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Safety and efficacy of a freeze-dried trivalent antivenom for snakebites in the Brazilian Amazon: An open randomized controlled phase IIb clinical trial
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jps.1040openalex-snapshot
Annealing to optimize the primary drying rate, reduce freezing‐induced drying rate heterogeneity, and determine T'g in pharmaceutical lyophilization
inferredcites →https://doi.org/10.1002/jps.22000openalex-snapshot
Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins I: Stability after freeze‐drying
inferredcites →https://doi.org/10.1016/0035-9203(90)90358-lopenalex-snapshot
Acute myocardial infarction-like enzyme profile in human victims of Crotalus durissus terrificus envenoming
inferredcites →https://doi.org/10.1016/0035-9203(95)90105-1openalex-snapshot
Treatment of snake bites by Bothrops species and Lachesis muta in Ecuador: laboratory screening of candidate antivenoms
inferredcites →https://doi.org/10.1016/0035-9203(95)90678-9openalex-snapshot
A randomized ‘blinded’ comparison of two doses of antivenom in the treatment of Bothrops envenoming in São Paulo, Brazil
inferredcites →https://doi.org/10.1016/0041-0101(86)90147-9openalex-snapshot
A critical reappraisal of the use of enzyme-linked immunosorbent assays in the study of snake bite
inferredcites →https://doi.org/10.1016/0041-0101(87)90134-6openalex-snapshot
Evidence that Crotalus durissus terrificus (South American rattlesnake) envenomation in humans causes myolysis rather than hemolysis
inferredcites →https://doi.org/10.1016/0041-0101(90)90011-uopenalex-snapshot
Effect of storage temperature on the stability of the liquid polyvalent antivenom produced in Costa Rica
inferredcites →https://doi.org/10.1016/0041-0101(91)90106-2openalex-snapshot
Comparative study of nine Bothrops snake venoms from adult female snakes and their offspring
inferredcites →https://doi.org/10.1016/0041-0101(94)90388-3openalex-snapshot
Reliability of the simple 20 minute whole blood clotting test (WBCT20) as an indicator of low plasma fibrinogen concentration in patients envenomed by Bothrops snakes
inferredcites →https://doi.org/10.1016/0041-0101(95)00125-5openalex-snapshot
High incidence of bites and stings by snakes and other animals among rubber tappers and amazonian indians of the Juruá Valley, Acre State, Brazil
inferredcites →https://doi.org/10.1016/0305-0491(92)90071-xopenalex-snapshot
Biochemical and biological differentiation of the venoms of the lancehead vipers (Bothrops atrox, Bothrops asper, Bothrops marajoensis and Bothrops moojeni)
inferredcites →https://doi.org/10.1016/j.actatropica.2004.09.008openalex-snapshot
Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment
inferredcites →https://doi.org/10.1016/j.ajem.2009.02.008openalex-snapshot
Improving Crotalidae polyvalent immune Fab reconstitution times
inferredcites →https://doi.org/10.1016/j.biochi.2015.08.006openalex-snapshot
Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of Batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species
inferredcites →https://doi.org/10.1016/j.toxicon.2004.03.020openalex-snapshot
Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms
inferredcites →https://doi.org/10.1016/j.toxicon.2009.01.012openalex-snapshot
Stability of equine IgG antivenoms obtained by caprylic acid precipitation: Towards a liquid formulation stable at tropical room temperature
inferredcites →https://doi.org/10.1016/j.toxicon.2009.07.001openalex-snapshot
Epidemiological, clinical and therapeutic aspects of Bothrops asper bites
inferredcites →https://doi.org/10.1016/j.toxicon.2011.11.017openalex-snapshot
Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab′)2] antivenoms, in Bothrops asper bites in Colombia
inferredcites →https://doi.org/10.1016/j.toxicon.2012.12.005openalex-snapshot
Validating a faster method for reconstitution of Crotalidae Polyvalent Immune Fab (ovine)
