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A potential revolution in cancer treatment: A topical review of FLASH radiotherapy

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/acm2.13433openalex-snapshot

Implementation and validation of a beam‐current transformer on a medical pulsed electron beam LINAC for FLASH‐RT beam monitoring

inferredcites →https://doi.org/10.1002/acm2.13790openalex-snapshot

A potential revolution in cancer treatment: A topical review of FLASH radiotherapy

inferredcites →https://doi.org/10.1002/mp.12713openalex-snapshot

High dose‐per‐pulse electron beam dosimetry: Commissioning of the Oriatron eRT6 prototype linear accelerator for preclinical use

inferredcites →https://doi.org/10.1002/mp.13685openalex-snapshot

FLASH radiotherapy: Newsflash or flash in the pan?

inferredcites →https://doi.org/10.1002/mp.13858openalex-snapshot

On the capabilities of conventional x‐ray tubes to deliver ultra‐high (FLASH) dose rates

inferredcites →https://doi.org/10.1002/mp.14036openalex-snapshot

A new open‐source GPU‐based microscopic Monte Carlo simulation tool for the calculations of DNA damages caused by ionizing radiation — Part II: sensitivity and uncertainty analysis

inferredcites →https://doi.org/10.1002/mp.14037openalex-snapshot

A new open‐source GPU‐based microscopic Monte Carlo simulation tool for the calculations of DNA damages caused by ionizing radiation ‐‐‐ Part I: Core algorithm and validation

inferredcites →https://doi.org/10.1002/mp.14253openalex-snapshot

Feasibility of proton FLASH irradiation using a synchrocyclotron for preclinical studies

inferredcites →https://doi.org/10.1002/mp.14456openalex-snapshot

A framework for defining FLASH dose rate for pencil beam scanning

inferredcites →https://doi.org/10.1002/mp.14548openalex-snapshot

Oxygen depletion in FLASH ultra‐high‐dose‐rate radiotherapy: A molecular dynamics simulation

inferredcites →https://doi.org/10.1002/mp.14730openalex-snapshot

FLASH proton irradiation setup with a modulator wheel for a single mouse eye

inferredcites →https://doi.org/10.1002/mp.14882openalex-snapshot

Characterization of a high‐resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery

inferredcites →https://doi.org/10.1002/mp.14885openalex-snapshot

Commissioning of an ultra‐high dose rate pulsed electron beam medical LINAC for FLASH RT preclinical animal experiments and future clinical human protocols

inferredcites →https://doi.org/10.1002/mp.14917openalex-snapshot

Does FLASH deplete oxygen? Experimental evaluation for photons, protons, and carbon ions

inferredcites →https://doi.org/10.1002/mp.14933openalex-snapshot

Commissioning of a clinical pencil beam scanning proton therapy unit for ultra‐high dose rates (FLASH)

inferredcites →https://doi.org/10.1002/mp.15129openalex-snapshot

Model studies of the role of oxygen in the FLASH effect

inferredcites →https://doi.org/10.1002/mp.15642openalex-snapshot

3D computational model of oxygen depletion kinetics in brain vasculature during FLASH RT and its implications for in vivo oximetry experiments

inferredcites →https://doi.org/10.1007/s00411-016-0652-7openalex-snapshot

Radiobiological influence of megavoltage electron pulses of ultra-high pulse dose rate on normal tissue cells

inferredcites →https://doi.org/10.1016/j.adro.2018.02.006openalex-snapshot

Multiple energy extraction reduces beam delivery time for a synchrotron-based proton spot-scanning system

inferredcites →https://doi.org/10.1016/j.anucene.2014.11.007openalex-snapshot

Overview of the FLUKA code

inferredcites →https://doi.org/10.1016/j.canrad.2019.11.004openalex-snapshot

Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment

inferredcites →https://doi.org/10.1016/j.clon.2019.04.001openalex-snapshot

Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken

inferredcites →https://doi.org/10.1016/j.ejmp.2019.03.016openalex-snapshot

Simulation and experimental validation of a prototype electron beam linear accelerator for preclinical studies

inferredcites →https://doi.org/10.1016/j.ejmp.2020.08.005openalex-snapshot

Technical challenges for FLASH proton therapy

inferredcites →https://doi.org/10.1016/j.ejmp.2020.11.001openalex-snapshot

External beam radiation therapy with kilovoltage x-rays

inferredcites →https://doi.org/10.1016/j.ijrobp.2006.05.014openalex-snapshot

Optimal number of beams for stereotactic body radiotherapy of lung and liver lesions

inferredcites →https://doi.org/10.1016/j.ijrobp.2016.09.018openalex-snapshot

Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator

inferredcites →https://doi.org/10.1016/j.ijrobp.2017.02.101openalex-snapshot

(P003) Delivery of Ultra-Rapid Flash Radiation Therapy and Demonstration of Normal Tissue Sparing After Abdominal Irradiation of Mice

inferredcites →https://doi.org/10.1016/j.ijrobp.2018.06.403openalex-snapshot

Experimental Set-up for FLASH Proton Irradiation of Small Animals Using a Clinical System

