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Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

https://doi.org/10.1259/bjr.20130676
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer
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Tumor hypoxia in pelvic recurrences of cervical cancer
inferredcites →https://doi.org/10.1002/1097-0142(20001101)89:9<2018::aid-cncr19>3.0.co;2-yopenalex-snapshot
Increasing levels of hypoxia in prostate carcinoma correlate significantly with increasing clinical stage and patient age
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The role of radiotherapy in cancer treatment
inferredcites →https://doi.org/10.1002/ijc.23418openalex-snapshot
Hypoxia selects for androgen independent LNCaP cells with a more malignant geno‐ and phenotype
inferredcites →https://doi.org/10.1002/ijc.27796openalex-snapshot
Androgen deprivation results in time‐dependent hypoxia in LNCaP prostate tumours: Informed scheduling of the bioreductive drug AQ4N improves treatment response
inferredcites →https://doi.org/10.1002/iub.93openalex-snapshot
Hypoxia‐inducible factor 1 and cancer pathogenesis
inferredcites →https://doi.org/10.1002/jcb.22956openalex-snapshot
Hypoxia‐mediated biological control
inferredcites →https://doi.org/10.1002/jcp.21690openalex-snapshot
Hypoxia or in situ normoxia: The stem cell paradigm
inferredcites →https://doi.org/10.1007/bf00689633openalex-snapshot
Hypoxia and drug resistance
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Oxygenation Status of Gynecologic Tumors: What is the Optimal Hemoglobin Level?
inferredcites →https://doi.org/10.1007/s00066-012-0085-4openalex-snapshot
Acute versus chronic hypoxia in tumors
inferredcites →https://doi.org/10.1007/s00384-008-0497-xopenalex-snapshot
The role of hypoxia in recurrence following resection of Dukes’ B colorectal cancer
inferredcites →https://doi.org/10.1007/s00432-012-1310-3openalex-snapshot
A tumor hypoxic niche protects human colon cancer stem cells from chemotherapy
inferredcites →https://doi.org/10.1007/s004320000215openalex-snapshot
Recombinant human erythropoietin increases the radiosensitivity of xenografted human tumours in anaemic nude mice
inferredcites →https://doi.org/10.1007/s10555-007-9063-1openalex-snapshot
Hypoxia, gene expression, and metastasis
inferredcites →https://doi.org/10.1016/0167-8140(91)90195-mopenalex-snapshot
Drug induced perturbations in tumor blood flow: therapeutic potential and possible limitations
inferredcites →https://doi.org/10.1016/0360-3016(92)90840-eopenalex-snapshot
Measurement of oxygen diffusion distance in tumor cubes using a fluorescent hypoxia probe
inferredcites →https://doi.org/10.1016/j.canlet.2011.09.023openalex-snapshot
Hypoxia, stem cells and bone tumor
inferredcites →https://doi.org/10.1016/j.canlet.2012.11.019openalex-snapshot
Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia
inferredcites →https://doi.org/10.1016/j.ccr.2009.01.021openalex-snapshot
Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
inferredcites →https://doi.org/10.1016/j.ccr.2009.01.027openalex-snapshot
Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis
inferredcites →https://doi.org/10.1016/j.ccr.2012.11.010openalex-snapshot
The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man
inferredcites →https://doi.org/10.1016/j.ceb.2012.01.005openalex-snapshot
From stem cells to cancer stem cells: HIF takes the stage
inferredcites →https://doi.org/10.1016/j.clon.2007.03.006openalex-snapshot
Bioreductive Drugs: from Concept to Clinic
inferredcites →https://doi.org/10.1016/j.ctrv.2008.01.001openalex-snapshot
Hyperbaric oxygenation for tumour sensitisation to radiotherapy: A systematic review of randomised controlled trials
inferredcites →https://doi.org/10.1016/j.ctrv.2011.02.002openalex-snapshot
Novel angiogenesis inhibitors: Addressing the issue of redundancy in the angiogenic signaling pathway
inferredcites →https://doi.org/10.1016/j.ijrobp.2005.04.049openalex-snapshot
Anemia, tumor hypoxemia, and the cancer patient
inferredcites →https://doi.org/10.1016/j.ijrobp.2007.04.063openalex-snapshot
Radiotherapy With or Without Erythropoietin for Anemic Patients With Head and Neck Cancer: A Randomized Trial of the Radiation Therapy Oncology Group (RTOG 99-03)
inferredcites →https://doi.org/10.1016/j.ijrobp.2008.06.1950openalex-snapshot
Accelerated Radiotherapy, Carbogen, and Nicotinamide (ARCON) in the Treatment of Advanced Bladder Cancer: Mature Results of a Phase II Nonrandomized Study
inferredcites →https://doi.org/10.1016/j.ijrobp.2011.05.037openalex-snapshot
Hypoxic Prostate/Muscle Po2 Ratio Predicts for Outcome in Patients With Localized Prostate Cancer: Long-Term Results
inferredcites →https://doi.org/10.1016/j.molmed.2012.08.001openalex-snapshot
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
inferredcites →https://doi.org/10.1016/j.semcancer.2010.06.004openalex-snapshot
Tumour-microenvironmental interactions: paths to progression and targets for treatment
inferredcites →https://doi.org/10.1016/j.stem.2009.08.009openalex-snapshot
PO2 Matters in Stem Cell Culture
inferredcites →https://doi.org/10.1016/s0076-6879(04)81023-1openalex-snapshot
Tumor Hypoxia and Malignant Progression
inferredcites →https://doi.org/10.1016/s0090-4295(02)01858-7openalex-snapshot
Hypoxic prostate/muscle po2 ratio predicts for biochemical failure in patients with prostate cancer: preliminary findings
inferredcites →https://doi.org/10.1016/s0090-4295(98)00500-7openalex-snapshot
Hypoxic regions exist in human prostate carcinoma
inferredcites →https://doi.org/10.1016/s0140-6736(03)14567-9openalex-snapshot
Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial
inferredcites →https://doi.org/10.1016/s0360-3016(00)00803-8openalex-snapshot
Pancreatic tumors show high levels of hypoxia
inferredcites →https://doi.org/10.1016/s0360-3016(02)04503-0openalex-snapshot
Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients
inferredcites →https://doi.org/10.1016/s0360-3016(03)01621-3openalex-snapshot
Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer
inferredcites →https://doi.org/10.1016/s0360-3016(98)00182-5openalex-snapshot
Oxygenation of squamous cell carcinoma of the head and neck: comparison of primary tumors, neck node metastases, and normal tissue
inferredcites →https://doi.org/10.1016/s1470-2045(02)00929-4openalex-snapshot
ARCON: a novel biology-based approach in radiotherapy
inferredcites →https://doi.org/10.1016/s1470-2045(05)70292-8openalex-snapshot
Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial
inferredcites →https://doi.org/10.1023/a:1022939318102openalex-snapshot
The hypoxic tumour microenvironment and metastatic progression
inferredcites →https://doi.org/10.1023/b:canc.0000031768.89246.d7openalex-snapshot
Hypoxic gene expression and metastasis
inferredcites →https://doi.org/10.1038/379088a0openalex-snapshot
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
inferredcites →https://doi.org/10.1038/bjc.1955.55openalex-snapshot
The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
inferredcites →https://doi.org/10.1038/bjc.1992.386openalex-snapshot
The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography
inferredcites →https://doi.org/10.1038/bjc.1993.417openalex-snapshot
The effect of recombinant human erythropoietin treatment on tumour radiosensitivity and cancer-associated anaemia in the mouse
inferredcites →https://doi.org/10.1038/cdd.2008.21openalex-snapshot
The role of hypoxia-inducible factors in tumorigenesis
inferredcites →https://doi.org/10.1038/nature04695openalex-snapshot
Lysyl oxidase is essential for hypoxia-induced metastasis
inferredcites →https://doi.org/10.1038/nature10144openalex-snapshot
Molecular mechanisms and clinical applications of angiogenesis
inferredcites →https://doi.org/10.1038/ncomms1786openalex-snapshot
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
inferredcites →https://doi.org/10.1038/nrc1367openalex-snapshot
Exploiting tumour hypoxia in cancer treatment
inferredcites →https://doi.org/10.1038/nrc2344openalex-snapshot
Hypoxia, DNA repair and genetic instability
inferredcites →https://doi.org/10.1038/nrc2442openalex-snapshot
Modes of resistance to anti-angiogenic therapy
inferredcites →https://doi.org/10.1038/nrc2468openalex-snapshot
Hypoxia, HIF1 and glucose metabolism in the solid tumour
inferredcites →https://doi.org/10.1038/nrc2501openalex-snapshot
Hypoxia signalling through mTOR and the unfolded protein response in cancer
inferredcites →https://doi.org/10.1038/nrc3064openalex-snapshot
Targeting hypoxia in cancer therapy
inferredcites →https://doi.org/10.1038/nrc3298openalex-snapshot
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
inferredcites →https://doi.org/10.1038/nrc704openalex-snapshot
Hypoxia — a key regulatory factor in tumour growth
inferredcites →https://doi.org/10.1038/nrclinonc.2012.171openalex-snapshot
Imaging hypoxia to improve radiotherapy outcome
inferredcites →https://doi.org/10.1038/sj.bjc.6604804openalex-snapshot
Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer
inferredcites →https://doi.org/10.1038/sj.onc.1209128openalex-snapshot
Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors
inferredcites →https://doi.org/10.1073/pnas.85.24.9533openalex-snapshot
Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells.
inferredcites →https://doi.org/10.1073/pnas.91.6.2081openalex-snapshot
Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.
inferredcites →https://doi.org/10.1080/028418601750071163openalex-snapshot
Polarographic pO2Measurements of Intra-abdominal Adenocarcinoma in Connection with Intraoperative Radiotherapy Before and After Change of Oxygen Concentration of Anaesthetic Gases
inferredcites →https://doi.org/10.1080/095530000138259openalex-snapshot
Microenvironment-induced cancer metastasis
inferredcites →https://doi.org/10.1080/09553000601002324openalex-snapshot
Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
inferredcites →https://doi.org/10.1089/ars.2007.1628openalex-snapshot
Detection and Characterization of Tumor Hypoxia Using pO 2 Histography
inferredcites →https://doi.org/10.1089/ham.2012.1043openalex-snapshot
Hypoxia-Mediated Regulation of Stem Cell Fate
inferredcites →https://doi.org/10.1093/jnci/82.5.371openalex-snapshot
Effects of Reoxygenation on Cells From Hypoxic Regions of Solid Tumors: Anticancer Drug Sensitivity and Metastatic Potential
inferredcites →https://doi.org/10.1093/jnci/93.4.266openalex-snapshot
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
inferredcites →https://doi.org/10.1093/jnci/djm135openalex-snapshot
Drug Resistance and the Solid Tumor Microenvironment
inferredcites →https://doi.org/10.1096/fj.04-1918fjeopenalex-snapshot
Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways
inferredcites →https://doi.org/10.1097/00000421-200110000-00009openalex-snapshot
Hypoxia in Human Prostate Carcinoma
inferredcites →https://doi.org/10.1097/00003072-199501000-00029openalex-snapshot
Radiobiology for the Radiologist
inferredcites →https://doi.org/10.1097/00008390-199710000-00006openalex-snapshot
Intratumoral oxygen tension in metastatic melanoma
inferredcites →https://doi.org/10.1101/cshperspect.a006486openalex-snapshot
Vascular Normalization as a Therapeutic Strategy for Malignant and Nonmalignant Disease
inferredcites →https://doi.org/10.1111/j.1447-0756.2010.01377.xopenalex-snapshot
