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Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

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What this work says

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inferred← citeshttps://doi.org/10.1016/b978-0-12-409548-9.11737-3openalex-snapshot

Cancer Risk Assessment and Communication

inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.64942-5openalex-snapshot

Toxicology and Risk Assessment of Chemical Mixtures and Multiple Stressors

inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.95691-5openalex-snapshot

Carcinogenic Polycyclic Aromatic Hydrocarbons

inferred← citeshttps://doi.org/10.1016/b978-0-12-811745-3.00135-xopenalex-snapshot

References

inferred← citeshttps://doi.org/10.1016/b978-0-12-812433-8.00013-7openalex-snapshot

Incorporating Epigenetics Into a Risk Assessment Framework

inferred← citeshttps://doi.org/10.1016/b978-0-12-819092-0.00003-0openalex-snapshot

Oxidative stress status and industrial discharges

inferred← citeshttps://doi.org/10.1016/b978-0-12-820490-0.00022-5openalex-snapshot

Residual Risk of Nicotine

inferred← citeshttps://doi.org/10.1016/b978-0-12-821044-4.00013-3openalex-snapshot

Carcinogenesis: Mechanisms and Evaluation

inferred← citeshttps://doi.org/10.1016/b978-0-12-821848-8.00118-9openalex-snapshot

Cancer: Carcinogenic substances in food

inferred← citeshttps://doi.org/10.1016/b978-0-323-91081-1.00015-7openalex-snapshot

The interplay between DNA damage and epigenetics in cancer

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00035-8openalex-snapshot

Immunotoxicity Studies

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00087-5openalex-snapshot

Carcinogenic Polycyclic Aromatic Hydrocarbons

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00102-9openalex-snapshot

Toxicity of Airborne Metals

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00103-0openalex-snapshot

Chronic Effects of Cigarette Smoke on the Respiratory Tract

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00106-6openalex-snapshot

Ionizing Radiation as a Carcinogen

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00113-3openalex-snapshot

Carcinogenic Mycotoxins

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00114-5openalex-snapshot

Viruses and Carcinogenesis

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00133-9openalex-snapshot

Non-Genotoxic Carcinogenesis

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00193-5openalex-snapshot

Aromatic Amines, Aromatic Amides, and Heterocyclic Aromatic Amines

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00194-7openalex-snapshot

Carcinogenic Inorganic Chemicals

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00216-3openalex-snapshot

Mutational Signatures in Cancer Genomics and Toxicology

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00247-3openalex-snapshot

Carcinogenic Alkylating Agents

inferred← citeshttps://doi.org/10.1016/b978-0-443-14158-4.00020-8openalex-snapshot

Tea and cancer risk

inferred← citeshttps://doi.org/10.1016/b978-0-443-30120-9.00013-1openalex-snapshot

Industrial emissions and pollutants linked to lung cancer

inferred← citeshttps://doi.org/10.1016/b978-0-443-36474-7.00004-1openalex-snapshot

Modern modeling approaches for data gap filling

inferred← citeshttps://doi.org/10.1016/b978-0-443-36474-7.00030-2openalex-snapshot

Emerging advances in modeling chemical mutagenicity and carcinogenicity

inferred← citeshttps://doi.org/10.1016/b978-0-443-36500-3.00007-6openalex-snapshot

Inflammation's role in cancer: Unveiling the molecular connections

inferred← citeshttps://doi.org/10.1016/b978-0-443-44322-0.00007-0openalex-snapshot

Environmental exposures and cancer risk: An exposomics perspective in low- and middle-income countries

inferred← citeshttps://doi.org/10.1016/b978-0-443-44322-0.00017-3openalex-snapshot

Artificial intelligence, big data, and the exposome: Transforming cancer risk assessment

inferred← citeshttps://doi.org/10.1016/bs.apha.2022.10.003openalex-snapshot

Breast carcinogenesis induced by organophosphorous pesticides

inferred← citeshttps://doi.org/10.1016/j.advnut.2025.100552openalex-snapshot

Lack of Genotoxic and Carcinogenic Potential for Nonsugar Sweeteners: A Review of Animal and Mechanistic Evidence

inferred← citeshttps://doi.org/10.1016/j.amsu.2022.104022openalex-snapshot

Tumor-promoting inflammation in lung cancer: A literature review

inferred← citeshttps://doi.org/10.1016/j.annepidem.2017.03.003openalex-snapshot

2,4-dichlorophenoxyacetic acid (2,4-D) and risk of non-Hodgkin lymphoma: a meta-analysis accounting for exposure levels