inferredcites →https://doi.org/10.1016/j.toxicon.2014.07.015openalex-snapshot
Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test
inferredcites →https://doi.org/10.1016/j.toxicon.2016.12.004openalex-snapshot
Physicochemical characterization of commercial freeze-dried snake antivenoms
inferredcites →https://doi.org/10.1016/j.toxicon.2017.02.008openalex-snapshot
Thermal stabilization of anti-α-cobratoxin single domain antibodies
inferredcites →https://doi.org/10.1016/j.trstmh.2006.01.006openalex-snapshot
Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia
inferredcites →https://doi.org/10.1016/s0035-9203(03)00005-1openalex-snapshot
Clinical trial of two antivenoms for the treatment of Bothrops and Lachesis bites in the north eastern Amazon region of Brazil
inferredcites →https://doi.org/10.1016/s0035-9203(96)90442-3openalex-snapshot
A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia
inferredcites →https://doi.org/10.1016/s0041-0101(00)00198-7openalex-snapshot
Time to reconstitution: purified Fab antivenom vs. unpurified IgG antivenom
inferredcites →https://doi.org/10.1016/s0041-0101(02)00104-6openalex-snapshot
Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital
inferredcites →https://doi.org/10.1016/s0041-0101(02)00393-8openalex-snapshot
Report of a WHO workshop on the standardization and control of antivenoms
inferredcites →https://doi.org/10.1016/s0041-0101(97)00015-9openalex-snapshot
Purification and stability studies of immunoglobulins from Lachesis muta muta antivenom
inferredcites →https://doi.org/10.1016/s0041-0101(97)00101-3openalex-snapshot
Thermal stability studies of hyperimmune horse antivenoms
inferredcites →https://doi.org/10.1016/s0041-0101(98)00220-7openalex-snapshot
A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms
inferredcites →https://doi.org/10.1016/s0140-6736(95)92825-1openalex-snapshot
Coagulation disorders in bushmaster envenomation
inferredcites →https://doi.org/10.1021/js980383nopenalex-snapshot
Effects of buffer composition and processing conditions on aggregation of bovine IgG during freeze-drying
inferredcites →https://doi.org/10.1051/jbio/2009043openalex-snapshot
Recommandations pour la production, le contrôle et l'enregistrement des immunoglobulines antivenimeuses
inferredcites →https://doi.org/10.1080/10915810590953446openalex-snapshot
The Venomous Reptiles of the Western Hemisphere
inferredcites →https://doi.org/10.1093/oxfordjournals.qjmed.a068818openalex-snapshot
Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers ( Bothrops jararaca ) in São Paulo, Brazil
inferredcites →https://doi.org/10.1136/bmj.318.7196.1451openalex-snapshot
Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites
inferredcites →https://doi.org/10.1136/bmj.329.7475.1129openalex-snapshot
Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms
inferredcites →https://doi.org/10.1208/aapsj080366openalex-snapshot
Protein aggregation and bioprocessing
inferredcites →https://doi.org/10.1371/journal.pmed.0050218openalex-snapshot
The Global Burden of Snakebite: A Literature Analysis and Modelling Based on Regional Estimates of Envenoming and Deaths
inferredcites →https://doi.org/10.1371/journal.pntd.0002442openalex-snapshot
Comparison of Phylogeny, Venom Composition and Neutralization by Antivenom in Diverse Species of Bothrops Complex
inferredcites →https://doi.org/10.1371/journal.pntd.0003701openalex-snapshot
Snakebites and Scorpion Stings in the Brazilian Amazon: Identifying Research Priorities for a Largely Neglected Problem
inferredcites →https://doi.org/10.1371/journal.pone.0132237openalex-snapshot
Older Age and Time to Medical Assistance Are Associated with Severity and Mortality of Snakebites in the Brazilian Amazon: A Case-Control Study
inferredcites →https://doi.org/10.1590/0037-8682-0105-2013openalex-snapshot
Snakebites as a largely neglected problem in the Brazilian Amazon: highlights of the epidemiological trends in the State of Amazonas
inferredcites →https://doi.org/10.1590/s0036-46651986000400003openalex-snapshot