Tumor hypoxia and genetic alterations in sporadic cancers
inferredcites →https://doi.org/10.1111/j.1464-410x.2005.05681.xopenalex-snapshot
Assessing regional hypoxia in human renal tumours using 18 F‐fluoromisonidazole positron emission tomography
inferredcites →https://doi.org/10.1111/j.1537-2995.2012.03774.xopenalex-snapshot
Oxygen: the poison is in the dose
inferredcites →https://doi.org/10.1111/j.1582-4934.2011.01258.xopenalex-snapshot
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
inferredcites →https://doi.org/10.1126/science.123.3191.309openalex-snapshot
On the Origin of Cancer Cells
inferredcites →https://doi.org/10.1136/bmj.317.7169.1370openalex-snapshot
Oxygen transport2. Tissue hypoxia
inferredcites →https://doi.org/10.1152/ajpcell.1996.271.4.c1172openalex-snapshot
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
inferredcites →https://doi.org/10.1152/ajplung.2001.281.4.l1021openalex-snapshot
Limitations to oxygen diffusion and equilibration in in vitro cell exposure systems in hyperoxia and hypoxia
inferredcites →https://doi.org/10.1155/2010/132641openalex-snapshot
Tumor Angiogenesis: Insights and Innovations
inferredcites →https://doi.org/10.1158/0008-5472.can-03-2958openalex-snapshot
Direct Demonstration of Instabilities in Oxygen Concentrations within the Extravascular Compartment of an Experimental Tumor
inferredcites →https://doi.org/10.1158/0008-5472.can-03-3038openalex-snapshot
Hypoxia Enhances Metastatic Efficiency by Up-Regulating Mdm2 in KHT Cells and Increasing Resistance to Apoptosis
inferredcites →https://doi.org/10.1158/0008-5472.can-03-3196openalex-snapshot
Acute Hypoxia Enhances Spontaneous Lymph Node Metastasis in an Orthotopic Murine Model of Human Cervical Carcinoma
inferredcites →https://doi.org/10.1158/0008-5472.can-04-3395openalex-snapshot
Anoxia Is Necessary for Tumor Cell Toxicity Caused by a Low-Oxygen Environment
inferredcites →https://doi.org/10.1158/0008-5472.can-06-4221openalex-snapshot
Hypoxia Enhances Metastatic Efficiency in HT1080 Fibrosarcoma Cells by Increasing Cell Survival in Lungs, Not Cell Adhesion and Invasion
inferredcites →https://doi.org/10.1158/0008-5472.can-10-4049openalex-snapshot
Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-2049openalex-snapshot
An Evaluation of Tumor Oxygenation and Gene Expression in Patients with Early Stage Non–Small Cell Lung Cancers
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-1285openalex-snapshot
Expression of Erythropoietin and Erythropoietin Receptor in Cervical Cancer and Relationship to Survival, Hypoxia, and Apoptosis
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-1439openalex-snapshot
Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-3425openalex-snapshot
Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of TH-302, a Hypoxia-Activated Prodrug, in Patients with Advanced Solid Malignancies
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-2094openalex-snapshot
Prognostic and Predictive Significance of Plasma HGF and IL-8 in a Phase III Trial of Chemoradiation with or without Tirapazamine in Locoregionally Advanced Head and Neck Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-2711openalex-snapshot
Tumor Hypoxia Predicts Biochemical Failure following Radiotherapy for Clinically Localized Prostate Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-3114openalex-snapshot
The Pancreas Cancer Microenvironment
inferredcites →https://doi.org/10.1172/jci67230openalex-snapshot
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
inferredcites →https://doi.org/10.1186/1423-0127-19-102openalex-snapshot
Hypoxia-regulated target genes implicated in tumor metastasis
inferredcites →https://doi.org/10.1186/1471-2407-11-432openalex-snapshot
A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients
inferredcites →https://doi.org/10.1186/1471-2407-11-504openalex-snapshot
Targeting hypoxic tumour cells to overcome metastasis
inferredcites →https://doi.org/10.1186/1471-2407-12-496openalex-snapshot
PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours
inferredcites →https://doi.org/10.1200/jco.2005.01.3771openalex-snapshot
Phase III Trial of Paclitaxel Plus Carboplatin With or Without Tirapazamine in Advanced Non–Small-Cell Lung Cancer: Southwest Oncology Group Trial S0003
inferredcites →https://doi.org/10.1200/jco.2007.12.7878openalex-snapshot
Hypoxic Radiosensitization: Adored and Ignored
inferredcites →https://doi.org/10.1200/jco.2009.27.4449openalex-snapshot
Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group
inferredcites →https://doi.org/10.1200/jco.2011.35.9315openalex-snapshot
Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial
inferredcites →https://doi.org/10.1259/0007-1285-26-312-638openalex-snapshot
The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy
inferredcites →https://doi.org/10.1634/theoncologist.13-s3-21openalex-snapshot
Hypoxia and Aggressive Tumor Phenotype: Implications for Therapy and Prognosis
inferredcites →https://doi.org/10.1667/rr1926.1openalex-snapshot
Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress
inferredcites →https://doi.org/10.3109/02841869409098433openalex-snapshot
Measurement of Human Tumour Oxygenation Status by a Polarographic Needle Electrode: An analysis of inter- and intratumour heterogeneity
inferredcites →https://doi.org/10.3389/fphar.2012.00094openalex-snapshot
Targeting Tumor Perfusion and Oxygenation to Improve the Outcome of Anticancer Therapy1
inferredcites →https://doi.org/10.4161/cbt.11.8.15274openalex-snapshot
EMT: A new vision of hypoxia promoting cancer progression
inferredcites →https://doi.org/10.4161/cc.8.20.9741openalex-snapshot
Hypoxia, angiogenesis and cancer therapy: To breathe or not to breathe?