inferred← citeshttps://doi.org/10.1016/j.bbamem.2017.06.015openalex-snapshot

An update on minding the gap in cancer

inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188489openalex-snapshot

Gut mycobiome: A promising target for colorectal cancer

inferred← citeshttps://doi.org/10.1016/j.bbrep.2025.102294openalex-snapshot

Promotional effects of aged ZnO nanoparticles on migration, invasion and metastasis of human breast cancer MCF-7 cells in vitro and in vivo

inferred← citeshttps://doi.org/10.1016/j.biocel.2022.106346openalex-snapshot

Free radicals: Relationship to Human Diseases and Potential Therapeutic applications

inferred← citeshttps://doi.org/10.1016/j.bpg.2017.09.016openalex-snapshot

Key role of local acetaldehyde in upper GI tract carcinogenesis

inferred← citeshttps://doi.org/10.1016/j.bulcan.2019.08.017openalex-snapshot

Cancers et expositions environnementales : entre certitudes et incertitudes

inferred← citeshttps://doi.org/10.1016/j.canep.2025.102941openalex-snapshot

Historical parallels between harms of tobacco and e-cigarettes

inferred← citeshttps://doi.org/10.1016/j.canep.2026.103165openalex-snapshot

Identifying carcinogenic hazards among pharmaceutical agents: An update from the IARC Monographs programme

inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216302openalex-snapshot

Gut fungal mycobiome: A significant factor of tumor occurrence and development

inferred← citeshttps://doi.org/10.1016/j.carbon.2025.119997openalex-snapshot

Toxicity of carbon nanomaterials: A model to predict ROS production from easily measurable surface characteristics

inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.134308openalex-snapshot

The study of human serum metabolome on the health effects of glyphosate and early warning of potential damage

inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.137658openalex-snapshot

Human functional genomics reveals toxicological mechanism underlying genotoxicants-induced inflammatory responses under low doses exposure

inferred← citeshttps://doi.org/10.1016/j.chemosphere.2023.139572openalex-snapshot

Mapping the key characteristics of carcinogens for glyphosate and its formulations: A systematic review

inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.143745openalex-snapshot

Clinical, histological, molecular, and toxicokinetic renal outcomes of per-/polyfluoroalkyl substances (PFAS) exposure: Systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1016/j.chemosphere.2025.144508openalex-snapshot

Human exposure and toxicity of per- and polyfluoroalkyl substances: Narrative review and perspectives

inferred← citeshttps://doi.org/10.1016/j.clay.2025.107917openalex-snapshot

Evaluation of the potential toxicity of respirable halloysite elongate mineral particles: Insights from the Fibre Potential Toxicity Index (FPTI) model

inferred← citeshttps://doi.org/10.1016/j.clml.2025.11.005openalex-snapshot

An Update of Evidence that the Herbicide Glyphosate (Roundup) is a Cause of Non-Hodgkin Lymphoma

inferred← citeshttps://doi.org/10.1016/j.comtox.2017.11.003openalex-snapshot

BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening

inferred← citeshttps://doi.org/10.1016/j.comtox.2018.06.003openalex-snapshot

Novel application of normalized pointwise mutual information (NPMI) to mine biomedical literature for gene sets associated with disease: Use case in breast carcinogenesis

inferred← citeshttps://doi.org/10.1016/j.comtox.2021.100185openalex-snapshot

Integrating publicly available information to screen potential candidates for chemical prioritization under the Toxic Substances Control Act: A proof of concept case study using genotoxicity and carcinogenicity

inferred← citeshttps://doi.org/10.1016/j.comtox.2021.100188openalex-snapshot

In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities

inferred← citeshttps://doi.org/10.1016/j.comtox.2021.100191openalex-snapshot

In silico approaches in carcinogenicity hazard assessment: Current status and future needs

inferred← citeshttps://doi.org/10.1016/j.comtox.2022.100223openalex-snapshot

Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches

inferred← citeshttps://doi.org/10.1016/j.cotox.2017.06.007openalex-snapshot

Epigenetics in chemical-induced genotoxic carcinogenesis

inferred← citeshttps://doi.org/10.1016/j.cotox.2017.08.006openalex-snapshot

Genetic and epigenetic determinants of inter-individual variability in responses to toxicants

inferred← citeshttps://doi.org/10.1016/j.cotox.2017.09.002openalex-snapshot

Application of epigenetic data in human health risk assessment

inferred← citeshttps://doi.org/10.1016/j.cotox.2017.11.006openalex-snapshot

Editorial overview of the special issue on genomic toxicology epigenetics

inferred← citeshttps://doi.org/10.1016/j.cotox.2019.02.003openalex-snapshot

Regulatory use and acceptance of alternative methods for chemical hazard identification

