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Hydroxylated Polybrominated Biphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein–Coupled Estrogen Receptor Mediated Pathways

https://doi.org/10.1289/ehp2387
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/etc.2562openalex-snapshot
Endocrine disruption and reproduction impairment in zebrafish after long-term exposure to DE-71
inferredcites →https://doi.org/10.1002/jcc.20291openalex-snapshot
GROMACS: Fast, flexible, and free
inferredcites →https://doi.org/10.1002/minf.201200136openalex-snapshot
G Protein‐Coupled Estrogen Receptor (GPER) Agonist Dual Binding Mode Analyses Toward Understanding of Its Activation Mechanism: A Comparative Homology Modeling Approach
inferredcites →https://doi.org/10.1002/mnfr.201300323openalex-snapshot
Oleuropein and hydroxytyrosol activate GPER / GPR 30‐dependent pathways leading to apoptosis of ER ‐negative SKBR 3 breast cancer cells
inferredcites →https://doi.org/10.1006/jmbi.1993.1626openalex-snapshot
Comparative Protein Modelling by Satisfaction of Spatial Restraints
inferredcites →https://doi.org/10.1007/bf00128336openalex-snapshot
MOPAC: A semiempirical molecular orbital program
inferredcites →https://doi.org/10.1007/s11356-015-4515-6openalex-snapshot
Polybrominated diphenyl ethers in articles: a review of its applications and legislation
inferredcites →https://doi.org/10.1007/s12032-015-0558-2openalex-snapshot
G protein-coupled estrogen receptor (GPER) mediates NSCLC progression induced by 17β-estradiol (E2) and selective agonist G1
inferredcites →https://doi.org/10.1007/s40572-014-0010-3openalex-snapshot
Developmental Exposure to Polybrominated Diphenyl Ethers and Neurodevelopment
inferredcites →https://doi.org/10.1016/j.bcp.2009.11.006openalex-snapshot
Endocrine disruptors and thyroid hormone physiology
inferredcites →https://doi.org/10.1016/j.chemosphere.2008.04.081openalex-snapshot
New insights into the endocrine disrupting effects of brominated flame retardants
inferredcites →https://doi.org/10.1016/j.ijheh.2015.08.004openalex-snapshot
Brominated flame retardants – Exposure and risk assessment for the general population
inferredcites →https://doi.org/10.1016/j.jsbmb.2006.09.017openalex-snapshot
Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: A potential novel mechanism of endocrine disruption
inferredcites →https://doi.org/10.1016/j.mce.2010.02.006openalex-snapshot
Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells
inferredcites →https://doi.org/10.1016/j.mce.2014.02.002openalex-snapshot
Estrogen biology: New insights into GPER function and clinical opportunities
inferredcites →https://doi.org/10.1016/j.phrs.2015.08.014openalex-snapshot
The effects of (−)-epicatechin on endothelial cells involve the G protein-coupled estrogen receptor (GPER)
inferredcites →https://doi.org/10.1016/j.taap.2013.01.026openalex-snapshot
Hydroxylated polybrominated diphenyl ethers exhibit different activities on thyroid hormone receptors depending on their degree of bromination
inferredcites →https://doi.org/10.1016/j.tox.2005.12.004openalex-snapshot
Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB
inferredcites →https://doi.org/10.1016/j.tox.2013.04.001openalex-snapshot
Structure-dependent activities of hydroxylated polybrominated diphenyl ethers on human estrogen receptor
inferredcites →https://doi.org/10.1021/acs.est.7b03336openalex-snapshot
Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway
inferredcites →https://doi.org/10.1021/cb700072nopenalex-snapshot
Synthetic Estrogen Derivatives Demonstrate the Functionality of Intracellular GPR30
inferredcites →https://doi.org/10.1021/ci500020mopenalex-snapshot
g_mmpbsa —A GROMACS Tool for High-Throughput MM-PBSA Calculations
inferredcites →https://doi.org/10.1021/es2046074openalex-snapshot
Assessment of the Binding of Hydroxylated Polybrominated Diphenyl Ethers to Thyroid Hormone Transport Proteins Using a Site-Specific Fluorescence Probe
inferredcites →https://doi.org/10.1021/tx100231nopenalex-snapshot
Endocrine Disrupting Chemicals Targeting Estrogen Receptor Signaling: Identification and Mechanisms of Action
inferredcites →https://doi.org/10.1038/emboj.2008.304openalex-snapshot
Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF
inferredcites →https://doi.org/10.1038/nchembio775openalex-snapshot
Virtual and biomolecular screening converge on a selective agonist for GPR30
inferredcites →https://doi.org/10.1039/c0ay00571aopenalex-snapshot
Determination of polybrominated diphenyl ethers and their methoxylated and hydroxylated metabolites in human serum from electronic waste dismantling workers
inferredcites →https://doi.org/10.1080/07391102.2014.994102openalex-snapshot
Deciphering the GPER/GPR30-agonist and antagonists interactions using molecular modeling studies, molecular dynamics, and docking simulations
inferredcites →https://doi.org/10.1095/biolreprod.115.132316openalex-snapshot
Bisphenol A and Related Alkylphenols Exert Nongenomic Estrogenic Actions Through a G Protein-Coupled Estrogen Receptor 1 (Gper)/Epidermal Growth Factor Receptor (Egfr) Pathway to Inhibit Meiotic Maturation of Zebrafish Oocytes1
inferredcites →https://doi.org/10.1126/science.1106943openalex-snapshot
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
inferredcites →https://doi.org/10.1158/1541-7786.mcr-14-0128-topenalex-snapshot
G Protein–Coupled Estrogen Receptor Regulates Mammary Tumorigenesis and Metastasis
inferredcites →https://doi.org/10.1177/0960327115578974openalex-snapshot
2,2′,4,4′-Tetrabromodiphenyl ether promotes human neuroblastoma SH-SY5Y cells migration via the GPER/PI3K/Akt signal pathway
inferredcites →https://doi.org/10.1210/en.2004-1064openalex-snapshot
Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells
inferredcites →https://doi.org/10.1289/ehp.01109399openalex-snapshot
In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds.
