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Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

https://doi.org/10.1172/jci82204
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hep.20701openalex-snapshot
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
inferredcites →https://doi.org/10.1002/hep.26226openalex-snapshot
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
inferredcites →https://doi.org/10.1002/hep.26285openalex-snapshot
Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect
inferredcites →https://doi.org/10.1007/bf01759778openalex-snapshot
Contribution of various substrates to total citric acid cycle flux and ]anaplerosis as determined by13C isotopomer analysis and O2 consumption in the heart
inferredcites →https://doi.org/10.1016/0005-2728(93)90079-uopenalex-snapshot
The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesis
inferredcites →https://doi.org/10.1016/0014-5793(80)80572-2openalex-snapshot
Regulation of the citric acid cycle in mammalian systems
inferredcites →https://doi.org/10.1016/0026-0495(95)90133-7openalex-snapshot
Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver
inferredcites →https://doi.org/10.1016/0065-2571(69)90030-2openalex-snapshot
Equilibrium relations between pyridine nucleotides and adenine nucleotides and their roles in the regulation of metabolic processes
inferredcites →https://doi.org/10.1016/0168-8278(95)80226-6openalex-snapshot
Histological grading and staging of chronic hepatitis
inferredcites →https://doi.org/10.1016/j.ab.2003.12.036openalex-snapshot
Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative
inferredcites →https://doi.org/10.1016/j.cmet.2007.03.004openalex-snapshot
Cytosolic Phosphoenolpyruvate Carboxykinase Does Not Solely Control the Rate of Hepatic Gluconeogenesis in the Intact Mouse Liver
inferredcites →https://doi.org/10.1016/j.cmet.2011.11.004openalex-snapshot
Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease
inferredcites →https://doi.org/10.1016/j.cmet.2015.04.004openalex-snapshot
Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis
inferredcites →https://doi.org/10.1016/j.it.2007.09.003openalex-snapshot
Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
inferredcites →https://doi.org/10.1016/j.jhep.2009.11.030openalex-snapshot
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
inferredcites →https://doi.org/10.1016/j.jnutbio.2012.03.005openalex-snapshot
The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism
inferredcites →https://doi.org/10.1016/j.mce.2012.06.018openalex-snapshot
Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver
inferredcites →https://doi.org/10.1016/j.mce.2013.06.002openalex-snapshot
Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver disease
inferredcites →https://doi.org/10.1016/j.metabol.2013.10.009openalex-snapshot
Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes
inferredcites →https://doi.org/10.1016/j.molmet.2014.05.004openalex-snapshot
ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload
inferredcites →https://doi.org/10.1016/j.tem.2011.12.008openalex-snapshot
Linking mitochondrial bioenergetics to insulin resistance via redox biology
inferredcites →https://doi.org/10.1016/j.ymthe.2005.08.026openalex-snapshot
Overcoming Diabetes-Induced Hyperglycemia through Inhibition of Hepatic Phosphoenolpyruvate Carboxykinase (GTP) with RNAi
inferredcites →https://doi.org/10.1016/s0014-5793(97)00764-3openalex-snapshot
Measurement of gluconeogenesis and pyruvate recycling in the rat liver: a simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3‐13C3]propionate
inferredcites →https://doi.org/10.1016/s0021-9258(18)46965-7openalex-snapshot
Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.
inferredcites →https://doi.org/10.1016/s0021-9258(18)53594-8openalex-snapshot
Rates of gluconeogenesis and citric acid cycle in perfused livers, assessed from the mass spectrometric assay of the 13C labeling pattern of glutamate.
inferredcites →https://doi.org/10.1016/s0021-9258(18)93669-0openalex-snapshot
Control Mechanisms of Gluconeogenesis and Ketogenesis
inferredcites →https://doi.org/10.1016/s0021-9258(18)96571-3openalex-snapshot
Paths of Carbon in Gluconeogenesis and Lipogenesis
inferredcites →https://doi.org/10.1016/s0021-9258(20)89598-2openalex-snapshot
Noninvasive tracing of Krebs cycle metabolism in liver.