Insuficiência renal aguda secundária a acidentes ofídicos botrópico e crotálico. Análise de 63 casos
inferredcites →https://doi.org/10.1590/s0036-46651994000500010openalex-snapshot
Envenenamento ofídico em crianças: frequência de reações precoces ao antiveneno em pacientes que receberam pré-tratamento com antagonistas H1 e H2 da histamina e hidrocortisona
inferredcites →https://doi.org/10.1590/s0036-46652003000600009openalex-snapshot
Venomous animals in Brazil: biology, clinic and therapeutics of envenomations
inferredcites →https://doi.org/10.1592/phco.2005.25.6.886openalex-snapshot
Intravenous Immunoglobulin–Associated Acute Renal Failure: Case Series and Literature Review
inferredcites →https://doi.org/10.2165/11592050-000000000-00000openalex-snapshot
Effect of Pre-Medication on Early Adverse Reactions Following Antivenom Use in Snakebite
inferredcites →https://doi.org/10.3390/toxins10040170openalex-snapshot
Snakebite: When the Human Touch Becomes a Bad Touch
inferredcites →https://doi.org/10.4269/ajtmh.1995.52.419openalex-snapshot
Prevention of Thromboses in Human Patients with Bothrops Lanceolatus Envenoming in Martinique: Failure of Anticoagulants and Efficacy of a Monospecific Antivenom
inferredcites →https://doi.org/10.4269/ajtmh.1998.58.183openalex-snapshot
A randomized, blinded, comparative trial of one pepsin-digested and two whole IgG antivenoms for Bothrops snake bites in Uraba, Colombia. The Regional Group on Antivenom Therapy Research (REGATHER).
inferredcites →https://doi.org/10.5860/choice.42-4027openalex-snapshot
The venomous reptiles of the Western Hemisphere
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Development of An Optimised Oral Regimen of Unithiol for the Treatment of Snakebite Envenoming: a Phase 1 Dose-Escalation Trial and Pharmacokinetic Analysis in Healthy Kenyan Adults
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Free‐Form Microfluidic Microneedle Array Patches
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Bothrops Snakebite Envenomings in the Amazon Region
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Rattlesnakes bites in the Brazilian Amazon: Clinical epidemiology, spatial distribution and ecological determinants
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Kinetic modeling and stability enhancement of laccase from Trametes sanguinea IIP-32 for sustainable xenobiotic degradation
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Lower levels of CXCL-8 and IL-2 on admission as predictors of early adverse reactions to Bothrops antivenom in the Brazilian Amazon
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Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults
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The commercial polyvalent antivenom against the “Big Four” venomous snakes of India shows poor immune recognition and neutralization of lethality and toxicity of Trimeresurus popeiorum venom proteins in the mouse model
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.154578openalex-snapshot
An equine bivalent F(ab’)2 antivenom developed against the venoms of two neglected pit viper species from Northeast India—Trimeresurus erythrurus and T. popeiorum—exhibits enhanced in vitro and preclinical neutralisation efficacy when compared to Indian commercial polyvalent antivenom
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Remarkable intrapopulation venom variability in the monocellate cobra (Naja kaouthia) unveils neglected aspects of India's snakebite problem
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Addressing the global snakebite crisis with geo-spatial analyses – Recent advances and future direction
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Clinical management of snakebite envenoming: Future perspectives
inferred← citeshttps://doi.org/10.1016/j.toxcx.2022.100137openalex-snapshot
Mapping of clinical management resources for snakebites and other animal envenomings in the Brazilian Amazon
