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The Challenges of Chagas Disease— Grim Outlook or Glimmer of Hope?

https://doi.org/10.1371/journal.pmed.0040332

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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High correlation between Chagas' disease serology and PCR-based detection of Trypanosoma cruzi kinetoplast DNA in Bolivian children living in an endemic area

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The oral transmission of Chagas' disease: An acute form of infection responsible for regional outbreaks

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Specific chemotherapy of Chagas disease: controversies and advances

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The future of Chagas disease control

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Parasite persistence in the aetiology of Chagas disease

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Chagas' disease—an epidemic that can no longer be ignored

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Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection

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Clinical and epidemiological aspects of Chagas disease

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Comparison of four serological tests for the diagnosis of Chagas disease in a Colombian endemic area

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Development and Validation of a Risk Score for Predicting Death in Chagas' Heart Disease

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Chagas' Disease — Can We Stop the Deaths?

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The validity of serologic tests for Trypanosoma cruzi and the effectiveness of transfusional screening strategies in a hyperendemic region

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Chagas’ disease: application of TESA‐blot in inconclusive sera from a Brazilian blood bank

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Transfusion‐acquired Trypanosoma cruzi infection

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Modeling Household Transmission of American Trypanosomiasis

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The Trypanosoma cruzi Proteome

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The Genome Sequence of Trypanosoma cruzi , Etiologic Agent of Chagas Disease

inferredcites →https://doi.org/10.1128/cdli.10.5.826-830.2003openalex-snapshot

Enzyme-Linked Immunoassay Using Recombinant trans -Sialidase of Trypanosoma cruzi Can Be Employed for Monitoring of Patients with Chagas' Disease after Drug Treatment

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Evaluation of Serological Tests To Identify Trypanosoma cruzi Infection in Humans and Determine Cross-Reactivity with Trypanosoma rangeli and Leishmania spp

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High Resistance to Pyrethroid Insecticides Associated with Ineffective Field Treatments in Triatoma infestans (Hemiptera: Reduviidae) from Northern Argentina

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Chagas Disease in a Domestic Transmission Cycle in Southern Texas, USA

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Congenital Transmission ofTrypanosoma cruziInfection in Argentina

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Trypanosoma cruziin Persons without Serologic Evidence of Disease, Argentina

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Reinfestation Sources for Chagas Disease Vector,Triatoma infestans, Argentina

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Autochthonous Transmission ofTrypanosoma cruzi, Louisiana

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Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease.

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PREVENTION OF THE TRANSMISSION OF CHAGAS’ DISEASE WITH PYRETHROID-IMPREGNATED MATERIALS

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SHORT REPORT: BENZNIDAZOLE EFFICACY AMONG TRYPANOSOMA CRUZI-INFECTED ADOLESCENTS AFTER A SIX-YEAR FOLLOW-UP

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EXTINCTION OF EXPERIMENTAL TRIATOMA INFESTANS POPULATIONS FOLLOWING CONTINUOUS EXPOSURE TO DOGS WEARING DELTAMETHRIN-TREATED COLLARS

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CONGENITAL TRANSMISSION OF TRYPANOSOMA CRUZI IN EUROPE (SPAIN): A CASE REPORT

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Long-Term Cardiac Outcomes of Treating Chronic Chagas Disease with Benznidazole versus No Treatment

What points at this work

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Chagas Disease: History, Pathophysiology and Therapeutic Treatment

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Ergosterol Biosynthesis for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials

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Laboratory and field studies for the control of Chagas disease vectors using the fungus Metarhizium anisopliae

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Social Constructionist and Social Engineer

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Chagas Disease: A Neglected Disease

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Genetic Relationships and Spatial Genetic Structure Among Populations of Rhodnius prolixus (Hemiptera: Reduviidae) in Colombia and Venezuela Based on Mitochondrial Cytochrome-b Sequences

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Pathological Consequences of Host Response to Parasite

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Kissing Bugs. The Vectors of Chagas

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Chagas Cardiomyopathy

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Synthesis of the hexasaccharide from Trypanosoma cruzi mucins with the Galp(1 → 2)Galf unit constructed with a superarmed thiogalactopyranosyl donor

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Corticosterone evaluation in Wistar rats infected with the Y strain of Trypanosoma cruzi during the chronic phase

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A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease

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Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme

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Maladie de Chagas

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C57BL/6 α‑1,3-Galactosyltransferase Knockout Mouse as an Animal Model for Experimental Chagas Disease

