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The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s004270050224openalex-snapshot
Distinct structural domains in the planarian brain defined by the expression of evolutionarily conserved homeobox genes
inferredcites →https://doi.org/10.1016/j.cell.2006.01.036openalex-snapshot
RNAi Components Are Required for Nuclear Clustering of Polycomb Group Response Elements
inferredcites →https://doi.org/10.1016/j.cell.2007.01.043openalex-snapshot
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
inferredcites →https://doi.org/10.1016/j.cell.2007.03.026openalex-snapshot
A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
inferredcites →https://doi.org/10.1016/j.cell.2007.03.028openalex-snapshot
Mighty Piwis Defend the Germline against Genome Intruders
inferredcites →https://doi.org/10.1016/j.cub.2006.08.051openalex-snapshot
The Role of PIWI and the miRNA Machinery in Drosophila Germline Determination
inferredcites →https://doi.org/10.1016/j.cub.2007.06.030openalex-snapshot
The Drosophila RNA Methyltransferase, DmHen1, Modifies Germline piRNAs and Single-Stranded siRNAs in RISC
inferredcites →https://doi.org/10.1016/j.devcel.2005.02.014openalex-snapshot
Identification of Genes Needed for Regeneration, Stem Cell Function, and Tissue Homeostasis by Systematic Gene Perturbation in Planaria
inferredcites →https://doi.org/10.1016/j.devcel.2006.06.004openalex-snapshot
A bruno-like Gene Is Required for Stem Cell Maintenance in Planarians
inferredcites →https://doi.org/10.1016/j.devcel.2006.12.001openalex-snapshot
Drosophila rasiRNA Pathway Mutations Disrupt Embryonic Axis Specification through Activation of an ATR/Chk2 DNA Damage Response
inferredcites →https://doi.org/10.1016/j.devcel.2007.03.001openalex-snapshot
MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline
inferredcites →https://doi.org/10.1016/s0378-1119(00)00579-5openalex-snapshot
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans
inferredcites →https://doi.org/10.1016/s1534-5807(02)00165-xopenalex-snapshot
miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis
inferredcites →https://doi.org/10.1038/446864aopenalex-snapshot
Genomic defence with a slice of pi
inferredcites →https://doi.org/10.1038/nature03959openalex-snapshot
Genome sequencing in microfabricated high-density picolitre reactors
inferredcites →https://doi.org/10.1038/nature04917openalex-snapshot
A germline-specific class of small RNAs binds mammalian Piwi proteins
inferredcites →https://doi.org/10.1038/nature06263openalex-snapshot
An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster
inferredcites →https://doi.org/10.1038/nchembio848openalex-snapshot
Slicer and the Argonautes
inferredcites →https://doi.org/10.1038/nrg759openalex-snapshot
Not your father's planarian: a classic model enters the era of functional genomics
inferredcites →https://doi.org/10.1038/nsmb1218openalex-snapshot
Mouse Piwi-interacting RNAs are 2′-O-methylated at their 3′ termini
inferredcites →https://doi.org/10.1038/nsmb1220openalex-snapshot
The 3′ termini of mouse Piwi-interacting RNAs are 2′-O-methylated
inferredcites →https://doi.org/10.1073/pnas.0509507102openalex-snapshot
The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: Analysis of ESTs from the hermaphroditic strain
inferredcites →https://doi.org/10.1073/pnas.0609708104openalex-snapshot
nanos function is essential for development and regeneration of planarian germ cells
inferredcites →https://doi.org/10.1073/pnas.1834205100openalex-snapshot
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians
inferredcites →https://doi.org/10.1093/nar/25.17.3389openalex-snapshot
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
inferredcites →https://doi.org/10.1101/gad.1434406openalex-snapshot
A novel class of small RNAs in mouse spermatogenic cells
inferredcites →https://doi.org/10.1101/gad.1456106openalex-snapshot
Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes
inferredcites →https://doi.org/10.1101/gad.1563607openalex-snapshot
Pimet, the Drosophila homolog of HEN1, mediates 2′- O -methylation of Piwi- interacting RNAs at their 3′ ends
inferredcites →https://doi.org/10.1101/gad.1564307openalex-snapshot
Drosophila PIWI associates with chromatin and interacts directly with HP1a
inferredcites →https://doi.org/10.1101/gr.175701openalex-snapshot
Computational Inference of Homologous Gene Structures in the Human Genome
inferredcites →https://doi.org/10.1101/gr.9.9.868openalex-snapshot
CAP3: A DNA Sequence Assembly Program
inferredcites →https://doi.org/10.1111/j.1440-169x.2006.00876.xopenalex-snapshot
Isolation of planarian X‐ray‐sensitive stem cells by fluorescence‐activated cell sorting
inferredcites →https://doi.org/10.1126/science.1092653openalex-snapshot
Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery
inferredcites →https://doi.org/10.1126/science.1102513openalex-snapshot
Argonaute2 Is the Catalytic Engine of Mammalian RNAi
inferredcites →https://doi.org/10.1126/science.1102514openalex-snapshot
Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity
inferredcites →https://doi.org/10.1126/science.1116110openalex-snapshot
SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells
