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It takes a village: channeling fatty acid metabolism and triacylglycerol formation via protein interactomes

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Cytochemistry of centrifuged hyphae of Neurospora

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The molecular biology of Euglena gracilis

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Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV)

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The metabolic capacity of lipid droplet localized acyl-CoA synthetase 3 is not sufficient to support local triglyceride synthesis independent of the endoplasmic reticulum in A431 cells

inferredcites →https://doi.org/10.1016/j.cmet.2005.06.006openalex-snapshot

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

inferredcites →https://doi.org/10.1016/j.cmet.2010.05.012openalex-snapshot

Adipose Acyl-CoA Synthetase-1 Directs Fatty Acids toward β-Oxidation and Is Required for Cold Thermogenesis

inferredcites →https://doi.org/10.1016/j.tibs.2016.09.009openalex-snapshot

A New View into the Regulation of Purine Metabolism: The Purinosome

inferredcites →https://doi.org/10.1016/s0021-9258(18)66142-3openalex-snapshot

ENZYMATIC SYNTHESIS OF THE COENZYME A DERIVATIVES OF LONG CHAIN FATTY ACIDS

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Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.

inferredcites →https://doi.org/10.1016/s0074-7696(08)60529-xopenalex-snapshot

Macromolecular Compartmentation and Channeling

inferredcites →https://doi.org/10.1016/s0163-7827(01)00010-8openalex-snapshot

Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

inferredcites →https://doi.org/10.1021/cr100404wopenalex-snapshot

Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling

inferredcites →https://doi.org/10.1038/s41467-018-04543-8openalex-snapshot

The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation

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Glycogen and its metabolism: some new developments and old themes

inferredcites →https://doi.org/10.1042/bj3380783openalex-snapshot

AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target

inferredcites →https://doi.org/10.1053/j.gastro.2013.11.049openalex-snapshot

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

inferredcites →https://doi.org/10.1073/pnas.0609140103openalex-snapshot

Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis

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Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

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Identification of Glycerol-3-phosphate Acyltransferase as an Adipocyte Determination and Differentiation Factor 1- and Sterol Regulatory Element-binding Protein-responsive Gene

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Liver-specific Loss of Long Chain Acyl-CoA Synthetase-1 Decreases Triacylglycerol Synthesis and β-Oxidation and Alters Phospholipid Fatty Acid Composition

inferredcites →https://doi.org/10.1074/jbc.m111.228692openalex-snapshot

Mitochondrial Carnitine Palmitoyltransferase 1a (CPT1a) Is Part of an Outer Membrane Fatty Acid Transfer Complex

inferredcites →https://doi.org/10.1074/jbc.m113.485219openalex-snapshot

Glycerol-3-phosphate Acyltransferase (GPAT)-1, but Not GPAT4, Incorporates Newly Synthesized Fatty Acids into Triacylglycerol and Diminishes Fatty Acid Oxidation

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Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown Adipocytes

inferredcites →https://doi.org/10.1074/jbc.m410422200openalex-snapshot

Phosphorylation of Rat Liver Mitochondrial Glycerol-3-phosphate Acyltransferase by Casein Kinase 2

inferredcites →https://doi.org/10.1074/jbc.m503181200openalex-snapshot

Mitochondrial Glycerol-3-phosphate Acyltransferase-1 Is Essential inLiver for the Metabolism of ExcessAcyl-CoAs

inferredcites →https://doi.org/10.1074/jbc.m708151200openalex-snapshot

AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate Acyltransferase

inferredcites →https://doi.org/10.1074/jbc.r115.663260openalex-snapshot

Physiological Consequences of Compartmentalized Acyl-CoA Metabolism

inferredcites →https://doi.org/10.1074/jbc.ra118.004049openalex-snapshot

Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways

inferredcites →https://doi.org/10.1083/jcb.201112098openalex-snapshot

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

inferredcites →https://doi.org/10.1096/fj.15-272732openalex-snapshot

Loss of long‐chain acyl‐CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation

inferredcites →https://doi.org/10.1111/j.1742-4658.2008.06806.xopenalex-snapshot

SREBPs: physiology and pathophysiology of the SREBP family

inferredcites →https://doi.org/10.1128/jb.182.13.3613-3618.2000openalex-snapshot

Ten Commandments: Lessons from the Enzymology of DNA Replication

inferredcites →https://doi.org/10.1128/mcb.01085-10openalex-snapshot

Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy

inferredcites →https://doi.org/10.1128/mcb.22.23.8204-8214.2002openalex-snapshot

Mitochondrial Glycerol-3-Phosphate Acyltransferase-Deficient Mice Have Reduced Weight and Liver Triacylglycerol Content and Altered Glycerolipid Fatty Acid Composition

inferredcites →https://doi.org/10.1146/annurev.bi.56.070187.000513openalex-snapshot

COMPLEXES OF SEQUENTIAL METABOLIC ENZYMES

inferredcites →https://doi.org/10.1152/ajpendo.00034.2014openalex-snapshot

Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor

inferredcites →https://doi.org/10.1172/jci0215593openalex-snapshot

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

inferredcites →https://doi.org/10.1172/jci15593openalex-snapshot

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

inferredcites →https://doi.org/10.1194/jlr.m081836openalex-snapshot

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice

inferredcites →https://doi.org/10.1194/jlr.m500553-jlr200openalex-snapshot

Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity

inferredcites →https://doi.org/10.1194/jlr.m500556-jlr200openalex-snapshot

Agpat6—a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium

inferredcites →https://doi.org/10.1194/jlr.m700378-jlr200openalex-snapshot

Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

inferredcites →https://doi.org/10.1194/jlr.m700592-jlr200openalex-snapshot

Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6−/− mice

inferredcites →https://doi.org/10.1530/joe-13-0327openalex-snapshot

Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

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Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention

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Glycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity

inferredcites →https://doi.org/10.2337/db13-1070openalex-snapshot

Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis

inferredcites →https://doi.org/10.3390/ijms17060817openalex-snapshot

Nutritional and Hormonal Regulation of Citrate and Carnitine/Acylcarnitine Transporters: Two Mitochondrial Carriers Involved in Fatty Acid Metabolism

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Additional file 1 of Characterization of Auxenochlorella protothecoides acyltransferases and potential of their protein interactions to promote the enrichment of oleic acid

inferred← citeshttps://doi.org/10.6084/m9.figshare.22678247openalex-snapshot

Additional file 2 of Characterization of Auxenochlorella protothecoides acyltransferases and potential of their protein interactions to promote the enrichment of oleic acid

inferred← citeshttps://doi.org/10.6084/m9.figshare.26600731openalex-snapshot

Additional file 1 of Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs

inferred← citeshttps://doi.org/10.6084/m9.figshare.26600734openalex-snapshot

Additional file 2 of Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs

inferred← citeshttps://doi.org/10.6084/m9.figshare.26600737openalex-snapshot

Additional file 3 of Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs

inferred← citeshttps://doi.org/10.6084/m9.figshare.26600740openalex-snapshot

Additional file 4 of Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs

inferred← citeshttps://doi.org/10.6084/m9.figshare.26600743openalex-snapshot

Additional file 5 of Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs

inferred← citeshttps://doi.org/10.6084/m9.figshare.26600746openalex-snapshot

Additional file 6 of Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs

inferred← citeshttps://doi.org/10.6084/m9.figshare.26600749openalex-snapshot

Additional file 7 of Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs

inferred← citeshttps://doi.org/10.70675/736bed4ezbc57z4b48z92f9z3830180e94b2openalex-snapshot

Détermination de la composition en acyles gras des glycérolipides et glycérophospholipides par techniques séparatives couplées à la spectrométrie de masse haute résolution

inferred← citeshttps://doi.org/10.7150/ijbs.57099openalex-snapshot

Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation

inferred← citeshttps://doi.org/10.7554/elife.47733openalex-snapshot

Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity

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