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Improved Proteomic Approach for the Discovery of Potential Vaccine Targets in Trypanosoma cruzi

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Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice

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Selenosemicarbazones as potent cruzipain inhibitors and their antiparasitic properties against Trypanosoma cruzi

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Synthesis of the O-linked hexasaccharide containing β-d-Galf-(1→2)-β-d-Galf in Trypanosoma cruzi mucins

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Antitrypanosomal Therapy for Chronic Chagas' Disease

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Molecular analysis of a UDP-GlcNAc:polypeptide α-N-acetylglucosaminyltransferase implicated in the initiation of mucin-type O-glycosylation in Trypanosoma cruzi

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Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody

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Experimental control of Triatoma infestans in poor rural villages of Bolivia through community participation

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Bottlenecks in domestic animal populations can facilitate the emergence of Trypanosoma cruzi , the aetiological agent of Chagas disease

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The role of parasite persistence in pathogenesis of Chagas heart disease

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Evaluation of a CO2-free commercial mosquito attractant to capture triatomines in the laboratory

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Recent Clinical Trials for the Etiological Treatment of Chronic Chagas Disease: Advances, Challenges and Perspectives

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Myocardial scars correlate with eletrocardiographic changes in chronic Trypanosoma cruzi infection for dogs treated with Benznidazole

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Trypanosoma cruzi and Chagas' Disease in the United States

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Differential Expression and Characterization of a Member of the Mucin-Associated Surface Protein Family Secreted by Trypanosoma cruzi

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Otimização do flavonoide tilirosídeo como inibidor da enzima gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi

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NADH desidrogenase mitocondrial de Trypanosoma cruzi: subunidade 7 para diagnóstico diferencial de isolados humanos e análise funcional.

inferred← citeshttps://doi.org/10.11606/t.60.2017.tde-12122016-154937openalex-snapshot

Estratégias terapêuticas usando o ácido ursólico sobre infecções determinadas por tripanosomatideos

inferred← citeshttps://doi.org/10.1161/cir.0000000000000599openalex-snapshot

Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association

inferred← citeshttps://doi.org/10.1172/jci33945openalex-snapshot

Kinetoplastids: related protozoan pathogens, different diseases

inferred← citeshttps://doi.org/10.1177/003335491613100112openalex-snapshot

A Critical Assessment of Officially Reported Chagas Disease Surveillance Data in Mexico

inferred← citeshttps://doi.org/10.1177/1757913916671160openalex-snapshot

Evolution of Chagas’ disease in Brazil. Epidemiological perspective and challenges for the future: a critical review

inferred← citeshttps://doi.org/10.1186/1476-072x-12-48openalex-snapshot

A country bug in the city: urban infestation by the Chagas disease vector Triatoma infestans in Arequipa, Peru

inferred← citeshttps://doi.org/10.1186/s12889-019-7525-3openalex-snapshot

A behavioral design approach to improving a Chagas disease vector control campaign in Peru

inferred← citeshttps://doi.org/10.1186/s13071-018-3069-0openalex-snapshot

High levels of human infection with Trypanosoma cruzi associated with the domestic density of infected vectors and hosts in a rural area of northeastern Argentina

inferred← citeshttps://doi.org/10.1189/jlb.1211589openalex-snapshot

Caspase-8 and caspase-9 mediate thymocyte apoptosis in Trypanosoma cruzi acutely infected mice

inferred← citeshttps://doi.org/10.12794/metadc2332659openalex-snapshot

Trypanosoma cruzi: Awareness and Knowledge Levels of Professional "Dog People" Exposure Rates in a Select Group of North Texas Client Owned Dogs, and a Historical Perspective of Screening Efforts in Domestic Dogs

inferred← citeshttps://doi.org/10.1358/dof.2010.035.05.1484391openalex-snapshot

New insights in Chagas disease treatment

inferred← citeshttps://doi.org/10.1371/annotation/2ec725b2-0f56-4fab-95fd-747b416b0337openalex-snapshot

Correction: Post-Control Surveillance of Triatoma infestans and Triatoma sordida with Chemically-Baited Sticky Traps

inferred← citeshttps://doi.org/10.1371/annotation/b5fe70a2-b190-496c-80b4-53e2aa4885d2openalex-snapshot