inferredcites →https://doi.org/10.1126/science.1129333openalex-snapshot
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
inferredcites →https://doi.org/10.1126/science.1130164openalex-snapshot
Characterization of the piRNA Complex from Rat Testes
inferredcites →https://doi.org/10.1126/science.1137543openalex-snapshot
piRNAs in the Germ Line
inferredcites →https://doi.org/10.1126/science.1140494openalex-snapshot
A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila
inferredcites →https://doi.org/10.1126/science.1142612openalex-snapshot
Developmentally Regulated piRNA Clusters Implicate MILI in Transposon Control
inferredcites →https://doi.org/10.1242/dev.00167openalex-snapshot
The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration
inferredcites →https://doi.org/10.1242/dev.006635openalex-snapshot
smedinx-11 is a planarian stem cell gap junction gene required for regeneration and homeostasis
inferredcites →https://doi.org/10.1242/dev.01941openalex-snapshot
Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture
inferredcites →https://doi.org/10.1242/dev.107.1.77openalex-snapshot
Regeneration and pattern formation in planarians: III. Evidence that neoblasts are totipotent stem cells and the source of blastema cells
inferredcites →https://doi.org/10.1242/dev.122.5.1631openalex-snapshot
aubergine enhances oskar translation in the Drosophila ovary
inferredcites →https://doi.org/10.1242/dev.83.1.63openalex-snapshot
Regeneration and pattern formation in planarians I. The pattern of mitosis in anterior and posterior regeneration in Dugesia (G) tigrina, and a new proposal for blastema formation
inferredcites →https://doi.org/10.1261/rna.117206openalex-snapshot
MicroRNAs from the Planarian Schmidtea mediterranea: A model system for stem cell biology

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4822917openalex-extracted
A Comparative Roadmap of PIWI-Interacting RNAs (piRNAs) Across Seven Species Reveals Insights Into de novo piRNA Precursor Formation in Mammals
inferred← citeshttps://doi.org/10.1002/9780470015902.a0001097.pub2openalex-snapshot
An Introduction to Planarians and Their Stem Cells
inferred← citeshttps://doi.org/10.1002/bies.201700068openalex-snapshot
The PIWI‐Interacting RNA Molecular Pathway: Insights From Cultured Silkworm Germline Cells
inferred← citeshttps://doi.org/10.1002/dvdy.21623openalex-snapshot
Gene nomenclature guidelines for the planarian Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1002/dvdy.23950openalex-snapshot
RNA interference by feeding in vitro–synthesized double‐stranded RNA to planarians: Methodology and dynamics
inferred← citeshttps://doi.org/10.1002/mrd.22115openalex-snapshot
Next generation organelles: Structure and role of germ granules in the germline
inferred← citeshttps://doi.org/10.1002/reg2.26openalex-snapshot
Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis
inferred← citeshttps://doi.org/10.1002/stem.1144openalex-snapshot
A Comparative Transcriptomic Analysis Reveals Conserved Features of Stem Cell Pluripotency in Planarians and Mammals
inferred← citeshttps://doi.org/10.1002/stem.3233openalex-snapshot
The epitranscriptome landscape of small noncoding RNAs in stem cells
inferred← citeshttps://doi.org/10.1002/wdev.82openalex-snapshot
The history and enduring contributions of planarians to the study of animal regeneration
inferred← citeshttps://doi.org/10.1007/978-1-0716-3275-8_2openalex-snapshot
Isolation and Library Preparation of Planarian piRNAs
inferred← citeshttps://doi.org/10.1007/978-1-0716-3275-8_3openalex-snapshot
Genome-Wide Analysis of Planarian piRNAs
inferred← citeshttps://doi.org/10.1007/978-1-4939-1221-6_5openalex-snapshot
Piwi Proteins and piRNAs Step onto the Systems Biology Stage
inferred← citeshttps://doi.org/10.1007/978-1-4939-7802-1_2openalex-snapshot
Stem Cells, Patterning and Regeneration in Planarians: Self-Organization at the Organismal Scale
inferred← citeshttps://doi.org/10.1007/978-3-642-22517-8_1openalex-snapshot
Renaissance of the Regulatory RNAs
inferred← citeshttps://doi.org/10.1007/978-4-431-56609-0_7openalex-snapshot
Roles of Germline Stem Cells and Somatic Multipotent Stem Cells in Hydra Sexual Reproduction
inferred← citeshttps://doi.org/10.1007/s00427-012-0417-5openalex-snapshot
The stem cell system in demosponges: suggested involvement of two types of cells: archeocytes (active stem cells) and choanocytes (food-entrapping flagellated cells)
inferred← citeshttps://doi.org/10.1007/s00427-012-0426-4openalex-snapshot
Stem cell systems and regeneration in planaria
inferred← citeshttps://doi.org/10.1007/s00441-009-0915-6openalex-snapshot
Potential of Macrostomum lignano to recover from γ-ray irradiation
inferred← citeshttps://doi.org/10.1007/s10126-010-9292-0openalex-snapshot
Uncovering the Mechanisms of Shrimp Innate Immune Response by RNA Interference
inferred← citeshttps://doi.org/10.1007/s10126-011-9426-zopenalex-snapshot
Identification and Characterization of piRNA-Like Small RNAs in the Gonad of Sea Urchin (Strongylocentrotus nudus)
inferred← citeshttps://doi.org/10.1007/s10528-011-9452-6openalex-snapshot
Cloning and Identification of MicroRNAs in Earthworm (Eisenia fetida)
