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Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity

https://doi.org/10.1371/journal.pone.0030378

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inferred← citeshttps://doi.org/10.1016/j.neuroscience.2013.08.044openalex-snapshot

Inter-relationships among diet, obesity and hippocampal-dependent cognitive function

inferred← citeshttps://doi.org/10.1016/j.obmed.2020.100246openalex-snapshot

Effects of obesity on hippocampus function: Synaptic plasticity hypothesis

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2022.108122openalex-snapshot

Physiology and pharmacology of amyloid precursor protein

inferred← citeshttps://doi.org/10.1016/j.phymed.2024.156248openalex-snapshot

Huang-Lian-Jie-Du decoction alleviates cognitive impairment in high-fat diet-induced obese mice via Trem2/Dap12/Syk pathway

inferred← citeshttps://doi.org/10.1016/j.tjnut.2026.101407openalex-snapshot

Neuroinflammation in Alzheimer’s Disease: The Role of Obesity, Gut Microbiota, and Therapeutic Potential of Omega-3 Fatty Acids and Neural Stem Cells

inferred← citeshttps://doi.org/10.1021/acschemneuro.5b00240openalex-snapshot

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline

inferred← citeshttps://doi.org/10.1038/s41366-018-0275-yopenalex-snapshot

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity

inferred← citeshttps://doi.org/10.1038/s41440-025-02315-8openalex-snapshot

Copy number loss Of APP cause thoracic aortic dissection

inferred← citeshttps://doi.org/10.1038/s41574-018-0048-7openalex-snapshot

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

inferred← citeshttps://doi.org/10.1038/s41598-017-05096-4openalex-snapshot

Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet

inferred← citeshttps://doi.org/10.1038/s41598-018-23644-4openalex-snapshot

Altered DNA repair; an early pathogenic pathway in Alzheimer’s disease and obesity

inferred← citeshttps://doi.org/10.1038/s41598-020-65908-yopenalex-snapshot

High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow

inferred← citeshttps://doi.org/10.1038/s41598-020-75576-7openalex-snapshot

Effects of high-fat diet and Apoe deficiency on retinal structure and function in mice

inferred← citeshttps://doi.org/10.1038/s41598-022-14812-8openalex-snapshot

Near-infrared light reduces glia activation and modulates neuroinflammation in the brains of diet-induced obese mice

inferred← citeshttps://doi.org/10.1038/s42255-019-0149-1openalex-snapshot

Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity

inferred← citeshttps://doi.org/10.1038/s44324-024-00029-yopenalex-snapshot

Ketone body metabolism and cardiometabolic implications for cognitive health

inferred← citeshttps://doi.org/10.1038/srep43725openalex-snapshot

Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain

inferred← citeshttps://doi.org/10.1080/1028415x.2025.2600516openalex-snapshot

Perinatal and adult western diet exposure alters hippocampal inflammatory and synaptic plasticity-related gene expression in rats

inferred← citeshttps://doi.org/10.1080/1028415x.2026.2734187openalex-snapshot

Ketogenic diet reverses obesity-associated hippocampal dysfunction and cognitive impairment in rats: a dietary comparison study

inferred← citeshttps://doi.org/10.1080/19768354.2014.940383openalex-snapshot

Altered gene expression of amyloid precursor protein in the adipose tissue and brain of obese mice fed with long-term high-fat diet and streptozotocin-induced diabetic mice

inferred← citeshttps://doi.org/10.1093/gerona/glu100openalex-snapshot

Differentiating the Influences of Aging and Adiposity on Brain Weights, Levels of Serum and Brain Cytokines, Gastrointestinal Hormones, and Amyloid Precursor Protein

inferred← citeshttps://doi.org/10.1093/nutrit/nuab118openalex-snapshot

Role of ketone bodies in diabetes-induced dementia: sirtuins, insulin resistance, synaptic plasticity, mitochondrial dysfunction, and neurotransmitter

inferred← citeshttps://doi.org/10.1097/psy.0000000000000212openalex-snapshot

Obesity and Aging

inferred← citeshttps://doi.org/10.1101/2019.12.16.878397openalex-snapshot

High fat diet worsens pathology and impairment in an Alzheimer’s mouse model, but not by synergistically decreasing cerebral blood flow