inferredcites →https://doi.org/10.5732/cjc.012.10285openalex-snapshot
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia
inferredcites →https://doi.org/10.7326/0003-4819-80-3-438_1openalex-snapshot
Radiobiology for the Radiologist.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/cac2.70018openalex-snapshot
Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells
inferred← citeshttps://doi.org/10.1002/cam4.6717openalex-snapshot
The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review
inferred← citeshttps://doi.org/10.1002/cbic.70560openalex-snapshot
Mechanistic Analysis of Albumin–Ruthenium Conjugates Reveals Redox‐Sensitive Catalytic Persistence for Extracellular Prodrug Uncaging
inferred← citeshttps://doi.org/10.1002/chem.202001505openalex-snapshot
Partially Fluorinated Copolymers as Oxygen Sensitive 19F MRI Agents
inferred← citeshttps://doi.org/10.1002/chem.202300511openalex-snapshot
A Cyclodextrin Polymer as Supramolecular Matrix for Scalable Green Photooxygenation of Hydrophobic Substrates in Homogeneous Phase
inferred← citeshttps://doi.org/10.1002/chem.71136openalex-snapshot
Cyclen Tetra‐Amide Ligands as a Privileged Class of Ligands for Studying Second‐Sphere Coordination Environments
inferred← citeshttps://doi.org/10.1002/cnr2.1384openalex-snapshot
A NIR fluorescent smart probe for imaging tumor hypoxia
inferred← citeshttps://doi.org/10.1002/cnr2.1795openalex-snapshot
Metabolomics in oncology
inferred← citeshttps://doi.org/10.1002/cso2.1040openalex-snapshot
Modelling the role of HIF in the regulation of metabolic key genes LDH and PDH: Emergence of Warburg Phenotype
inferred← citeshttps://doi.org/10.1002/eji.70274openalex-snapshot
SHIP1 Restrains Hypoxia/Reoxygenation‐Induced Cytokine Secretion in Mouse Bone Marrow–Derived Mast Cells
inferred← citeshttps://doi.org/10.1002/ejic.202500540openalex-snapshot
The Chemistry of Deception: Exploiting Tumor Hypoxia With Cobalt Prodrugs
inferred← citeshttps://doi.org/10.1002/exp2.70209openalex-snapshot
Zero‐Valent Ruthenium‐Anchored Nanozymes Remodel Tumor Microenvironment for Malignant Tumor Treatment in Combination With αPD‐L1 Immunotherapy
inferred← citeshttps://doi.org/10.1002/hlca.201800134openalex-snapshot
Hydrogen as a Bio‐Orthogonal Trigger for Spatiotemporally Controlled Caged Prodrug Activation
inferred← citeshttps://doi.org/10.1002/ijc.33863openalex-snapshot
Effect and mechanism of circRNAs in tumor angiogenesis and clinical application
inferred← citeshttps://doi.org/10.1002/ijc.70340openalex-snapshot
Th17 cells favor migration and invasiveness of cervical cancer cells under hypoxia in an IGF2BP2 ‐dependent manner
inferred← citeshttps://doi.org/10.1002/iub.2275openalex-snapshot
How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?
inferred← citeshttps://doi.org/10.1002/iub.2619openalex-snapshot
Targeting DNA topoisomerase IIα ( TOP2A ) in the hypoxic tumour microenvironment using unidirectional hypoxia‐activated prodrugs ( uHAPs )
inferred← citeshttps://doi.org/10.1002/jbio.201800378openalex-snapshot
Widefield fluorescence lifetime imaging of protoporphyrin IX for fluorescence‐guided neurosurgery: An ex vivo feasibility study
inferred← citeshttps://doi.org/10.1002/jbm.a.37882openalex-snapshot
Amniotic Membrane‐Derived Extracellular Matrix for Developing a Cost‐Effective Xenofree Hepatocellular Carcinoma Organoid Model
inferred← citeshttps://doi.org/10.1002/jbm4.10125openalex-snapshot
Tumor Cell Dormancy and Reactivation in Bone: Skeletal Biology and Therapeutic Opportunities
inferred← citeshttps://doi.org/10.1002/jcp.27399openalex-snapshot
Colorectal cancer invasiveness in vitro: Predominant contribution of neonatal Nav1.5 under normoxia and hypoxia
inferred← citeshttps://doi.org/10.1002/jcp.29548openalex-snapshot
miR‐210 is induced by hypoxia and regulates neural cell adhesion molecule in prostate cells
inferred← citeshttps://doi.org/10.1002/jex2.115openalex-snapshot
Cell culture‐derived extracellular vesicles: Considerations for reporting cell culturing parameters
inferred← citeshttps://doi.org/10.1002/jmv.29280openalex-snapshot
The impact of cycling hypoxia on the phenotype of HPV‐positive cervical cancer cells
inferred← citeshttps://doi.org/10.1002/mabi.202400181openalex-snapshot
The Effect of Co‐Delivery of Oxygen and Anticancer Drugs on the Viability of Healthy and Cancer Cells under Normoxic and Hypoxic Conditions
inferred← citeshttps://doi.org/10.1002/mds3.10064openalex-snapshot
Portable, low‐cost hypoxia chamber for simulating hypoxic environments: Development, characterization and applications
inferred← citeshttps://doi.org/10.1002/mds3.10149openalex-snapshot
Biodegradable oxygen biosensors via electrospinning
inferred← citeshttps://doi.org/10.1002/mp.13514openalex-snapshot
Impact of SBRT fractionation in hypoxia dose painting — Accounting for heterogeneous and dynamic tumor oxygenation
inferred← citeshttps://doi.org/10.1002/mp.15129openalex-snapshot
Model studies of the role of oxygen in the FLASH effect
inferred← citeshttps://doi.org/10.1002/mp.17999openalex-snapshot
Experimental investigation of oxygen diffusion in the peak and valley region of minibeam patterns during x‐ray irradiation
inferred← citeshttps://doi.org/10.1002/mp.70176openalex-snapshot
Combining IMPT and spot‐scanning hadron arc to efficiently boost dose and LET in hypoxic target volumes
inferred← citeshttps://doi.org/10.1002/mp.70576openalex-snapshot
TOPAS‐nBio simulation of the impact of ultrahigh dose rate and oxygen concentration on the Fenton reaction using the Fricke solution
inferred← citeshttps://doi.org/10.1002/mrm.29811openalex-snapshot
