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Protein aggregation and bioprocessing
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Effective elution of antibodies by arginine and arginine derivatives in affinity column chromatography
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Protein aggregation during overexpression limited by peptide extensions with large net negative charge
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[39] Dityrosine: A marker for oxidatively modified proteins and selective proteolysis
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Kinetics and Thermodynamics of Dimer Formation and Dissociation for a Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor
inferredcites →https://doi.org/10.1021/bk-1994-0567.ch006openalex-snapshot
Disulfide-Linked Oligomerization of Basic Fibroblast Growth Factor
inferredcites →https://doi.org/10.1021/bp025511zopenalex-snapshot
Free Sulfhydryl in Recombinant Monoclonal Antibodies
inferredcites →https://doi.org/10.1021/bp0497029openalex-snapshot
Effect of Copper Sulfate on Performance of a Serum-Free CHO Cell Culture Process and the Level of Free Thiol in the Recombinant Antibody Expressed
inferredcites →https://doi.org/10.1023/a:1025771421906openalex-snapshot
Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation
inferredcites →https://doi.org/10.1080/146532401753174061openalex-snapshot
Manufacture and quality control of CAMPATH-1 antibodies for clinical trials
inferredcites →https://doi.org/10.1111/j.1751-1097.1984.tb03891.xopenalex-snapshot
THE PHOTOPHYSICS AND PHOTOCHEMISTRY OF THE NEAR‐UV ABSORBING AMINO ACIDS–II. TYROSINE AND ITS SIMPLE DERIVATIVES
inferredcites →https://doi.org/10.1128/jvi.73.2.1392-1398.1999openalex-snapshot
Coxsackievirus and Adenovirus Receptor Amino-Terminal Immunoglobulin V-Related Domain Binds Adenovirus Type 2 and Fiber Knob from Adenovirus Type 12
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Effects of protein aggregates: An immunologic perspective
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Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations
inferredcites →https://doi.org/10.2337/diab.37.8.1059openalex-snapshot
Pharmacokinetic Model of Circulating Covalent Aggregates of Insulin
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Experimental Detection and Characterization of Protein Aggregates
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Separation‐Based Analytical Methods for Measuring Protein Aggregation
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Characterization of Aggregates and Particles Using Emerging Techniques
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Non‐native protein aggregation kinetics
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Use of a folding model and in situ spectroscopic techniques for rational formulation development and stability testing of monoclonal antibody therapeutics**Gauri Rao and Vandana Iyer contributed equally to this work.
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Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products
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Forced Degradation of Therapeutic Proteins
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A Systematic Multitechnique Approach for Detection and Characterization of Reversible Self-Association during Formulation Development of Therapeutic Antibodies
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Characterization of Fc-Fusion Protein Aggregates Derived from Extracellular Domain Disulfide Bond Rearrangements
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Transmission Electron Microscopy as an Orthogonal Method to Characterize Protein Aggregates
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Characterizing Soluble Protein Aggregates Using Native Mass Spectrometry Coupled with Temperature-Controlled Electrospray Ionization and Size-Excl usion Chromatography
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Biophysical Techniques for Protein Size Distribution Analysis
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Molecular Structural Analysis
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Molecule and Manufacturability Assessment Leading to Robust Commercial Formulation for Therapeutic Proteins
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A Screening Methodology for Purifying Proteins with Aggregation Problems
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Application of QbD Elements in the Development and Scale-Up of a Commercial Filtration Process
