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Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques

https://doi.org/10.1371/journal.pmed.1002535
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Immune Responses to Novel Adenovirus Type 26 and Modified Vaccinia Virus Ankara–Vectored Ebola Vaccines at 1 Year
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Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials
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Post-exposure efficacy of Oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model
inferredcites →https://doi.org/10.1016/j.antiviral.2014.02.014openalex-snapshot
Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model
inferredcites →https://doi.org/10.1016/j.antiviral.2015.07.003openalex-snapshot
Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever
inferredcites →https://doi.org/10.1016/j.antiviral.2017.01.017openalex-snapshot
Implementation of a non-human primate model of Ebola disease: Infection of Mauritian cynomolgus macaques and analysis of virus populations
inferredcites →https://doi.org/10.1016/j.virusres.2017.03.014openalex-snapshot
Favipiravir can evoke lethal mutagenesis and extinction of foot-and-mouth disease virus
inferredcites →https://doi.org/10.1016/s0002-9440(10)63591-2openalex-snapshot
Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques
inferredcites →https://doi.org/10.1016/s0140-6736(15)61117-5openalex-snapshot
Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial
inferredcites →https://doi.org/10.1016/s0140-6736(16)30386-5openalex-snapshot
Late Ebola virus relapse causing meningoencephalitis: a case report
inferredcites →https://doi.org/10.1016/s0140-6736(99)11433-8openalex-snapshot
Influenza virus neuraminidase inhibitors
inferredcites →https://doi.org/10.1016/s1473-3099(14)71047-3openalex-snapshot
Dose regimen of favipiravir for Ebola virus disease
inferredcites →https://doi.org/10.1016/s2214-109x(16)30243-1openalex-snapshot
Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study
inferredcites →https://doi.org/10.1038/nature13777openalex-snapshot
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
inferredcites →https://doi.org/10.1038/nature14442openalex-snapshot
Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates
inferredcites →https://doi.org/10.1038/nature17180openalex-snapshot
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
inferredcites →https://doi.org/10.1056/nejmoa1511812openalex-snapshot
Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea
inferredcites →https://doi.org/10.1056/nejmoa1604330openalex-snapshot
A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection
inferredcites →https://doi.org/10.1056/nejmoa1614067openalex-snapshot
Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia
inferredcites →https://doi.org/10.1073/pnas.1704011114openalex-snapshot
Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies
inferredcites →https://doi.org/10.1093/cid/ciw571openalex-snapshot
Clinical and Virological Characteristics of Ebola Virus Disease Patients Treated With Favipiravir (T-705)—Sierra Leone, 2014
inferredcites →https://doi.org/10.1093/cid/cix210openalex-snapshot
Dynamics of Ebola RNA Persistence in Semen: A Report From the Postebogui Cohort in Guinea
inferredcites →https://doi.org/10.1093/infdis/jiv284openalex-snapshot
Considerations in the Use of Nonhuman Primate Models of Ebola Virus and Marburg Virus Infection: Table 1.
inferredcites →https://doi.org/10.1093/infdis/jiv522openalex-snapshot
Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever
inferredcites →https://doi.org/10.1093/jac/dkp274openalex-snapshot
Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells
inferredcites →https://doi.org/10.1128/aac.00649-13openalex-snapshot
Mechanism of Action of T-705 Ribosyl Triphosphate against Influenza Virus RNA Polymerase
inferredcites →https://doi.org/10.1128/aac.01305-16openalex-snapshot
Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses
inferredcites →https://doi.org/10.1128/aac.01400-17openalex-snapshot
Extinction of West Nile Virus by Favipiravir through Lethal Mutagenesis
inferredcites →https://doi.org/10.1128/aac.49.3.981-986.2005openalex-snapshot
Mechanism of Action of T-705 against Influenza Virus
inferredcites →https://doi.org/10.1128/jcm.39.11.4125-4130.2001openalex-snapshot
Development and Evaluation of a Fluorogenic 5′ Nuclease Assay To Detect and Differentiate between Ebola Virus Subtypes Zaire and Sudan
inferredcites →https://doi.org/10.1128/jvi.02346-12openalex-snapshot
T-705 (Favipiravir) Induces Lethal Mutagenesis in Influenza A H1N1 Viruses In Vitro
inferredcites →https://doi.org/10.1371/journal.pmed.1001908openalex-snapshot
Use of Viremia to Evaluate the Baseline Case Fatality Ratio of Ebola Virus Disease and Inform Treatment Studies: A Retrospective Cohort Study
inferredcites →https://doi.org/10.1371/journal.pmed.1001967openalex-snapshot
Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea
inferredcites →https://doi.org/10.1371/journal.pmed.1001997openalex-snapshot
Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial
inferredcites →https://doi.org/10.1371/journal.pntd.0002804openalex-snapshot
Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever
inferredcites →https://doi.org/10.1371/journal.pntd.0005389openalex-snapshot
Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted
inferredcites →https://doi.org/10.1371/journal.pone.0162199openalex-snapshot
Experimental Treatment of Ebola Virus Disease with Brincidofovir
inferredcites →https://doi.org/10.1371/journal.pone.0164691openalex-snapshot
Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice
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T-705 induces lethal mutagenesis in Ebola and Marburg populations in macaques
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Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates
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High doses of favipiravir in two men survivors of Ebola virus disease carrying Ebola virus in semen in Guinea
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Prodrugs of the Phosphoribosylated Forms of Hydroxypyrazinecarboxamide Pseudobase T-705 and Its De-Fluoro Analogue T-1105 as Potent Influenza Virus Inhibitors
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Toward the Target: Tilorone, Quinacrine, and Pyronaridine Bind to Ebola Virus Glycoprotein
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Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model
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Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates
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Rare haplotype load as marker for lethal mutagenesis
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Therapeutic Strategies against Ebola Virus Infection
inferred← citeshttps://doi.org/10.3390/v16071101openalex-snapshot
Comparison of Routes of Administration, Frequency, and Duration of Favipiravir Treatment in Mouse and Guinea Pig Models of Ebola Virus Disease
inferred← citeshttps://doi.org/10.3390/v17010074openalex-snapshot
A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection
inferred← citeshttps://doi.org/10.3390/v17081022openalex-snapshot
Kyasanur Forest Disease Virus: Epidemiological Insights, Pathogenesis, Therapeutic Strategies, and Advances in Vaccines and Diagnostics
inferred← citeshttps://doi.org/10.3390/vaccines10060963openalex-snapshot
Natural History of Sudan ebolavirus to Support Medical Countermeasure Development
inferred← citeshttps://doi.org/10.36233/0372-9311-114openalex-snapshot
Favipiravir: the hidden threat of mutagenic action
inferred← citeshttps://doi.org/10.36233/0507-4088-23openalex-snapshot
Ebola virus (Filoviridae: Ebolavirus: Zaire ebolavirus): fatal adaptation mutations
inferred← citeshttps://doi.org/10.36348/sijtcm.2020.v03i08.001openalex-snapshot
Mutation in hprt1 Gene or HPRT Deficiency May be a Restricting Progeny of Favipiravir in Covid-19
inferred← citeshttps://doi.org/10.37506/ijfmt.v14i4.12557openalex-snapshot
Awareness on Ebola Virus among Undergraduate Dental Students in a Private Dental Institution, Chennai - A Questionnaire Survey
inferred← citeshttps://doi.org/10.3934/mbe.2026053openalex-snapshot
A close look at the viral reduction rate in target cell limited models
inferred← citeshttps://doi.org/10.4155/fmc-2018-0457openalex-snapshot
The Increasing Impact of Lethal Mutagenesis of Viruses
inferred← citeshttps://doi.org/10.4236/oalib.1105504openalex-snapshot
Knowledge, Attitudes and Practices of Health Care Professionals on Ebola Virus Disease in Democratic Republic of the Congo
inferred← citeshttps://doi.org/10.51449/ajpr.2020.1101openalex-snapshot
THE EPIDEMIOLOGICAL AND CLINICAL FEATURES OF COVID-19 AND LESSONS FROM THIS GLOBAL INFECTIOUS PUBLIC
inferred← citeshttps://doi.org/10.52547/umj.32.10.782openalex-snapshot
EFFICACY AND SAFETY OF FAVIPIRAVIR IN PATIENTS WITH COVID-19: A REVIEW OF SYSTEMATIC REVIEWS AND META-ANALYSIS
inferred← citeshttps://doi.org/10.5812/ijpr-127034openalex-snapshot
A Single-Centered Cohort Study on Favipiravir Safety and Efficacy in Pediatric Patients with COVID-19
inferred← citeshttps://doi.org/10.62487/saimsara976931fcopenalex-snapshot
Ebola Virus Disease, Vaccines, Therapeutics, Transmission, and Long-Term Sequelae: Scoping Review with ☸SAIMSARA
inferred← citeshttps://doi.org/10.70675/13583afdz69fez4706z9d47zaf14799f8a88openalex-snapshot
Étude des quasi-espèces du virus Ebola en réponse au traitement par favipiravir dans un modèle de primate non-humain par séquençage haut débit
inferred← citeshttps://doi.org/10.70675/dd457ab8z171az4e41z97edze8a6d8359e8aopenalex-snapshot
Les méthyltransférases des Mononegavirales, une cible antivirale attractive
inferred← citeshttps://doi.org/10.70675/ea8fc87dz94a1z4c62z80f5z4e0d7cd1cbd3openalex-snapshot
Aspects cliniques, biologiques et pronostiques de la fièvre de Lassa en contexte endémo-épidémique en Afrique de l’Ouest : exemple du Nigeria
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