Evaluation of a deuterated triarylmethyl spin probe for in vivo R 2 ∗ ‐based EPR oximetric imaging with enhanced dynamic range
inferred← citeshttps://doi.org/10.1002/pol.20250859openalex-snapshot
Intracellular Oxygen Sensors Based on Block Copolymer Micelles Loaded With Phosphorescent Ir( III ) and Pt( II ) Complexes
inferred← citeshttps://doi.org/10.1002/pros.23434openalex-snapshot
The unidirectional hypoxia‐activated prodrug OCT1002 inhibits growth and vascular development in castrate‐resistant prostate tumors
inferred← citeshttps://doi.org/10.1002/ptr.7716openalex-snapshot
Combinatorial treatment with Silybum marianum essential oil enhances the therapeutic efficacy of a 5‐fluorouracil base therapy for hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1002/rcm.9878openalex-snapshot
Understanding natural isotopic variations in cultured cancer cells
inferred← citeshttps://doi.org/10.1002/slct.202405699openalex-snapshot
The Effect of Co‐Delivery of Oxygen and Antibacterial Drug Gentamicin From Alginate‐Based Nanocomposite Hydrogels on Bacterial Apoptosis and Cell Viability
inferred← citeshttps://doi.org/10.1002/slct.202501699openalex-snapshot
Encapsulation of Eleclazine Into Chitosan‐Based Nanocarriers and Functional Effects on MDA‐MB‐231 Human Breast Cancer Cells
inferred← citeshttps://doi.org/10.1002/smll.202006091openalex-snapshot
Study 3D Endothelial Cell Network Formation under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside‐Down Microfluidic Devices
inferred← citeshttps://doi.org/10.1002/smll.202307955openalex-snapshot
[Ru(dpp) 3 ]Cl 2 ‐Embedded Oxygen Nano Polymeric Sensors: A Promising Tool for Monitoring Intracellular and Intratumoral Oxygen Gradients with High Quantum Yield and Long Lifetime
inferred← citeshttps://doi.org/10.1002/smll.202505343openalex-snapshot
Novel Diffuse Midline Glioma‐on‐Chip Recapitulating Tumor Biophysical Microenvironment to Assess the Heterogeneity of Response to Therapies
inferred← citeshttps://doi.org/10.1002/stem.2763openalex-snapshot
Human Mesenchymal Stem Cell Failure to Adapt to Glucose Shortage and Rapidly Use Intracellular Energy Reserves Through Glycolysis Explains Poor Cell Survival After Implantation
inferred← citeshttps://doi.org/10.1002/wnan.1937openalex-snapshot
Nanotechnology‐mediated photodynamic therapy: Focus on overcoming tumor hypoxia
inferred← citeshttps://doi.org/10.1007/16833_2024_299openalex-snapshot
Current Overview of the Biological Effects of GRID, Microbeam, and FLASH Radiotherapy
inferred← citeshttps://doi.org/10.1007/978-1-0716-2099-1_1openalex-snapshot
Application of Monolayer Cell Cultures for Investigating Basic Mechanisms of Photodynamic Therapy
inferred← citeshttps://doi.org/10.1007/978-1-0716-3044-0_2openalex-snapshot
Complexity of Abiotic Stress Stimuli: Mimicking Hypoxic Conditions Experimentally on the Basis of Naturally Occurring Environments
inferred← citeshttps://doi.org/10.1007/978-1-0716-4264-1_9openalex-snapshot
Creating Physiological Cell Environments In Vitro: Adjusting Cell Culture Media Composition and Oxygen Levels to Investigate Mitochondrial Function and Cancer Metabolism
inferred← citeshttps://doi.org/10.1007/978-1-4939-7659-1_9openalex-snapshot
Induction and Assessment of Hypoxia in Glioblastoma Cells In Vitro
inferred← citeshttps://doi.org/10.1007/978-1-4939-9463-2_10openalex-snapshot
Working with Hypoxia
inferred← citeshttps://doi.org/10.1007/978-3-030-37184-5_4openalex-snapshot
Hepatic Stellate Cells in Liver Tumor
inferred← citeshttps://doi.org/10.1007/978-3-030-53786-9_16openalex-snapshot
Cancer Cell Metabolism in Pancreatic Ductal Adenocarcinoma
inferred← citeshttps://doi.org/10.1007/978-3-030-66749-8_1openalex-snapshot
Introduction to 3D Cell Culture
inferred← citeshttps://doi.org/10.1007/978-3-030-80962-1_412-1openalex-snapshot
Tumor Microenvironment-Responsive Nanoplatforms for Triggering Drug Delivery
inferred← citeshttps://doi.org/10.1007/978-3-031-14190-4_43openalex-snapshot
Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy
inferred← citeshttps://doi.org/10.1007/978-3-031-35715-2_4openalex-snapshot
Modelling HIF-PHD Dynamics and Related Downstream Pathways
inferred← citeshttps://doi.org/10.1007/978-3-032-00773-5_412openalex-snapshot
Tumor Microenvironment-Responsive Nanoplatforms for Triggering Drug Delivery
inferred← citeshttps://doi.org/10.1007/978-981-10-4499-1_1openalex-snapshot
Microenvironment Cytometry
inferred← citeshttps://doi.org/10.1007/978-981-10-7296-3_5openalex-snapshot
The Functional Interplay Between Pro-oncogenic RUNX2 and Hypoxia-Inducible Factor-1α (HIF-1α) During Hypoxia-Mediated Tumor Progression
inferred← citeshttps://doi.org/10.1007/978-981-16-4752-9_9openalex-snapshot
Oncology: Biochemists’ Perspective
inferred← citeshttps://doi.org/10.1007/978-981-95-2744-1_3openalex-snapshot
Stimuli-Responsive Polymeric Nanoparticles for Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-981-96-1016-7_7openalex-snapshot
Regulation of Angiogenesis by Cancer Hypoxia and Role of Hypoxia Inducible Factors with Therapeutic Paradigm
inferred← citeshttps://doi.org/10.1007/978-981-97-7022-9_5openalex-snapshot
Combination Therapies for the Management of Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1007/978-981-99-0313-9_16openalex-snapshot
Hypoxia-Targeting Drugs as New Cancer Chemotherapy Agents: Molecular Insights
inferred← citeshttps://doi.org/10.1007/978-981-99-0313-9_2openalex-snapshot
Hypoxia’s Function in Cancer
inferred← citeshttps://doi.org/10.1007/s00018-024-05537-0openalex-snapshot
HIF-1 and HIF-2 in cancer: structure, regulation, and therapeutic prospects
