On the public citation graph
Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness
0 signed · 359 inferred · view as graph
Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
Is this your work? Sign in with ORCID and put your name on the
claims that are yours.
Reference health. See whether every reference in this work resolves to a
known work and none has been retracted — and get a dated CiteStamped
badge you can embed.
What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ddr.430320408openalex-snapshot
Safety pharmacology of the respiratory system: Techniques and study design
inferredcites →https://doi.org/10.1002/em.2850190212openalex-snapshot
Evaluation of the mutagenic and genotoxic activities of 48 nitroimidazoles and related imidazole derivatives by the Ames test and the SOS Chromotest
inferredcites →https://doi.org/10.1002/em.2860030403openalex-snapshot
Evidence for the existence of a family of bacterial nitroreductases capable of activating nitrated polycyclics to mutagens
inferredcites →https://doi.org/10.1002/j.1460-2075.1985.tb03772.xopenalex-snapshot
Cultivation in a semi‐defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense.
inferredcites →https://doi.org/10.1007/bf00401402openalex-snapshot
Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse
inferredcites →https://doi.org/10.1007/bf00926669openalex-snapshot
The use of the 2 substituted 5-nitroimidazole, fexinidazole (Hoe 239) in the treatment of chronicT. brucei infections in mice
inferredcites →https://doi.org/10.1016/0001-706x(95)00109-ropenalex-snapshot
Effect of megazol on Trypanosoma brucei brucei acute and subacute infections in Swiss mice
inferredcites →https://doi.org/10.1016/0165-1110(81)90006-3openalex-snapshot
On the mutagenicity of nitroimidazoles
inferredcites →https://doi.org/10.1016/0165-1161(83)90010-9openalex-snapshot
Revised methods for the Salmonella mutagenicity test
inferredcites →https://doi.org/10.1016/j.actatropica.2008.07.006openalex-snapshot
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis
inferredcites →https://doi.org/10.1016/j.drudis.2009.09.004openalex-snapshot
HTS and hit finding in academia – from chemical genomics to drug discovery
inferredcites →https://doi.org/10.1016/j.ijpharm.2004.10.007openalex-snapshot
Evaluation of the MDR-MDCK cell line as a permeability screen for the blood–brain barrier
inferredcites →https://doi.org/10.1016/j.mrgentox.2004.02.013openalex-snapshot
In vitro and in vivo chromosomal aberrations induced by megazol
inferredcites →https://doi.org/10.1016/s0001-706x(97)00079-xopenalex-snapshot
The Alamar Blue® assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro
inferredcites →https://doi.org/10.1016/s0022-3565(24)36999-xopenalex-snapshot
The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
inferredcites →https://doi.org/10.1016/s0027-5107(00)00117-2openalex-snapshot
In vivo rodent micronucleus assay: protocol, conduct and data interpretation
inferredcites →https://doi.org/10.1016/s0140-6736(09)60829-1openalex-snapshot
Human African trypanosomiasis
inferredcites →https://doi.org/10.1016/s0140-6736(09)61117-xopenalex-snapshot
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
inferredcites →https://doi.org/10.1016/s0140-6736(09)61163-6openalex-snapshot
NECT trial: more than a small victory over sleeping sickness
inferredcites →https://doi.org/10.1016/s1383-5718(02)00105-5openalex-snapshot
Genotoxicity assessment of the antiepileptic drug AMP397, an Ames-positive aromatic nitro compound
inferredcites →https://doi.org/10.1016/s1473-3099(02)00321-3openalex-snapshot
Treatment of human African trypanosomiasis—present situation and needs for research and development
inferredcites →https://doi.org/10.1021/bp050208uopenalex-snapshot
Role of Caco-2 Cell Monolayers in Prediction of Intestinal Drug Absorption
inferredcites →https://doi.org/10.1021/tx000002xopenalex-snapshot
Mutagenicity of Nitroaromatic Compounds
inferredcites →https://doi.org/10.1038/35016103openalex-snapshot
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
inferredcites →https://doi.org/10.1038/bjp.2008.280openalex-snapshot
Principles of Safety Pharmacology
inferredcites →https://doi.org/10.1038/nprot.2007.77openalex-snapshot
Cytokinesis-block micronucleus cytome assay