inferred← citeshttps://doi.org/10.1007/s11010-016-2906-8openalex-snapshot
Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway
inferred← citeshttps://doi.org/10.1007/s11033-012-1535-xopenalex-snapshot
Characterization and expression analysis of a trypsin-like serine protease from planarian Dugesia japonica
inferred← citeshttps://doi.org/10.1007/s11033-012-2485-zopenalex-snapshot
Deep sequencing identifies regulated small RNAs in Dugesia japonica
inferred← citeshttps://doi.org/10.1007/s12015-026-11169-7openalex-snapshot
Primordial Germ Cell Development in Teleosts: Their Origin, Fate and Role in Sex Determination
inferred← citeshttps://doi.org/10.1007/s13238-018-0512-0openalex-snapshot
Neoblast-enriched zinc finger protein FIR1 triggers local proliferation during planarian regeneration
inferred← citeshttps://doi.org/10.1016/b978-0-12-815669-8.00013-0openalex-snapshot
piRNAs in the pathophysiology of disease and potential clinical applications
inferred← citeshttps://doi.org/10.1016/b978-0-12-820719-2.00029-6openalex-snapshot
MitomiRs in Regenerative Medicine
inferred← citeshttps://doi.org/10.1016/b978-0-444-63660-7.00010-3openalex-snapshot
Noncoding RNAs as Critical Players in Regulatory Accuracy, Redox Signaling, and Immune Cell Functions
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2019.04.001openalex-snapshot
From worm to germ: Germ cell development and regeneration in planarians
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2015.06.005openalex-snapshot
Regeneration, Stem Cells, and Aging in the Tunicate Ciona
inferred← citeshttps://doi.org/10.1016/j.biocel.2010.03.005openalex-snapshot
Small RNAs in the animal gonad: Guarding genomes and guiding development
inferred← citeshttps://doi.org/10.1016/j.cdev.2021.203710openalex-snapshot
Co-localization of DrPiwi-1 and DrPiwi-2 in the oogonial cytoplasm is essential for oocyte differentiation in sexualized planarians
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109776openalex-snapshot
PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114777openalex-snapshot
A comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116401openalex-snapshot
Molecular and cellular characterization of planarian stem cell microenvironments
inferred← citeshttps://doi.org/10.1016/j.cub.2011.01.016openalex-snapshot
Noggin and Noggin-Like Genes Control Dorsoventral Axis Regeneration in Planarians
inferred← citeshttps://doi.org/10.1016/j.dci.2016.08.010openalex-snapshot
The role of a novel C-type lectin-like protein from planarian in innate immunity and regeneration
inferred← citeshttps://doi.org/10.1016/j.devcel.2016.04.009openalex-snapshot
Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian
inferred← citeshttps://doi.org/10.1016/j.devcel.2016.04.022openalex-snapshot
DjPiwiB: A Rich Nuclear Inheritance for Descendants of Planarian Stem Cells
inferred← citeshttps://doi.org/10.1016/j.ebiom.2017.04.031openalex-snapshot
Staphylococcus aureus Promotes Smed-PGRP-2/Smed-setd8-1 Methyltransferase Signalling in Planarian Neoblasts to Sensitize Anti-bacterial Gene Responses During Re-infection
inferred← citeshttps://doi.org/10.1016/j.ejcb.2017.09.004openalex-snapshot
PIWI family emerging as a decisive factor of cell fate: An overview
inferred← citeshttps://doi.org/10.1016/j.fbr.2026.100516openalex-snapshot
Chromatin and RNA-mediated regulation of cellular quiescence in Schizosaccharomyces pombe
inferred← citeshttps://doi.org/10.1016/j.gdata.2017.10.004openalex-snapshot
Small RNAome sequencing delineates the small RNA landscape of pluripotent adult stem cells in the planarian Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1016/j.gde.2012.09.006openalex-snapshot
Regeneration and reprogramming
inferred← citeshttps://doi.org/10.1016/j.gene.2017.02.024openalex-snapshot
Identification and characterization of a novel multifunctional placenta specific protein 8 in Dugesia japonica
inferred← citeshttps://doi.org/10.1016/j.gene.2018.04.009openalex-snapshot
Insight into stem cell regulation from sub-lethally irradiated worms
inferred← citeshttps://doi.org/10.1016/j.gep.2008.12.008openalex-snapshot
Expression pattern of the expanded noggin gene family in the planarian Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1016/j.heliyon.2025.e41833openalex-snapshot
Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians
inferred← citeshttps://doi.org/10.1016/j.ijpara.2015.06.007openalex-snapshot
The miRnome of Fasciola hepatica juveniles endorses the existence of a reduced set of highly divergent micro RNAs in parasitic flatworms
inferred← citeshttps://doi.org/10.1016/j.it.2019.09.003openalex-snapshot
piRNA-Guided CRISPR-like Immunity in Eukaryotes
inferred← citeshttps://doi.org/10.1016/j.mad.2018.03.009openalex-snapshot
PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage
inferred← citeshttps://doi.org/10.1016/j.mod.2011.09.001openalex-snapshot
Role of Vasa, Piwi, and Myc-expressing coelomic cells in gonad regeneration of the colonial tunicate, Botryllus primigenus
inferred← citeshttps://doi.org/10.1016/j.pt.2014.01.001openalex-snapshot
How might flukes and tapeworms maintain genome integrity without a canonical piRNA pathway?
