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Minireview: G Protein-Coupled Estrogen Receptor-1, GPER-1: Its Mechanism of Action and Role in Female Reproductive Cancer, Renal and Vascular Physiology
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1 of the 82 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1289/ehp.11297 (notice 2014-02-01).
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cne.20271openalex-snapshotImmunohistochemical visualization of corticotropin‐releasing factor type 1 (CRF1) receptors in monkey brain
inferredcites →https://doi.org/10.1002/jbmr.209openalex-snapshotGPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice
inferredcites →https://doi.org/10.1006/bbrc.1996.1654openalex-snapshotCloning of Human cDNA Encoding a Novel Heptahelix Receptor Expressed in Burkitt's Lymphoma and Widely Distributed in Brain and Peripheral Tissues
inferredcites →https://doi.org/10.1006/geno.1997.4972openalex-snapshotIdentification of a Gene (GPR30) with Homology to the G-Protein-Coupled Receptor Superfamily Associated with Estrogen Receptor Expression in Breast Cancer
inferredcites →https://doi.org/10.1016/j.jsbmb.2006.09.017openalex-snapshotBinding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: A potential novel mechanism of endocrine disruption
inferredcites →https://doi.org/10.1016/j.yfrne.2008.01.001openalex-snapshotCharacteristics of membrane progestin receptor alpha (mPRα) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions
inferredcites →https://doi.org/10.1016/s0960-0760(01)00190-xopenalex-snapshotEpidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
inferredcites →https://doi.org/10.1038/cdd.2010.20openalex-snapshotActivation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G2 cell-cycle arrest
inferredcites →https://doi.org/10.1074/jbc.m111.224071openalex-snapshotDown-modulation of the G-protein-coupled Estrogen Receptor, GPER, from the Cell Surface Occurs via a trans-Golgi-Proteasome Pathway
inferredcites →https://doi.org/10.1095/biolreprod.108.070250openalex-snapshotIdentification of a Membrane Estrogen Receptor in Zebrafish with Homology to Mammalian GPER and Its High Expression in Early Germ Cells of the Testis1
inferredcites →https://doi.org/10.1095/biolreprod.110.088765openalex-snapshotInvolvement of Epidermal Growth Factor Receptor Signaling in Estrogen Inhibition of Oocyte Maturation Mediated Through the G Protein-Coupled Estrogen Receptor (Gper) in Zebrafish (Danio rerio)1
inferredcites →https://doi.org/10.1111/j.1349-7006.2009.01148.xopenalex-snapshotEstrogenic G protein‐coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin‐6 secretion via the MEK/ERK mitogen‐activated protein kinase pathway
inferredcites →https://doi.org/10.1124/mol.106.026344openalex-snapshotRETRACTED: 17β-Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30
inferredcites →https://doi.org/10.1124/mol.110.069500openalex-snapshotG Protein-Coupled Estrogen Receptor 1/G Protein-Coupled Receptor 30 Localizes in the Plasma Membrane and Traffics Intracellularly on Cytokeratin Intermediate Filaments
inferredcites →https://doi.org/10.1158/0008-5472.can-06-2909openalex-snapshotG Protein–Coupled Receptor 30 (GPR30) Mediates Gene Expression Changes and Growth Response to 17β-Estradiol and Selective GPR30 Ligand G-1 in Ovarian Cancer Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-0860openalex-snapshotDistribution of GPR30, a Seven Membrane–Spanning Estrogen Receptor, in Primary Breast Cancer and its Association with Clinicopathologic Determinants of Tumor Progression
inferredcites →https://doi.org/10.1210/en.2003-0806openalex-snapshotThe Unusual Binding Properties of the Third Distinct Teleost Estrogen Receptor Subtype ERβa Are Accompanied by Highly Conserved Amino Acid Changes in the Ligand Binding Domain
inferredcites →https://doi.org/10.1210/en.2007-1663openalex-snapshotEstrogen Signaling Characteristics of Atlantic Croaker G Protein-Coupled Receptor 30 (GPR30) and Evidence It Is Involved in Maintenance of Oocyte Meiotic Arrest