inferredcites →https://doi.org/10.1038/sj.bjp.0707354openalex-snapshot
Human African trypanosomiasis: pharmacological re‐engagement with a neglected disease
inferredcites →https://doi.org/10.1046/j.1365-3156.2001.00712.xopenalex-snapshot
Melarsoprol refractory T. b. gambiense from Omugo, north‐western Uganda
inferredcites →https://doi.org/10.1063/1.555843openalex-snapshot
Reduction Potentials of One-Electron Couples Involving Free Radicals in Aqueous Solution
inferredcites →https://doi.org/10.1073/pnas.0711014105openalex-snapshot
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
inferredcites →https://doi.org/10.1080/00034983.1983.11811668openalex-snapshot
The activity of fexinidazole (HOE 239) against experimental infections with Trypanosoma cruzi, trichomonads and Entamoeba histolytica
inferredcites →https://doi.org/10.1080/10590500902885593openalex-snapshot
Predictive Models for Carcinogenicity and Mutagenicity: Frameworks, State-of-the-Art, and Perspectives
inferredcites →https://doi.org/10.1086/432576openalex-snapshot
Eflornithine Is Safer than Melarsoprol for the Treatment of Second-Stage Trypanosoma brucei gambiense Human African Trypanosomiasis
inferredcites →https://doi.org/10.1093/mutage/gem006openalex-snapshot
In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results
inferredcites →https://doi.org/10.1096/fj.07-9574lsfopenalex-snapshot
Dose translation from animal to human studies revisited
inferredcites →https://doi.org/10.1126/science.1095920openalex-snapshot
Protein Kinase Inhibitors: Insights into Drug Design from Structure
inferredcites →https://doi.org/10.1128/aac.00225-09openalex-snapshot
New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289
inferredcites →https://doi.org/10.1128/aac.42.11.2858openalex-snapshot
In Vitro and In Vivo Activities of Trybizine Hydrochloride against Various Pathogenic Trypanosome Species
inferredcites →https://doi.org/10.1128/aac.47.10.3368-3370.2003openalex-snapshot
Activity of Megazol, a Trypanocidal Nitroimidazole, Is Associated with DNA Damage
inferredcites →https://doi.org/10.1172/jci200421052openalex-snapshot
Human African trypanosomiasis of the CNS: current issues and challenges
inferredcites →https://doi.org/10.1201/9781420084498-31openalex-snapshot
Section XXIV. Partition Chromatographs
inferredcites →https://doi.org/10.1371/journal.pmed.0030466openalex-snapshot
OPC-67683, a Nitro-Dihydro-Imidazooxazole Derivative with Promising Action against Tuberculosis In Vitro and In Mice
inferredcites →https://doi.org/10.1371/journal.pmed.0050055openalex-snapshot
Eliminating Human African Trypanosomiasis: Where Do We Stand and What Comes Next?
inferredcites →https://doi.org/10.2174/1381612043383214openalex-snapshot
Prospects for Clinical Introduction of Nitroimidazole Antibiotics for the Treatment of Tuberculosis
inferredcites →https://doi.org/10.3201/eid1406.071266openalex-snapshot
High Failure Rates of Melarsoprol for Sleeping Sickness, Democratic Republic of Congo
inferredcites →https://doi.org/10.3201/eid1602.090967openalex-snapshot
Human African Trypanosomiasis in Areas without Surveillance
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1051/parasite/2013038zenodo-depositor-declared
Evaluation of trypanocidal drugs used for human African trypanosomosis againstTrypanosoma lewisi
inferred← citeshttps://doi.org/10.2139/ssrn.4797648openalex-extracted
An Open-Label Study of the Effectiveness and Safety of Fexinidazole for Gambiense Human African Trypanosomiasis, Including an Exploration of Adherence in Outpatients
inferred← citeshttps://doi.org/10.1002/0471266949.bmc235.pub2openalex-snapshot
Drug Discovery and Development for Kinetoplastid Diseases
inferred← citeshttps://doi.org/10.1002/14651858.cd015374openalex-snapshot
Chemotherapy for second-stage human African trypanosomiasis: drugs in use
inferred← citeshttps://doi.org/10.1002/9783527670383.ch27openalex-snapshot
New Developments in the Treatment of Late‐Stage Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1002/9783527808656.ch5openalex-snapshot
Drug Discovery and Development for Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1002/ardp.202100338openalex-snapshot
Antiprotozoal agents: How have they changed over a decade?