inferred← citeshttps://doi.org/10.1016/j.semcdb.2015.10.025openalex-snapshot
A piece of the pi(e): The diverse roles of animal piRNAs and their PIWI partners
inferred← citeshttps://doi.org/10.1016/j.semcdb.2017.08.028openalex-snapshot
Secrets from immortal worms: What can we learn about biological ageing from the planarian model system?
inferred← citeshttps://doi.org/10.1016/j.semcdb.2018.05.013openalex-snapshot
Post-transcriptional regulation in planarian stem cells
inferred← citeshttps://doi.org/10.1016/j.stem.2012.01.016openalex-snapshot
Genetic Regulators of a Pluripotent Adult Stem Cell System in Planarians Identified by RNAi and Clonal Analysis
inferred← citeshttps://doi.org/10.1016/j.stem.2014.06.007openalex-snapshot
Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment
inferred← citeshttps://doi.org/10.1016/j.tcb.2010.05.004openalex-snapshot
Building RNA–protein granules: insight from the germline
inferred← citeshttps://doi.org/10.1016/j.tcb.2011.01.005openalex-snapshot
Planarian stem cells: a simple paradigm for regeneration
inferred← citeshttps://doi.org/10.1016/j.ydbio.2009.01.043openalex-snapshot
Spoltud-1 is a chromatoid body component required for planarian long-term stem cell self-renewal
inferred← citeshttps://doi.org/10.1016/j.ydbio.2009.04.025openalex-snapshot
Vasa and the germ line lineage in a colonial urochordate
inferred← citeshttps://doi.org/10.1016/j.ydbio.2009.07.019openalex-snapshot
Stem cells are differentially regulated during development, regeneration and homeostasis in flatworms
inferred← citeshttps://doi.org/10.1016/j.ydbio.2009.10.030openalex-snapshot
Nanos functions to maintain the fate of the small micromere lineage in the sea urchin embryo
inferred← citeshttps://doi.org/10.1016/j.ydbio.2010.02.037openalex-snapshot
Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance
inferred← citeshttps://doi.org/10.1016/j.ydbio.2011.05.669openalex-snapshot
Stem cell-based growth, regeneration, and remodeling of the planarian intestine
inferred← citeshttps://doi.org/10.1016/j.ydbio.2011.06.030openalex-snapshot
Boule-like genes regulate male and female gametogenesis in the flatworm Macrostomum lignano
inferred← citeshttps://doi.org/10.1016/j.ydbio.2011.10.014openalex-snapshot
Drpiwi-1 is essential for germline cell formation during sexualization of the planarian Dugesia ryukyuensis
inferred← citeshttps://doi.org/10.1016/j.ydbio.2012.07.021openalex-snapshot
Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl
inferred← citeshttps://doi.org/10.1016/j.ydbio.2014.08.032openalex-snapshot
vasa and piwi are required for mitotic integrity in early embryogenesis in the spider Parasteatoda tepidariorum
inferred← citeshttps://doi.org/10.1016/j.ydbio.2017.07.022openalex-snapshot
Girardia dorotocephala transcriptome sequence, assembly, and validation through characterization of piwi homologs and stem cell progeny markers
inferred← citeshttps://doi.org/10.1016/j.ydbio.2017.10.010openalex-snapshot
EvoRegen in animals: Time to uncover deep conservation or convergence of adult stem cell evolution and regenerative processes
inferred← citeshttps://doi.org/10.1016/j.ydbio.2019.09.010openalex-snapshot
The exon junction complex is required for stem and progenitor cell maintenance in planarians
inferred← citeshttps://doi.org/10.1016/j.ydbio.2021.02.004openalex-snapshot
CBP/p300 homologs CBP2 and CBP3 play distinct roles in planarian stem cell function
inferred← citeshttps://doi.org/10.1016/j.ydbio.2024.12.018openalex-snapshot
Oogenesis involves a novel nuclear envelop remodeling mechanism in Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1016/j.ygcen.2011.11.044openalex-snapshot
Human chorionic gonadotropin suppresses expression of Piwis in common carp (Cyprinus carpio) ovaries
inferred← citeshttps://doi.org/10.1016/j.ygeno.2012.03.001openalex-snapshot
Identification of small non-coding RNAs in the planarian Dugesia japonica via deep sequencing
inferred← citeshttps://doi.org/10.1016/j.ympev.2012.11.014openalex-snapshot
Phylogenetic analysis of the Argonaute protein family in platyhelminths
inferred← citeshttps://doi.org/10.1016/s0091-679x(10)96014-7openalex-snapshot
Electron Microscopy of Flatworms
inferred← citeshttps://doi.org/10.1017/s0031182009991727openalex-snapshot
Echinococcus multilocularisas an experimental model in stem cell research and molecular host-parasite interaction
inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00393openalex-snapshot
PIWI-Interacting RNA in Drosophila : Biogenesis, Transposon Regulation, and Beyond
inferred← citeshttps://doi.org/10.1038/cr.2011.151openalex-snapshot
Argonaute-2 regulates the proliferation of adult stem cells in planarian
inferred← citeshttps://doi.org/10.1038/nature12987openalex-snapshot
PIWI proteins and PIWI-interacting RNAs in the soma
inferred← citeshttps://doi.org/10.1038/nrm2621openalex-snapshot
MicroRNAs: key regulators of stem cells
inferred← citeshttps://doi.org/10.1038/s41388-026-03791-zopenalex-snapshot
PIWIL1 activates the R2TP-TELO2-mTORC1 axis independently of piRNA to promote TOP mRNA translation in gastric cancer
inferred← citeshttps://doi.org/10.1038/s41556-021-00734-6openalex-snapshot
Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1038/s41559-017-0403-4openalex-snapshot
Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements
inferred← citeshttps://doi.org/10.1038/s41580-022-00528-0openalex-snapshot
Emerging roles and functional mechanisms of PIWI-interacting RNAs
inferred← citeshttps://doi.org/10.1038/s41598-018-24319-wopenalex-snapshot
piRNA-like small RNAs are responsible for the maternal-specific knockdown in the ascidian Ciona intestinalis Type A
inferred← citeshttps://doi.org/10.1038/s41598-018-32635-4openalex-snapshot
Comprehensive Evolutionary Analysis of the Major RNA-Induced Silencing Complex Members
inferred← citeshttps://doi.org/10.1038/s41598-024-75098-6openalex-snapshot
PIWIL1 is recruited to centrosomes during mitosis in colorectal cancer cells and is linked to cell cycle progression
inferred← citeshttps://doi.org/10.1038/s42003-018-0141-4openalex-snapshot
PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation
inferred← citeshttps://doi.org/10.1073/pnas.0905222106openalex-snapshot
High-resolution profiling and discovery of planarian small RNAs
inferred← citeshttps://doi.org/10.1073/pnas.2008724117openalex-snapshot
PIWIL1 promotes gastric cancer via a piRNA-independent mechanism
inferred← citeshttps://doi.org/10.1073/pnas.2103723118openalex-snapshot
A chromodomain protein mediates heterochromatin-directed piRNA expression
inferred← citeshttps://doi.org/10.1074/jbc.m110.193888openalex-snapshot
The Yb Body, a Major Site for Piwi-associated RNA Biogenesis and a Gateway for Piwi Expression and Transport to the Nucleus in Somatic Cells
inferred← citeshttps://doi.org/10.1074/jbc.ra118.004445openalex-snapshot
Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1083/jcb.201006034openalex-snapshot
piRNAs, transposon silencing, and Drosophila germline development
inferred← citeshttps://doi.org/10.1084/jem.20161371openalex-snapshot
A transit-amplifying population underpins the efficient regenerative capacity of the testis
inferred← citeshttps://doi.org/10.1093/gbe/evae082openalex-snapshot
Conserved Genes in Highly Regenerative Metazoans Are Associated with Planarian Regeneration
inferred← citeshttps://doi.org/10.1093/gbe/evv126openalex-snapshot
A Novel Terminal-Repeat Retrotransposon in Miniature (TRIM) Is Massively Expressed inEchinococcus multilocularisStem Cells
inferred← citeshttps://doi.org/10.1093/gbe/evw018openalex-snapshot
Duplication and Diversification of Dipteran Argonaute Genes, and the Evolutionary Divergence of Piwi and Aubergine
inferred← citeshttps://doi.org/10.1093/icb/icu084openalex-snapshot
Piwi and Potency: PIWI Proteins in Animal Stem Cells and Regeneration
inferred← citeshttps://doi.org/10.1093/nar/gkad1212openalex-snapshot
piRNA generation is associated with the pioneer round of translation in stem cells
inferred← citeshttps://doi.org/10.1093/nar/gks1020openalex-snapshot
Deep sequencing reveals unique small RNA repertoire that is regulated during head regeneration in Hydra magnipapillata
inferred← citeshttps://doi.org/10.1093/nar/gku620openalex-snapshot
The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells
inferred← citeshttps://doi.org/10.1093/nar/gkw1368openalex-snapshot
Histone-derived piRNA biogenesis depends on the ping-pong partners Piwi5 and Ago3 inAedes aegypti
inferred← citeshttps://doi.org/10.1093/nsr/nwu014openalex-snapshot
PIWI proteins and their interactors in piRNA biogenesis, germline development and gene expression
inferred← citeshttps://doi.org/10.1096/fj.201600637rropenalex-snapshot
piRNAs and their diverse roles: a transposable element‐driven tactic for gene regulation?