inferredcites →https://doi.org/10.1016/j.ijrobp.2019.06.1033openalex-snapshot

Characterization of Radiation-Induced Lung Fibrosis and Mode of Cell Death Using Single and Multi-Pulsed Proton Flash Irradiation

inferredcites →https://doi.org/10.1016/j.ijrobp.2019.06.187openalex-snapshot

Improved Tumor Control Through T-cell Infiltration Modulated by Ultra-High Dose Rate Proton FLASH Using a Clinical Pencil Beam Scanning Proton System

inferredcites →https://doi.org/10.1016/j.ijrobp.2019.10.049openalex-snapshot

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

inferredcites →https://doi.org/10.1016/j.ijrobp.2020.02.634openalex-snapshot

A Quantitative Analysis of the Role of Oxygen Tension in FLASH Radiation Therapy

inferredcites →https://doi.org/10.1016/j.ijrobp.2020.10.012openalex-snapshot

Ultra-high-dose-rate FLASH and Conventional-Dose-Rate Irradiation Differentially Affect Human Acute Lymphoblastic Leukemia and Normal Hematopoiesis

inferredcites →https://doi.org/10.1016/j.ijrobp.2020.11.012openalex-snapshot

Effects of Ultra-high doserate FLASH Irradiation on the Tumor Microenvironment in Lewis Lung Carcinoma: Role of Myosin Light Chain

inferredcites →https://doi.org/10.1016/j.ijrobp.2021.01.050openalex-snapshot

Multicellular Spheroids as In Vitro Models of Oxygen Depletion During FLASH Irradiation

inferredcites →https://doi.org/10.1016/j.ijrobp.2021.03.056openalex-snapshot

Quantification of Oxygen Depletion During FLASH Irradiation In Vitro and In Vivo

inferredcites →https://doi.org/10.1016/j.ijrobp.2021.07.097openalex-snapshot

Intracavitary Electron FLASH Radiotherapy in a Canine Cancer Patient With Oral Malignant Melanoma

inferredcites →https://doi.org/10.1016/j.ijrobp.2021.08.004openalex-snapshot

Irradiation at Ultra-High (FLASH) Dose Rates Reduces Acute Normal Tissue Toxicity in the Mouse Gastrointestinal System

inferredcites →https://doi.org/10.1016/j.ijrobp.2021.10.148openalex-snapshot

Treatment Planning System for Electron FLASH Radiation Therapy: Open-Source for Clinical Implementation

inferredcites →https://doi.org/10.1016/j.ijrobp.2022.01.009openalex-snapshot

A Universal Range Shifter and Range Compensator Can Enable Proton Pencil Beam Scanning Single-Energy Bragg Peak FLASH-RT Treatment Using Current Commercially Available Proton Systems

inferredcites →https://doi.org/10.1016/j.nima.2017.11.080openalex-snapshot

The CLEAR user facility at CERN

inferredcites →https://doi.org/10.1016/j.nima.2019.162537openalex-snapshot

Time-resolved dosimetry of pulsed electron beams in very high dose-rate, FLASH irradiation for radiotherapy preclinical studies

inferredcites →https://doi.org/10.1016/j.nimb.2013.12.033openalex-snapshot

Experimental studies of systematic multiple-energy operation at HIMAC synchrotron

inferredcites →https://doi.org/10.1016/j.nimb.2020.09.008openalex-snapshot

Influence of heterogeneous media on Very High Energy Electron (VHEE) dose penetration and a Monte Carlo-based comparison with existing radiotherapy modalities

inferredcites →https://doi.org/10.1016/j.radmp.2020.02.002openalex-snapshot

Mechanisms underlying FLASH radiotherapy, a novel way to enlarge the differential responses to ionizing radiation between normal and tumor tissues

inferredcites →https://doi.org/10.1016/j.radonc.2016.01.017openalex-snapshot

Assessment of the quality of very high-energy electron radiotherapy planning

inferredcites →https://doi.org/10.1016/j.radonc.2017.05.003openalex-snapshot

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

inferredcites →https://doi.org/10.1016/j.radonc.2018.08.016openalex-snapshot

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

inferredcites →https://doi.org/10.1016/j.radonc.2019.01.031openalex-snapshot

Modifying a clinical linear accelerator for delivery of ultra-high dose rate irradiation

inferredcites →https://doi.org/10.1016/j.radonc.2019.02.009openalex-snapshot

Biological effects in normal cells exposed to FLASH dose rate protons

inferredcites →https://doi.org/10.1016/j.radonc.2019.03.028openalex-snapshot

An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses

inferredcites →https://doi.org/10.1016/j.radonc.2019.04.008openalex-snapshot

Clinical translation of FLASH radiotherapy: Why and how?

inferredcites →https://doi.org/10.1016/j.radonc.2019.05.005openalex-snapshot

PHASER: A platform for clinical translation of FLASH cancer radiotherapy

inferredcites →https://doi.org/10.1016/j.radonc.2019.06.006openalex-snapshot

Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation

inferredcites →https://doi.org/10.1016/j.radonc.2019.06.019openalex-snapshot

Treatment of a first patient with FLASH-radiotherapy

inferredcites →https://doi.org/10.1016/j.radonc.2019.06.024openalex-snapshot

Feasibility of proton FLASH effect tested by zebrafish embryo irradiation

inferredcites →https://doi.org/10.1016/j.radonc.2020.04.054openalex-snapshot

Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?