inferred← citeshttps://doi.org/10.1002/ardp.202400059openalex-snapshot
New 2‐nitroimidazole‐N‐acylhydrazones, analogs of benznidazole, as anti‐Trypanosoma cruzi agents
inferred← citeshttps://doi.org/10.1002/ardp.202400626openalex-snapshot
The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases
inferred← citeshttps://doi.org/10.1002/bmc.70158openalex-snapshot
Validated LC‐MS/MS Method for Quantifying the Antiparasitic Nitroimidazole DNDI‐0690 in Preclinical Target Site PK/PD Studies
inferred← citeshttps://doi.org/10.1002/cbdv.202403020openalex-snapshot
Exploring USFDA‐Approved Imidazole‐Based Small Molecules in Drug Discovery: A Mini Perspective
inferred← citeshttps://doi.org/10.1002/cbic.202000246openalex-snapshot
Fragment‐Based Discovery of Non‐bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase
inferred← citeshttps://doi.org/10.1002/cmdc.201300072openalex-snapshot
From On‐Target to Off‐Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti‐Trypanosoma brucei Drug Discovery Lead Molecules
inferred← citeshttps://doi.org/10.1002/cmdc.201700259openalex-snapshot
Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases
inferred← citeshttps://doi.org/10.1002/ddr.21664openalex-snapshot
The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets
inferred← citeshttps://doi.org/10.1002/jlcr.1914openalex-snapshot
Synthesis of 2H‐ and 14C‐labeled fexinidazole and its primary metabolites labeled with 2H
inferred← citeshttps://doi.org/10.1002/slct.201601059openalex-snapshot
Scoping Studies into the Structure‐Activity Relationship (SAR) of Phenylephrine‐Derived Analogues as Inhibitors of Trypanosoma brucei rhodesiense
inferred← citeshttps://doi.org/10.1007/978-1-0716-0294-2_46openalex-snapshot
In Vitro Drug Efficacy Testing Against Trypanosoma brucei
inferred← citeshttps://doi.org/10.1007/978-1-4939-2089-1_21openalex-snapshot
African Sleeping Sickness
inferred← citeshttps://doi.org/10.1007/978-1-4939-6578-6_47openalex-snapshot
Sleep Disturbances in General Medical Disorders
inferred← citeshttps://doi.org/10.1007/978-3-030-44054-1_8openalex-snapshot
Etiologic Treatment of Chagas Disease: Old Drugs, New Insights, Challenges, and Perspectives
inferred← citeshttps://doi.org/10.1007/978-3-031-26078-0_11openalex-snapshot
Newly Approved Anti-parasitic Drugs for Malaria, Fascioliasis, Onchocerciasis, Chagas Disease, and African Trypanosomiasis
inferred← citeshttps://doi.org/10.1007/978-3-031-53901-5_4openalex-snapshot
Human African Trypanosomiasis (HAT)
inferred← citeshttps://doi.org/10.1007/978-3-319-25471-5_4openalex-snapshot
Human African Trypanosomiasis (HAT)
inferred← citeshttps://doi.org/10.1007/978-3-319-46718-4_43openalex-snapshot
Drug Resistance in Trypanosoma brucei
inferred← citeshttps://doi.org/10.1007/978-3-319-47266-9_36openalex-snapshot
Drug Resistance Assays for Parasitic Diseases
inferred← citeshttps://doi.org/10.1007/978-3-7091-1556-5_9openalex-snapshot
Progress Towards New Treatments for Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1007/s00044-014-1085-yopenalex-snapshot
Comparative atom-based 3D QSAR study of 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines analogs for its anti-trypanosomal activities
inferred← citeshttps://doi.org/10.1007/s11306-022-01880-0openalex-snapshot
Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery
inferred← citeshttps://doi.org/10.1007/s13346-020-00764-xopenalex-snapshot
Nanotechnological interventions for treatment of trypanosomiasis in humans and animals
inferred← citeshttps://doi.org/10.1007/s40261-025-01508-wopenalex-snapshot
Unexpected Clinical Drug-Drug Interaction of Fexinidazole on Midazolam Pharmacokinetics: Insights into Underlying Mechanisms from Clinical Phase I Study Results and Supporting In Vivo/Vitro Evidence
inferred← citeshttps://doi.org/10.1007/s40261-026-01588-2openalex-snapshot
Pharmacokinetics and Tolerability of Fexinidazole in Subjects with Hepatic Impairment
inferred← citeshttps://doi.org/10.1007/s40262-014-0136-3openalex-snapshot
Determination of an Optimal Dosing Regimen for Fexinidazole, a Novel Oral Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Studies
inferred← citeshttps://doi.org/10.1007/s40262-023-01216-8openalex-snapshot
Determination of the Optimal Single Dose Treatment for Acoziborole, a Novel Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Study
inferred← citeshttps://doi.org/10.1007/s40265-019-1051-6openalex-snapshot
Fexinidazole: First Global Approval
inferred← citeshttps://doi.org/10.1007/s40267-019-00672-2openalex-snapshot
Fexinidazole in human African trypanosomiasis: a profile of its use
inferred← citeshttps://doi.org/10.1007/s41061-025-00515-xopenalex-snapshot
Total Syntheses of Deuterated Drugs: A Comprehensive Review
inferred← citeshttps://doi.org/10.1016/b978-0-12-386882-4.00039-6openalex-snapshot
Advances in Understanding and Treatment of Human African Trypanosomiasis: Divergent Diseases Caused by Distinct Parasites
inferred← citeshttps://doi.org/10.1016/b978-0-12-813806-9.00014-7openalex-snapshot
The Challenge of Finding New Therapies for Sleeping Sickness
inferred← citeshttps://doi.org/10.1016/b978-0-12-815723-7.00007-9openalex-snapshot
Plant-derived compounds against protozoan neglected diseases: toward sustainable drug development
inferred← citeshttps://doi.org/10.1016/b978-0-12-818731-9.00096-3openalex-snapshot
Anti-Parasite Agents and Vaccines
inferred← citeshttps://doi.org/10.1016/b978-0-443-19130-5.00016-2openalex-snapshot
African trypanosomiasis: Comprehending the parasite pathogenesis in the brain
