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A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

https://doi.org/10.1371/journal.pone.0037004
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/9780470454923openalex-snapshot
Emerging Technology Platforms for Stem Cells
inferredcites →https://doi.org/10.1002/9780470454923.ch13openalex-snapshot
Media and Extra Cellular Matrix Requirements for Large‐Scale ESC Growth
inferredcites →https://doi.org/10.1002/bit.24375openalex-snapshot
Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics
inferredcites →https://doi.org/10.1002/dmrr.329openalex-snapshot
Glucose‐stimulated signaling pathways in biphasic insulin secretion
inferredcites →https://doi.org/10.1006/bbrc.2001.6145openalex-snapshot
Differential Sensitivity of GLUT1- and GLUT2-Expressing β Cells to Streptozotocin
inferredcites →https://doi.org/10.1007/s00125-007-0634-zopenalex-snapshot
Directed differentiation of human embryonic stem cells towards a pancreatic cell fate
inferredcites →https://doi.org/10.1007/s00285-008-0164-4openalex-snapshot
Modeling cell interactions under flow
inferredcites →https://doi.org/10.1007/s12015-010-9149-yopenalex-snapshot
Suspension Culture of Undifferentiated Human Embryonic and Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.1016/b978-0-12-374729-7.00044-5openalex-snapshot
Feeder-free Culture
inferredcites →https://doi.org/10.1016/b978-012369454-6/50060-1openalex-snapshot
Clinical Chemistry of the Laboratory Mouse
inferredcites →https://doi.org/10.1016/c2013-0-10677-0openalex-snapshot
The Mouse in Biomedical Research
inferredcites →https://doi.org/10.1016/j.bbrc.2007.03.017openalex-snapshot
Glucose responsive insulin production from human embryonic germ (EG) cell derivatives
inferredcites →https://doi.org/10.1016/j.bpj.2010.02.029openalex-snapshot
Individual Cell Movement, Asymmetric Colony Expansion, Rho-Associated Kinase, and E-Cadherin Impact the Clonogenicity of Human Embryonic Stem Cells
inferredcites →https://doi.org/10.1016/j.cryobiol.2011.10.002openalex-snapshot
Pinacidil enhances survival of cryopreserved human embryonic stem cells
inferredcites →https://doi.org/10.1016/j.jbiotec.2008.07.1997openalex-snapshot
Attachment and growth of human embryonic stem cells on microcarriers
inferredcites →https://doi.org/10.1016/j.scr.2009.02.005openalex-snapshot
Long-term microcarrier suspension cultures of human embryonic stem cells
inferredcites →https://doi.org/10.1016/j.scr.2009.09.001openalex-snapshot
Modeling the evolution of culture-adapted human embryonic stem cells
inferredcites →https://doi.org/10.1016/j.scr.2010.03.001openalex-snapshot
Up-scaling single cell-inoculated suspension culture of human embryonic stem cells
inferredcites →https://doi.org/10.1016/j.scr.2010.03.005openalex-snapshot
Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium
inferredcites →https://doi.org/10.1016/j.stem.2007.10.004openalex-snapshot
The Generation of Six Clinical-Grade Human Embryonic Stem Cell Lines
inferredcites →https://doi.org/10.1038/cr.2007.28openalex-snapshot
In vitro derivation of functional insulin-producing cells from human embryonic stem cells
inferredcites →https://doi.org/10.1038/nbt.1931openalex-snapshot
Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells
inferredcites →https://doi.org/10.1038/nbt.2141openalex-snapshot
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
inferredcites →https://doi.org/10.1038/nbt0308-293openalex-snapshot
Digital mRNA profiling
inferredcites →https://doi.org/10.1038/nbt1163openalex-snapshot
Efficient differentiation of human embryonic stem cells to definitive endoderm
inferredcites →https://doi.org/10.1038/nbt1259openalex-snapshot
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
inferredcites →https://doi.org/10.1038/nbt1385openalex-snapshot
Direct multiplexed measurement of gene expression with color-coded probe pairs
inferredcites →https://doi.org/10.1038/nbt1393openalex-snapshot
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
inferredcites →https://doi.org/10.1038/nbt922openalex-snapshot
Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells
inferredcites →https://doi.org/10.1038/ng1631openalex-snapshot
Genomic alterations in cultured human embryonic stem cells
inferredcites →https://doi.org/10.1042/cs20090072openalex-snapshot
Are stem cells a cure for diabetes?
inferredcites →https://doi.org/10.1053/j.gastro.2010.02.056openalex-snapshot
Noggin, Retinoids, and Fibroblast Growth Factor Regulate Hepatic or Pancreatic Fate of Human Embryonic Stem Cells
inferredcites →https://doi.org/10.1056/nejm200007273430401openalex-snapshot
Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen
inferredcites →https://doi.org/10.1056/nejmoa061267openalex-snapshot
International Trial of the Edmonton Protocol for Islet Transplantation
inferredcites →https://doi.org/10.1073/pnas.91.20.9253openalex-snapshot
Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.