inferredcites →https://doi.org/10.1016/j.radonc.2020.06.001openalex-snapshot

A physicochemical model of reaction kinetics supports peroxyl radical recombination as the main determinant of the FLASH effect

inferredcites →https://doi.org/10.1016/j.radonc.2021.02.003openalex-snapshot

Electron dose rate and oxygen depletion protect zebrafish embryos from radiation damage

inferredcites →https://doi.org/10.1016/j.radphyschem.2021.109398openalex-snapshot

Linear accelerator for security, industrial and medical applications with rapid beam parameter variation

inferredcites →https://doi.org/10.1016/j.zemedi.2020.06.008openalex-snapshot

Monte Carlo simulations and dose measurements of 2D range-modulators for scanned particle therapy

inferredcites →https://doi.org/10.1016/s0168-9002(03)01368-8openalex-snapshot

Geant4—a simulation toolkit

inferredcites →https://doi.org/10.1016/s0360-3016(01)01630-3openalex-snapshot

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

inferredcites →https://doi.org/10.1016/s0360-3016(02)02724-4openalex-snapshot

Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience

inferredcites →https://doi.org/10.1016/s0920-5632(03)90969-8openalex-snapshot

GATE (geant4 application for tomographic emission): a PET/SPECT general-purpose simulation platform

inferredcites →https://doi.org/10.1038/1831450a0openalex-snapshot

Modification of the Oxygen Effect when Bacteria are given Large Pulses of Radiation

inferredcites →https://doi.org/10.1038/210212a0openalex-snapshot

Unexpected Dose-rate Effect in the Killing of Mice by Radiation

inferredcites →https://doi.org/10.1038/nrc2344openalex-snapshot

Hypoxia, DNA repair and genetic instability

inferredcites →https://doi.org/10.1038/s41467-019-11906-2openalex-snapshot

Tumor-reprogrammed resident T cells resist radiation to control tumors

inferredcites →https://doi.org/10.1038/s41598-018-30543-1openalex-snapshot

Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model

inferredcites →https://doi.org/10.1038/s41598-019-53562-yopenalex-snapshot

Ultra high dose rate (35 Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome

inferredcites →https://doi.org/10.1038/s41598-020-78017-7openalex-snapshot

Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice

inferredcites →https://doi.org/10.1038/s41598-021-82772-6openalex-snapshot

Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage

inferredcites →https://doi.org/10.1073/pnas.1901777116openalex-snapshot

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species

inferredcites →https://doi.org/10.1080/10619127.2019.1571833openalex-snapshot

The PRAE Multidisciplinary Project

inferredcites →https://doi.org/10.1088/0031-9155/49/19/007openalex-snapshot

GATE: a simulation toolkit for PET and SPECT

inferredcites →https://doi.org/10.1088/0031-9155/50/21/010openalex-snapshot

A pencil beam algorithm for intensity modulated proton therapy derived from Monte Carlo simulations

inferredcites →https://doi.org/10.1088/1361-6560/ab3769openalex-snapshot

A computational model of radiolytic oxygen depletion during FLASH irradiation and its effect on the oxygen enhancement ratio

inferredcites →https://doi.org/10.1088/1361-6560/abaa28openalex-snapshot

Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review

inferredcites →https://doi.org/10.1088/1361-6560/abc93bopenalex-snapshot

Modeling the effect of oxygen on the chemical stage of water radiolysis using GPU-based microscopic Monte Carlo simulations, with an application in FLASH radiotherapy

inferredcites →https://doi.org/10.1088/1361-6560/abd22dopenalex-snapshot

Proton FLASH: passive scattering or pencil beam scanning?

inferredcites →https://doi.org/10.1088/1361-6560/abe2eaopenalex-snapshot

Determining the parameter space for effective oxygen depletion for FLASH radiation therapy

inferredcites →https://doi.org/10.1088/1361-6560/abf2faopenalex-snapshot

Ultrahigh dose-rate (FLASH) x-ray irradiator for pre-clinical laboratory research

inferredcites →https://doi.org/10.1088/2057-1976/1/4/045209openalex-snapshot

A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio

inferredcites →https://doi.org/10.1089/ars.2013.5668openalex-snapshot

Ionizing Radiation-Induced DNA Damage, Response, and Repair

inferredcites →https://doi.org/10.1117/12.2595299openalex-snapshot

Focused beam dosimetry of short VHEE bunches

inferredcites →https://doi.org/10.1118/1.4758060openalex-snapshot

TOPAS: An innovative proton Monte Carlo platform for research and clinical applications

inferredcites →https://doi.org/10.1118/1.4914371openalex-snapshot

Comparison of film measurements and Monte Carlo simulations of dose delivered with very high‐energy electron beams in a polystyrene phantom