inferred← citeshttps://doi.org/10.1016/b978-0-444-63460-3.00002-xopenalex-snapshot
From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)
inferred← citeshttps://doi.org/10.1016/b978-0-7020-5101-2.00046-7openalex-snapshot
Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1016/bs.apha.2014.06.003openalex-snapshot
Delivery of Antihuman African Trypanosomiasis Drugs Across the Blood–Brain and Blood–CSF Barriers
inferred← citeshttps://doi.org/10.1016/bs.armc.2018.08.003openalex-snapshot
Drugs and Drug Resistance in African and American Trypanosomiasis
inferred← citeshttps://doi.org/10.1016/bs.pmbts.2024.05.001openalex-snapshot
Drug repurposing for parasitic protozoan diseases
inferred← citeshttps://doi.org/10.1016/bs.pmch.2014.12.001openalex-snapshot
A New Era for Chagas Disease Drug Discovery?
inferred← citeshttps://doi.org/10.1016/j.arabjc.2016.03.005openalex-snapshot
The structure design of biotransformed unsymmetrical nitro-contained 1,5-diaryl-3-oxo-1,4-pentadienyls for the anti-parasitic activities
inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.103590openalex-snapshot
Activity of diphenyl ether benzyl amines against Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1016/j.bmc.2013.08.022openalex-snapshot
Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.04.006openalex-snapshot
Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense
inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116073openalex-snapshot
Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study
inferred← citeshttps://doi.org/10.1016/j.bmc.2024.117751openalex-snapshot
Synthesis and biological evaluation of orally active anti-Trypanosoma agents
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.06.004openalex-snapshot
Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies
inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.09.051openalex-snapshot
Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.03.069openalex-snapshot
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.10.067openalex-snapshot
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides
inferred← citeshttps://doi.org/10.1016/j.bmcl.2020.127207openalex-snapshot
Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT
inferred← citeshttps://doi.org/10.1016/j.coph.2012.05.001openalex-snapshot
Antiparasitic agents: new drugs on the horizon
inferred← citeshttps://doi.org/10.1016/j.crchbi.2023.100047openalex-snapshot
Synthesis and characterization of I-BET151 derivatives for use in identifying protein targets in the African trypanosome
inferred← citeshttps://doi.org/10.1016/j.ejmech.2011.01.071openalex-snapshot
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.05.007openalex-snapshot
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.09.045openalex-snapshot
Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.04.064openalex-snapshot
Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.06.001openalex-snapshot
Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.07.064openalex-snapshot
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111887openalex-snapshot
Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112047openalex-snapshot
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112802openalex-snapshot
Design, synthesis, antitrypanosomal activity, DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113913openalex-snapshot
Synthesis and in vitro antitrypanosomal evaluation of novel 6-heteroarylidene-substituted quinolone derivatives
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115451openalex-snapshot
Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115954openalex-snapshot
Discovery of an orally active nitrothiophene-based antitrypanosomal agent
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.119281openalex-snapshot
FDA-approved imidazole- and benzimidazole-based drugs: An update
inferred← citeshttps://doi.org/10.1016/j.exppara.2019.04.011openalex-snapshot
Trypanostatic activity of geranylacetone: Mitigation of Trypanosoma congolense-associated pathological pertubations and insight into the mechanism of anaemia amelioration using in vitro and in silico models
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2011.03.004openalex-snapshot
Antiprotozoal compounds: state of the art and new developments
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2016.09.017openalex-snapshot
Nelfinavir and lopinavir impair Trypanosoma cruzi trypomastigote infection in mammalian host cells and show anti-amastigote activity
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2017.01.038openalex-snapshot
Dose-dependent effect and pharmacokinetics of fexinidazole and its metabolites in a mouse model of human African trypanosomiasis
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2020.105906openalex-snapshot
Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2022.122505openalex-snapshot
A new oral self-emulsifying drug delivery system improves the antileishmania efficacy of fexinidazole in vivo
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2018.07.008openalex-snapshot
Syntheses and biological studies of nitroimidazole conjugated heteroscorpionate ligands and related Cu(I) and Cu(II) complexes
inferred← citeshttps://doi.org/10.1016/j.lanmic.2024.100972openalex-snapshot
Challenges and advancements in the development of vaccines and therapies against Chagas disease
inferred← citeshttps://doi.org/10.1016/j.neurol.2011.12.004openalex-snapshot
La maladie du sommeil, fin d’une épidémie ?