inferredcites →https://doi.org/10.1021/jp105723ropenalex-snapshot
The Effect of pH and Free Mg2+ on ATP Linked Enzymes and the Calculation of Gibbs Free Energy of ATP Hydrolysis
inferredcites →https://doi.org/10.1038/nm.2049openalex-snapshot
Foxo1 integrates insulin signaling with mitochondrial function in the liver
inferredcites →https://doi.org/10.1038/nm.3415openalex-snapshot
Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy
inferredcites →https://doi.org/10.1038/nrendo.2013.256openalex-snapshot
Metformin—mode of action and clinical implications for diabetes and cancer
inferredcites →https://doi.org/10.1038/nri3071openalex-snapshot
Macrophage-mediated inflammation in metabolic disease
inferredcites →https://doi.org/10.1042/bj0940017copenalex-snapshot
Concentrations of Acetoacetate and d -(−)-3-Hydroxybutyrate in Rat Liver and Blood
inferredcites →https://doi.org/10.1042/bj20080868openalex-snapshot
High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo
inferredcites →https://doi.org/10.1042/bj20081386openalex-snapshot
How mitochondria produce reactive oxygen species
inferredcites →https://doi.org/10.1042/bst20120041openalex-snapshot
Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA
inferredcites →https://doi.org/10.1053/j.gastro.2010.05.039openalex-snapshot
Fatty Acid Metabolism in the Liver, Measured by Positron Emission Tomography, Is Increased in Obese Individuals
inferredcites →https://doi.org/10.1053/j.gastro.2013.11.049openalex-snapshot
Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease
inferredcites →https://doi.org/10.1073/pnas.0500660102openalex-snapshot
Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
inferredcites →https://doi.org/10.1074/jbc.270.4.1509openalex-snapshot
Tracing Hepatic Gluconeogenesis Relative to Citric Acid Cycle Activity in Vitro and in Vivo
inferredcites →https://doi.org/10.1074/jbc.m110.128694openalex-snapshot
The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPK Pathways
inferredcites →https://doi.org/10.1074/jbc.m111.252502openalex-snapshot
Evidence for Two Sites of Superoxide Production by Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)
inferredcites →https://doi.org/10.1074/jbc.m113.545301openalex-snapshot
The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I
inferredcites →https://doi.org/10.1074/jbc.m200964200openalex-snapshot
Phosphoenolpyruvate Carboxykinase Overexpression Selectively Attenuates Insulin Signaling and Hepatic Insulin Sensitivity in Transgenic Mice
inferredcites →https://doi.org/10.1074/jbc.m407120200openalex-snapshot
Impaired Tricarboxylic Acid Cycle Activity in Mouse Livers Lacking Cytosolic Phosphoenolpyruvate Carboxykinase
inferredcites →https://doi.org/10.1074/jbc.m600050200openalex-snapshot
Diminished Hepatic Gluconeogenesis via Defects in Tricarboxylic Acid Cycle Flux in Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α)-deficient Mice
inferredcites →https://doi.org/10.1074/jbc.m901488200openalex-snapshot
Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria
inferredcites →https://doi.org/10.1074/jbc.r200006200openalex-snapshot
The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function
inferredcites →https://doi.org/10.1080/10409230590935479openalex-snapshot
Factors That Control the Tissue-Specific Transcription of the Gene for Phosphoenolpyruvate Carboxykinase-C
inferredcites →https://doi.org/10.1096/fasebj.9.8.7768357openalex-snapshot
Insulin, ketone bodies, and mitochondrial energy transduction
inferredcites →https://doi.org/10.1097/shk.0b013e318219ff2aopenalex-snapshot
Hypoxia-Inducible Factor 1α Regulates the Expression of the Mitochondrial ATPase Inhibitor Protein (IF1) in Rat Liver
inferredcites →https://doi.org/10.1111/febs.12086openalex-snapshot
Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I
inferredcites →https://doi.org/10.1128/.20.17.6508-6517.2000openalex-snapshot
Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism
inferredcites →https://doi.org/10.1146/annurev.ph.54.030192.004321openalex-snapshot
Molecular Physiology Of The Regulation Of Hepatic Gluconeogenesis And Glycolysis
inferredcites →https://doi.org/10.1152/ajpendo.00003.2015openalex-snapshot
Mass spectrometry-based microassay of2H and13C plasma glucose labeling to quantify liver metabolic fluxes in vivo
inferredcites →https://doi.org/10.1152/ajpendo.00033.2010openalex-snapshot
Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet
inferredcites →https://doi.org/10.1152/ajpendo.00601.2004openalex-snapshot
Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting
inferredcites →https://doi.org/10.1152/ajpendo.1993.265.4.e636openalex-snapshot
14C-labeled propionate metabolism in vivo and estimates of hepatic gluconeogenesis relative to Krebs cycle flux
inferredcites →https://doi.org/10.1152/ajpendo.2001.281.4.e848openalex-snapshot
An integrated2H and13C NMR study of gluconeogenesis and TCA cycle flux in humans
inferredcites →https://doi.org/10.1172/jci107593openalex-snapshot
Splanchnic glucose and amino acid metabolism in obesity.