inferredcites →https://doi.org/10.1118/1.4918923openalex-snapshot

Treatment planning for radiotherapy with very high‐energy electron beams and comparison of VHEE and VMAT plans

inferredcites →https://doi.org/10.1126/scitranslmed.3008973openalex-snapshot

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

inferredcites →https://doi.org/10.1142/s1793962310000122openalex-snapshot

THE GEANT4-DNA PROJECT

inferredcites →https://doi.org/10.1158/0008-5472.can-14-3511openalex-snapshot

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

inferredcites →https://doi.org/10.1158/0008-5472.can-21-1500openalex-snapshot

FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

inferredcites →https://doi.org/10.1158/1078-0432.ccr-17-3375openalex-snapshot

The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients

inferredcites →https://doi.org/10.1158/1078-0432.ccr-19-1440openalex-snapshot

FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence

inferredcites →https://doi.org/10.1158/1078-0432.ccr-20-0894openalex-snapshot

Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in Mice

inferredcites →https://doi.org/10.1186/1748-717x-6-139openalex-snapshot

Survival of tumor cells after proton irradiation with ultra-high dose rates

inferredcites →https://doi.org/10.1186/s40425-018-0356-4openalex-snapshot

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

inferredcites →https://doi.org/10.1259/bjr.20130676openalex-snapshot

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

inferredcites →https://doi.org/10.1259/bjr.20170628openalex-snapshot

Faster and safer? FLASH ultra-high dose rate in radiotherapy

inferredcites →https://doi.org/10.1259/bjr.20190702openalex-snapshot

The FLASH effect depends on oxygen concentration

inferredcites →https://doi.org/10.1259/bjr.20200217openalex-snapshot

History and current perspectives on the biological effects of high-dose spatial fractionation and high dose-rate approaches: GRID, Microbeam & FLASH radiotherapy

inferredcites →https://doi.org/10.1259/bjr/17827549openalex-snapshot

Revisiting the ultra-high dose rate effect: implications for charged particle radiotherapy using protons and light ions

inferredcites →https://doi.org/10.14338/ijpt.19-ptcog-6.4openalex-snapshot

Proceedings to the 58th Annual Conference of the Particle Therapy Cooperative Group (PTCOG58)

inferredcites →https://doi.org/10.1667/rade-19-00015.1openalex-snapshot

Ultra-High Dose-Rate, Pulsed (FLASH) Radiotherapy with Carbon Ions: Generation of Early, Transient, Highly Oxygenated Conditions in the Tumor Environment

inferredcites →https://doi.org/10.1667/rade-20-00060.1openalex-snapshot

Maintenance of Tight Junction Integrity in the Absence of Vascular Dilation in the Brain of Mice Exposed to Ultra-High-Dose-Rate FLASH Irradiation

inferredcites →https://doi.org/10.1667/rade-20-00062.1openalex-snapshot

Proton Irradiation Platforms for Preclinical Studies of High-Dose-Rate (FLASH) Effects at RARAF

inferredcites →https://doi.org/10.1667/rade-20-00067.1openalex-snapshot

Ultra-High-Dose-Rate FLASH Irradiation Limits Reactive Gliosis in the Brain

inferredcites →https://doi.org/10.1667/rade-20-00068.1openalex-snapshot

FLASH Investigations Using Protons: Design of Delivery System, Preclinical Setup and Confirmation of FLASH Effect with Protons in Animal Systems

inferredcites →https://doi.org/10.1667/rade-20-00084.1openalex-snapshot

LET-Dependent Intertrack Yields in Proton Irradiation at Ultra-High Dose Rates Relevant for FLASH Therapy

inferredcites →https://doi.org/10.1667/rade-20-00090openalex-snapshot

FLASH Irradiation Results in Reduced Severe Skin Toxicity Compared to Conventional-Dose-Rate Irradiation

inferredcites →https://doi.org/10.1667/rade-20-00168.1openalex-snapshot

A Computer Modeling Study of Water Radiolysis at High Dose Rates. Relevance to FLASH Radiotherapy

inferredcites →https://doi.org/10.1667/rr13464.1openalex-snapshot

The Effects of Ultra-High Dose Rate Proton Irradiation on Growth Delay in the Treatment of Human Tumor Xenografts in Nude Mice

inferredcites →https://doi.org/10.1667/rr15226.1openalex-snapshot

TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology

inferredcites →https://doi.org/10.2217/fon-2020-0063openalex-snapshot

The future of radiation-induced abscopal response: beyond conventional radiotherapy approaches

inferredcites →https://doi.org/10.3389/fcell.2021.672693openalex-snapshot

Association of Cancer Stem Cell Radio-Resistance Under Ultra-High Dose Rate FLASH Irradiation With Lysosome-Mediated Autophagy

inferredcites →https://doi.org/10.3389/fcell.2021.672929openalex-snapshot

Ultra-High Dose Rate FLASH Irradiation Induced Radio-Resistance of Normal Fibroblast Cells Can Be Enhanced by Hypoxia and Mitochondrial Dysfunction Resulting From Loss of Cytochrome C