inferred← citeshttps://doi.org/10.1016/j.parint.2017.03.009openalex-snapshot
Deciphering the effects of nelfinavir and lopinavir on epimastigote forms of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.parint.2019.101968openalex-snapshot
In vitro effects of the asymmetric peptidomimetic 157, containing l-tartaric acid core and valine/leucine substituents, on Leishmania amazonensis promastigotes and amastigotes
inferred← citeshttps://doi.org/10.1016/j.pt.2012.05.003openalex-snapshot
An alternative form of melarsoprol in sleeping sickness
inferred← citeshttps://doi.org/10.1016/j.pt.2014.04.003openalex-snapshot
Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects
inferred← citeshttps://doi.org/10.1016/j.pt.2017.12.002openalex-snapshot
Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon
inferred← citeshttps://doi.org/10.1016/j.pt.2018.08.006openalex-snapshot
The Long Wait for a New Drug for Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1016/s0140-6736(09)60829-1openalex-snapshot
Human African trypanosomiasis
inferred← citeshttps://doi.org/10.1016/s0140-6736(17)32758-7openalex-snapshot
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial
inferred← citeshttps://doi.org/10.1016/s0140-6736(18)30019-9openalex-snapshot
Oral fexinidazole for human African trypanosomiasis
inferred← citeshttps://doi.org/10.1016/s1166-8598(13)50128-1openalex-snapshot
10.1016/s1166-8598(13)50128-1
inferred← citeshttps://doi.org/10.1016/s1473-3099(23)00651-5openalex-snapshot
Efficacy and safety of fexinidazole for treatment of chronic indeterminate Chagas disease (FEXI-12): a multicentre, randomised, double-blind, phase 2 trial
inferred← citeshttps://doi.org/10.1016/s1474-4422(12)70296-xopenalex-snapshot
Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)
inferred← citeshttps://doi.org/10.1016/s2214-109x(14)70226-8openalex-snapshot
The challenge of serodiagnosis of sleeping sickness in the context of elimination
inferred← citeshttps://doi.org/10.1016/s2214-109x(24)00526-6openalex-snapshot
Effectiveness and safety of fexinidazole for gambiense human African trypanosomiasis and exploration of adherence in outpatients: a phase 3b, prospective, open-label, non-randomised, cohort study
inferred← citeshttps://doi.org/10.1016/s2214-109x(25)00016-6openalex-snapshot
Fexinidazole as a new oral treatment for human African trypanosomiasis due to Trypanosoma brucei rhodesiense: a prospective, open-label, single-arm, phase 2–3, non-randomised study
inferred← citeshttps://doi.org/10.1016/s2221-1691(12)60277-9openalex-snapshot
Phytochemical properties of Ganoderma applanatum as potential agents in the application of nanotechnology in modern day medical practice
inferred← citeshttps://doi.org/10.1017/s003118201300098xopenalex-snapshot
Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1017/s0031182013002102openalex-snapshot
The journey towards elimination of gambiense human African trypanosomiasis: not far, nor easy
inferred← citeshttps://doi.org/10.1017/s0031182014000882openalex-snapshot
Therapeutic responses to different anti-Trypanosoma cruzidrugs in experimental infection by benznidazole-resistant parasite stock
inferred← citeshttps://doi.org/10.1017/s0031182021001001openalex-snapshot
Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.2c02201openalex-snapshot
Zinc(II) Complex with Pyrazolone-Based Hydrazones is Strongly Effective against Trypanosoma brucei Which Causes African Sleeping Sickness
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00972openalex-snapshot
Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01745openalex-snapshot
Design and Synthesis of Novel 3-Nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted Analogs as Promising Antitrypanosomatid Agents: Evaluation of In Vitro Activity against Chagas Disease and Leishmaniasis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c01799openalex-snapshot
Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02863openalex-snapshot
What Do Oral Drugs Really Look Like? Dose Regimen, Pharmacokinetics, and Safety of Recently Approved Small-Molecule Oral Drugs
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c03640openalex-snapshot