inferredcites →https://doi.org/10.1172/jci76388openalex-snapshot
Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia
inferredcites →https://doi.org/10.1186/1743-7075-2-33openalex-snapshot
Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism
inferredcites →https://doi.org/10.1194/jlr.m023382openalex-snapshot
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
inferredcites →https://doi.org/10.1210/jc.2012-3056openalex-snapshot
Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia
inferredcites →https://doi.org/10.2337/db08-0226openalex-snapshot
Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism
inferredcites →https://doi.org/10.2337/diabetes.49.5.701openalex-snapshot
Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.
inferredcites →https://doi.org/10.3748/wjg.14.193openalex-snapshot
Nonalcoholic fatty liver disease and mitochondrial dysfunction

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3219265openalex-extracted
Targeting Hepatic Glutaminase 1 Ameliorates Non-Alcoholic Steatohepatitis by Restoring Disrupted Hepatic Very-Low Density Lipoproteins Triglyceride Assembly
inferred← citeshttps://doi.org/10.2139/ssrn.4118388openalex-extracted
inferred← citeshttps://doi.org/10.2139/ssrn.4563031openalex-extracted
Higher Hepatic Glucose Production and Gluconeogenesis are Features of Severe Metabolic Dysfunction-Associated Steatohepatitis Even in Absence of T2D
inferred← citeshttps://doi.org/10.1002/9783527696130.ch2openalex-snapshot
13C Flux Analysis in Biotechnology and Medicine
inferred← citeshttps://doi.org/10.1002/adhm.201601163openalex-snapshot
Ultrasound Detection of Regional Oxidative Stress in Deep Tissues Using Novel Enzyme Loaded Nanoparticles
inferred← citeshttps://doi.org/10.1002/advs.202306890openalex-snapshot
Soy Peptide Supplementation Mitigates Undernutrition through Reprogramming Hepatic Metabolism in a Novel Undernourished Non‐Human Primate Model
inferred← citeshttps://doi.org/10.1002/ar.23954openalex-snapshot
Role of MicroRNAs in the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1002/hep.28482openalex-snapshot
Hepatic mitochondrial dysfunction in nonalcoholic steatohepatitis: Read‐out or reason?
inferred← citeshttps://doi.org/10.1002/hep.30541openalex-snapshot
Glial Cell Line–Derived Neurotrophic Factor Enhances Autophagic Flux in Mouse and Rat Hepatocytes and Protects Against Palmitate Lipotoxicity
inferred← citeshttps://doi.org/10.1002/hep.32324openalex-snapshot
Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD
inferred← citeshttps://doi.org/10.1002/hep4.1012openalex-snapshot
Hepatic inositol 1,4,5 trisphosphate receptor type 1 mediates fatty liver
inferred← citeshttps://doi.org/10.1002/hep4.1036openalex-snapshot
Treating fatty liver disease by modulating mitochondrial pyruvate metabolism
inferred← citeshttps://doi.org/10.1002/hep4.1151openalex-snapshot
Vinyl chloride dysregulates metabolic homeostasis and enhances diet‐induced liver injury in mice
inferred← citeshttps://doi.org/10.1002/iid3.1226openalex-snapshot
Unveiling global research trends and hotspots on mitochondria in NAFLD from 2000 to 2023: A bibliometric analysis
inferred← citeshttps://doi.org/10.1002/jcsm.13466openalex-snapshot
Hepatic signal transducer and activator of transcription‐3 signalling drives early‐stage pancreatic cancer cachexia via suppressed ketogenesis
inferred← citeshttps://doi.org/10.1002/jmri.28202openalex-snapshot
Editorial for “ Whole‐Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [ 1‐13C ]pyruvate MRI”
inferred← citeshttps://doi.org/10.1002/lci2.70003openalex-snapshot
Hepatocyte‐Specific Knockout of Na+/H+ Exchanger‐1 Does Not Ameliorate NASH ‐Associated Liver Damage in Mice
inferred← citeshttps://doi.org/10.1002/mnfr.201900811openalex-snapshot
Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia‐TLR4‐NFκB‐Mediated Inflammation
inferred← citeshttps://doi.org/10.1002/mnfr.201900942openalex-snapshot
Mitochondrial Dysfunction is a Key Pathway that Links Saturated Fat Intake to the Development and Progression of NAFLD
inferred← citeshttps://doi.org/10.1002/mrc.5382openalex-snapshot
Observing exocrine pancreas metabolism using a novel pancreas perfusion technique in combination with hyperpolarized [1‐13C]pyruvate