inferredcites →https://doi.org/10.3389/fonc.2019.01563openalex-snapshot

Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

inferredcites →https://doi.org/10.3389/fonc.2021.658004openalex-snapshot

Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients

inferredcites →https://doi.org/10.3389/fphy.2020.00374openalex-snapshot

Transforming an IORT Linac Into a FLASH Research Machine: Procedure and Dosimetric Characterization

inferredcites →https://doi.org/10.3390/biomedicines9020181openalex-snapshot

Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results

inferredcites →https://doi.org/10.3390/cancers12061671openalex-snapshot

Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation

inferredcites →https://doi.org/10.3390/cancers13051012openalex-snapshot

FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice

inferredcites →https://doi.org/10.3390/cancers13143549openalex-snapshot

Quantitative Assessment of 3D Dose Rate for Proton Pencil Beam Scanning FLASH Radiotherapy and Its Application for Lung Hypofractionation Treatment Planning

inferredcites →https://doi.org/10.3390/ijms21186492openalex-snapshot

FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy

inferredcites →https://doi.org/10.3390/ijms21218151openalex-snapshot

Immunomodulatory Effects of Radiotherapy

inferredcites →https://doi.org/10.3390/ijms22116023openalex-snapshot

Geant4-DNA Modeling of Water Radiolysis beyond the Microsecond: An On-Lattice Stochastic Approach

inferredcites →https://doi.org/10.3390/ijms22126615openalex-snapshot

Recent Developments on gMicroMC: Transport Simulations of Proton and Heavy Ions and Concurrent Transport of Radicals and DNA

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4751806openalex-extracted

Average Dose Rate is the Primary Determinant of Lipid Peroxidation in Liposome Membranes Exposed to Pulsed Electron Beam

inferred← citeshttps://doi.org/10.1002/acm2.13974openalex-snapshot

Is singlet oxygen involved in FLASH‐RT?

inferred← citeshttps://doi.org/10.1002/acm2.14091openalex-snapshot

FLASH instead of proton arc therapy is a more promising advancement for the next generation proton radiotherapy

inferred← citeshttps://doi.org/10.1002/acm2.14159openalex-snapshot

Initial experience with an electron FLASH research extension (FLEX) for the Clinac system

inferred← citeshttps://doi.org/10.1002/acm2.70357openalex-snapshot

Commissioning of a gantry‐mounted synchrocyclotron for preclinical FLASH studies utilizing spread‐out Bragg peaks

inferred← citeshttps://doi.org/10.1002/cnma.70326openalex-snapshot

Integrating Biological and Physical Principles of Next‐Generation Radiotherapy to Fabricate Engineered Nanoplatforms for Improving Radiotherapy Efficacy

inferred← citeshttps://doi.org/10.1002/mp.16370openalex-snapshot

Feasibility study of hybrid inverse planning with transmission beams and single‐energy spread‐out Bragg peaks for proton FLASH radiotherapy

inferred← citeshttps://doi.org/10.1002/mp.17050openalex-snapshot

Secondary neutron dosimetry for conformal FLASH proton therapy

inferred← citeshttps://doi.org/10.1002/mp.17185openalex-snapshot

Technical note: Dosimetry and FLASH potential of UHDR proton PBS for small lung tumors: Bragg‐peak‐based delivery versus transmission beam and IMPT

inferred← citeshttps://doi.org/10.1002/mp.17245openalex-snapshot

Radiation safety of ultra‐high dose rate electron accelerators for FLASH radiotherapy

inferred← citeshttps://doi.org/10.1002/mp.17398openalex-snapshot

A microscopic oxygen transport model for ultra‐high dose rate radiotherapy in vivo: The impact of physiological conditions on FLASH effect

inferred← citeshttps://doi.org/10.1002/mp.17496openalex-snapshot

Oxygen consumption measurements at ultra‐high dose rate over a wide LET range

inferred← citeshttps://doi.org/10.1002/mp.17553openalex-snapshot

Pulsed beam monitoring for electron FLASH

inferred← citeshttps://doi.org/10.1002/mp.17847openalex-snapshot

Characterization of commercial detectors for absolute proton UHDR dosimetry on a compact clinical proton synchrocyclotron

inferred← citeshttps://doi.org/10.1002/mp.17926openalex-snapshot

Acoustic signal‐based precise positioning of Bragg peak for laser‐accelerated monoenergetic proton pulses

inferred← citeshttps://doi.org/10.1002/mp.18046openalex-snapshot

A regularized‐multi‐field optimization algorithm for robust IMPT

inferred← citeshttps://doi.org/10.1002/mp.70071openalex-snapshot

A GPU‐based Monte Carlo model for water radiolysis under ultra‐high dose rate irradiation: Development and validation with MPEXS2.1‐DNA

inferred← citeshttps://doi.org/10.1002/mp.70291openalex-snapshot

Single‐field‐uniform‐dose‐per‐fraction simultaneous dose and dose rate optimization (SFUDPF–SDDRO) method for proton FLASH therapy

inferred← citeshttps://doi.org/10.1002/mp.70522openalex-snapshot

Development and validation of a novel pulse optimization and beam control system for conventional and ultra high dose‐per‐pulse (FLASH) irradiation