inferred← citeshttps://doi.org/10.1016/j.toxicon.2018.06.070openalex-snapshot
History and perspectives on how to ensure antivenom accessibility in the most remote areas in Brazil
inferred← citeshttps://doi.org/10.1016/j.toxicon.2018.06.084openalex-snapshot
Current technology for the industrial manufacture of snake antivenoms
inferred← citeshttps://doi.org/10.1016/j.toxicon.2019.11.011openalex-snapshot
Coral snake bites in Brazilian Amazonia: Perpetrating species, epidemiology and clinical aspects
inferred← citeshttps://doi.org/10.1016/j.toxicon.2020.07.009openalex-snapshot
Envenomations by coral snakes in an Amazonian metropolis: Ecological, epidemiological and clinical aspects
inferred← citeshttps://doi.org/10.1016/j.toxicon.2021.06.015openalex-snapshot
Use of freeze-dried trivalent antivenom to neutralize the toxic activities of Bothrops atrox snake venoms from the Amazon
inferred← citeshttps://doi.org/10.1016/j.toxicon.2022.09.010openalex-snapshot
The severity of acute kidney injury correlates with plasma venom levels in Bothrops atrox envenomings
inferred← citeshttps://doi.org/10.1016/j.toxicon.2022.106935openalex-snapshot
Adverse reactions to four types of monovalent antivenom used in the treatment of snakebite envenoming in South China
inferred← citeshttps://doi.org/10.1016/j.toxicon.2022.106995openalex-snapshot
Perceptions of nurses regarding the management of snakebite envenomations: Limits and possibilities
inferred← citeshttps://doi.org/10.1016/j.toxicon.2024.108075openalex-snapshot
Sex-related differences in toxic manifestations induced by Bothrops atrox venom in mice
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Ability of brazilian Bothrops-Lachesis-Crotalus antivenom in neutralizing some biological activities of Crotalus durissus ruruima rattlesnake venom
inferred← citeshttps://doi.org/10.1016/j.toxicon.2025.108329openalex-snapshot
Why do antivenoms still terrify Brazilian doctors? Lessons from the penicillin treatment decentralization
inferred← citeshttps://doi.org/10.1016/j.toxicon.2025.108610openalex-snapshot
Fatal Bothrops atrox snakebite with thrombotic microangiopathy, hemorrhagic stroke and acute kidney injury
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Inadequate immunorecognition and ineffective paraspecific neutralisation of lethality and toxicity of Trimeresurus erythrurus venom by Indian polyvalent antivenom compared to Trimeresurus popeiorum venom
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Antivenom efficacy and traditional practices for Snakebite in Brazil: Where do they meet?
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Bothrops snakebites in the Amazon: recovery from hemostatic disorders after Brazilian antivenom therapy
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Failure of a Mexican antivenom on recovery from snakebite-related coagulopathy in French Guiana
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A systematic review of commercial snake antivenoms from seven regions of the world
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Haemotoxicity of snakes: a review of pathogenesis, clinical manifestations, novel diagnostics and challenges in management
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A wolf in another wolf’s clothing: Post-genomic regulation dictates venom profiles of medically-important cryptic kraits in India
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Snake Hunting System Supplied with Solar Energy in the Ecuadorial Forest for Strictly Curative Purposes, Promoting Ancestral Knowledge, Natural Medicine and Indigenous Cultural Products from Rural Areas. Case Study: Peru
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Comparación de la eficacia, la seguridad y la farmacocinética de los antivenenos antiofídicos: revisión de literatura
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Analysis of snakebite data in Volta and Oti Regions, Ghana, 2019.