inferred← citeshttps://doi.org/10.1002/mrm.26662openalex-snapshot
In vivo assessment of intracellular redox state in rat liver using hyperpolarized [1‐ 13 C]Alanine
inferred← citeshttps://doi.org/10.1002/nbm.5309openalex-snapshot
Deuterium Metabolic Imaging Enables the Tracing of Substrate Fluxes Through the Tricarboxylic Acid Cycle in the Liver
inferred← citeshttps://doi.org/10.1002/oby.22964openalex-snapshot
A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD
inferred← citeshttps://doi.org/10.1007/978-1-0716-0159-4_6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-1-0716-1433-4_12openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-030-22009-9_45openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-030-85686-1_11openalex-snapshot
Hepatic Glucose Metabolism and Its Disorders in Fish
inferred← citeshttps://doi.org/10.1007/978-3-319-61013-9_4openalex-snapshot
Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes
inferred← citeshttps://doi.org/10.1007/978-3-319-69892-2_45-1openalex-snapshot
Human Aging, Mitochondrial and Metabolic Defects (The Novel Protective Role of Glutathione)
inferred← citeshttps://doi.org/10.1007/978-3-319-95828-6_6openalex-snapshot
Mechanisms of Fibrogenesis in NASH
inferred← citeshttps://doi.org/10.1007/978-981-13-1465-0_10openalex-snapshot
Role of Oxidative Stress in Alcoholic/Non-Alcoholic Liver Diseases
inferred← citeshttps://doi.org/10.1007/s00125-016-3952-1openalex-snapshot
Treatment of patients with type 2 diabetes and non-alcoholic fatty liver disease: current approaches and future directions
inferred← citeshttps://doi.org/10.1007/s00125-016-4084-3openalex-snapshot
Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice
inferred← citeshttps://doi.org/10.1007/s00424-018-02250-3openalex-snapshot
Ablation of catalase promotes non-alcoholic fatty liver via oxidative stress and mitochondrial dysfunction in diet-induced obese mice
inferred← citeshttps://doi.org/10.1007/s10238-025-01828-3openalex-snapshot
Polymyositis-like hypothyroid myopathy: diagnostic challenges and therapeutic outcomes in a case series
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Long-Term Fructose Intake Induces Moderate Liver Inflammation but Does not Overlap with the Detrimental Effects of the Ketogenic Diet on Hepatic Steatosis in Rats
inferred← citeshttps://doi.org/10.1007/s11033-022-07565-0openalex-snapshot
Krüppel-like factors in glycolipid metabolic diseases
inferred← citeshttps://doi.org/10.1007/s11064-019-02779-4openalex-snapshot
Mitochondrial Dynamics Impairment in Dexamethasone-Treated Neuronal Cells
inferred← citeshttps://doi.org/10.1007/s11259-025-10846-1openalex-snapshot
Lysozyme and dandelion extract alleviate tearing eye disease by reducing inflammation and oxidative stress through canine corneal fibroblast model established
inferred← citeshttps://doi.org/10.1007/s11892-019-1224-4openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12272-022-01410-5openalex-snapshot
Mouse models of nonalcoholic steatohepatitis and their application to new drug development
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The Role of Mitochondrial Adaptation and Metabolic Flexibility in the Pathophysiology of Obesity and Insulin Resistance: an Updated Overview
inferred← citeshttps://doi.org/10.1016/b978-0-12-811752-1.00008-0openalex-snapshot
Role of Mitochondria in the Liver Metabolism in Obesity and Type 2 Diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-12-811752-1.00015-8openalex-snapshot
Mitochondrial Dysfunction Induced by Xenobiotics: Involvement in Steatosis and Steatohepatitis
inferred← citeshttps://doi.org/10.1016/b978-0-12-824315-2.00071-3openalex-snapshot
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Drug-induced liver injury in obesity and nonalcoholic fatty liver disease
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Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis
inferred← citeshttps://doi.org/10.1016/j.advnut.2025.100375openalex-snapshot
Macronutrient Modulation in Metabolic Dysfunction-Associated Steatotic Liver Disease—the Molecular Role of Fatty Acids compared with Sugars in Human Metabolism and Disease Progression
inferred← citeshttps://doi.org/10.1016/j.apsb.2021.09.002openalex-snapshot
Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?