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Application of QbD Elements in the Development and Scale-up of Commercial Filling Process
inferred← citeshttps://doi.org/10.1007/978-1-4939-3389-1_27openalex-snapshot
Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates
inferred← citeshttps://doi.org/10.1007/978-1-4939-4014-1_12openalex-snapshot
Characterization of Chemical and Physical Modifications of Human Serum Albumin by Capillary Zone Electrophoresis
inferred← citeshttps://doi.org/10.1007/978-1-4939-9929-3_21openalex-snapshot
Physical Stability Studies of Antibody-Drug Conjugates (ADCs) Under Stressed Conditions
inferred← citeshttps://doi.org/10.1007/978-1-61779-433-9_32openalex-snapshot
Engineering the Chaperone Network of CHO Cells for Optimal Recombinant Protein Production and Authenticity
inferred← citeshttps://doi.org/10.1007/978-3-030-31415-6_1openalex-snapshot
Chapter 1: Monoclonal Antibodies: Structure, Physicochemical Stability, and Protein Engineering
inferred← citeshttps://doi.org/10.1007/978-3-030-31415-6_17openalex-snapshot
Chapter 17: Scale-Down Models for Robust Biologics Drug Product Process Development
inferred← citeshttps://doi.org/10.1007/978-3-030-32622-7_34openalex-snapshot
ANTISOMA: A Computational Pipeline for the Reduction of the Aggregation Propensity of Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1007/978-3-030-76367-1_17openalex-snapshot
Ophthalmic Product Development for Biologics
inferred← citeshttps://doi.org/10.1007/978-3-031-59478-6_19openalex-snapshot
Peptides, Proteins and Antibodies
inferred← citeshttps://doi.org/10.1007/978-3-031-62007-2_14openalex-snapshot
Biopharmaceutical Informatics: A Strategic Vision for Discovering Developable Biotherapeutic Drug Candidates
inferred← citeshttps://doi.org/10.1007/978-3-031-63164-1_4openalex-snapshot
Changes in Structure, Dispersity and Phase Behavior of Proteins: The Virus-Like Particles in the Presence of Nucleic Acids
inferred← citeshttps://doi.org/10.1007/978-3-319-90603-4_2openalex-snapshot
Polysorbate Degradation and Quality
inferred← citeshttps://doi.org/10.1007/978-3-319-90603-4_5openalex-snapshot
Solubility, Opalescence, and Particulate Matter
inferred← citeshttps://doi.org/10.1007/978-3-319-90603-4_6openalex-snapshot
Analytical Characterization and Predictive Tools for Highly Concentrated Protein Formulations
inferred← citeshttps://doi.org/10.1007/978-4-431-55985-6_19openalex-snapshot
Use of Analytical Ultracentrifugation as an Orthogonal Method for Size Exclusion Chromatography: Assuring Quality for Therapeutic Protein Products and Meeting Regulatory Expectations
inferred← citeshttps://doi.org/10.1007/978-81-322-2467-9_4openalex-snapshot
Protein Folding and Aggregation: A Revisit of Basic Conception
inferred← citeshttps://doi.org/10.1007/978-94-007-1257-7_13openalex-snapshot
Quality Issues Arising from Post-translational Modification of Recombinant Antibodies
inferred← citeshttps://doi.org/10.1007/978-94-024-1069-3_7openalex-snapshot
Prediction of Protein Aggregation and Amyloid Formation
inferred← citeshttps://doi.org/10.1007/s00114-013-1013-xopenalex-snapshot
Serous cutaneous glands in anurans: Fourier transform analysis of the repeating secretory granule substructure
inferred← citeshttps://doi.org/10.1007/s00216-013-7462-4openalex-snapshot
Hollow-fiber flow field-flow fractionation with multi-angle laser scattering detection for aggregation studies of therapeutic proteins
inferred← citeshttps://doi.org/10.1007/s00216-014-8065-4openalex-snapshot
Separation and quantification of monoclonal-antibody aggregates by hollow-fiber-flow field-flow fractionation
inferred← citeshttps://doi.org/10.1007/s00216-014-8108-xopenalex-snapshot
Post-translational structural modifications of immunoglobulin G and their effect on biological activity
inferred← citeshttps://doi.org/10.1007/s00216-015-8672-8openalex-snapshot
Fluorescence dye-based detection of mAb aggregates in CHO culture supernatants
inferred← citeshttps://doi.org/10.1007/s00216-017-0362-2openalex-snapshot
High-throughput analysis of sub-visible mAb aggregate particles using automated fluorescence microscopy imaging
inferred← citeshttps://doi.org/10.1007/s00249-009-0404-6openalex-snapshot
Insights into protein–polysorbate interactions analysed by means of isothermal titration and differential scanning calorimetry
inferred← citeshttps://doi.org/10.1007/s00253-012-4347-yopenalex-snapshot
RETRACTED ARTICLE: Simultaneous expression of antibody light and heavy chains in Pichia pastoris: improving retransformation outcome by linearizing vector at a different site
inferred← citeshttps://doi.org/10.1007/s00253-017-8312-7openalex-snapshot