inferredcites →https://doi.org/10.1289/ehp.0900753openalex-snapshot
Nuclear Hormone Receptor Activity of Polybrominated Diphenyl Ethers and Their Hydroxylated and Methoxylated Metabolites in Transactivation Assays Using Chinese Hamster Ovary Cells
inferredcites →https://doi.org/10.1289/ehp.0901457openalex-snapshot
Hormone Activity of Hydroxylated Polybrominated Diphenyl Ethers on Human Thyroid Receptor-β: In Vitro and In Silico Investigations
inferredcites →https://doi.org/10.1289/ehp.10643openalex-snapshot
The Polybrominated Diphenyl Ether Mixture DE-71 Is Mildly Estrogenic
inferredcites →https://doi.org/10.1289/ehp.10713openalex-snapshot
Polybrominated Diphenyl Ethers (PBDEs) and Bioaccumulative Hydroxylated PBDE Metabolites in Young Humans from Managua, Nicaragua
inferredcites →https://doi.org/10.1289/ehp.1104051openalex-snapshot
Effects of Decabrominated Diphenyl Ether (PBDE-209) in Regulation of Growth and Apoptosis of Breast, Ovarian, and Cervical Cancer Cells
inferredcites →https://doi.org/10.1289/ehp.1104526openalex-snapshot
Bisphenol A Induces Gene Expression Changes and Proliferative Effects through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts
inferredcites →https://doi.org/10.1289/ehp.11343openalex-snapshot
Hydroxylated Metabolites of the Polybrominated Diphenyl Ether Mixture DE-71 Are Weak Estrogen Receptor-α Ligands
inferredcites →https://doi.org/10.1289/ehp.11660openalex-snapshot
Hydroxylated Metabolites of Polybrominated Diphenyl Ethers in Human Blood Samples from the United States
inferredcites →https://doi.org/10.1289/ehp.11707openalex-snapshot
Hormone Disruption by PBDEs in Adult Male Sport Fish Consumers
inferredcites →https://doi.org/10.1289/ehp.1408586openalex-snapshot
Effects of Atrazine on Estrogen Receptor α – and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts
inferredcites →https://doi.org/10.1289/ehp.8391openalex-snapshot
Effects of Developmental Exposure to 2,2′,4,4′,5-Pentabromodiphenyl Ether (PBDE-99) on Sex Steroids, Sexual Development, and Sexually Dimorphic Behavior in Rats
inferredcites →https://doi.org/10.2174/092986712799320556openalex-snapshot
Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies
inferredcites →https://doi.org/10.2174/156800912800673284openalex-snapshot
Two Novel GPER Agonists Induce Gene Expression Changes and Growth Effects in Cancer Cells
inferredcites →https://doi.org/10.5301/tj.5000229openalex-snapshot
BDE-99 (2,2′,4,4′,5-pentabromodiphenyl Ether) Triggers Epithelial-mesenchymal Transition in Colorectal Cancer Cells via PI3K/Akt/Snail Signaling Pathway

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1007/978-3-031-86002-7_26openalex-snapshot
Comparative Lipid Profile and Oxidative Stress in Synodontis clarias and Tilapia zillii Exposed to Polybrominated Diphenyl Ethers (PBDEs) in Lekki Lagoon, Nigeria
inferred← citeshttps://doi.org/10.1007/978-3-031-86002-7_28openalex-snapshot
Infliction of Oxidative Stress by Bioaccumulated Polybrominated Diphenyl Ethers (PBDEs) in Tilapia zilli Sampled from Lekki Lagoon, Lagos
inferred← citeshttps://doi.org/10.1007/s11356-023-26107-0openalex-snapshot
Differential binding of CREB and REST/NRSF to NMDAR1 promoter is associated with the sex-selective cognitive deficit following postnatal PBDE-209 exposure in mice
inferred← citeshttps://doi.org/10.1007/s12595-025-00570-8openalex-snapshot
GPER a Potent Target of Xenoestrogens: An Overview on Biological Activity and Mechanism of Action in Cancer and Immunogenic Pathway
inferred← citeshttps://doi.org/10.1007/s42452-025-07837-xopenalex-snapshot
Impact of environmental endocrine disruptors on adolescent sexual development: a comprehensive review with a focus on specific chemicals
inferred← citeshttps://doi.org/10.1016/j.cbi.2026.112055openalex-snapshot
Benzotriazole ultraviolet stabilizers impair trophoblast function at nanomolar concentrations via GPER signaling: implications for placental health
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2021.131620openalex-snapshot
Hepatic demethylation of methoxy-bromodiphenyl ethers and conjugation of the resulting hydroxy-bromodiphenyl ethers in a marine fish, the red snapper, Lutjanus campechanus, and a freshwater fish, the channel catfish, Ictalurus punctatus
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Multiple catalytic roles of chloroperoxidase in the transformation of phenol: Products and pathways
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Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism
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Comparison of the mechanisms of estrogen disrupting effects between triphenyl phosphate (TPhP) and tris(1,3-dichloro-2-propyl) phosphate (TDCIPP)