inferred← citeshttps://doi.org/10.1007/978-981-97-8389-2_14openalex-snapshot

Electron Beams

inferred← citeshttps://doi.org/10.1007/978-981-97-8389-2_5openalex-snapshot

Clinical Radiation Physics

inferred← citeshttps://doi.org/10.1007/s10278-024-01346-wopenalex-snapshot

Cone Beam Computed Tomography Image-Quality Improvement Using “One-Shot” Super-resolution

inferred← citeshttps://doi.org/10.1007/s12553-024-00864-5openalex-snapshot

SEEIIST – a new research facility for tumor treatment and biomedical investigations with proton and ion beams

inferred← citeshttps://doi.org/10.1007/s41365-025-01673-9openalex-snapshot

Calculation algorithm for the space charge force of a train with infinite bunches

inferred← citeshttps://doi.org/10.1016/bs.ircmb.2025.01.005openalex-snapshot

Clinical development complexity of TGF-β inhibition: From fibrosis to cancer immunotherapy

inferred← citeshttps://doi.org/10.1016/j.ejmp.2026.105723openalex-snapshot

Performance evaluation of EBT3, EBT-XD, and OrthoChromic OC-1 films for reference dosimetry in Ultra-High dose rate electron beams radiotherapy

inferred← citeshttps://doi.org/10.1016/j.hoc.2024.11.008openalex-snapshot

FLASH Radiotherapy

inferred← citeshttps://doi.org/10.1016/j.ijpt.2026.101949openalex-snapshot

Neural Representation Learning for Compact and Efficient Modeling of Monte Carlo Phase Space Data

inferred← citeshttps://doi.org/10.1016/j.ijrobp.2024.11.077openalex-snapshot

Data-Driven Volumetric Computed Tomography Image Generation From Surface Structures Using a Patient-Specific Deep Leaning Model

inferred← citeshttps://doi.org/10.1016/j.nima.2023.168737openalex-snapshot

Design and simulation of a radius-varying active plasma lens for focusing laser-accelerated protons

inferred← citeshttps://doi.org/10.1016/j.nima.2025.171038openalex-snapshot

Single-shot spectrometer with pointing angle correction for laser-driven electron beams featuring pointing instability and transverse inhomogeneity

inferred← citeshttps://doi.org/10.1016/j.oraloncology.2023.106342openalex-snapshot

Flash radiotherapy-gateway to promised land or another mirage

inferred← citeshttps://doi.org/10.1016/j.otc.2023.02.018openalex-snapshot

The Future of Vestibular Schwannoma Management

inferred← citeshttps://doi.org/10.1016/j.phro.2026.100915openalex-snapshot

Systematic analysis of biological endpoint variability and implications for quantitative modeling of the FLASH sparing effect

inferred← citeshttps://doi.org/10.1016/j.radmeas.2024.107125openalex-snapshot

Radioluminescence-based fibre-optic dosimeters in radiotherapy: a review

inferred← citeshttps://doi.org/10.1016/j.radmeas.2024.107214openalex-snapshot

Secondary neutrons in proton and light ion beam therapy: a review of current status, needs and potential solutions

inferred← citeshttps://doi.org/10.1016/j.radmeas.2024.107330openalex-snapshot

Dosimetry for FLASH and other non-standard radiotherapy sources

inferred← citeshttps://doi.org/10.1016/j.radmeas.2026.107625openalex-snapshot

Scintillation dosimetry for FLASH radiotherapy

inferred← citeshttps://doi.org/10.1016/j.radonc.2024.110238openalex-snapshot

Infrared microspectroscopy to elucidate the underlying biomolecular mechanisms of FLASH radiotherapy

inferred← citeshttps://doi.org/10.1016/j.radonc.2024.110539openalex-snapshot

In vivo measurements of change in tissue oxygen level during irradiation reveal novel dose rate dependence

inferred← citeshttps://doi.org/10.1016/j.radphyschem.2024.111887openalex-snapshot

Average dose rate is the primary determinant of lipid peroxidation in liposome membranes exposed to pulsed electron FLASH beam

inferred← citeshttps://doi.org/10.1016/j.semradonc.2024.02.001openalex-snapshot

FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma?

inferred← citeshttps://doi.org/10.1016/j.sna.2025.116539openalex-snapshot

Stem effect-free (Y,Yb)AG-based detectors for ultra-high dose rate electron beam dosimetry

inferred← citeshttps://doi.org/10.1016/j.tranon.2024.102183openalex-snapshot

FLASH radiotherapy combined with immunotherapy: From biological mechanisms to blockbuster therapeutics

inferred← citeshttps://doi.org/10.1038/s41598-024-61869-8openalex-snapshot

MRI-only based material mass density and relative stopping power estimation via deep learning for proton therapy: a preliminary study

inferred← citeshttps://doi.org/10.1038/s41598-025-94534-9openalex-snapshot

Effects of whole brain proton irradiation at conventional or ultra-high dose rate (FLASH), in adult male Sprague Dawley rats