Different fermentation processes produced variants of an anti-CD52 monoclonal antibody that have divergent in vitro and in vivo characteristics
inferred← citeshttps://doi.org/10.1007/s00253-020-10744-3openalex-snapshot
Investigation into the impact of tyrosine on the product formation and quality attributes of mAbs in rCHO cell cultures
inferred← citeshttps://doi.org/10.1007/s00253-022-11977-0openalex-snapshot
Recombinant antibodies aggregation and overcoming strategies in CHO cells
inferred← citeshttps://doi.org/10.1007/s00449-013-1010-7openalex-snapshot
Development of a magnetic biocatalyst useful for the synthesis of ethyloleate
inferred← citeshttps://doi.org/10.1007/s00449-019-02103-yopenalex-snapshot
Precipitation of complex antibody solutions: influence of contaminant composition and cell culture medium on the precipitation behavior
inferred← citeshttps://doi.org/10.1007/s00449-019-02239-xopenalex-snapshot
Apparent protein cloud point temperature determination using a low volume high-throughput cryogenic device in combination with automated imaging
inferred← citeshttps://doi.org/10.1007/s00723-020-01227-9openalex-snapshot
NMR Relaxation of Nuclei of Buffer as a Probe for Monitoring Protein Solutions Including Aggregation Processes
inferred← citeshttps://doi.org/10.1007/s10068-018-0361-xopenalex-snapshot
Effects of homogenization on the molecular flexibility and emulsifying properties of soy protein isolate
inferred← citeshttps://doi.org/10.1007/s10157-007-0487-2openalex-snapshot
Through the looking glass: the protein science of biosimilars
inferred← citeshttps://doi.org/10.1007/s10295-010-0766-xopenalex-snapshot
Enzyme replacement therapy for Morquio A: an active recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in Escherichia coli BL21
inferred← citeshttps://doi.org/10.1007/s10529-010-0469-4openalex-snapshot
Effects of shear on proteins in solution
inferred← citeshttps://doi.org/10.1007/s10600-014-1057-yopenalex-snapshot
Domain Organization of Lectin from the Mussel Crenomytilus grayanus
inferred← citeshttps://doi.org/10.1007/s10822-023-00501-9openalex-snapshot
Structural mechanism of Fab domain dissociation as a measure of interface stability
inferred← citeshttps://doi.org/10.1007/s10847-019-00947-1openalex-snapshot
Effect of macrocyclic compounds to protein aggregation
inferred← citeshttps://doi.org/10.1007/s10895-013-1162-5openalex-snapshot
Consequential secondary structure alterations and aggregation during prolonged casein glycation
inferred← citeshttps://doi.org/10.1007/s10930-019-09837-4openalex-snapshot
Investigation on Secondary Structure Alterations of Protein Drugs as an Indicator of Their Biological Activity Upon Thermal Exposure
inferred← citeshttps://doi.org/10.1007/s10930-025-10302-8openalex-snapshot
Strategic Approaches for Overcoming Peptide and Protein Drug Limitations
inferred← citeshttps://doi.org/10.1007/s10989-023-10492-8openalex-snapshot
A Review on Forced Degradation Strategies to Establish the Stability of Therapeutic Peptide Formulations
inferred← citeshttps://doi.org/10.1007/s11095-007-9516-9openalex-snapshot
Extrinsic Fluorescent Dyes as Tools for Protein Characterization
inferred← citeshttps://doi.org/10.1007/s11095-009-0045-6openalex-snapshot
Stability of Protein Pharmaceuticals: An Update
inferred← citeshttps://doi.org/10.1007/s11095-009-9963-6openalex-snapshot
Carboxylate-Dependent Gelation of a Monoclonal Antibody
inferred← citeshttps://doi.org/10.1007/s11095-010-0073-2openalex-snapshot
Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates
inferred← citeshttps://doi.org/10.1007/s11095-010-0143-5openalex-snapshot
Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis
inferred← citeshttps://doi.org/10.1007/s11095-010-0224-5openalex-snapshot
Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography
inferred← citeshttps://doi.org/10.1007/s11095-011-0374-0openalex-snapshot
Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations
inferred← citeshttps://doi.org/10.1007/s11095-011-0385-xopenalex-snapshot
The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics
inferred← citeshttps://doi.org/10.1007/s11095-011-0410-0openalex-snapshot
Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1007/s11095-011-0416-7openalex-snapshot
Aggregation Stability of a Monoclonal Antibody During Downstream Processing
inferred← citeshttps://doi.org/10.1007/s11095-012-0732-6openalex-snapshot
Structure and Function of Purified Monoclonal Antibody Dimers Induced by Different Stress Conditions
inferred← citeshttps://doi.org/10.1007/s11095-012-0749-xopenalex-snapshot
Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum
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