inferred← citeshttps://doi.org/10.1016/j.cotox.2019.09.001openalex-snapshot

Mechanistic integration of exposure and effects: advances to apply systems toxicology in support of regulatory decision-making

inferred← citeshttps://doi.org/10.1016/j.cotox.2024.100459openalex-snapshot

Single cell approaches to understand environmental impacts on aggressive breast cancers

inferred← citeshttps://doi.org/10.1016/j.cotox.2024.100515openalex-snapshot

The key characteristics concept

inferred← citeshttps://doi.org/10.1016/j.cotox.2026.100607openalex-snapshot

Use of the IARC key characteristics of carcinogens KC1 (electrophilicity), KC2 (genotoxicity), and KC3 (DNA repair/genomic instability) for cancer hazard identification

inferred← citeshttps://doi.org/10.1016/j.cotox.2026.100619openalex-snapshot

Advancing cancer and carcinogenesis research through new approach methodologies

inferred← citeshttps://doi.org/10.1016/j.cppeds.2016.08.004openalex-snapshot

Childhood Leukemia and Primary Prevention

inferred← citeshttps://doi.org/10.1016/j.crtox.2021.01.005openalex-snapshot

Bridging the gap between toxicity and carcinogenicity of mineral fibres by connecting the fibre crystal-chemical and physical parameters to the key characteristics of cancer

inferred← citeshttps://doi.org/10.1016/j.crtox.2024.100202openalex-snapshot

Bridging the gap between toxicity and carcinogenicity of mineral fibres by connecting the fibre parameters to the key characteristics of carcinogens: A comprehensive model inspiring asbestos-induced cancer prevention strategies

inferred← citeshttps://doi.org/10.1016/j.crtox.2025.100224openalex-snapshot

Systematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in humans based on animal cancer studies and mechanistic data

inferred← citeshttps://doi.org/10.1016/j.crtox.2025.100270openalex-snapshot

Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans; lack of concern based on animal cancer studies and mechanistic data

inferred← citeshttps://doi.org/10.1016/j.crtox.2026.100284openalex-snapshot

Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence

inferred← citeshttps://doi.org/10.1016/j.crtox.2026.100290openalex-snapshot

A mechanistic evaluation of the metabolism disrupting potential of methyl tert-butyl ether

inferred← citeshttps://doi.org/10.1016/j.crtox.2026.100295openalex-snapshot

Evaluating the potential carcinogenic hazard of diisononyl phthalate in humans via systematic integration of human, animal cancer studies, and mechanistic data

inferred← citeshttps://doi.org/10.1016/j.cyto.2020.155299openalex-snapshot

Differences in biomarkers of inflammation and immune responses in chronic smokers and moist snuff users

inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104831openalex-snapshot

Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer risk

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.113757openalex-snapshot

SIRT1 regulated hexokinase-2 promoting glycolysis is involved in hydroquinone-enhanced malignant progression in human lymphoblastoid TK6 cells

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.114964openalex-snapshot

Regioselective oxidation of heterocyclic aromatic hydrocarbons catalyzed by cytochrome P450: A case study of carbazole

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.117222openalex-snapshot

Comprehensive analysis of adverse outcome pathway, potency, human exposure supports carcinogenicity of polyhexamethylene guanidine phosphate in lung cancer

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2026.120283openalex-snapshot

Integrated multi-endpoint hazard prioritization of unregulated industrial contaminants: A safety-first screening framework for emerging environmental threats

inferred← citeshttps://doi.org/10.1016/j.envint.2018.06.006openalex-snapshot

Environmental determinants of polycyclic aromatic hydrocarbons exposure at home, at kindergartens and during a commute

inferred← citeshttps://doi.org/10.1016/j.envint.2019.04.067openalex-snapshot

Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment

inferred← citeshttps://doi.org/10.1016/j.envint.2020.105887openalex-snapshot

What is new in the exposome?

inferred← citeshttps://doi.org/10.1016/j.envint.2020.105926openalex-snapshot

Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER)

inferred← citeshttps://doi.org/10.1016/j.envint.2021.106386openalex-snapshot

Genotoxicity of radiofrequency electromagnetic fields: Protocol for a systematic review of in vitro studies

inferred← citeshttps://doi.org/10.1016/j.envint.2021.106624openalex-snapshot

Prioritizing cancer hazard assessments for IARC Monographs using an integrated approach of database fusion and text mining

inferred← citeshttps://doi.org/10.1016/j.envint.2021.106923openalex-snapshot

ZnO nanoparticles promote the malignant transformation of colorectal epithelial cells in APC mice

inferred← citeshttps://doi.org/10.1016/j.envint.2021.106954openalex-snapshot

Simultaneous toxicokinetics characterization of acrylamide and its primary metabolites using a novel microdialysis isotope-dilution liquid chromatography mass spectrometry method