inferred← citeshttps://doi.org/10.1101/2020.07.09.180265openalex-snapshot

DIET INFLUENCES PERIPHERAL AMYLOID β METABOLISM: A ROLE FOR CIRCULATING INSULIN-LIKE GROWTH FACTOR I

inferred← citeshttps://doi.org/10.1101/2023.07.28.550986openalex-snapshot

Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction

inferred← citeshttps://doi.org/10.1111/bph.12862openalex-snapshot

Molecular targets of the multifunctional iron‐chelating drug, M 30, in the brains of mouse models of type 2 diabetes mellitus

inferred← citeshttps://doi.org/10.1111/cns.12420openalex-snapshot

Lovastatin Differentially Affects Neuronal Cholesterol and Amyloid‐β Production in vivo and in vitro

inferred← citeshttps://doi.org/10.1111/ejn.14758openalex-snapshot

Obesity and Alzheimer’s disease: Molecular bases

inferred← citeshttps://doi.org/10.1111/jnc.14256openalex-snapshot

Shared pathological pathways of Alzheimer's disease with specific comorbidities: current perspectives and interventions

inferred← citeshttps://doi.org/10.1111/obr.13200openalex-snapshot

Adipose tissue macrophages as a therapeutic target in obesity‐associated diseases

inferred← citeshttps://doi.org/10.1113/jp288032openalex-snapshot

The link between sarcopenic obesity and Alzheimer's disease: a brain‐derived neurotrophic factor point of view

inferred← citeshttps://doi.org/10.1139/apnm-2019-0910openalex-snapshot

Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer’s disease risk

inferred← citeshttps://doi.org/10.1152/ajpendo.00279.2018openalex-snapshot

Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues

inferred← citeshttps://doi.org/10.1152/ajpregu.00496.2013openalex-snapshot

Remembering to eat: hippocampal regulation of meal onset

inferred← citeshttps://doi.org/10.1159/000536586openalex-snapshot

Impact of Long-Term Dietary High Fat and Eicosapentaenoic Acid on Behavior and Hypothalamic-Pituitary-Adrenal Axis Activity in Amyloidogenic APPswe/PSEN1dE9 Mice

inferred← citeshttps://doi.org/10.1167/iovs.15-16504openalex-snapshot

High-Fat Diet Induces Toll-Like Receptor 4-Dependent Macrophage/Microglial Cell Activation and Retinal Impairment

inferred← citeshttps://doi.org/10.1172/jci64595openalex-snapshot

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

inferred← citeshttps://doi.org/10.11817/j.issn.1672-7347.2024.240025openalex-snapshot

Correlation between obesity and Alzheimer's disease and the mechanisms.

inferred← citeshttps://doi.org/10.1186/s12974-016-0578-7openalex-snapshot

Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning

inferred← citeshttps://doi.org/10.1186/s12974-016-0641-4openalex-snapshot

Adult obese mice suffer from chronic secondary brain injury after mild TBI

inferred← citeshttps://doi.org/10.1186/s12974-016-0700-xopenalex-snapshot

Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET

inferred← citeshttps://doi.org/10.1186/s12974-020-01956-5openalex-snapshot

Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s12974-024-03107-6openalex-snapshot

Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction

inferred← citeshttps://doi.org/10.1186/s13024-018-0246-8openalex-snapshot

Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells

inferred← citeshttps://doi.org/10.1186/s13024-020-00391-7openalex-snapshot

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1210/jendso/bvag206openalex-snapshot

Potential links between PCOS/PMOS and Alzheimer disease and related dementias

inferred← citeshttps://doi.org/10.1371/journal.pone.0043193openalex-snapshot

Mutant Amyloid Precursor Protein Differentially Alters Adipose Biology under Obesogenic and Non-Obesogenic Conditions

inferred← citeshttps://doi.org/10.1371/journal.pone.0178490openalex-snapshot

Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice

inferred← citeshttps://doi.org/10.14748/adipo.v5.293openalex-snapshot

NGF-PC-AD connection

inferred← citeshttps://doi.org/10.14748/adipo.v6.1136openalex-snapshot

Adipose tissue: The renaissance marked by four paradigm shifts

inferred← citeshttps://doi.org/10.14748/adipo.v7.1559openalex-snapshot

Adipobiology of the brain: From brain diabetes to adipose Alzheimer‘s disease

inferred← citeshttps://doi.org/10.14800/ics.805openalex-snapshot

Comparison of molecular functions of lactoferrin and amyloid precursor protein support their functional roles in the innate immune system and links with infection in Alzheimer’s disease risk

inferred← citeshttps://doi.org/10.14814/phy2.13729openalex-snapshot

Evaluation of neuropathological effects of a high-fat high-sucrose diet in middle-aged male C57BL6/J mice