inferred← citeshttps://doi.org/10.1101/122135openalex-snapshot
Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone modifications in animal stem cells
inferred← citeshttps://doi.org/10.1101/185694openalex-snapshot
Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements
inferred← citeshttps://doi.org/10.1101/2020.06.04.132753openalex-snapshot
Identification of rare transient somatic cell states induced by injury and required for whole-body regeneration
inferred← citeshttps://doi.org/10.1101/2021.04.30.442165openalex-snapshot
A somatic piRNA pathway regulates epithelial-to-mesenchymal transition of chick neural crest cells
inferred← citeshttps://doi.org/10.1101/2023.12.07.570436openalex-snapshot
Nanos2+ cells give rise to germline and somatic lineages in the sea anemone Nematostella vectensis
inferred← citeshttps://doi.org/10.1101/377390openalex-snapshot
The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans
inferred← citeshttps://doi.org/10.1101/573725openalex-snapshot
Retaining pluripotency and exogenous mRNA introduction in planarian stem cell culture
inferred← citeshttps://doi.org/10.1101/620609openalex-snapshot
Subcellular analyses of planarian meiosis implicates a novel, double-membraned vesiculation process in nuclear envelope breakdown
inferred← citeshttps://doi.org/10.1101/cshperspect.a002717openalex-snapshot
Small Noncoding RNAs in the Germline
inferred← citeshttps://doi.org/10.1101/gad.1951010openalex-snapshot
A functional genomic screen in planarians identifies novel regulators of germ cell development
inferred← citeshttps://doi.org/10.1101/gad.238105.114openalex-snapshot
PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans
inferred← citeshttps://doi.org/10.1101/gad.319293.118openalex-snapshot
The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans
inferred← citeshttps://doi.org/10.1101/gad.322776.118openalex-snapshot
Planarians recruit piRNAs for mRNA turnover in adult stem cells
inferred← citeshttps://doi.org/10.1101/gr.239848.118openalex-snapshot
Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone modifications in animal stem cells
inferred← citeshttps://doi.org/10.1101/sqb.2008.73.022openalex-snapshot
Germ Cell Specification and Regeneration in Planarians
inferred← citeshttps://doi.org/10.1101/sqb.2008.73.056openalex-snapshot
A Novel Epigenetic Mechanism in Drosophila Somatic Cells Mediated by PIWI and piRNAs
inferred← citeshttps://doi.org/10.1101/sqb.2008.73.058openalex-snapshot
Small RNA Silencing Pathways in Germ and Stem Cells
inferred← citeshttps://doi.org/10.1111/acel.12487openalex-snapshot
Maintenance of somatic tissue regeneration with age in short‐ and long‐lived species of sea urchins
inferred← citeshttps://doi.org/10.1111/brv.12801openalex-snapshot
A pan‐metazoan concept for adult stem cells: the wobbling Penrose landscape
inferred← citeshttps://doi.org/10.1111/dgd.12211openalex-snapshot
Evolution of germline segregation processes in animal development
inferred← citeshttps://doi.org/10.1111/dgd.12536openalex-snapshot
Searching for non‐transposable targets of planarian nuclear PIWI in pluripotent stem cells and differentiated cells
inferred← citeshttps://doi.org/10.1111/dgd.12688openalex-snapshot
What is the role of PIWI family proteins in adult pluripotent stem cells? Insights from asexually reproducing animals, planarians
inferred← citeshttps://doi.org/10.1111/febs.17360openalex-snapshot
pi RNA processing within non‐membrane structures is governed by constituent proteins and their functional motifs
inferred← citeshttps://doi.org/10.1111/j.1440-169x.2008.01066.xopenalex-snapshot
Neoblast‐enriched fraction rescues eye formation in eye‐defective planarian ‘menashi’Dugesia ryukyuensis
inferred← citeshttps://doi.org/10.1111/j.1440-169x.2009.01155.xopenalex-snapshot
Cellular and molecular dissection of pluripotent adult somatic stem cells in planarians
inferred← citeshttps://doi.org/10.1111/j.1440-169x.2009.01157.xopenalex-snapshot
Single‐cell gene profiling of planarian stem cells using fluorescent activated cell sorting and its “index sorting” function for stem cell research
inferred← citeshttps://doi.org/10.1111/j.1440-169x.2009.01162.xopenalex-snapshot
The stem cell system in demosponges: Insights into the origin of somatic stem cells
inferred← citeshttps://doi.org/10.1111/j.1440-169x.2010.01196.xopenalex-snapshot
Piwi‐expressing hemoblasts serve as germline stem cells during postembryonic germ cell specification in colonial ascidian, Botryllus primigenus
inferred← citeshttps://doi.org/10.1126/sciadv.abn1441openalex-snapshot
Co-option of the piRNA pathway to regulate neural crest specification
inferred← citeshttps://doi.org/10.1126/sciadv.ado0424openalex-snapshot
Nanos2 marks precursors of somatic lineages and is required for germline formation in the sea anemone Nematostella vectensis