inferred← citeshttps://doi.org/10.1016/j.envint.2022.107109openalex-snapshot

Biological plausibility in environmental health systematic reviews: a GRADE concept paper

inferred← citeshttps://doi.org/10.1016/j.envint.2022.107408openalex-snapshot

The PFAS-Tox Database: A systematic evidence map of health studies on 29 per- and polyfluoroalkyl substances

inferred← citeshttps://doi.org/10.1016/j.envint.2023.108161openalex-snapshot

A vision for safer food contact materials: Public health concerns as drivers for improved testing

inferred← citeshttps://doi.org/10.1016/j.envint.2024.108864openalex-snapshot

Impact of perfluorooctanoic acid (PFOA) and perfluorobutanoic acid (PFBA) on oxidative stress and metabolic biomarkers in human neuronal cells (SH-SY5Y)

inferred← citeshttps://doi.org/10.1016/j.envint.2024.109104openalex-snapshot

Genotoxicity of radiofrequency electromagnetic fields on mammalian cells in vitro: A systematic review with narrative synthesis

inferred← citeshttps://doi.org/10.1016/j.envint.2024.109203openalex-snapshot

Serum metabolome associated with novel and legacy per- and polyfluoroalkyl substances exposure and thyroid cancer risk: A multi-module integrated analysis based on machine learning

inferred← citeshttps://doi.org/10.1016/j.envint.2025.109278openalex-snapshot

Health effects of occupational exposure to jet fuels used in the military: A systematic review of the epidemiologic literature

inferred← citeshttps://doi.org/10.1016/j.envint.2026.110465openalex-snapshot

Mapping disease-linked AOPs to inform bioassay selection for chemical hazard assessment

inferred← citeshttps://doi.org/10.1016/j.envint.2026.110517openalex-snapshot

Novel and rigorous methods for identifying cancer hazards: The updated Report on Carcinogens Handbook

inferred← citeshttps://doi.org/10.1016/j.envpol.2020.114607openalex-snapshot

Cross-sectional and longitudinal associations between global DNA (hydroxy) methylation and exposure biomarkers of the Hebei Spirit oil spill cohort in Taean, Korea

inferred← citeshttps://doi.org/10.1016/j.envpol.2020.116185openalex-snapshot

BTEX compounds leachates from cigarette butts into water environment: A primary study

inferred← citeshttps://doi.org/10.1016/j.envpol.2022.120719openalex-snapshot

Long-term exposure to nitrogen dioxide air pollution and breast cancer risk: A nested case-control within the French E3N cohort study

inferred← citeshttps://doi.org/10.1016/j.envpol.2025.127519openalex-snapshot

Toxicophore-informed machine learning integrating Tox21 assay readouts for organ system–specific carcinogenicity prediction

inferred← citeshttps://doi.org/10.1016/j.envres.2017.08.045openalex-snapshot

Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms

inferred← citeshttps://doi.org/10.1016/j.envres.2018.09.010openalex-snapshot

Commentary on the utility of the National Toxicology Program study on cell phone radiofrequency radiation data for assessing human health risks despite unfounded criticisms aimed at minimizing the findings of adverse health effects

inferred← citeshttps://doi.org/10.1016/j.envres.2021.110743openalex-snapshot

Long-term atmospheric exposure to PCB153 and breast cancer risk in a case-control study nested in the French E3N cohort from 1990 to 2011

inferred← citeshttps://doi.org/10.1016/j.envres.2021.111214openalex-snapshot

Association between long-term exposure to high levels of ambient air pollution and incidence of lung cancer in a population-based cohort

inferred← citeshttps://doi.org/10.1016/j.envres.2022.115188openalex-snapshot

A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure

inferred← citeshttps://doi.org/10.1016/j.envres.2023.115424openalex-snapshot

Short-chain per- and polyfluoralkyl substances (PFAS) effects on oxidative stress biomarkers in human liver, kidney, muscle, and microglia cell lines

inferred← citeshttps://doi.org/10.1016/j.envres.2025.121174openalex-snapshot

Occupational pesticide use and relative leukocyte telomere length in the biomarkers of exposure and effect in agriculture study

inferred← citeshttps://doi.org/10.1016/j.envres.2025.121539openalex-snapshot

Organochlorine pesticide use and mosaic loss of chromosome Y in a study of male farmers

inferred← citeshttps://doi.org/10.1016/j.envres.2025.122001openalex-snapshot

Continuous exposure to low concentrations of antimony(III) induces inflammation, apoptosis, oxidative and endoplasmic reticulum stress in Caco-2 intestinal epithelial cells

showing the first 200 of 647

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