inferred← citeshttps://doi.org/10.1007/s00120-022-01913-5openalex-snapshot
Prostata- und Mammakarzinom: Gemeinsamkeiten und Unterschiede
inferred← citeshttps://doi.org/10.1007/s00262-023-03614-0openalex-snapshot
Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression
inferred← citeshttps://doi.org/10.1007/s00280-017-3473-8openalex-snapshot
The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer
inferred← citeshttps://doi.org/10.1007/s00366-024-01964-6openalex-snapshot
Image-based biomarkers for engineering neuroblastoma patient-specific computational models
inferred← citeshttps://doi.org/10.1007/s00401-024-02831-wopenalex-snapshot
Functional profiling of murine glioma models highlights targetable immune evasion phenotypes
inferred← citeshttps://doi.org/10.1007/s00432-021-03701-8openalex-snapshot
Targeting tumor vascularization: promising strategies for vascular normalization
inferred← citeshttps://doi.org/10.1007/s00464-026-12569-zopenalex-snapshot
Novel physiological analysis using oxygen saturation imaging endoscopy for colorectal polyps: a pilot study (with video)
inferred← citeshttps://doi.org/10.1007/s00535-024-02140-9openalex-snapshot
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia
inferred← citeshttps://doi.org/10.1007/s10334-025-01229-3openalex-snapshot
Comparing repeatability metrics for quantitative susceptibility mapping in the head and neck
inferred← citeshttps://doi.org/10.1007/s10404-025-02797-5openalex-snapshot
Proliferation and weak aerotaxis changes the cancer cell distribution in oxygen gradients at physiological level
inferred← citeshttps://doi.org/10.1007/s10544-022-00615-1openalex-snapshot
A new insight into a thermoplastic microfluidic device aimed at improvement of oxygenation process and avoidance of shear stress during cell culture
inferred← citeshttps://doi.org/10.1007/s10585-018-9930-xopenalex-snapshot
The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies
inferred← citeshttps://doi.org/10.1007/s10585-023-10224-8openalex-snapshot
Travelling under pressure - hypoxia and shear stress in the metastatic journey
inferred← citeshttps://doi.org/10.1007/s10620-025-09117-5openalex-snapshot
Functional Roles and Mechanistic Insights of YEATS Domain Proteins in Digestive System Tumors
inferred← citeshttps://doi.org/10.1007/s10751-026-02400-5openalex-snapshot
Monte Carlo simulations of the depth of maximum muon dose in tumors
inferred← citeshttps://doi.org/10.1007/s11010-022-04549-3openalex-snapshot
Hypoxic regulation of ADAMTS-2 and -3 (a disintegrin and matrix metalloproteinase with thrombospondin motifs 2 and 3) procollagen N proteinases by HIF-1α in endothelial cells
inferred← citeshttps://doi.org/10.1007/s11033-021-06950-5openalex-snapshot
Induction of estrogen receptor β-mediated autophagy sensitizes breast cancer cells to TAD1822-7, a novel biphenyl urea taspine derivative
inferred← citeshttps://doi.org/10.1007/s11538-022-01034-2openalex-snapshot
Combining Mechanisms of Growth Arrest in Solid Tumours: A Mathematical Investigation
inferred← citeshttps://doi.org/10.1007/s11538-024-01359-0openalex-snapshot
Characterising Cancer Cell Responses to Cyclic Hypoxia Using Mathematical Modelling
inferred← citeshttps://doi.org/10.1007/s11538-024-01391-0openalex-snapshot
Modelling the Impact of HIF on Metabolism and the Extracellular Matrix: Consequences for Tumour Growth and Invasion
inferred← citeshttps://doi.org/10.1007/s11538-024-01408-8openalex-snapshot
A Simple Framework for Agent-Based Modeling with Extracellular Matrix
inferred← citeshttps://doi.org/10.1007/s12013-024-01386-7openalex-snapshot
The Importance of Hypoxia-Related to Hemoglobin Concentration in Breast Cancer
inferred← citeshttps://doi.org/10.1007/s12194-025-00921-2openalex-snapshot
Human glioblastoma (U87) cells grown in 3D culture showed a radio-resistance to X-ray and proton radiation
inferred← citeshttps://doi.org/10.1007/s12272-022-01389-zopenalex-snapshot
Crosstalk between angiogenesis and immune regulation in the tumor microenvironment
inferred← citeshttps://doi.org/10.1007/s12602-022-09985-7openalex-snapshot
The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management
inferred← citeshttps://doi.org/10.1007/s12672-023-00836-7openalex-snapshot
Associations between HIFs and tumor immune checkpoints: mechanism and therapy
inferred← citeshttps://doi.org/10.1007/s12672-026-05691-wopenalex-snapshot
A novel hypoxia-related signature for predicting prognosis, immune characteristics, and therapeutic response in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s13105-026-01187-xopenalex-snapshot
Hypoxia-inducible factor-1α: Dual roles in maintaining neuronal homeostasis and neuronal degeneration via regulation of oxidative stress, mitochondrial dynamics, and bioenergetics
inferred← citeshttps://doi.org/10.1007/s13346-024-01673-zopenalex-snapshot
Unravelling the role of tumor microenvironment responsive nanobiomaterials in spatiotemporal controlled drug delivery for lung cancer therapy
inferred← citeshttps://doi.org/10.1007/s13402-020-00510-yopenalex-snapshot
IL-17A and IL-17F orchestrate macrophages to promote lung cancer
inferred← citeshttps://doi.org/10.1007/s13402-021-00625-wopenalex-snapshot
Mild chronic hypoxia-induced HIF-2α interacts with c-MYC through competition with HIF-1α to induce hepatocellular carcinoma cell proliferation
inferred← citeshttps://doi.org/10.1007/s13555-022-00756-4openalex-snapshot
Maternal and Perinatal Risk Factors for Infantile Hemangioma: A Matched Case-Control Study with a Large Sample Size
inferred← citeshttps://doi.org/10.1007/s13770-025-00726-9openalex-snapshot