inferredcites →https://doi.org/10.1210/en.2008-0623openalex-snapshotDeletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice
inferredcites →https://doi.org/10.1210/en.2008-1664openalex-snapshotChronic Treatment with the G Protein-Coupled Receptor 30 Agonist G-1 Decreases Blood Pressure in Ovariectomized mRen2.Lewis Rats
inferredcites →https://doi.org/10.1210/en.2010-1368openalex-snapshotGPR30 Activation Opposes Estrogen-Dependent Uterine Growth via Inhibition of Stromal ERK1/2 and Estrogen Receptor Alpha (ERα) Phosphorylation Signals
inferredcites →https://doi.org/10.1210/me.14.10.1649openalex-snapshotEstrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF
inferredcites →https://doi.org/10.1210/me.2005-0280openalex-snapshotThe G Protein-Coupled Receptor GPR30 Mediates the Proliferative Effects Induced by 17β-Estradiol and Hydroxytamoxifen in Endometrial Cancer Cells
inferredcites →https://doi.org/10.1210/me.2008-0262openalex-snapshotCoordinate Regulation of Estrogen-Mediated Fibronectin Matrix Assembly and Epidermal Growth Factor Receptor Transactivation by the G Protein-Coupled Receptor, GPR30
inferredcites →https://doi.org/10.1289/ehp.1103781openalex-snapshotLow Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α
inferredcites →https://doi.org/10.1289/ehp.11297openalex-snapshotRetracted: G-Protein–Coupled Receptor 30 and Estrogen Receptor-α Are Involved in the Proliferative Effects Induced by Atrazine in Ovarian Cancer Cells
inferredcites →https://doi.org/10.1677/joe-07-0017openalex-snapshotDistribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4781335openalex-extractedThe Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes
inferred← citeshttps://doi.org/10.1002/cam4.1391openalex-snapshotAssociation between preoperative serum insulin levels and lymph node metastasis in endometrial cancer—a prospective cohort study
inferred← citeshttps://doi.org/10.1002/cbf.70072openalex-snapshotEstrogen G‐Protein Coupled Receptor Antagonist G15 Promotes Tau Clearance in 2D and 3D Tauopathy Models
inferred← citeshttps://doi.org/10.1002/cbin.10269openalex-snapshotLong‐term exposure of 3T3 fibroblast cells to endocrine disruptors alters sensitivity to oxidative injury
inferred← citeshttps://doi.org/10.1002/cne.24978openalex-snapshotEstrogen receptor alpha, G‐protein coupled estrogen receptor 1, and aromatase: Developmental, sex, and region‐specific differences across the rat caudate–putamen, nucleus accumbens core and shell
inferred← citeshttps://doi.org/10.1002/etc.4691openalex-snapshotThe Effects of 17α-Ethinylestradiol on the Heart Rate of Embryonic Japanese Medaka (Oryzias latipes)
inferred← citeshttps://doi.org/10.1002/jbmr.3364openalex-snapshotEstrogen Deficiency–Mediated M2 Macrophage Osteoclastogenesis Contributes to M1/M2 Ratio Alteration in Ovariectomized Osteoporotic Mice
inferred← citeshttps://doi.org/10.1002/jez.1871openalex-snapshotG‐protein coupled estrogen receptor, estrogen receptor α, and progesterone receptor immunohistochemistry in the hypothalamus of aging female rhesus macaques given long‐term estradiol treatment
inferred← citeshttps://doi.org/10.1002/jez.70011openalex-snapshotPopulation Variation in Steroid Hormone‐Related Gene Expression and Sexually Dimorphic Communication in the Electric Fish Apteronotus albifrons
inferred← citeshttps://doi.org/10.1002/prp2.995openalex-snapshotCorrelation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist
inferred← citeshttps://doi.org/10.1002/ptr.8417openalex-snapshotExploring the Complex Mechanisms of Isoflavones: From Cell Bioavailability, to Cell Dynamics and Breast Cancer
inferred← citeshttps://doi.org/10.1007/bf03401288openalex-snapshotThe estrogen receptor: two or more molecules, multiple variants, diverse localizations, signaling and functions. Are we undergoing a paradigm-shift as regards their significance in breast cancer?