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Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction
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Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome
inferred← citeshttps://doi.org/10.1016/j.bbadis.2019.03.006openalex-snapshot
Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation
inferred← citeshttps://doi.org/10.1016/j.bbadis.2025.167674openalex-snapshot
Suppression of PCK1 attenuates neuronal injury and improves post-resuscitation outcomes
inferred← citeshttps://doi.org/10.1016/j.bbalip.2022.159209openalex-snapshot
Integrating the contributions of mitochondrial oxidative metabolism to lipotoxicity and inflammation in NAFLD pathogenesis
inferred← citeshttps://doi.org/10.1016/j.bbalip.2022.159264openalex-snapshot
Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy
inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.05.144openalex-snapshot
Liver receptor homolog-1 regulates mouse superoxide dismutase 2
inferred← citeshttps://doi.org/10.1016/j.bcp.2018.11.020openalex-snapshot
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2023.122072openalex-snapshot
An orally delivered bacteria‐based coacervate antidote for alcohol detoxification
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.12.077openalex-snapshot
Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats
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State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy
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Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity
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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.06.006openalex-snapshot
Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity
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Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107986openalex-snapshot
In Vivo Estimates of Liver Metabolic Flux Assessed by 13C-Propionate and 13C-Lactate Are Impacted by Tracer Recycling and Equilibrium Assumptions
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115591openalex-snapshot
Simultaneous in vivo multi-organ fluxomics reveals divergent metabolic adaptations in liver, heart, and skeletal muscle during obesity
inferred← citeshttps://doi.org/10.1016/j.clnu.2024.04.029openalex-snapshot
Ketogenic diet time-dependently prevents NAFLD through upregulating the expression of antioxidant protein metallothionein-2
inferred← citeshttps://doi.org/10.1016/j.cmet.2016.06.005openalex-snapshot
Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by 13C Magnetic Resonance Spectroscopy
inferred← citeshttps://doi.org/10.1016/j.cmet.2016.12.022openalex-snapshot
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.03.014openalex-snapshot
Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.05.013openalex-snapshot
Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword
inferred← citeshttps://doi.org/10.1016/j.cmet.2020.01.013openalex-snapshot
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly
inferred← citeshttps://doi.org/10.1016/j.cmet.2024.02.004openalex-snapshot
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2025.104924openalex-snapshot
Crosstalk between ROS and ferroptosis, cuproptosis, and PANoptosis in liver cancer: Mechanisms and therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.diabres.2026.113300openalex-snapshot
Stage dependent alterations in PBMC mitochondrial bioenergetics in pediatric obesity: from insulin resistance to type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.dld.2020.05.034openalex-snapshot
Increased risk of acute liver failure by pain killer drugs in NAFLD: Focus on nuclear receptors and their coactivators
inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104714openalex-snapshot
Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases
inferred← citeshttps://doi.org/10.1016/j.ecl.2016.06.005openalex-snapshot
Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177978openalex-snapshot
Exogenous ATP-induced lipolysis and its correlation with skeletal muscle atrophy and hepatic damage in fasting mice
inferred← citeshttps://doi.org/10.1016/j.fbio.2022.102172openalex-snapshot
Pu'er raw tea extract alleviates lipid deposition in both LO2 cells and Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1016/j.foodres.2022.111196openalex-snapshot
Que Zui tea ameliorates hepatic lipid accumulation and oxidative stress in high fat diet induced nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2017.09.026openalex-snapshot
Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.04.003openalex-snapshot
Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.02.025openalex-snapshot
Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2021.08.232openalex-snapshot
Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2021.09.007openalex-snapshot
PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.06.226openalex-snapshot
Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2024.09.044openalex-snapshot
GTPBP8 mitigates nonalcoholic steatohepatitis (NASH) by depressing hepatic oxidative stress and mitochondrial dysfunction via PGC-1α signaling
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e29860openalex-snapshot
Machine learning deciphers the significance of mitochondrial regulators on the diagnosis and subtype classification in non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.isci.2020.101931openalex-snapshot
A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis
inferred← citeshttps://doi.org/10.1016/j.isci.2021.102149openalex-snapshot
GSK3 inhibitor ameliorates steatosis through the modulation of mitochondrial dysfunction in hepatocytes of obese patients