Physicochemical Modulation Strategies for Mass Production of Extracellular Vesicle
inferred← citeshttps://doi.org/10.1007/s40336-020-00358-0openalex-snapshot
Hypoxia PET imaging beyond 18F-FMISO in patients with high-grade glioma: 18F-FAZA and other hypoxia radiotracers
inferred← citeshttps://doi.org/10.1007/s43152-020-00021-wopenalex-snapshot
Biophysical and Epigenetic Regulation of Cancer Stemness, Invasiveness, and Immune Action
inferred← citeshttps://doi.org/10.1007/s43630-024-00620-8openalex-snapshot
Generation of singlet oxygen inside living cells: correlation between phosphorescence decay lifetime, localization and outcome of photodynamic action
inferred← citeshttps://doi.org/10.1007/s44164-024-00066-3openalex-snapshot
Biological characterization of breast cancer spheroid formed by fast fabrication method
inferred← citeshttps://doi.org/10.1007/s44178-022-00011-yopenalex-snapshot
A mechanistic consideration of oxygen enhancement ratio, oxygen transport and their relevancies for normal tissue sparing under FLASH irradiation
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12450-3openalex-snapshot
Discovery of the Hypoxia-Activated Prodrug SN30000
inferred← citeshttps://doi.org/10.1016/b978-0-12-816388-7.00002-4openalex-snapshot
Role of Reactive Species in Destructions
inferred← citeshttps://doi.org/10.1016/b978-0-12-816388-7.00004-8openalex-snapshot
Disturbances in Energy Supply
inferred← citeshttps://doi.org/10.1016/b978-0-12-816388-7.00009-7openalex-snapshot
Cell and Tissue Destruction in Selected Disorders
inferred← citeshttps://doi.org/10.1016/b978-0-12-816963-6.00011-xopenalex-snapshot
Dendrimer-Based Nanoparticulate Delivery System for Cancer Therapy
inferred← citeshttps://doi.org/10.1016/b978-0-12-818128-7.00027-7openalex-snapshot
Understanding the impact of controlled oxygen delivery to 3D cancer cell culture
inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.00090-6openalex-snapshot
Mitochondria and Tumor Metabolic Flexibility: Mechanisms and Therapeutic Perspectives
inferred← citeshttps://doi.org/10.1016/b978-0-12-822416-8.00001-4openalex-snapshot
Mitochondrial metabolism and carcinogenesis
inferred← citeshttps://doi.org/10.1016/b978-0-12-823144-9.00037-6openalex-snapshot
Photoactive metallodrugs
inferred← citeshttps://doi.org/10.1016/b978-0-323-47674-4.00009-8openalex-snapshot
Cancer Metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-323-98806-3.00007-6openalex-snapshot
Tumor microenvironment in heptocellular carcinoma
inferred← citeshttps://doi.org/10.1016/b978-0-323-98807-0.00021-1openalex-snapshot
Proliferative signaling pathways in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/b978-0-323-99879-6.00008-0openalex-snapshot
Metabolic dysregulation in cancer progression
inferred← citeshttps://doi.org/10.1016/b978-0-443-15280-1.00003-0openalex-snapshot
Emerging role of biosimilars: Focus on Bevacizumab and hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/b978-0-443-33910-3.00005-4openalex-snapshot
Hindrance in immunotherapy resistant glioblastoma
inferred← citeshttps://doi.org/10.1016/b978-0-443-40431-3.00005-0openalex-snapshot
Synergistic nanoparticle-enhanced photodynamic therapy and radiotherapy combination
inferred← citeshttps://doi.org/10.1016/b978-0-443-43884-4.00014-3openalex-snapshot
The role of oxygen availability in embryonic development
inferred← citeshttps://doi.org/10.1016/j.abb.2019.05.025openalex-snapshot
Hypoxia differentially regulates estrogen receptor alpha in 2D and 3D culture formats
inferred← citeshttps://doi.org/10.1016/j.addr.2022.114360openalex-snapshot
Two-dimensional nanomaterials for tumor microenvironment modulation and anticancer therapy
inferred← citeshttps://doi.org/10.1016/j.adro.2023.101437openalex-snapshot
Generality Assessment of a Model Considering Heterogeneous Cancer Cells for Predicting Tumor Control Probability for Stereotactic Body Radiation Therapy Against Non-Small Cell Lung Cancer
inferred← citeshttps://doi.org/10.1016/j.advms.2023.03.003openalex-snapshot
Effect of hypoxia on HIF-1α and NOS3 expressions in CD34+ cells of JAK2V617F-positive myeloproliferative neoplasms
inferred← citeshttps://doi.org/10.1016/j.afos.2022.03.001openalex-snapshot
Role of prolyl hydroxylase domain proteins in bone metabolism
inferred← citeshttps://doi.org/10.1016/j.ajpath.2019.02.017openalex-snapshot
Functional Organotypic Cultures of Prostate Tissues
inferred← citeshttps://doi.org/10.1016/j.amolm.2025.100068openalex-snapshot
The role of Irisin in modulating hypoxia-related disorders: New insights and implications for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.arres.2021.100018openalex-snapshot
The role of circadian and redox rhythms in cancer hypoxia
inferred← citeshttps://doi.org/10.1016/j.aspetd.2026.100029openalex-snapshot
Emerging concepts on one-carbon metabolism as a unique and actionable vulnerability in cancer
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2024.118529openalex-snapshot
Engineering next generation vascularized organoids
inferred← citeshttps://doi.org/10.1016/j.bbadis.2022.166530openalex-snapshot
Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2
inferred← citeshttps://doi.org/10.1016/j.bbadis.2023.166686openalex-snapshot
Charged multivesicular body protein 2B ameliorates biliary injury in the liver from donation after cardiac death rats via autophagy with air-oxygenated normothermic machine perfusion
inferred← citeshttps://doi.org/10.1016/j.bbadis.2025.167677openalex-snapshot
The microenvironment of secondary lymphedema. The key to finding effective treatments?