inferred← citeshttps://doi.org/10.1186/s13104-020-05134-xopenalex-snapshot
Comparative therapeutic index, lethal time and safety margin of various toxicants and snake antivenoms using newly derived and old formulas
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Outcomes in intervention research on snakebite envenomation: a systematic review
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Animal derived antibodies should be considered alongside convalescent human plasma to deliver treatments for COVID-19
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Beyond the ‘big four’: Venom profiling of the medically important yet neglected Indian snakes reveals disturbing antivenom deficiencies
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Interventions for the management of snakebite envenoming: An overview of systematic reviews
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Biogeographic venom variation in Russell’s viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots
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Clinical outcomes and outcome measurement tools reported in randomised controlled trials of treatment for snakebite envenoming: A systematic review
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Correction: Safety and efficacy of a freeze-dried trivalent antivenom for snakebites in the Brazilian Amazon: An open randomized controlled phase IIb clinical trial
inferred← citeshttps://doi.org/10.1371/journal.pntd.0011242openalex-snapshot
Effect of the time to antivenom administration on recovery from snakebite envenoming-related coagulopathy in French Guiana
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Development and validation of a minimum requirements checklist for snakebite envenoming treatment in the Brazilian Amazonia
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Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations
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The validity, reliability and minimal clinically important difference of the patient specific functional scale in snake envenomation
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Hemorrhagic stroke following viper bites and delayed antivenom administration: three case reports from the Western Brazilian Amazon
inferred← citeshttps://doi.org/10.1590/0037-8682-0462-2025openalex-snapshot
Snakebite Envenomations In The Brazilian Amazon: A Little Less Neglected
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Epidemiological and clinical aspects of snakebites in the upper Juruá River region, western Brazilian Amazonia
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A phase IV, prospective, observational study of the clinical safety of snake antivenoms
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Profile of snakebite victims reported in a public teaching hospital: a cross-sectional study
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Rabdomiólise maciça e hepatite aguda secundários ao envenenamento crotálico: um relato de caso
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Systematic review and meta-analysis of global prevalence of neurotoxic and hemotoxic snakebite envenomation
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Les envenimations vipérines en Guyane française
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Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom
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Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology
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Venomics of the Enigmatic Andaman Cobra (Naja sagittifera) and the Preclinical Failure of Indian Antivenoms in Andaman and Nicobar Islands
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Effectiveness of Lyoprotectants in Protein Stabilization During Lyophilization
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Snakebite: When the Human Touch Becomes a Bad Touch
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Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon
inferred← citeshttps://doi.org/10.3390/toxins12090554openalex-snapshot
Bleeding Disorders in Bothrops atrox Envenomations in the Brazilian Amazon: Participation of Hemostatic Factors and the Impact of Tissue Factor
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Clinical Features and Management of Snakebite Envenoming in French Guiana
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A Wolf in Another Wolf’s Clothing: Post-Genomic Regulation Dictates Venom Profiles of Medically-Important Cryptic Kraits in India
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The Preclinical Evaluation of a Second-Generation Antivenom for Treating Snake Envenoming in India
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Validation of a Culturally Relevant Snakebite Envenomation Clinical Practice Guideline in Brazil
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“Two Cultures in Favor of a Dying Patient”: Experiences of Health Care Professionals Providing Snakebite Care to Indigenous Peoples in the Brazilian Amazon
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Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology
inferred← citeshttps://doi.org/10.4269/ajtmh.24-0030openalex-snapshot
A Nationwide Study on the Risks of Complications and Healthcare Costs of Snakebite Envenomation in Taiwan
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Pesquisa em Saúde: Relatos, Fundamentos e Práticas
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Perfil epidemiológico do ofidismo no Estado de Minas Gerais, Brasil
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Fatores associados à realização de exame preventivo para câncer de mama
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Análise epidemiológica dos principais condicionantes de risco para COVID-19 e pandemias futuras no Brasil
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O atual panorama do câncer de mama feminino no Brasil: uma revisão da literatura
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Perfil epidemiológico dos casos de suicídio no estado do Mato Grosso de 2008 a 2018: uma análise descritiva e quantitativa
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Excesso de peso corporal e fatores associados em adolescentes
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Psychometric Evaluation of the Snakebite Severity Score (SSS) in a Multinational Randomized Clinical Trial
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