Correction: Post-Control Surveillance of Triatoma infestans and Triatoma sordida with Chemically-Baited Sticky Traps

inferred← citeshttps://doi.org/10.1371/annotation/f9e422fc-25c1-45dc-a558-35763a944c0dopenalex-snapshot

Correction: Post-Control Surveillance of Triatoma infestans and Triatoma sordida with Chemically-Baited Sticky Traps

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000168openalex-snapshot

Combining Residual Insecticide Spraying Campaigns with Targeted Detection and Specific Chemotherapy for Trypanosoma cruzi Infection in Children

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000256openalex-snapshot

Neglected Infections of Poverty in the United States of America

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000300openalex-snapshot

The Neglected Tropical Diseases of Latin America and the Caribbean: A Review of Disease Burden and Distribution and a Roadmap for Control and Elimination

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000363openalex-snapshot

Cost-Effectiveness of Chagas Disease Vector Control Strategies in Northwestern Argentina

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000384openalex-snapshot

Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000416openalex-snapshot

Optimization of Control Strategies for Non-Domiciliated Triatoma dimidiata, Chagas Disease Vector in the Yucatán Peninsula, Mexico

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000417openalex-snapshot

Differential Regional Immune Response in Chagas Disease

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000484openalex-snapshot

New, Improved Treatments for Chagas Disease: From the R&D Pipeline to the Patients

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000488openalex-snapshot

Feasibility, Drug Safety, and Effectiveness of Etiological Treatment Programs for Chagas Disease in Honduras, Guatemala, and Bolivia: 10-Year Experience of Médecins Sans Frontières

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000620openalex-snapshot

Modeling Disease Vector Occurrence when Detection Is Imperfect: Infestation of Amazonian Palm Trees by Triatomine Bugs at Three Spatial Scales

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000740openalex-snapshot

In Vitro and In Vivo High-Throughput Assays for the Testing of Anti-Trypanosoma cruzi Compounds

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000836openalex-snapshot

Chagas Disease Risk in Texas

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000916openalex-snapshot

The Potential Economic Value of a Trypanosoma cruzi (Chagas Disease) Vaccine in Latin America

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000970openalex-snapshot

A History of Chagas Disease Transmission, Control, and Re-Emergence in Peri-Rural La Joya, Peru

inferred← citeshttps://doi.org/10.1371/journal.pntd.0001207openalex-snapshot

Community Participation in Chagas Disease Vector Surveillance: Systematic Review

inferred← citeshttps://doi.org/10.1371/journal.pntd.0001468openalex-snapshot

A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru

inferred← citeshttps://doi.org/10.1371/journal.pntd.0001788openalex-snapshot

Spatial Heterogeneity and Risk Maps of Community Infestation by Triatoma infestans in Rural Northwestern Argentina

inferred← citeshttps://doi.org/10.1371/journal.pntd.0001822openalex-snapshot

Post-Control Surveillance of Triatoma infestans and Triatoma sordida with Chemically-Baited Sticky Traps

inferred← citeshttps://doi.org/10.1371/journal.pntd.0001861openalex-snapshot

Is Chagas Disease Really the “New HIV/AIDS of the Americas”?

inferred← citeshttps://doi.org/10.1371/journal.pntd.0002488openalex-snapshot

Barriers to Treatment Access for Chagas Disease in Mexico

inferred← citeshttps://doi.org/10.1371/journal.pntd.0002907openalex-snapshot

Population Pharmacokinetic Study of Benznidazole in Pediatric Chagas Disease Suggests Efficacy despite Lower Plasma Concentrations than in Adults

inferred← citeshttps://doi.org/10.1371/journal.pntd.0003259openalex-snapshot

High Throughput Screening for Anti–Trypanosoma cruzi Drug Discovery

inferred← citeshttps://doi.org/10.1371/journal.pntd.0003458openalex-snapshot

Deep Sequencing of the Trypanosoma cruzi GP63 Surface Proteases Reveals Diversity and Diversifying Selection among Chronic and Congenital Chagas Disease Patients

inferred← citeshttps://doi.org/10.1371/journal.pntd.0003493openalex-snapshot

Automated High-Content Assay for Compounds Selectively Toxic to Trypanosoma cruzi in a Myoblastic Cell Line

inferred← citeshttps://doi.org/10.1371/journal.pntd.0005710openalex-snapshot

2b-RAD genotyping for population genomic studies of Chagas disease vectors: Rhodnius ecuadoriensis in Ecuador