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GPR39-mediated ERK1/2 signaling reduces permethrin-induced proliferation of estrogen receptor α-negative cells
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The potential endocrine disruption of pesticide transformation products (TPs): The blind spot of pesticide risk assessment
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Tricresyl phosphate isomers exert estrogenic effects via G protein-coupled estrogen receptor-mediated pathways
inferred← citeshttps://doi.org/10.1016/j.envpol.2021.116826openalex-snapshot
Environmental Estrogens and Their Biological Effects through GPER Mediated Signal Pathways
inferred← citeshttps://doi.org/10.1016/j.envpol.2021.117091openalex-snapshot
Sublethal effects of DBE-DBCH diastereomers on physiology, behavior, and gene expression of Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.jes.2021.04.030openalex-snapshot
Dechloranes exhibit binding potency and activity to thyroid hormone receptors
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2020.123674openalex-snapshot
Current progress in degradation and removal methods of polybrominated diphenyl ethers from water and soil: A review
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The aryl hydrocarbon receptor: A predominant mediator for the toxicity of emerging dioxin-like compounds
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2020.138484openalex-snapshot
In vitro estrogen-disrupting effects of organophosphate flame retardants
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2021.147722openalex-snapshot
Perfluorinated iodine alkanes induce tissue-specific expression of estrogen receptor and its phosphorylation
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.164714openalex-snapshot
Toxicity and risk priority ranking of polybrominated diphenyl ethers (PBDEs): A relative receptor-bound concentration approach
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.172782openalex-snapshot
Triclocarban and triclosan promote breast cancer progression in vitro and in vivo via activating G protein-coupled estrogen receptor signaling pathways
inferred← citeshttps://doi.org/10.1016/j.talanta.2026.129867openalex-snapshot
Stereoselective cyclic peptide assisted DART-MS for rapidly screening environmental disruptors of dopamine receptors
inferred← citeshttps://doi.org/10.1021/acs.analchem.6c03009openalex-snapshot
Effect-Based Photoelectrochemical Screening of Estrogenic Activity in Wastewater via Cell-Free ERα-ERE Assembly
inferred← citeshttps://doi.org/10.1021/acs.est.3c05622openalex-snapshot
Congener Variation of Genetic Dependent-Developmental Toxicology in Two Emerging Classes of Dioxin-like Compounds
inferred← citeshttps://doi.org/10.1021/acs.est.4c13961openalex-snapshot
6PPD and 6PPD Quinone Induce Endometrial Cell Dysfunction via Activating ERα and GPER at Human-Relevant Levels
inferred← citeshttps://doi.org/10.1021/acs.est.8b02509openalex-snapshot
Structure-Dependent Activity of Polybrominated Diphenyl Ethers and Their Hydroxylated Metabolites on Estrogen Related Receptor γ: in Vitro and in Silico Study
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Comparative in Vitro and in Vivo Evaluation of the Estrogenic Effect of Hexafluoropropylene Oxide Homologues
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Chlorinated Polyfluoroalkylether Sulfonic Acids Exhibit Stronger Estrogenic Effects than Perfluorooctane Sulfonate by Activating Nuclear Estrogen Receptor Pathways
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Photoexcitation dynamics of bromodiphenyl ethers in acetonitrile-d 3 studied by femtosecond time-resolved infrared spectroscopy
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Natural bioactive compounds as a new source of promising G protein-coupled estrogen receptor (GPER) modulators: comprehensive in silico approach
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Endocrine disrupting chemicals: Impact on human health, wildlife and the environment
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Plasma concentration of brominated flame retardants and postmenopausal breast cancer risk: a nested case-control study in the French E3N cohort
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Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food
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inferred← citeshttps://doi.org/10.3389/fendo.2020.578536openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fendo.2024.1429142openalex-snapshot
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Exploring the Biological Activity and Mechanism of Xenoestrogens and Phytoestrogens in Cancers: Emerging Methods and Concepts
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