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2022.194900openalex-snapshot
Histone acetyltransferase 1 (HAT1) acetylates hypoxia-inducible factor 2 alpha (HIF2A) to execute hypoxia response
inferred← citeshttps://doi.org/10.1016/j.bbamem.2018.11.008openalex-snapshot
Interaction of Artepillin C with model membranes: Effects of pH and ionic strength
inferred← citeshttps://doi.org/10.1016/j.bbcan.2021.188553openalex-snapshot
Oxygen gradient and tumor heterogeneity: The chronicle of a toxic relationship
inferred← citeshttps://doi.org/10.1016/j.bbcan.2023.188942openalex-snapshot
Advanced in vitro models for renal cell carcinoma therapy design
inferred← citeshttps://doi.org/10.1016/j.bbcan.2024.189244openalex-snapshot
Hypoxia as a critical player in extracellular vesicles-mediated intercellular communication between tumor cells and their surrounding microenvironment
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189275openalex-snapshot
Extracellular vesicles and the tumour microenvironment
inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.06.017openalex-snapshot
Silencing HIF-1α induces TET2 expression and augments ascorbic acid induced 5-hydroxymethylation of DNA in human metastatic melanoma cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.10.025openalex-snapshot
Identification of a selective inhibitor of human monocarboxylate transporter 4
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.07.043openalex-snapshot
Dynamics of oxygen level-driven regulators in modulating autophagy in colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.154465openalex-snapshot
Tumor microenvironment and its implications for atomic force microscopy-based nanomechanics of cancer cells: a perspective
inferred← citeshttps://doi.org/10.1016/j.bbrep.2025.102284openalex-snapshot
Hypoxia response in glioblastoma cells: effect of trehalose on macropinocytosis, autophagy and cell survival
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2022.05.002openalex-snapshot
Mg-based materials diminish tumor spreading and cancer metastases
inferred← citeshttps://doi.org/10.1016/j.bioelechem.2020.107636openalex-snapshot
To breathe or not to breathe? Hypoxia after pulsed-electric field treatment reduces the effectiveness of electrochemotherapy in vitro
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2019.119400openalex-snapshot
Mechanically and chemically defined hydrogel matrices for patient-derived colorectal tumor organoid culture
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2019.119578openalex-snapshot
Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia
inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.103975openalex-snapshot
A novel multifunctional 2-nitroimidazole-based bioreductive linker and its application in hypoxia-activated prodrugs
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113068openalex-snapshot
Hypoxia, a key factor in the immune microenvironment
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113485openalex-snapshot
Reprogramming of central carbon metabolism in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114504openalex-snapshot
The role of metabolic reprogramming of tumor-associated macrophages in shaping the immunosuppressive tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115533openalex-snapshot
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118946openalex-snapshot
Hypoxia induces alterations in the volatile signature of pleural mesothelioma cells
inferred← citeshttps://doi.org/10.1016/j.bios.2018.07.035openalex-snapshot
Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems
inferred← citeshttps://doi.org/10.1016/j.bmc.2025.118485openalex-snapshot
Exogenous/endogenous stimuli-responsive antitumor prodrugs advance precision chemotherapy
inferred← citeshttps://doi.org/10.1016/j.bmcl.2020.127697openalex-snapshot
Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer
inferred← citeshttps://doi.org/10.1016/j.bmcl.2026.130565openalex-snapshot
Radiolabeled probes for tumor hypoxia imaging
inferred← citeshttps://doi.org/10.1016/j.bpj.2026.04.026openalex-snapshot
Biophysical membrane responses of hypoxic prostate cancer cells depend on kindlin-2
inferred← citeshttps://doi.org/10.1016/j.camwa.2023.09.046openalex-snapshot
An optimization based 3D-1D coupling strategy for tissue perfusion and chemical transport during tumor-induced angiogenesis
inferred← citeshttps://doi.org/10.1016/j.canlet.2020.07.041openalex-snapshot
Hypoxia: Friend or Foe for drug delivery in Pancreatic Cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2026.218373openalex-snapshot
A longitudinal analysis of radiosensitizer development in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.cej.2024.148610openalex-snapshot
Acid-etched layered double hydroxides armed with dual “Doorkeepers” for Immunomodulatory-NIR III photodynamic therapy of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.cell.2025.06.048openalex-snapshot
Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories
inferred← citeshttps://doi.org/10.1016/j.cellin.2025.100277openalex-snapshot
Hypoxia-induced MT2A-tetrameric PKM2 interaction maintains PKM2 activity in a copper-ion-dependent manner
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108542openalex-snapshot
Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112129openalex-snapshot
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116827openalex-snapshot
In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117612openalex-snapshot
Histone lactylation-driven intratumoral IGFBP2+ NK cells promote tumor immune evasion
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