inferred← citeshttps://doi.org/10.1371/journal.pntd.0006069openalex-snapshot

Polyclonal antibodies for the detection of Trypanosoma cruzi circulating antigens

inferred← citeshttps://doi.org/10.1371/journal.pntd.0007472openalex-snapshot

Home improvement and system-based health promotion for sustainable prevention of Chagas disease: A qualitative study

inferred← citeshttps://doi.org/10.1371/journal.pntd.0008833openalex-snapshot

A voluntary use of insecticide treated nets can stop the vector transmission of Chagas disease

inferred← citeshttps://doi.org/10.1371/journal.pntd.0009774openalex-snapshot

Communication in Neglected Tropical Diseases’ elimination: A scoping review and call for action

inferred← citeshttps://doi.org/10.1371/journal.pntd.0009935openalex-snapshot

High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA

inferred← citeshttps://doi.org/10.1371/journal.pntd.0010850openalex-snapshot

Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation

inferred← citeshttps://doi.org/10.1371/journal.pone.0019733openalex-snapshot

Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection

inferred← citeshttps://doi.org/10.1371/journal.pone.0026550openalex-snapshot

3-Hydroxy Kynurenine Treatment Controls T. cruzi Replication and the Inflammatory Pathology Preventing the Clinical Symptoms of Chronic Chagas Disease

inferred← citeshttps://doi.org/10.1371/journal.pone.0034657openalex-snapshot

A New Endemic Focus of Chagas Disease in the Northern Region of Veraguas Province, Western Half Panama, Central America

inferred← citeshttps://doi.org/10.1371/journal.pone.0144033openalex-snapshot

The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process

inferred← citeshttps://doi.org/10.1371/journal.ppat.1007410openalex-snapshot

Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection

inferred← citeshttps://doi.org/10.1515/2161-962x.1005openalex-snapshot

Use of Individual-level Covariates to Improve Latent Class Analysis of Trypanosoma cruzi Diagnostic Tests

inferred← citeshttps://doi.org/10.1515/em-2020-0001openalex-snapshot

A real-time search strategy for finding urban disease vector infestations

inferred← citeshttps://doi.org/10.1517/14728220802623881openalex-snapshot

Trypanosoma cruzitargets for new chemotherapeutic approaches

inferred← citeshttps://doi.org/10.1517/17460441.2011.573782openalex-snapshot

Methodological advances in drug discovery for Chagas disease

inferred← citeshttps://doi.org/10.1517/17460441.2013.845554openalex-snapshot

Design or screening of drugs for the treatment of Chagas disease: what shows the most promise?

inferred← citeshttps://doi.org/10.15761/rri.1000152openalex-snapshot

Parasitic (Protozoan) cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management

inferred← citeshttps://doi.org/10.1586/eri.10.74openalex-snapshot

Congenital transmission of Chagas disease: a clinical approach

inferred← citeshttps://doi.org/10.1586/erv.09.45openalex-snapshot

Vaccination approaches againstTrypanosoma cruziinfection

inferred← citeshttps://doi.org/10.1590/0074-02760160334openalex-snapshot

Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial

inferred← citeshttps://doi.org/10.1590/0074-02760210479chgsaopenalex-snapshot

How is global change affecting Chagas disease landscapes?

inferred← citeshttps://doi.org/10.1590/1414-462x201900030456openalex-snapshot

Reações adversas ao benzonidazol no tratamento da Doença de Chagas: revisão sistemática de ensaios clínicos randomizados e controlados

inferred← citeshttps://doi.org/10.1590/s0074-02762009000900009openalex-snapshot

Sustainability of vector control strategies in the Gran Chaco Region: current challenges and possible approaches

inferred← citeshttps://doi.org/10.1590/s0074-02762009000900018openalex-snapshot

Usefulness of PCR-based assays to assess drug efficacy in Chagas disease chemotherapy: value and limitations

inferred← citeshttps://doi.org/10.1590/s0074-02762009000900041openalex-snapshot

Ergosterol biosynthesis and drug development for Chagas disease

inferred← citeshttps://doi.org/10.1590/s1516-84842009005000037openalex-snapshot

Terapia celular na doença de Chagas

inferred← citeshttps://doi.org/10.1603/me14014openalex-snapshot

Flight Behavior and Performance ofRhodnius pallescens(Hemiptera: Reduviidae) on a Tethered Flight Mill