inferred← citeshttps://doi.org/10.1007/s00204-015-1615-5openalex-snapshotG protein-coupled receptor 30 ligand G-1 increases aryl hydrocarbon receptor signalling by inhibition of tubulin assembly and cell cycle arrest in human MCF-7 cells
inferred← citeshttps://doi.org/10.1007/s11064-017-2237-5openalex-snapshotOxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells
inferred← citeshttps://doi.org/10.1016/j.cbd.2018.04.001openalex-snapshotDe novo transcriptome analysis and differentially expressed genes in the ovary and testis of the Japanese mantis shrimp Oratosquilla oratoria by RNA-Seq
inferred← citeshttps://doi.org/10.1016/j.cbi.2024.111065openalex-snapshotG protein-coupled estrogen receptor selective agonist, G1, improves the molecular and biochemical markers in a cisplatin mouse model of CKD
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2015.12.083openalex-snapshotRegulation of vitellogenin (vtg1) and estrogen receptor (er) gene expression in zebrafish (Danio rerio) following the administration of Cd2+ and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
inferred← citeshttps://doi.org/10.1016/j.domaniend.2012.08.002openalex-snapshotRole of estrogen receptor-α (ESR1) and the type 1 insulin-like growth factor receptor (IGFR1) in estradiol-stimulated proliferation of cultured bovine satellite cells
inferred← citeshttps://doi.org/10.1016/j.domaniend.2015.05.003openalex-snapshotPlacental development during early pregnancy in sheep: estrogen and progesterone receptor messenger RNA expression in pregnancies derived from in vivo–produced and in vitro–produced embryos
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2021.111945openalex-snapshotThe influence of phenolic environmental estrogen on the transcriptome of uterine leiomyoma cells: A whole transcriptome profiling-based analysis
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.113387openalex-snapshotThe adverse outcome pathway (AOP) of estrogen interference effect induced by triphenyl phosphate (TPP): Integrated multi-omics and molecular dynamics approaches
inferred← citeshttps://doi.org/10.1016/j.fct.2024.115079openalex-snapshotG protein-coupled estrogen receptor activation attenuates cisplatin-induced CKD in C57BL/6 mice: An insight into sex-related differences
inferred← citeshttps://doi.org/10.1016/j.jmb.2021.166843openalex-snapshotFormation of Kiss1R/GPER Heterocomplexes Negatively Regulates Kiss1R-mediated Signalling through Limiting Receptor Cell Surface Expression
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2015.07.018openalex-snapshotStructural and functional characterization of aromatase, estrogen receptor, and their genes in endocrine-responsive and –resistant breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2016.06.011openalex-snapshotTreatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2017.05.005openalex-snapshotA role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2024.106540openalex-snapshot17β-estradiol promotes myeloid-derived suppressor cells functions and alleviates inflammatory bowel disease by activation of Stat3 and NF-κB signalings
inferred← citeshttps://doi.org/10.1016/j.mce.2013.05.023openalex-snapshotThe nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs)
inferred← citeshttps://doi.org/10.1016/j.mce.2013.11.005openalex-snapshotAnatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone
inferred← citeshttps://doi.org/10.1016/j.mce.2019.110537openalex-snapshotAldosterone, STX and amyloid-β1-42 peptides modulate GPER (GPR30) signalling in an embryonic mouse hippocampal cell line (mHippoE-18)
inferred← citeshttps://doi.org/10.1016/j.neo.2018.08.010openalex-snapshotEstrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression
inferred← citeshttps://doi.org/10.1016/j.psyneuen.2015.03.020openalex-snapshotObject recognition memory deficit and depressive-like behavior caused by chronic ovariectomy can be transitorialy recovered by the acute activation of hippocampal estrogen receptors
inferred← citeshttps://doi.org/10.1016/j.theriogenology.2016.02.019openalex-snapshotAre aryl hydrocarbon receptor and G-protein–coupled receptor 30 involved in the regulation of seasonal testis activity in photosensitive rodent—the bank vole (Myodes glareolus)?