inferred← citeshttps://doi.org/10.1523/jneurosci.4654-15.2016openalex-snapshot

APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease

inferred← citeshttps://doi.org/10.21203/rs.3.rs-2724928/v1openalex-snapshot

Sex differences in response to obesity and caloric restriction on cognition and hippocampal markers of autophagic-lysosomal pathway function

inferred← citeshttps://doi.org/10.21203/rs.3.rs-4546271/v1openalex-snapshot

Overexpressed amyloid precursor protein, and its C-terminal fragment, augment mitochondrial dysfunction in kidney and adipose tissues in a diet-induced obesity model

inferred← citeshttps://doi.org/10.21608/scumj.2017.43563openalex-snapshot

Association of Leptin Gene G2548A Polymorphism and Leptin Resistance with Insulin Resistance and Obesity among Egyptians

inferred← citeshttps://doi.org/10.2174/187152712800792767openalex-snapshot

Alzheimer’s Disease And Type 2 Diabetes: Exploring The Association To Obesity And Tyrosine Hydroxylase

inferred← citeshttps://doi.org/10.25557/2310-0435.2023.03.4-10openalex-snapshot

Pathophysiological mechanisms of cerebral insufficiency in type 1 diabetes mellitus

inferred← citeshttps://doi.org/10.3109/10408363.2015.1115820openalex-snapshot

Pharmacological modulation of dietary lipid-induced cerebral capillary dysfunction: Considerations for reducing risk for Alzheimer’s disease

inferred← citeshttps://doi.org/10.3233/jad-160150openalex-snapshot

Evaluation of Neuropathological Effects of a High-Fat Diet in a Presymptomatic Alzheimer’s Disease Stage in APP/PS1 Mice

inferred← citeshttps://doi.org/10.3233/jad-190123openalex-snapshot

Resveratrol and Metformin Recover Prefrontal Cortex AMPK Activation in Diet-Induced Obese Mice but Reduce BDNF and Synaptophysin Protein Content

inferred← citeshttps://doi.org/10.32539/sjm.v4i2.106openalex-snapshot

The Impact of Body Fat Percentage towards the Attention Aspect of the Cognitive Function in Pre-Clinical University Students of Atma Jaya

inferred← citeshttps://doi.org/10.33448/rsd-v11i3.26299openalex-snapshot

Impacto de dietas obesogênicas em aspectos comportamentais e em biomarcadores preditivos de doença de Alzheimer: uma revisão de literatura

inferred← citeshttps://doi.org/10.3389/fnagi.2018.00398openalex-snapshot

An Investigation Into Physical Frailty as a Link Between the Gut Microbiome and Cognitive Health

inferred← citeshttps://doi.org/10.3389/fnagi.2019.00170openalex-snapshot

Microbiome and Cognitive Impairment: Can Any Diets Influence Learning Processes in a Positive Way?

inferred← citeshttps://doi.org/10.3389/fnbeh.2017.00009openalex-snapshot

Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment

inferred← citeshttps://doi.org/10.3389/fncel.2023.1294420openalex-snapshot

The complex relationship between obesity and neurodegenerative diseases: an updated review

inferred← citeshttps://doi.org/10.3389/fnhum.2020.602360openalex-snapshot

Exploiting Common Aspects of Obesity and Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3389/fnins.2014.00375openalex-snapshot

Obesity and cognitive decline: role of inflammation and vascular changes

inferred← citeshttps://doi.org/10.3389/fnins.2019.00513openalex-snapshot

The Complex Interactions Between Obesity, Metabolism and the Brain

inferred← citeshttps://doi.org/10.3389/fnins.2022.1002266openalex-snapshot

Diet-microbiome-gut-brain nexus in acute and chronic brain injury

inferred← citeshttps://doi.org/10.3389/fnut.2023.1126534openalex-snapshot

Refueling the post COVID-19 brain: potential role of ketogenic medium chain triglyceride supplementation: an hypothesis

inferred← citeshttps://doi.org/10.3389/fpsyg.2020.564413openalex-snapshot

Western Diet: Implications for Brain Function and Behavior

inferred← citeshttps://doi.org/10.3390/cells15111033openalex-snapshot

Diet-Induced Amyloid Precursor Protein Dysregulation in Kidney and Adipose Tissue Mediates Mitochondrial Dysfunction

inferred← citeshttps://doi.org/10.3390/ijms13067424openalex-snapshot

Dietary Supplementations as Neuroprotective Therapies: Focus on NT-020 Diet Benefits in a Rat Model of Stroke