inferred← citeshttps://doi.org/10.1645/ge-2329.1openalex-snapshot

Anti-Trypanosomatid Activity of Ceragenins

inferred← citeshttps://doi.org/10.17992/lbl.2011.12.404openalex-snapshot

Vanræktir sjúkdómar þróunarlanda - yfirlit

inferred← citeshttps://doi.org/10.21203/rs.3.rs-92241/v1openalex-snapshot

An Effective Live Vaccine Strain Of Trypanosoma Cruzi Prevents Chagas Disease In The Mouse Model

inferred← citeshttps://doi.org/10.2147/ijgm.s130828openalex-snapshot

Tropical diseases of the myocardium: a review

inferred← citeshttps://doi.org/10.21608/scvmj.2020.103055openalex-snapshot

Silica Animal Model for Autoimmune Disease and The Potential Use of Myrrh Compared with The Conventional Treatment

inferred← citeshttps://doi.org/10.2174/0929867322666151015120804openalex-snapshot

Current and Future Chemotherapy for Chagas Disease

inferred← citeshttps://doi.org/10.2174/0929867324666171023163752openalex-snapshot

Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases

inferred← citeshttps://doi.org/10.2174/1874421401004010167openalex-snapshot

Subcellular Proteomics and Global Analysis of Posttranslational Modifications to Study Functional Roles of Trypanosoma cruzi Molecules

inferred← citeshttps://doi.org/10.2217/nnm.14.185openalex-snapshot

Nanomedicines Against Chagas Disease: an Update on Therapeutics, Prophylaxis and Diagnosis

inferred← citeshttps://doi.org/10.3109/13880200903241853openalex-snapshot

Anti-trypanosomal activity of (8-hydroxymethylen)-trieicosanyl acetate against infective forms of Trypanosoma cruzi

inferred← citeshttps://doi.org/10.31235/osf.io/as3c2openalex-snapshot

A behavioral design approach to improving vector-control campaigns

inferred← citeshttps://doi.org/10.3389/fchem.2016.00042openalex-snapshot

Insight into the Exoproteome of the Tissue-Derived Trypomastigote form of Trypanosoma cruzi

inferred← citeshttps://doi.org/10.3389/fendo.2018.00334openalex-snapshot

Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions

inferred← citeshttps://doi.org/10.3389/fimmu.2013.00216openalex-snapshot

Trypanosoma cruzi Entrance through Systemic or Mucosal Infection Sites Differentially Modulates Regional Immune Response Following Acute Infection in Mice

inferred← citeshttps://doi.org/10.3389/fimmu.2018.01734openalex-snapshot

Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response

inferred← citeshttps://doi.org/10.3389/fimmu.2020.01838openalex-snapshot

The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation

inferred← citeshttps://doi.org/10.3389/fmicb.2016.00348openalex-snapshot

Role of Trypanosoma cruzi Trans-sialidase on the Escape from Host Immune Surveillance

inferred← citeshttps://doi.org/10.3390/books978-3-03842-246-4openalex-snapshot

Analysis of Hydrogen Bonds in Crystals

inferred← citeshttps://doi.org/10.3390/cryst6050056openalex-snapshot

Comparisons between Crystallography Data and Theoretical Parameters and the Formation of Intramolecular Hydrogen Bonds: Benznidazole

inferred← citeshttps://doi.org/10.3390/md10081631openalex-snapshot

Trypanocidal Action of (−)-Elatol Involves an Oxidative Stress Triggered by Mitochondria Dysfunction

inferred← citeshttps://doi.org/10.3390/molecules22111863openalex-snapshot

Benzoic Acid Derivatives with Trypanocidal Activity: Enzymatic Analysis and Molecular Docking Studies toward Trans-Sialidase

inferred← citeshttps://doi.org/10.3402/jev.v3.25040openalex-snapshot

Extracellular vesicles in parasitic diseases

inferred← citeshttps://doi.org/10.3410/f.7975956.8347054openalex-snapshot

Faculty Opinions recommendation of The potential economic value of a Trypanosoma cruzi (Chagas disease) vaccine in Latin America.

inferred← citeshttps://doi.org/10.3855/jidc.2576openalex-snapshot

ELISA seroprevalence of Trypanosoma cruzi in a cohort of heart disease patients

inferred← citeshttps://doi.org/10.3855/jidc.290openalex-snapshot

Chagas disease: an emerging food-borne entity?

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