inferred← citeshttps://doi.org/10.1128/jvi.00623-20openalex-snapshot
A Novel Taxon of Monosegmented Double-Stranded RNA Viruses Endemic to Triclad Flatworms
inferred← citeshttps://doi.org/10.1134/s0026893310010024openalex-snapshot
Characterization and expression of DjPreb gene in the planarian Dugesia japonica
inferred← citeshttps://doi.org/10.1134/s0026893310040114openalex-snapshot
Expression pattern of DjPreb gene during the planarian Dugesia japonica embryonic development
inferred← citeshttps://doi.org/10.1134/s106307402002011xopenalex-snapshot
The Immunocytochemical Identification of PIWI-Positive Cells during the Recovery of a Coelomocyte Population after Evisceration in the Holothurian Eupentacta fraudatrix (Djakonov et Baranova, 1958) (Holothuroidea: Dendrochirota)
inferred← citeshttps://doi.org/10.1146/annurev-genet-011725-091634openalex-snapshot
Genetic and Genomic Insights into Planarian Biology
inferred← citeshttps://doi.org/10.1146/annurev-genet-110410-132541openalex-snapshot
Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms
inferred← citeshttps://doi.org/10.1146/annurev.cellbio.24.110707.175327openalex-snapshot
The Biogenesis and Function of PIWI Proteins and piRNAs: Progress and Prospect
inferred← citeshttps://doi.org/10.1155/2016/6947395openalex-snapshot
Epigenetics and Shared Molecular Processes in the Regeneration of Complex Structures
inferred← citeshttps://doi.org/10.1155/2018/5848046openalex-snapshot
The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics
inferred← citeshttps://doi.org/10.1177/0748233712443148openalex-snapshot
Effects of N , N -dimethylformamide on behaviour and regeneration of planarian Dugesia japonica
inferred← citeshttps://doi.org/10.1186/1471-213x-9-69openalex-snapshot
Characterization of the stem cell system of the acoel Isodiametra pulchra
inferred← citeshttps://doi.org/10.1186/1471-2164-10-464openalex-snapshot
Homology-based annotation of non-coding RNAs in the genomes of Schistosoma mansoni and Schistosoma japonicum
inferred← citeshttps://doi.org/10.1186/1471-2407-10-38openalex-snapshot
Argonaute proteins: potential biomarkers for human colon cancer
inferred← citeshttps://doi.org/10.1186/gb-2012-13-3-r19openalex-snapshot
Defining the molecular profile of planarian pluripotent stem cells using a combinatorial RNA-seq, RNA interference and irradiation approach
inferred← citeshttps://doi.org/10.1186/s12862-017-1061-5openalex-snapshot
Conservation and diversification of small RNA pathways within flatworms
inferred← citeshttps://doi.org/10.1186/s12864-019-6292-yopenalex-snapshot
Efficient depletion of ribosomal RNA for RNA sequencing in planarians
inferred← citeshttps://doi.org/10.1186/s12864-020-07234-1openalex-snapshot
Different classes of small RNAs are essential for head regeneration in the planarian Dugesia japonica
inferred← citeshttps://doi.org/10.1186/s13071-015-0686-8openalex-snapshot
microRNA profiling in the zoonotic parasite Echinococcus canadensis using a high-throughput approach
inferred← citeshttps://doi.org/10.1200/jco.2011.29.15_suppl.e20500openalex-snapshot
The role of HIWI in stem cell maintenance and sarcomagenesis.
inferred← citeshttps://doi.org/10.1242/bio.20123400openalex-snapshot
Towards a bioinformatics of patterning: a computational approach to understanding regulative morphogenesis
inferred← citeshttps://doi.org/10.1242/dev.047969openalex-snapshot
A conserved germline multipotency program
inferred← citeshttps://doi.org/10.1242/dev.076182openalex-snapshot
PRMT5 and the role of symmetrical dimethylarginine in chromatoid bodies of planarian stem cells
inferred← citeshttps://doi.org/10.1242/dev.080499openalex-snapshot
Specialized progenitors and regeneration
inferred← citeshttps://doi.org/10.1242/dev.101618openalex-snapshot
PIWI homologs mediate Histone H4 mRNA localization to planarian chromatoid bodies
inferred← citeshttps://doi.org/10.1242/dev.152942openalex-snapshot
Cytoplasmic poly (A) binding protein (PABPC2) critically regulates epidermal maintenance and turnover in planarian Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1242/dev.161786openalex-snapshot
piRNAs and PIWI proteins: regulators of gene expression in development and stem cells
inferred← citeshttps://doi.org/10.1242/dev.191957openalex-snapshot
Transposon control as a checkpoint for tissue regeneration
inferred← citeshttps://doi.org/10.1242/dev.199449openalex-snapshot
Loss of plac8 expression rapidly leads pluripotent stem cells to enter active state during planarian regeneration
inferred← citeshttps://doi.org/10.1242/dev.204762openalex-snapshot
Enhanced RNA quality control maintains long-term regenerative ability in planarians
inferred← citeshttps://doi.org/10.1242/dmm.006692openalex-snapshot
The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration
inferred← citeshttps://doi.org/10.1242/jcs.259304openalex-snapshot