inferred← citeshttps://doi.org/10.3390/ijms20010063openalex-snapshot

The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk

inferred← citeshttps://doi.org/10.3390/ijms21175964openalex-snapshot

Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions

inferred← citeshttps://doi.org/10.3390/ijms21249675openalex-snapshot

Circulating Insulin-Like Growth Factor I is Involved in the Effect of High Fat Diet on Peripheral Amyloid β Clearance

inferred← citeshttps://doi.org/10.3390/ijms22083878openalex-snapshot

The Role of Molecular and Inflammatory Indicators in the Assessment of Cognitive Dysfunction in a Mouse Model of Diabetes

inferred← citeshttps://doi.org/10.3390/ijms22158075openalex-snapshot

Mechanisms and Effect of Coptidis Rhizoma on Obesity-Induced Inflammation: In Silico and In Vivo Approaches

inferred← citeshttps://doi.org/10.3390/ijms23147503openalex-snapshot

Impact of Nutrition, Microbiota Transplant and Weight Loss Surgery on Dopaminergic Alterations in Parkinson’s Disease and Obesity

inferred← citeshttps://doi.org/10.3390/ijms24087258openalex-snapshot

Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/ijms25010228openalex-snapshot

The Metabolically Obese, Normal-Weight Phenotype in Young Rats Is Associated with Cognitive Impairment and Partially Preventable with Leptin Intake during Lactation

inferred← citeshttps://doi.org/10.3390/ijms25137479openalex-snapshot

Association between Visceral Adipose Tissue Metabolism and Cerebral Glucose Metabolism in Patients with Cognitive Impairment

inferred← citeshttps://doi.org/10.3390/ijms26189241openalex-snapshot

High-Fat Diet Alters Behavior and Hippocampal Gene Expression

inferred← citeshttps://doi.org/10.3390/jcm7110407openalex-snapshot

The Role of Irisin in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/jcm8122181openalex-snapshot

Retinal Microperimetry: A Useful Tool for Detecting Insulin Resistance-Related Cognitive Impairment in Morbid Obesity

inferred← citeshttps://doi.org/10.3390/metabo12030258openalex-snapshot

Association between Visceral Adipose Tissue Metabolism and Alzheimer’s Disease Pathology

inferred← citeshttps://doi.org/10.3390/nu17142328openalex-snapshot

Cardiovascular Risk Factors, Alzheimer’s Disease, and the MIND Diet: A Narrative Review from Molecular Mechanisms to Clinical Outcomes

inferred← citeshttps://doi.org/10.4068/cmj.2021.57.2.108openalex-snapshot

Pathobiolgy and Management of Alzheimer's Disease

inferred← citeshttps://doi.org/10.4093/dmj.2019.0153openalex-snapshot

Contributing Factors to Diabetic Brain Injury and Cognitive Decline

inferred← citeshttps://doi.org/10.4161/21623945.2014.985020openalex-snapshot

Role of amyloid β in the induction of lipolysis and secretion of adipokines from human adipose tissue

inferred← citeshttps://doi.org/10.4172/1747-0862.s1-005openalex-snapshot

Obesity and Gut’s Dysbiosis Promote Neuroinflammation, Cognitive Impairment, and Vulnerability to Alzheimer’s disease: New Directions and Therapeutic Implications

inferred← citeshttps://doi.org/10.5772/intechopen.104318openalex-snapshot

Obesity - Recent Insights and Therapeutic Options

inferred← citeshttps://doi.org/10.5772/intechopen.110610openalex-snapshot

Diet-Induced Overweight Conditions: Effect on Brain Structure, Cognitive Function, and Neurogenesis

inferred← citeshttps://doi.org/10.5772/intechopen.70581openalex-snapshot

Caffeine with Links to NAFLD and Accelerated Brain Aging

inferred← citeshttps://doi.org/10.6084/m9.figshare.26714257openalex-snapshot

Additional file 1 of Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction

inferred← citeshttps://doi.org/10.7717/peerj.17676openalex-snapshot

PCSK9 inhibitor effectively alleviated cognitive dysfunction in a type 2 diabetes mellitus rat model

inferred← citeshttps://doi.org/10.7759/cureus.19176openalex-snapshot

The Effect of Type-2 Diabetes on Cognitive Status and the Role of Anti-diabetes Medications

inferred← citeshttps://doi.org/10.7759/cureus.75905openalex-snapshot

Vasant Kusumakar Rasa Ameliorates Diabetic Encephalopathy by Reducing Oxidative Stress and Neuroinflammation and Improving Neurotransmitter Levels in Experimental Animals

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