inferred← citeshttps://doi.org/10.1016/j.isci.2023.107046openalex-snapshot
Differential effects of bariatric surgery and caloric restriction on hepatic one-carbon and fatty acid metabolism
inferred← citeshttps://doi.org/10.1016/j.jcjd.2016.10.013openalex-snapshot
Early Metabolic Improvement After Bariatric Surgery: The First Steps Toward Remission of Type 2 Diabetes
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2018.09.017openalex-snapshot
Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate Metabolism
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2023.04.003openalex-snapshot
Alterations in Cytoskeleton and Mitochondria in the Development and Reversal of Steatosis in Human Hepatocytes
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2026.101853openalex-snapshot
Induced Pluripotent Stem Cell–Derived Hepatocytes From Patients With Metabolic Dysfunction–Associated Steatotic Liver Disease Exhibit Early Mitochondrial Dysfunction
inferred← citeshttps://doi.org/10.1016/j.jep.2024.118461openalex-snapshot
Mitochondrial structure and function: A new direction for the targeted treatment of chronic liver disease with Chinese herbal medicine
inferred← citeshttps://doi.org/10.1016/j.jep.2024.119069openalex-snapshot
Anti-inflammatory effects and mechanism of Plantago asiatica L. and Lonicera japonica Thunb. extracts based on canine and feline kidney cell models
inferred← citeshttps://doi.org/10.1016/j.jff.2023.105478openalex-snapshot
Trilobatin ameliorates HFD/STZ-induced glycolipid metabolism disorders through AMPK-mediated pathways
inferred← citeshttps://doi.org/10.1016/j.jhep.2022.09.020openalex-snapshot
Mitochondrial alterations in fatty liver diseases
inferred← citeshttps://doi.org/10.1016/j.jhep.2025.02.033openalex-snapshot
Integrative metabolism in MASLD and MASH: Pathophysiology and emerging mechanisms
inferred← citeshttps://doi.org/10.1016/j.jhepr.2022.100651openalex-snapshot
Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice
inferred← citeshttps://doi.org/10.1016/j.jlr.2024.100558openalex-snapshot
Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in mice
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2017.01.008openalex-snapshot
Chronic maternal calcium and 25-hydroxyvitamin D deficiency in Wistar rats programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2021.108888openalex-snapshot
Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2025.113311openalex-snapshot
A sulfonate-modified cyanine-based photoacoustic probe for selective detection of hydroxyl radicals in diabetic liver injury
inferred← citeshttps://doi.org/10.1016/j.jtos.2019.06.002openalex-snapshot
Hyperlipidemia induces meibomian gland dysfunction
inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120828openalex-snapshot
Sinapine Improves LPS-Induced Oxidative Stress in Hepatocytes by Down-Regulating MCJ Protein Expression
inferred← citeshttps://doi.org/10.1016/j.livres.2019.06.001openalex-snapshot
Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis
inferred← citeshttps://doi.org/10.1016/j.mehy.2016.05.026openalex-snapshot
Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance
inferred← citeshttps://doi.org/10.1016/j.metabol.2016.11.008openalex-snapshot
Effects of visceral adiposity on glycerol pathways in gluconeogenesis
inferred← citeshttps://doi.org/10.1016/j.mmm.2023.03.006openalex-snapshot
NAFLD et dysfonction mitochondriale
inferred← citeshttps://doi.org/10.1016/j.molmet.2017.09.002openalex-snapshot
The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity
inferred← citeshttps://doi.org/10.1016/j.molmet.2018.09.008openalex-snapshot
Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates
inferred← citeshttps://doi.org/10.1016/j.molmet.2019.11.015openalex-snapshot
Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.molmet.2020.101051openalex-snapshot
Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance
inferred← citeshttps://doi.org/10.1016/j.molmet.2020.101134openalex-snapshot
Mitochondrial oxidative function in NAFLD: Friend or foe?
inferred← citeshttps://doi.org/10.1016/j.molmet.2020.101154openalex-snapshot
Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101195openalex-snapshot
Role of NAD+ in regulating cellular and metabolic signaling pathways
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101269openalex-snapshot
Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101359openalex-snapshot
Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101494openalex-snapshot
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101566openalex-snapshot
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR
inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101723openalex-snapshot
Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway
inferred← citeshttps://doi.org/10.1016/j.molmet.2024.101908openalex-snapshot
VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism
inferred← citeshttps://doi.org/10.1016/j.molmet.2025.102112openalex-snapshot
The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2024.07.010openalex-snapshot
Diverse effects of synthetic glucocorticoid species on cell viability and stress response of neuroblastoma cells
inferred← citeshttps://doi.org/10.1016/j.numecd.2017.04.009openalex-snapshot
Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data
inferred← citeshttps://doi.org/10.1016/j.nutres.2019.01.005openalex-snapshot
Pilose antler polypeptides ameliorate inflammation and oxidative stress and improves gut microbiota in hypoxic-ischemic injured rats
inferred← citeshttps://doi.org/10.1016/j.peptides.2025.171391openalex-snapshot
Adropin: A cardio-metabolic hormone in the periphery, a neurohormone in the brain?