inferred← citeshttps://doi.org/10.1038/s41598-026-40281-4openalex-snapshot

Ultra-intense pulsed source of ionizing radiation based on direct laser acceleration of electrons for studying the FLASH effect

inferred← citeshttps://doi.org/10.1063/5.0146117openalex-snapshot

Dose rate assessment of spot-scanning very high energy electrons radiotherapy driven by laser plasma acceleration

inferred← citeshttps://doi.org/10.1088/1361-6463/ae0e2dopenalex-snapshot

Emerging strategies in radiation therapy: promises and challenges of spatial fractionation, ultra-high dose rates, and nanoparticles

inferred← citeshttps://doi.org/10.1088/1361-6528/adb8f2openalex-snapshot

A review of ultra-wide-bandgap semiconductor radiation detector for high-energy particles and photons

inferred← citeshttps://doi.org/10.1088/1361-6560/acdc7dopenalex-snapshot

A method to implement inter-track interactions in Monte Carlo simulations with TOPAS-nBio and their influence on simulated radical yields following water radiolysis

inferred← citeshttps://doi.org/10.1088/1361-6560/acf63eopenalex-snapshot

Pulse parameter optimizer: an efficient tool for achieving prescribed dose and dose rate with electron FLASH platforms

inferred← citeshttps://doi.org/10.1088/1361-6560/ada51aopenalex-snapshot

Monte Carlo in the mechanistic modelling of the FLASH effect: a review

inferred← citeshttps://doi.org/10.1088/1361-6560/adc96copenalex-snapshot

Towards improved prescription metrics in novel radiotherapy techniques: a machine learning study

inferred← citeshttps://doi.org/10.1088/1361-6560/ae023bopenalex-snapshot

Feasibility of prototype diamond detectors for pulsed UHDR PBS small-field proton dosimetry for proton FLASH experiments

inferred← citeshttps://doi.org/10.1088/1361-6560/ae0ef7openalex-snapshot

Bragg-peak FLASH biological optimization enables enhanced normal tissue sparing and dose escalation for ocular stereotactic body radiation therapy

inferred← citeshttps://doi.org/10.1088/1361-6560/ae6224openalex-snapshot

Feasibility of proton ultra-high-dose-rate spatially fractionated radiotherapy system for preclinical experiments on a compact proton synchrocyclotron

inferred← citeshttps://doi.org/10.1088/1361-6560/ae752fopenalex-snapshot

Simulation study on the dosimetric characteristics of focused electron beams with different energies for FLASH radiotherapy

inferred← citeshttps://doi.org/10.1088/1402-4896/ae8ec6openalex-snapshot

Design study of a ridge filter for FLASH application of proton minibeam radiotherapy

inferred← citeshttps://doi.org/10.1088/1748-0221/19/02/c02043openalex-snapshot

Test beam results of a fluorescence-based monitor for ultra-high dose rates

inferred← citeshttps://doi.org/10.1088/1748-0221/19/02/p02035openalex-snapshot

FLASH Radiation Therapy — Key physical irradiation parameters and beam characteristics

inferred← citeshttps://doi.org/10.1097/ppo.0000000000000816openalex-snapshot

FLASH Particle Radiotherapy

inferred← citeshttps://doi.org/10.1101/2024.04.10.588811openalex-snapshot

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

inferred← citeshttps://doi.org/10.1103/physrevaccelbeams.27.052801openalex-snapshot

High transmission efficiency collection system for laser-accelerated proton beams based on permanent magnet quadrupoles prefocusing

inferred← citeshttps://doi.org/10.1103/physrevaccelbeams.27.052802openalex-snapshot

Experimental demonstration of radius-varying active plasma lensing for laser-plasma-accelerated proton beams with increased collection angle

inferred← citeshttps://doi.org/10.1103/physrevapplied.21.064020openalex-snapshot

Quantitative elemental analysis of a specimen in air via external beam laser-driven particle-induced x-ray emission with a compact proton source

inferred← citeshttps://doi.org/10.1107/s1600577524006878openalex-snapshot

Prediction of the treatment effect of FLASH radiotherapy with synchrotron radiation from the Circular Electron–Positron Collider (CEPC)

inferred← citeshttps://doi.org/10.1109/lsens.2025.3587008openalex-snapshot

A High Performance Detector Based on HPHT-Diamond for Dosimetry of Ultra-High Dose-Rate Electron Beams

inferred← citeshttps://doi.org/10.1109/lsens.2025.3588265openalex-snapshot

A Novel Diamond-Based Radiation Monitoring System for Real-Time Diagnostics of Pulsed Electron Beams

inferred← citeshttps://doi.org/10.1109/trpms.2024.3439585openalex-snapshot

Deep Learning-Based Fast Volumetric Image Generation for Image-Guided Proton Radiotherapy

inferred← citeshttps://doi.org/10.1360/tb-2022-1042openalex-snapshot

Research status and prospect of tumor therapy by usinglaser-accelerated proton beams

inferred← citeshttps://doi.org/10.1360/tb-2022-1280openalex-snapshot

Application of capillary discharge plasma in the field of laser acceleration

inferred← citeshttps://doi.org/10.14338/ijpt-22-00027.1openalex-snapshot

Characterization of 250 MeV Protons from the Varian ProBeam PBS System for FLASH Radiation Therapy