Novel Dual Soft Drug Strategy Enables Development of Topical Androgen Receptor Antagonists with Enhanced Efficacy and Optimized Safety for Androgenetic Alopecia
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00442openalex-snapshot
Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01163openalex-snapshot
Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00143openalex-snapshot
Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01869openalex-snapshot
Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain andTrypanosoma bruceiInhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b02021openalex-snapshot
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections
inferred← citeshttps://doi.org/10.1021/acs.joc.5b02133openalex-snapshot
Silver(I)-Promoted ipso-Nitration of Carboxylic Acids by Nitronium Tetrafluoroborate
inferred← citeshttps://doi.org/10.1021/acsinfecdis.1c00118openalex-snapshot
From Magic Bullet to Magic Bomb: Reductive Bioactivation of Antiparasitic Agents
inferred← citeshttps://doi.org/10.1021/acsinfecdis.2c00331openalex-snapshot
Identification of Prazosin as a Potential Flagellum Attachment Zone 1(FAZ1) Inhibitor for the Treatment of Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1021/acsinfecdis.5b00068openalex-snapshot
In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei
inferred← citeshttps://doi.org/10.1021/acsinfecdis.6b00202openalex-snapshot
From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1021/acsinfecdis.7b00022openalex-snapshot
Identification ofTrypanosoma bruceiAdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay
inferred← citeshttps://doi.org/10.1021/acsinfecdis.7b00187openalex-snapshot
Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors
inferred← citeshttps://doi.org/10.1021/acsinfecdis.8b00358openalex-snapshot
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5c00374openalex-snapshot
Optimization of Quinazolines for Inhibition of Trypanosoma brucei Proliferation
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.9b00566openalex-snapshot
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi
inferred← citeshttps://doi.org/10.1021/acsomega.5c05115openalex-snapshot
Crystallographic and Electroanalytical Analyses of Fexinidazole and Its Major Metabolites
inferred← citeshttps://doi.org/10.1021/acsomega.6c03993openalex-snapshot
Synthesis and Biological Evaluation of Prazosin-Derived Antitrypanosomal Agents Putatively Targeting FAZ1
inferred← citeshttps://doi.org/10.1021/cr500098fopenalex-snapshot
Recent Approaches to Chemical Discovery and Development Against Malaria and the Neglected Tropical Diseases Human African Trypanosomiasis and Schistosomiasis
inferred← citeshttps://doi.org/10.1021/cr500365fopenalex-snapshot
Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1021/jm2012408openalex-snapshot
Chalcone–Benzoxaborole Hybrid Molecules as Potent Antitrypanosomal Agents
inferred← citeshttps://doi.org/10.1021/jm401178topenalex-snapshot
Substituted 2-Phenylimidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1021/ml400487topenalex-snapshot
Facile Synthesis and Preliminary Structure–Activity Analysis of New Sulfonamides Against Trypanosoma brucei
inferred← citeshttps://doi.org/10.1038/nrmicro.2016.193openalex-snapshot
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
inferred← citeshttps://doi.org/10.1038/s41586-018-0327-4openalex-snapshot
Challenges and recent progress in drug discovery for tropical diseases
inferred← citeshttps://doi.org/10.1038/s41598-022-23941-zopenalex-snapshot
Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1038/s41598-025-08659-yopenalex-snapshot
Role of the nucleotide excision repair endonuclease XPF in the kinetoplastid parasite Trypanosoma brucei
inferred← citeshttps://doi.org/10.1038/s41598-025-12230-0openalex-snapshot
Metronidazole induces genotoxicity, hepato- and nephrotoxicity by triggering DNA fragmentation in Swiss albino mice (Balb/c)
inferred← citeshttps://doi.org/10.1038/srep35351openalex-snapshot
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage
inferred← citeshttps://doi.org/10.1039/9781788010177-00153openalex-snapshot
Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs
inferred← citeshttps://doi.org/10.1039/9781849733496-00134openalex-snapshot
Drugs for Kinetoplastid Diseases – Current Situation and Challenges
inferred← citeshttps://doi.org/10.1039/c3mb70215dopenalex-snapshot
Metabonomic investigations of age- and batch-related variations in female NMRI mice using proton nuclear magnetic resonance spectroscopy
inferred← citeshttps://doi.org/10.1039/c7md00280gopenalex-snapshot
Novel lead compounds in pre-clinical development against African sleeping sickness
inferred← citeshttps://doi.org/10.1039/c7nj02061aopenalex-snapshot
γ radiation-induced damage of nucleic acid bases, calf thymus DNA and DNA within MCF-7 breast cancer cells by [Cu 2 (OAc) 4 (tnz) 2 ]: a potential radiosensitizer
inferred← citeshttps://doi.org/10.1039/d0md00277aopenalex-snapshot
Investigation of thiazolyl–benzothiophenamides as potential agents for African sleeping sickness
inferred← citeshttps://doi.org/10.1039/d4md00426dopenalex-snapshot
Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety
inferred← citeshttps://doi.org/10.1039/d5sc04631aopenalex-snapshot
DeepMetab: a comprehensive and mechanistically informed graph learning framework for end-to-end drug metabolism prediction
inferred← citeshttps://doi.org/10.1042/ebc20160077openalex-snapshot
Polishing the tarnished silver bullet: the quest for new antibiotics
inferred← citeshttps://doi.org/10.1042/etls20170103openalex-snapshot
Antileishmanial and antitrypanosomal drug identification
inferred← citeshttps://doi.org/10.1080/13543784.2020.1793955openalex-snapshot
Emerging agents for the treatment of Chagas disease: what is in the preclinical and clinical development pipeline?
inferred← citeshttps://doi.org/10.1080/17460441.2020.1806233openalex-snapshot
Animal models of Chagas disease and their translational value to drug development
inferred← citeshttps://doi.org/10.1093/9780198905325.001.0001openalex-snapshot
Pharmaceutical Knowledge Commons for the Most Neglected Populations in Global Health
inferred← citeshttps://doi.org/10.1093/9780198905325.002.0007openalex-snapshot
List of Abbreviations and Acronyms
inferred← citeshttps://doi.org/10.1093/9780198905325.003.0001openalex-snapshot
DNDi and the Global Politics of Neglected Tropical Diseases
inferred← citeshttps://doi.org/10.1093/9780198905325.003.0002openalex-snapshot
Pharmaceutical Knowledge Commons
inferred← citeshttps://doi.org/10.1093/9780198905325.003.0003openalex-snapshot
Piercing through the Silence of Chagas Disease
inferred← citeshttps://doi.org/10.1093/9780198905325.003.0004openalex-snapshot
Connecting World Regions to Resist Leishmania Parasites
inferred← citeshttps://doi.org/10.1093/9780198905325.003.0005openalex-snapshot
Transforming the Treatment for Sleeping Sickness with Oral Pills
inferred← citeshttps://doi.org/10.1093/9780198905325.003.0006openalex-snapshot
Situating DNDi’s Pharmaceutical Knowledge Commons in Global Health
inferred← citeshttps://doi.org/10.1093/bmb/lds031openalex-snapshot
Management of trypanosomiasis and leishmaniasis
inferred← citeshttps://doi.org/10.1093/cid/ciac579openalex-snapshot
A Phase 2, Randomized, Multicenter, Placebo-Controlled, Proof-of-Concept Trial of Oral Fexinidazole in Adults With Chronic Indeterminate Chagas Disease
inferred← citeshttps://doi.org/10.1093/cid/ciac884openalex-snapshot
Avoiding Clinical Trial Failures in Neglected Tropical Diseases: The Example of Chagas Disease
inferred← citeshttps://doi.org/10.1093/jac/dkz160openalex-snapshot
Optimal kinetic exposures for classic and candidate antitrypanosomals
inferred← citeshttps://doi.org/10.1093/jac/dkz172openalex-snapshot
In vitro activity and in vivo efficacy of fexinidazole against New World Leishmania species
inferred← citeshttps://doi.org/10.1093/mutage/ges015openalex-snapshot
Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness)
inferred← citeshttps://doi.org/10.1107/s2059798320004891openalex-snapshot
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor
inferred← citeshttps://doi.org/10.1111/j.1469-0691.2012.03801.xopenalex-snapshot
Symposia and Oral Presentations
inferred← citeshttps://doi.org/10.1111/tmi.12483openalex-snapshot
Contemporary and emerging strategies for eliminating human African trypanosomiasis due to Trypanosoma brucei gambiense: review