inferred← citeshttps://doi.org/10.1016/j.yhbeh.2024.105576openalex-snapshotSpecies Variation in Steroid Hormone-Related Gene Expression Contributes to Species Diversity in Sexually Dimorphic Communication in Electric Fishes
inferred← citeshttps://doi.org/10.1021/acs.joc.3c00331openalex-snapshotDivergent Synthesis of Highly Substituted Tetrahydroquinolines and Cyclopentenes via Lewis Base Catalyzed Switchable [4 + 2] and [3 + 2] Annulations of MBH-Carbonates with Activated Olefins
inferred← citeshttps://doi.org/10.1038/onc.2016.370openalex-snapshotCytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance
inferred← citeshttps://doi.org/10.1038/s41598-017-10135-1openalex-snapshotA single neonatal administration of Bisphenol A induces higher tumour weight associated to changes in tumour microenvironment in the adulthood
inferred← citeshttps://doi.org/10.1039/c7tx00184copenalex-snapshotModulation of estrogen synthesis and metabolism by phytoestrogensin vitroand the implications for women's health
inferred← citeshttps://doi.org/10.1042/bj20150744openalex-snapshotThe sequence Pro295–Thr311 of the hinge region of oestrogen receptor α is involved in ERK1/2 activation via GPR30 in leiomyoma cells
inferred← citeshttps://doi.org/10.1042/bsr20160134openalex-snapshotG-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice
inferred← citeshttps://doi.org/10.1073/pnas.1807765115openalex-snapshotShift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model
inferred← citeshttps://doi.org/10.1074/jbc.m115.641167openalex-snapshotDehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells
inferred← citeshttps://doi.org/10.1074/jbc.m115.697334openalex-snapshotEstrogen Enhances Linkage in the Vascular Endothelial Calmodulin Network via a Feedforward Mechanism at the G Protein-coupled Estrogen Receptor 1
inferred← citeshttps://doi.org/10.1089/gg.2017.0014openalex-snapshotEstrogen Stimulation Differentially Impacts Human Male and Female Antigen-Specific T Cell Anti-Tumor Function and Polyfunctionality
inferred← citeshttps://doi.org/10.1093/biolre/ioy227openalex-snapshotDifferential involvement of the three nuclear estrogen receptors during oogenesis in European sea bass (Dicentrarchus labrax)†
inferred← citeshttps://doi.org/10.1093/carcin/bgv041openalex-snapshot17β-estradiol inhibits spreading of metastatic cells from granulosa cell tumors through a non-genomic mechanism involving GPER1
inferred← citeshttps://doi.org/10.1093/cz/zoag034openalex-snapshotHigh-quality genome assemblies reveal intra-chromosomal rearrangements and molecular signatures of adaptation in vespertilionid bats
inferred← citeshttps://doi.org/10.1093/jnen/nlad061openalex-snapshotThe GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
inferred← citeshttps://doi.org/10.1093/toxsci/kfw152openalex-snapshotEditor’s Highlight: Development of anIn vitroAssay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment
inferred← citeshttps://doi.org/10.1095/biolreprod.114.125674openalex-snapshotThe Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes1
inferred← citeshttps://doi.org/10.1095/biolreprod.115.132316openalex-snapshotBisphenol A and Related Alkylphenols Exert Nongenomic Estrogenic Actions Through a G Protein-Coupled Estrogen Receptor 1 (Gper)/Epidermal Growth Factor Receptor (Egfr) Pathway to Inhibit Meiotic Maturation of Zebrafish Oocytes1
inferred← citeshttps://doi.org/10.1097/igc.0b013e31827912b8openalex-snapshotThe G Protein-Coupled Receptor GPR30 Mediates the Nontranscriptional Effect of Estrogen on the Activation of PI3K/Akt Pathway in Endometrial Cancer Cells
inferred← citeshttps://doi.org/10.1111/asj.12868openalex-snapshotThe membrane‐type estrogen receptor G‐protein‐coupled estrogen receptor suppresses lipopolysaccharide‐induced interleukin 6 via inhibition of nuclear factor‐kappa B pathway in murine macrophage cells
inferred← citeshttps://doi.org/10.1111/jnc.13066openalex-snapshotG protein‐coupled estrogen receptor‐mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells
inferred← citeshttps://doi.org/10.1124/pr.114.009712openalex-snapshotInternational Union of Basic and Clinical Pharmacology. XCVII. G Protein–Coupled Estrogen Receptor and Its Pharmacologic Modulators
inferred← citeshttps://doi.org/10.1152/ajpregu.00267.2020openalex-snapshotActivation of G protein-coupled estrogen receptor 1 ameliorates proximal tubular injury and proteinuria in Dahl salt-sensitive female rats
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