inferred← citeshttps://doi.org/10.1667/rade-24-00107.1openalex-snapshot

Dosimetry: Was and Is an Absolute Requirement for Quality Radiation Research

inferred← citeshttps://doi.org/10.20944/preprints202406.0689.v1openalex-snapshot

FLASH Radiotherapy versus Conventional Therapy in Cancer Treatment; Promises, Paradoxes and Problems

inferred← citeshttps://doi.org/10.21037/qims-23-1559openalex-snapshot

Pixelwise Gradient Model for Image Fusion (PGMIF): a multi-sequence magnetic resonance imaging (MRI) fusion model for tumor contrast enhancement of nasopharyngeal carcinoma

inferred← citeshttps://doi.org/10.21203/rs.3.rs-3112632/v1openalex-snapshot

Deep learning-based Fast Volumetric Image Generation for Image-guided Proton FLASH Radiotherapy

inferred← citeshttps://doi.org/10.21203/rs.3.rs-8503498/v1openalex-snapshot

A Physics-Informed Neural Network for In Vivo Dosimetry Using Quantitative Radiacoustic Imaging

inferred← citeshttps://doi.org/10.2478/pjmpe-2024-0031openalex-snapshot

Short-term response of melanoma spheroids and melanocytes to FLASH proton therapy - colorimetric and FTIR microscopy study

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1869222openalex-snapshot

FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap

inferred← citeshttps://doi.org/10.3389/fsens.2025.1622153openalex-snapshot

Silicon carbide sensors in radiotherapy dosimetry: progress, challenges, and perspectives

inferred← citeshttps://doi.org/10.3390/antiox14040406openalex-snapshot

Oxygen Depletion and the Role of Cellular Antioxidants in FLASH Radiotherapy: Mechanistic Insights from Monte Carlo Radiation-Chemical Modeling

inferred← citeshttps://doi.org/10.3390/app152010939openalex-snapshot

A Review of the Alanine Electron Paramagnetic Resonance Dosimetry Method as a Dose Verification Tool for Low-Dose Electron Beam Applications: Implications on Flash Radiotherapy

inferred← citeshttps://doi.org/10.3390/biom14070754openalex-snapshot

FLASH Radiotherapy: Mechanisms of Biological Effects and the Therapeutic Potential in Cancer

inferred← citeshttps://doi.org/10.3390/cancers15153883openalex-snapshot

FLASH Radiotherapy and the Use of Radiation Dosimeters

inferred← citeshttps://doi.org/10.3390/cancers16040798openalex-snapshot

Pencil Beam Scanning Proton Bragg Peak Conformal FLASH in Prostate Cancer Stereotactic Body Radiotherapy

inferred← citeshttps://doi.org/10.3390/cells13100835openalex-snapshot

Mechanisms of Action in FLASH Radiotherapy: A Comprehensive Review of Physicochemical and Biological Processes on Cancerous and Normal Cells

inferred← citeshttps://doi.org/10.3390/curroncol30070510openalex-snapshot

Twenty Years of Advancements in a Radiotherapy Facility: Clinical Protocols, Technology, and Management

inferred← citeshttps://doi.org/10.3390/ijms26020571openalex-snapshot

Probing Spatiotemporal Effects of Intertrack Recombination with a New Implementation of Simultaneous Multiple Tracks in TRAX-CHEM

inferred← citeshttps://doi.org/10.3390/ijtm4030038openalex-snapshot

FLASH Radiotherapy Versus Conventional Cancer Therapy: Promises, Paradoxes and Problems

inferred← citeshttps://doi.org/10.3390/radiation3030014openalex-snapshot

Early and Transient Formation of Highly Acidic pH Spikes in Water Radiolysis under the Combined Effect of High Dose Rate and High Linear Energy Transfer

inferred← citeshttps://doi.org/10.3390/radiation5040033openalex-snapshot

Establishing an Electron FLASH Platform for Preclinical Research in Low-Resource Settings

inferred← citeshttps://doi.org/10.48550/arxiv.2304.14594openalex-snapshot

Data-Driven Volumetric Image Generation from Surface Structures using a Patient-Specific Deep Leaning Model

inferred← citeshttps://doi.org/10.5604/01.3001.0054.1820openalex-snapshot

Application of an ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model – a proof of concept

inferred← citeshttps://doi.org/10.5604/01.3001.0054.1972openalex-snapshot

New trends in clinical and retrospective dosimetry

inferred← citeshttps://doi.org/10.62906/bs.book.311openalex-snapshot

Medical Physics: Imaging and Radiation Therapy

inferred← citeshttps://doi.org/10.69860/nobel.9786053359425.5openalex-snapshot

Flash Radiation Therapy: Current Insights and Future Prospects

inferred← citeshttps://doi.org/10.7759/cureus.101091openalex-snapshot

FLASH Radiotherapy in Lung Cancer: Translational Mechanisms, Preclinical Evidence, and Barriers

showing the first 98 of 99

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