inferred← citeshttps://doi.org/10.1124/dmd.123.001289openalex-snapshot
Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation
inferred← citeshttps://doi.org/10.1124/molpharm.121.000430openalex-snapshot
Physiologic Targets and Modes of Action for CBL0137, a Lead for Human African Trypanosomiasis Drug Development
inferred← citeshttps://doi.org/10.1126/scitranslmed.3003326openalex-snapshot
The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis
inferred← citeshttps://doi.org/10.1128/aac.00246-11openalex-snapshot
Antitrypanosomal Activity of Fexinidazole, a New Oral Nitroimidazole Drug Candidate for Treatment of Sleeping Sickness
inferred← citeshttps://doi.org/10.1128/aac.00596-15openalex-snapshot
Targeting the Parasite's DNA with Methyltriazenyl Purine Analogs Is a Safe, Selective, and Efficacious Antitrypanosomal Strategy
inferred← citeshttps://doi.org/10.1128/aac.00722-13openalex-snapshot
The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis
inferred← citeshttps://doi.org/10.1128/aac.00731-23openalex-snapshot
Antigiardial and antiamebic activities of fexinidazole and its metabolites: new drug leads for giardiasis and amebiasis
inferred← citeshttps://doi.org/10.1128/aac.01449-13openalex-snapshot
Characterization of a Melamino Nitroheterocycle as a Potential Lead for the Treatment of Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1128/aac.01459-13openalex-snapshot
Evaluating Aziridinyl Nitrobenzamide Compounds as Leishmanicidal Prodrugs
inferred← citeshttps://doi.org/10.1128/aac.01788-12openalex-snapshot
Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation
inferred← citeshttps://doi.org/10.1128/aac.01870-12openalex-snapshot
In Vitro and In Vivo Activities of 2-Aminopyrazines and 2-Aminopyridines in Experimental Models of Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1128/aac.02046-12openalex-snapshot
Evaluating 5-Nitrofurans as Trypanocidal Agents
inferred← citeshttps://doi.org/10.1128/aac.02116-15openalex-snapshot
Identification and Characterization of FTY720 for the Treatment of Human African Trypanosomiasis
inferred← citeshttps://doi.org/10.1128/aac.02515-18openalex-snapshot
Pharmacokinetic-Pharmacodynamic Assessment of the Hepatic and Bone Marrow Toxicities of the New Trypanoside Fexinidazole
inferred← citeshttps://doi.org/10.1128/aac.02754-13openalex-snapshot
Antitrypanosomal Activity of Fexinidazole Metabolites, Potential New Drug Candidates for Chagas Disease
inferred← citeshttps://doi.org/10.1128/aac.03958-14openalex-snapshot
A New Nonpolar N -Hydroxy Imidazoline Lead Compound with Improved Activity in a Murine Model of Late-Stage Trypanosoma brucei brucei Infection Is Not Cross-Resistant with Diamidines
inferred← citeshttps://doi.org/10.1128/cmr.00153-23openalex-snapshot
Transforming the chemotherapy of human African trypanosomiasis
inferred← citeshttps://doi.org/10.1155/2012/340538openalex-snapshot
Towards Point-of-Care Diagnostic and Staging Tools for Human African Trypanosomiaisis
inferred← citeshttps://doi.org/10.1155/2015/583262openalex-snapshot
Overview of the Diagnostic Methods Used in the Field for Human African Trypanosomiasis: What Could Change in the Next Years?
inferred← citeshttps://doi.org/10.1155/ipid/7565247openalex-snapshot
Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence
inferred← citeshttps://doi.org/10.11606/d.42.2018.tde-10032023-170640openalex-snapshot
Atividade anti->i /i
inferred← citeshttps://doi.org/10.11606/t.75.2018.tde-16012018-091612openalex-snapshot
Planejamento, síntese e avaliação de inibidores da enzima cruzaína e de agentes tripanossomicidas derivados de imidazopiridina
inferred← citeshttps://doi.org/10.11606/t.9.2021.tde-13052022-105310openalex-snapshot
Planejamento e desenvolvimento de novos compostos com atividade frente a >i /i< spp: Síntese, avaliação da atividade e toxicidade de derivados 5-nitro-2-furfurilidênicos e estudos de relações estrutura-atividade
inferred← citeshttps://doi.org/10.1177/1087057114550585openalex-snapshot
Chagas Disease Drug Discovery: Toward a New Era
showing the first 200 of 312 · page through all 312
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.