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Assessment of Repurposed Compounds Against Coronaviruses Highlights the Antiviral Broad-Spectrum Activity of Host-Targeting Iminosugars and Confirms the Activity of Potent Directly Acting Antivirals

https://doi.org/10.2139/ssrn.5010721
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Targeting Endoplasmic Reticulum α-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections
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Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19
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Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
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Dexamethasone in Hospitalized Patients with Covid-19
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Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients
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Iminosugars: Promising therapeutics for influenza infection
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inferredcites →https://doi.org/10.1093/glycob/cwaa091openalex-snapshot
The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication
inferredcites →https://doi.org/10.1097/qad.0b013e32830efd96openalex-snapshot
N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery
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Calnexin cycle – structural features of the ER chaperone system
inferredcites →https://doi.org/10.1126/science.abi4708openalex-snapshot
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
inferredcites →https://doi.org/10.1126/scitranslmed.abq4064openalex-snapshot
S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters
inferredcites →https://doi.org/10.1128/jvi.01250-12openalex-snapshot
Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus
inferredcites →https://doi.org/10.1177/1060028013500469openalex-snapshot
Gaucher Disease and Its Treatment Options
inferredcites →https://doi.org/10.1371/journal.pmed.1002535openalex-snapshot
Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques
inferredcites →https://doi.org/10.1371/journal.pntd.0004524openalex-snapshot
Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes
inferredcites →https://doi.org/10.1371/journal.pntd.0010636openalex-snapshot
Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects
inferredcites →https://doi.org/10.1371/journal.pone.0167018openalex-snapshot
Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model
inferredcites →https://doi.org/10.1371/journal.ppat.1009352openalex-snapshot
Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
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Advances in Our Understanding of the Molecular Mechanisms of Action of Cisplatin in Cancer Therapy
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UV-4B potently inhibits replication of multiple SARS-CoV-2 strains in clinically relevant human cell lines
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Pulmonary and Extra-Pulmonary Clinical Manifestations of COVID-19
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Iminosugars With Endoplasmic Reticulum α-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro
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An Update on SARS-CoV-2 Clinical Trial Results—What We Can Learn for the Next Pandemic
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Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays
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Inhibitors of Protein Glycosylation Are Active against the Coronavirus Severe Acute Respiratory Syndrome Coronavirus SARS-CoV-2
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Combination Therapy with UV-4B and Molnupiravir Enhances SARS-CoV-2 Suppression
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Current Perspectives on HIV-1 Antiretroviral Drug Resistance
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Mechanisms of Hepatitis C Viral Resistance to Direct Acting Antivirals
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SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site
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Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
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