/j.immuni.2019.03.001openalex-snapshot
A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils
inferred← citeshttps://doi.org/10.1016/j.immuni.2025.08.010openalex-snapshot
Trio fatale: Neutrophils, NETs, and necrosis
inferred← citeshttps://doi.org/10.1016/j.intimp.2011.03.003openalex-snapshot
Myeloid cell population dynamics in healthy and tumor-bearing mice
inferred← citeshttps://doi.org/10.1016/j.intimp.2013.05.029openalex-snapshot
Humoral immunity and delayed-type hypersensitivity in healthy subjects treated for 30days with MK-7123, a selective CXCR2 antagonist
inferred← citeshttps://doi.org/10.1016/j.intimp.2013.05.034openalex-snapshot
Neutrophil interactions with the vascular endothelium
inferred← citeshttps://doi.org/10.1016/j.intimp.2016.12.028openalex-snapshot
Transmembrane tumor necrosis factor-α promotes the recruitment of MDSCs to tumor tissue by upregulating CXCR4 expression via TNFR2
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.107567openalex-snapshot
Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues
inferred← citeshttps://doi.org/10.1016/j.intimp.2022.109037openalex-snapshot
Local IL-10 replacement therapy was effective for steroid-insensitive asthma in mice
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.111320openalex-snapshot
Trichinella-derived protein ameliorates colitis by altering the gut microbiome and improving intestinal barrier function
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.112888openalex-snapshot
Neutrophils as promising therapeutic targets in pancreatic cancer liver metastasis
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.114173openalex-snapshot
Novel neutrophil targeting platforms in treating Glioblastoma: Latest evidence and therapeutic approaches
inferred← citeshttps://doi.org/10.1016/j.isci.2020.101222openalex-snapshot
Inferring Gene Networks in Bone Marrow Hematopoietic Stem Cell-Supporting Stromal Niche Populations
inferred← citeshttps://doi.org/10.1016/j.isci.2025.112038openalex-snapshot
Bmal1 deficiency in neutrophils alleviates symptoms induced by high-fat diet
inferred← citeshttps://doi.org/10.1016/j.isci.2025.112083openalex-snapshot
CXCR4+ PD-L1+ neutrophils are increased in non-survived septic mice
inferred← citeshttps://doi.org/10.1016/j.isci.2025.113536openalex-snapshot
Cardiac mural cells are rate-limiting for coronary vascularization after heart injury
inferred← citeshttps://doi.org/10.1016/j.it.2011.06.008openalex-snapshot
Neutrophils cascading their way to inflammation
inferred← citeshttps://doi.org/10.1016/j.it.2016.03.005openalex-snapshot
Aging: A Temporal Dimension for Neutrophils
inferred← citeshttps://doi.org/10.1016/j.it.2019.05.004openalex-snapshot
Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act
inferred← citeshttps://doi.org/10.1016/j.jacbts.2021.11.005openalex-snapshot
H2 Inhibits the Formation of Neutrophil Extracellular Traps
inferred← citeshttps://doi.org/10.1016/j.jaci.2019.01.042openalex-snapshot
IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation
inferred← citeshttps://doi.org/10.1016/j.jaci.2022.12.004openalex-snapshot
Neutrophils in host defense, healing, and hypersensitivity: Dynamic cells within a dynamic host
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2022.05.003openalex-snapshot
Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling
inferred← citeshttps://doi.org/10.1016/j.jconrel.2021.02.002openalex-snapshot
Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy
inferred← citeshttps://doi.org/10.1016/j.jid.2024.08.022openalex-snapshot
ACKR3 in Skin Homeostasis, an Overlooked Player in the CXCR4/CXCL12 Axis
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2012.02.016openalex-snapshot
Chemokine receptor CXCR2: Physiology regulator and neuroinflammation controller?
inferred← citeshttps://doi.org/10.1016/j.labinv.2025.104174openalex-snapshot
Clinicopathologic Features and the Spectrum of Myelokathexis in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Syndrome
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118699openalex-snapshot
Tumor-associated neutrophils as new players in immunosuppressive process of the tumor microenvironment in breast cancer
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119952openalex-snapshot
Neutrophils as an emerging therapeutic target and tool for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.120158openalex-snapshot
NETosis in ischemic/reperfusion injuries: An organ-based review
inferred← citeshttps://doi.org/10.1016/j.mam.2020.100882openalex-snapshot
Structural and functional diversity of neutrophil glycosylation in innate immunity and related disorders
inferred← citeshttps://doi.org/10.1016/j.mayocp.2019.12.013openalex-snapshot
Hereditary Predisposition to Hematopoietic Neoplasms
inferred← citeshttps://doi.org/10.1016/j.medj.2020.07.002openalex-snapshot
Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis
inferred← citeshttps://doi.org/10.1016/j.molcel.2018.02.034openalex-snapshot
Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function
inferred← citeshttps://doi.org/10.1016/j.molcel.2025.01.024openalex-snapshot
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2
inferred← citeshttps://doi.org/10.1016/j.molimm.2016.11.007openalex-snapshot
The Fli-1 transcription factor is a critical regulator for controlling the expression of chemokine C-X-C motif ligand 2 (CXCL2)
inferred← citeshttps://doi.org/10.1016/j.mrrev.2023.108476openalex-snapshot
Congenital neutropenia: From lab bench to clinic bedside and back
inferred← citeshttps://doi.org/10.1016/j.mucimm.2023.05.005openalex-snapshot
Butyrate regulates neutrophil homeostasis and impairs early antimicrobial activity in the lung
inferred← citeshttps://doi.org/10.1016/j.mvr.2021.104268openalex-snapshot
Augmented early aged neutrophil infiltration contributes to late remodeling post myocardial infarction
inferred← citeshttps://doi.org/10.1016/j.neuint.2020.104790openalex-snapshot
The role of neutrophils in mediating stroke injury in the diabetic db/db mouse brain following hypoxia-ischemia
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2010.10.002openalex-snapshot
Targeting stem cell niches and trafficking for cardiovascular therapy
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107556openalex-snapshot
Rational targeting of immunosuppressive neutrophils in cancer
inferred← citeshttps://doi.org/10.1016/j.phrs.2014.05.012openalex-snapshot
Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.01.027openalex-snapshot
Neutrophils and arthritis: Role in disease and pharmacological perspectives
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2023.102488openalex-snapshot
Neutrophil biology in injuries and diseases of the central and peripheral nervous systems
inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.01.006openalex-snapshot
Surgery-mediated tumor-promoting effects on the immune microenvironment
inferred← citeshttps://doi.org/10.1016/j.smim.2017.12.004openalex-snapshot
Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells
inferred← citeshttps://doi.org/10.1016/j.smim.2020.101409openalex-snapshot
The complexity of neutrophils in health and disease: Focus on cancer
inferred← citeshttps://doi.org/10.1016/j.smim.2021.101531openalex-snapshot
Lessons in type 2 immunity: Neutrophils in Helminth infections
inferred← citeshttps://doi.org/10.1016/j.smim.2021.101538openalex-snapshot
Versatile neutrophil functions in cancer
inferred← citeshttps://doi.org/10.1016/j.stem.2014.06.005openalex-snapshot
A Systems Biology Approach for Defining the Molecular Framework of the Hematopoietic Stem Cell Niche
inferred← citeshttps://doi.org/10.1016/j.stem.2019.07.001openalex-snapshot
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
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