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2017.07.008openalex-snapshot
Stable isotope-based flux studies in nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105971openalex-snapshot
Exploring metformin as a candidate drug for rosacea through network pharmacology and experimental validation
inferred← citeshttps://doi.org/10.1016/j.phymed.2020.153209openalex-snapshot
Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155287openalex-snapshot
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice
inferred← citeshttps://doi.org/10.1016/j.physbeh.2020.113040openalex-snapshot
Relative contribution of fat diet and physical inactivity to the development of metabolic syndrome and non-alcoholic fat liver disease in Wistar rats
inferred← citeshttps://doi.org/10.1016/j.plipres.2026.101380openalex-snapshot
Nutrigenomics of fat-soluble vitamins and micronutrients in hepatocyte lipotoxicity and MASLD
inferred← citeshttps://doi.org/10.1016/j.psj.2023.103378openalex-snapshot
Dietary supplementation of magnolol alleviates fatty liver hemorrhage syndrome in postpeak Xinhua laying hens via regulation of liver lipid metabolism
inferred← citeshttps://doi.org/10.1016/j.redox.2019.101205openalex-snapshot
Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1
inferred← citeshttps://doi.org/10.1016/j.taap.2019.114745openalex-snapshot
Rapamycin attenuates liver injury caused by vinyl chloride metabolite chloroethanol and lipopolysaccharide in mice
inferred← citeshttps://doi.org/10.1016/j.taap.2021.115758openalex-snapshot
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3
inferred← citeshttps://doi.org/10.1016/j.tem.2016.02.008openalex-snapshot
Unraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease
inferred← citeshttps://doi.org/10.1016/j.tem.2016.11.006openalex-snapshot
Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies
inferred← citeshttps://doi.org/10.1016/j.tjnut.2025.04.030openalex-snapshot
Induction of Fructose Mediated De Novo Lipogenesis Coexists with the Upregulation of Mitochondrial Oxidative Function in Mice Livers
inferred← citeshttps://doi.org/10.1016/j.xpro.2023.102089openalex-snapshot
Measuring VLDL1 secretion in humans with an intravenous fat emulsion test
inferred← citeshttps://doi.org/10.1016/j.ymben.2021.12.009openalex-snapshot
INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis
inferred← citeshttps://doi.org/10.1017/s0954422422000038openalex-snapshot
Mitochondrial dysfunction and epigenetics underlying the link between early-life nutrition and non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1021/acs.jafc.0c04648openalex-snapshot
(−)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels
inferred← citeshttps://doi.org/10.1021/acs.jafc.1c05213openalex-snapshot
Erythritol Improves Nonalcoholic Fatty Liver Disease by Activating Nrf2 Antioxidant Capacity
inferred← citeshttps://doi.org/10.1038/bjc.2017.1openalex-snapshot
Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans
inferred← citeshttps://doi.org/10.1038/nrendo.2016.104openalex-snapshot
Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1038/nrgastro.2016.147openalex-snapshot
NAFLD and diabetes mellitus
inferred← citeshttps://doi.org/10.1038/s41388-017-0070-6openalex-snapshot
Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1038/s41392-024-02094-7openalex-snapshot
Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut
inferred← citeshttps://doi.org/10.1038/s41401-021-00681-wopenalex-snapshot
Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress
inferred← citeshttps://doi.org/10.1038/s41419-021-04108-6openalex-snapshot
Increased expression of fragmented tRNA promoted neuronal necrosis
inferred← citeshttps://doi.org/10.1038/s41430-018-0386-5openalex-snapshot
A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial
inferred← citeshttps://doi.org/10.1038/s41467-021-22107-1openalex-snapshot
The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase
inferred← citeshttps://doi.org/10.1038/s41467-023-37142-3openalex-snapshot
Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice
inferred← citeshttps://doi.org/10.1038/s41467-025-59747-6openalex-snapshot
Mapping pesticide-induced metabolic alterations in human gut bacteria
inferred← citeshttps://doi.org/10.1038/s41575-018-0089-3openalex-snapshot
Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators
inferred← citeshttps://doi.org/10.1038/s41575-021-00502-9openalex-snapshot
Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests
inferred← citeshttps://doi.org/10.1038/s41575-023-00888-8openalex-snapshot
Hepatic glucose metabolism in the steatotic liver
inferred← citeshttps://doi.org/10.1038/s41598-017-11744-6openalex-snapshot
Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD
inferred← citeshttps://doi.org/10.1038/s41598-017-11860-3openalex-snapshot
Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells
inferred← citeshttps://doi.org/10.1038/s41598-018-28494-8openalex-snapshot
Association of Lipoprotein-Associated Phospholipase A2 with the Prevalence of Nonalcoholic Fatty Liver Disease: A Result from the APAC Study
inferred← citeshttps://doi.org/10.1038/s41598-018-31835-2openalex-snapshot
Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model
inferred← citeshttps://doi.org/10.1038/s41598-018-34148-6openalex-snapshot
Loss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis
inferred← citeshttps://doi.org/10.1038/s41598-019-56715-1openalex-snapshot
Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken
inferred← citeshttps://doi.org/10.1038/s41598-020-69820-3openalex-snapshot
Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice
inferred← citeshttps://doi.org/10.1038/s41598-020-75956-zopenalex-snapshot
Palmitate and pyruvate carbon flux in response to choline and methionine in bovine neonatal hepatocytes
inferred← citeshttps://doi.org/10.1038/s41598-022-20101-1openalex-snapshot
Glial cell derived neurotrophic factor prevents western diet and palmitate-induced hepatocyte oxidative damage and death through SIRT3
inferred← citeshttps://doi.org/10.1038/s41598-023-34710-xopenalex-snapshot
Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis
inferred← citeshttps://doi.org/10.1038/s41598-024-65951-zopenalex-snapshot
Detection of early-stage NASH using non-invasive hyperpolarized 13C metabolic imaging
inferred← citeshttps://doi.org/10.1038/s41598-025-92572-xopenalex-snapshot
Skeletal muscle mitochondrial dysfunction is associated with increased Gdf15 expression and circulating GDF15 levels in aged mice
inferred← citeshttps://doi.org/10.1038/s42255-023-00935-3openalex-snapshot
Metabolic Messengers: ketone bodies
inferred← citeshttps://doi.org/10.1038/s42255-024-01119-3openalex-snapshot
Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
inferred← citeshttps://doi.org/10.1038/s44324-024-00020-7openalex-snapshot
Some paradoxes and unresolved aspects of hepatic de novo lipogenesis
inferred← citeshttps://doi.org/10.1039/c9fo00132hopenalex-snapshot
Protective effect of mulberry ( Morus atropurpurea ) fruit against diphenoxylate-induced constipation in mice through the modulation of gut microbiota
inferred← citeshttps://doi.org/10.1039/d0fo02623aopenalex-snapshot
Plant sterol ester of α-linolenic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice: association with regulating mitochondrial dysfunction and oxidative stress via activating AMPK signaling
inferred← citeshttps://doi.org/10.1042/bcj20160451openalex-snapshot
Mitochondrial form, function and signalling in aging
inferred← citeshttps://doi.org/10.1042/bcj20160503copenalex-snapshot
Molecular mechanisms of ROS production and oxidative stress in diabetes
inferred← citeshttps://doi.org/10.1053/j.gastro.2016.09.017openalex-snapshot
Estrogen Signals Through Peroxisome Proliferator-Activated Receptor−γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease
inferred← citeshttps://doi.org/10.1053/j.gastro.2019.03.016openalex-snapshot
Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice
inferred← citeshttps://doi.org/10.1055/s-0043-125148openalex-snapshot
The Effects of Folate Supplementation on Diabetes Biomarkers Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
inferred← citeshttps://doi.org/10.1074/jbc.m116.720631openalex-snapshot
Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism
inferred← citeshttps://doi.org/10.1074/jbc.ra118.004869openalex-snapshot
Glutamate–oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux
inferred← citeshttps://doi.org/10.1080/00071668.2025.2536340openalex-snapshot
Polygonatum sibiricum polysaccharides combat fatty liver haemorrhage syndrome in hens via regulation of lipid metabolism, oxidative stress and inflammatory response
inferred← citeshttps://doi.org/10.1080/10408398.2020.1809344openalex-snapshot
Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome
inferred← citeshttps://doi.org/10.1080/17474124.2017.1291340openalex-snapshot
Clinical implications of understanding the association between oxidative stress and pediatric NAFLD
inferred← citeshttps://doi.org/10.1080/21655979.2022.2051858openalex-snapshot
Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice
inferred← citeshttps://doi.org/10.1089/ars.2016.6776openalex-snapshot
Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis
inferred← citeshttps://doi.org/10.1089/ars.2021.0044openalex-snapshot
Sex Differences in Nonalcoholic Fatty Liver Disease: Estrogen Influence on the Liver–Adipose Tissue Crosstalk
inferred← citeshttps://doi.org/10.1089/ars.2021.0076openalex-snapshot
Signal Transduction and Molecular Regulation in Fatty Liver Disease
inferred← citeshttps://doi.org/10.1093/carcin/bgz107openalex-snapshot
Sex hormone-binding globulin suppresses NAFLD-triggered hepatocarcinogenesis after menopause
inferred← citeshttps://doi.org/10.1093/toxsci/kfae160openalex-snapshot
Haloacetamides exacerbate non-alcoholic fatty liver disease induced by a high-fat diet in C57BL/6J mice
inferred← citeshttps://doi.org/10.1096/fj.202001495ropenalex-snapshot
Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD
inferred← citeshttps://doi.org/10.1097/hc9.0000000000000810openalex-snapshot
Targeting hepatocyte-specific SLC2A8 blocks hepatic steatosis and dissociates TCA cycle flux inhibition from glutamine anaplerosis
inferred← citeshttps://doi.org/10.1097/j.pbj.0000000000000071openalex-snapshot
An albino mouse model of nonalcoholic fatty liver disease induced using high-fat liquid “Lieber-DeCarli” diet: a preliminary investigation
inferred← citeshttps://doi.org/10.1097/mco.0000000000000346openalex-snapshot
Update on lipid species and paediatric nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1097/mco.0000000000000393openalex-snapshot
Measurement of metabolic fluxes using stable isotope tracers in whole animals and human patients
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