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Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Back to the Future with Phenotypic Screening
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Pet dogs set to test anti-ageing drug
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Anti-ageing pill pushed as bona fide drug
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Resveratrol improves health and survival of mice on a high-calorie diet
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An antidepressant that extends lifespan in adult Caenorhabditis elegans
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Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
inferredcites →https://doi.org/10.1038/nature10440openalex-snapshot
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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The sirtuin SIRT6 regulates lifespan in male mice
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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
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A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol
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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
inferredcites →https://doi.org/10.1038/ncb1975openalex-snapshot
Induction of autophagy by spermidine promotes longevity
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Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
inferredcites →https://doi.org/10.1038/ncomms3192openalex-snapshot
Metformin improves healthspan and lifespan in mice
inferredcites →https://doi.org/10.1038/nm.4000openalex-snapshot
Cellular senescence in aging and age-related disease: from mechanisms to therapy
inferredcites →https://doi.org/10.1038/nm.4010openalex-snapshot
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
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Forging a signature of in vivo senescence
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Therapeutic potential of resveratrol: the in vivo evidence
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
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Cellular mechanisms and physiological consequences of redox-dependent signalling
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The Genesis of Ores
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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
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SRT1720 improves survival and healthspan of obese mice
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Repurposing metformin: an old drug with new tricks in its binding pockets
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Aspirin Dose and Duration of Use and Risk of Colorectal Cancer in Men
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10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
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Life extension in Drosophila by feeding a drug
inferredcites →https://doi.org/10.1073/pnas.0404184101openalex-snapshot
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
inferredcites →https://doi.org/10.1073/pnas.0801030105openalex-snapshot
FOXO3A genotype is strongly associated with human longevity
inferredcites →https://doi.org/10.1073/pnas.0809594106openalex-snapshot
Association of FOXO3A variation with human longevity confirmed in German centenarians
inferredcites →https://doi.org/10.1073/pnas.96.12.7059openalex-snapshot
Progressive hypertrophy and heart failure in β 1 -adrenergic receptor transgenic mice
inferredcites →https://doi.org/10.1074/jbc.m110.100420openalex-snapshot
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
inferredcites →https://doi.org/10.1074/jbc.m500655200openalex-snapshot
Substrate-specific Activation of Sirtuins by Resveratrol
inferredcites →https://doi.org/10.1074/jbc.m501250200openalex-snapshot
Mechanism of Human SIRT1 Activation by Resveratrol
inferredcites →https://doi.org/10.1074/jbc.m508246200openalex-snapshot
Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides
inferredcites →https://doi.org/10.1083/jcb.200505082openalex-snapshot
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
inferredcites →https://doi.org/10.1083/jcb.201009094openalex-snapshot
Four faces of cellular senescence
inferredcites →https://doi.org/10.1089/ars.2011.4151openalex-snapshot
Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and Extends Lifespan of Caenorhabditis elegans
inferredcites →https://doi.org/10.1089/jmf.2012.2194openalex-snapshot
Resveratrol Inhibits Inflammation Induced by Heat-Killed Listeria monocytogenes
inferredcites →https://doi.org/10.1089/rej.2008.0827openalex-snapshot
Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study
inferredcites →https://doi.org/10.1089/rej.2012.1349openalex-snapshot
Spermidine and Spermine Are Enriched in Whole Blood of Nona/Centenarians
inferredcites →https://doi.org/10.1089/rej.2012.1392openalex-snapshot
Fibroblast Growth Factor-21 Is a Promising Dietary Restriction Mimetic
inferredcites →https://doi.org/10.1093/gerona/gln072openalex-snapshot
Cell Stress and Aging: New Emphasis on Multiplex Resistance Mechanisms
inferredcites →https://doi.org/10.1093/gerona/glq033openalex-snapshot
Metformin Supplementation and Life Span in Fischer-344 Rats
inferredcites →https://doi.org/10.1093/gerona/glq178openalex-snapshot
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
inferredcites →https://doi.org/10.1093/gerona/gls070openalex-snapshot
Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice
inferredcites →https://doi.org/10.1093/gerona/glt056openalex-snapshot
Rapamycin Extends Life and Health in C57BL/6 Mice
inferredcites →https://doi.org/10.1093/gerona/glu101openalex-snapshot
Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset
inferredcites →https://doi.org/10.1093/gerona/glv309openalex-snapshot
17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization
inferredcites →https://doi.org/10.1093/hmg/ddp459openalex-snapshot
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations
inferredcites →https://doi.org/10.1093/jb/mvj003openalex-snapshot
Decrease in Polyamines with Aging and Their Ingestion from Food and Drink
inferredcites →https://doi.org/10.1093/jn/137.4.1078openalex-snapshot
Starving for Life: What Animal Studies Can and Cannot Tell Us about the Use of Caloric Restriction to Prolong Human Lifespan1,
inferredcites →https://doi.org/10.1093/jnci/93.20.1517openalex-snapshot
Rapamycin's Resurrection: A New Way to Target the Cancer Cell Cycle
inferredcites →https://doi.org/10.1093/jnci/dji173openalex-snapshot
A Large Cohort Study of Aspirin and Other Nonsteroidal Anti-inflammatory Drugs and Prostate Cancer Incidence
inferredcites →https://doi.org/10.1097/cad.0000000000000207openalex-snapshot
Complications of mammalian target of rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life-threatening
inferredcites →https://doi.org/10.1097/mco.0000000000000009openalex-snapshot
Antioxidant supplements and mortality
inferredcites →https://doi.org/10.1098/rsbl.2013.0432openalex-snapshot
Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal
inferredcites →https://doi.org/10.1101/cshperspect.a025924openalex-snapshot
Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin and Beyond
inferredcites →https://doi.org/10.1101/gad.13.19.2570openalex-snapshot
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
inferredcites →https://doi.org/10.1101/gad.1381406openalex-snapshot
Extension of chronological life span in yeast by decreased TOR pathway signaling
inferredcites →https://doi.org/10.1111/acel.12011openalex-snapshot
Common genetic variants of the β2‐adrenergic receptor affect its translational efficiency and are associated with human longevity
inferredcites →https://doi.org/10.1111/acel.12163openalex-snapshot
A pharmacological network for lifespan extension in C aenorhabditis elegans
inferredcites →https://doi.org/10.1111/acel.12170openalex-snapshot
Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
inferredcites →https://doi.org/10.1111/acel.12194openalex-snapshot
Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
inferredcites →https://doi.org/10.1111/acel.12220openalex-snapshot
SRT 2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
inferredcites →https://doi.org/10.1111/acel.12338openalex-snapshot
Interventions to Slow Aging in Humans: Are We Ready?
inferredcites →https://doi.org/10.1111/acel.12344openalex-snapshot
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
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DNA methylation and healthy human aging
inferredcites →https://doi.org/10.1111/acel.12405openalex-snapshot
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
inferredcites →https://doi.org/10.1111/acel.12432openalex-snapshot
A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans
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Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls
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The arachidonic acid 5‐lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor α activation of microglia and extends survival of G93A‐SOD1 transgenic mice
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Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease
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Annual fishes of the genus Nothobranchius as a model system for aging research
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Temperature affects longevity and age‐related locomotor and cognitive decay in the short‐lived fish Nothobranchius furzeri
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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
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Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
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Replication of an association of variation in the FOXO3A gene with human longevity using both case–control and longitudinal data
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Rapamycin slows aging in mice
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The number of p16INK4a positive cells in human skin reflects biological age
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‘Accelerated aging’: a primrose path to insight?
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Rebuttal to Miller: ‘Accelerated aging’: a primrose path to insight?’
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Resveratrol: a cardioprotective substance
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Regulation of Longevity and Stress Resistance by Sch9 in Yeast
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Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction
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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
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Extending Healthy Life Span—From Yeast to Humans
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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
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Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
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mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
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Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice
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Aspirin and other anti-inflammatory drugs
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Regulation of Immune Responses by mTOR
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What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Cryopreserved Placental Explants Increase Lifespan of Male Mice and Change Survival Features of Female Mice
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The failure of “engineered rejuvenation”: laboratory genomics do not translate into precision anti-aging therapies
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Caloric restriction induced epigenetic effects on aging
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