Restoration of DNA integrity and the cell cycle by electric stimulation in planarian tissues damaged by ionizing radiation
inferred← citeshttps://doi.org/10.1242/jcs.259900openalex-snapshot
S. mediterranea ETS-1 regulates the function of cathepsin-positive cells and the epidermal lineage landscape via basement membrane remodeling
inferred← citeshttps://doi.org/10.1242/jeb.244218openalex-snapshot
Effects of thermal acclimation on the proteome of the planarian Crenobia alpina from an alpine freshwater spring
inferred← citeshttps://doi.org/10.1261/rna.038653.113openalex-snapshot
Identification of neoblast- and regeneration-specific miRNAs in the planarian Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1261/rna.052456.115openalex-snapshot
Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano
inferred← citeshttps://doi.org/10.1261/rna.072835.119openalex-snapshot
PIWI–piRNA pathway-mediated transposable element repression in Hydra somatic stem cells
inferred← citeshttps://doi.org/10.1261/rna.077701.120openalex-snapshot
Comprehensive annotation and characterization of planarian tRNA and tRNA-derived fragments (tRFs)
inferred← citeshttps://doi.org/10.1261/rna.1702009openalex-snapshot
Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea
inferred← citeshttps://doi.org/10.13025/16683openalex-snapshot
Characterization of PIWI+ stem cells in Hydractinia
inferred← citeshttps://doi.org/10.13028/hq4s-ya26openalex-snapshot
Small RNA Sorting in Drosophila Produces Chemically Distinct Functional RNA-Protein Complexes: A Dissertation
inferred← citeshttps://doi.org/10.1371/annotation/984cd209-4e98-467c-b462-c11090e43be7openalex-snapshot
Correction: A Transcriptomic Analysis of Echinococcus granulosus Larval Stages: Implications for Parasite Biology and Host Adaptation
inferred← citeshttps://doi.org/10.1371/journal.pbio.3001472openalex-snapshot
A Krüppel-like factor is required for development and regeneration of germline and yolk cells from somatic stem cells in planarians
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1002481openalex-snapshot
Modeling Planarian Regeneration: A Primer for Reverse-Engineering the Worm
inferred← citeshttps://doi.org/10.1371/journal.pgen.1004003openalex-snapshot
The CCR4-NOT Complex Mediates Deadenylation and Degradation of Stem Cell mRNAs and Promotes Planarian Stem Cell Differentiation
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007828openalex-snapshot
The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1371/journal.pntd.0001745openalex-snapshot
Identification and Characterization of Argonaute Protein, Ago2 and Its Associated Small RNAs in Schistosoma japonicum
inferred← citeshttps://doi.org/10.1371/journal.pntd.0001897openalex-snapshot
A Transcriptomic Analysis of Echinococcus granulosus Larval Stages: Implications for Parasite Biology and Host Adaptation
inferred← citeshttps://doi.org/10.1371/journal.pntd.0001916openalex-snapshot
Molecular Changes in Opisthorchis viverrini (Southeast Asian Liver Fluke) during the Transition from the Juvenile to the Adult Stage
inferred← citeshttps://doi.org/10.1371/journal.pone.0005502openalex-snapshot
To Be or Not to Be a Flatworm: The Acoel Controversy
inferred← citeshttps://doi.org/10.1371/journal.pone.0015617openalex-snapshot
A Dual Platform Approach to Transcript Discovery for the Planarian Schmidtea Mediterranea to Establish RNAseq for Stem Cell and Regeneration Biology
inferred← citeshttps://doi.org/10.1371/journal.pone.0034447openalex-snapshot
Transcriptome Analysis Reveals Strain-Specific and Conserved Stemness Genes in Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1371/journal.pone.0037319openalex-snapshot
What Role Do Annelid Neoblasts Play? A Comparison of the Regeneration Patterns in a Neoblast-Bearing and a Neoblast-Lacking Enchytraeid Oligochaete
inferred← citeshttps://doi.org/10.1371/journal.pone.0133860openalex-snapshot
Tissue Regeneration and Biomineralization in Sea Urchins: Role of Notch Signaling and Presence of Stem Cell Markers
inferred← citeshttps://doi.org/10.1387/ijdb.113436aropenalex-snapshot
Small RNA pathways in Schmidtea mediterranea
inferred← citeshttps://doi.org/10.1387/ijdb.123509cfopenalex-snapshot
Germline stem cells and sex determination in Hydra
inferred← citeshttps://doi.org/10.13918/j.issn.2095-8137.2016.5.301openalex-snapshot
Identification of candidate piRNAs in the gonads of Paralichthys olivaceus (Japanese flounder).
inferred← citeshttps://doi.org/10.1515/9783111304847-008openalex-snapshot
465Chapter 8 Regeneration
inferred← citeshttps://doi.org/10.1515/hsz-2019-0445openalex-snapshot
The piRNA pathway in planarian flatworms: new model, new insights
inferred← citeshttps://doi.org/10.15252/embr.202050292openalex-snapshot
Identification of TOR-responsive slow-cycling neoblasts in planarians
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