inferredcites →https://doi.org/10.1089/scd.2004.13.585openalex-snapshot
Karyotypic Stability, Genotyping, Differentiation, Feeder-Free Maintenance, and Gene Expression Sampling in Three Human Embryonic Stem Cell Lines Derived Prior to August 9, 2001
inferredcites →https://doi.org/10.1089/scd.2010.0077openalex-snapshot
Investigations into the Metabolism of Two-Dimensional Colony and Suspended Microcarrier Cultures of Human Embryonic Stem Cells in Serum-Free Media
inferredcites →https://doi.org/10.1089/ten.tea.2008.0455openalex-snapshot
Expansion and Differentiation of Human Embryonic Stem Cells to Endoderm Progeny in a Microcarrier Stirred-Suspension Culture
inferredcites →https://doi.org/10.1089/ten.tea.2009.0454openalex-snapshot
Scalable Stirred-Suspension Bioreactor Culture of Human Pluripotent Stem Cells
inferredcites →https://doi.org/10.1093/jmcb/mjp037openalex-snapshot
Generation of Homogeneous PDX1+ Pancreatic Progenitors from Human ES Cell-derived Endoderm Cells
inferredcites →https://doi.org/10.1097/mot.0b013e32834252b5openalex-snapshot
Stem cell-derived islet cells for transplantation
inferredcites →https://doi.org/10.1159/000330691openalex-snapshot
Mass Transfer Limitations in Embryoid Bodies during Human Embryonic Stem Cell Differentiation
inferredcites →https://doi.org/10.1182/blood-2007-03-082586openalex-snapshot
Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling
inferredcites →https://doi.org/10.1182/blood.v73.5.1324.1324openalex-snapshot
Shear-dependent inhibition of granulocyte adhesion to cultured endothelium by dextran sulfate
inferredcites →https://doi.org/10.1242/dev.055236openalex-snapshot
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells
inferredcites →https://doi.org/10.1371/journal.pone.0004794openalex-snapshot
FGF4 and Retinoic Acid Direct Differentiation of hESCs into PDX1-Expressing Foregut Endoderm in a Time- and Concentration-Dependent Manner
inferredcites →https://doi.org/10.2337/db10-0573openalex-snapshot
Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells
inferredcites →https://doi.org/10.4093/dmj.2011.35.3.199openalex-snapshot
Clinical Allogeneic and Autologous Islet Cell Transplantation: Update

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/9781118660485.ch18openalex-snapshot
GENE AND CELL THERAPY
inferred← citeshttps://doi.org/10.1002/9781118846193.ch25openalex-snapshot
Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1002/adhm.201701148openalex-snapshot
Encapsulated Optically Responsive Cell Systems: Toward Smart Implants in Biomedicine
inferred← citeshttps://doi.org/10.1002/adhm.201800225openalex-snapshot
Thermoreversible Hyaluronic Acid‐PNIPAAm Hydrogel Systems for 3D Stem Cell Culture
inferred← citeshttps://doi.org/10.1002/anbr.202200173openalex-snapshot
Engineered Extracellular Vesicles from Human Skin Cells Induce Pro‐β‐Cell Conversions in Pancreatic Ductal Cells
inferred← citeshttps://doi.org/10.1002/biot.201400348openalex-snapshot
Human pluripotent stem cell‐derived products: Advances towards robust, scalable and cost‐effective manufacturing strategies
inferred← citeshttps://doi.org/10.1002/biot.201700099openalex-snapshot
Development of an Alginate Array Platform to Decouple the Effect of Multiparametric Perturbations on Human Pluripotent Stem Cells During Pancreatic Differentiation
inferred← citeshttps://doi.org/10.1002/biot.201800563openalex-snapshot
Bringing Stem Cell‐Based Therapies for Type 1 Diabetes to the Clinic: Early Insights from Bioprocess Economics and Cost‐Effectiveness Analysis
inferred← citeshttps://doi.org/10.1002/bit.27359openalex-snapshot
Insulin production from hiPSC‐derived pancreatic cells in a novel wicking matrix bioreactor
inferred← citeshttps://doi.org/10.1002/jcp.24771openalex-snapshot
Derivation of Endodermal Progenitors From Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1002/jcp.25459openalex-snapshot
Pancreatic Endoderm‐Derived From Diabetic Patient‐Specific Induced Pluripotent Stem Cell Generates Glucose‐Responsive Insulin‐Secreting Cells
inferred← citeshttps://doi.org/10.1002/jhbp.891openalex-snapshot
Clinical islet transplantation: Current progress and new frontiers
inferred← citeshttps://doi.org/10.1002/pmic.201400132openalex-snapshot
The human embryonic stem cell proteome revealed by multidimensional fractionation followed by tandem mass spectrometry
inferred← citeshttps://doi.org/10.1002/sctm.17-0005openalex-snapshot
Durable Control of Autoimmune Diabetes in Mice Achieved by Intraperitoneal Transplantation of “Neo-Islets,” Three-Dimensional Aggregates of Allogeneic Islet and “Mesenchymal Stem Cells”
inferred← citeshttps://doi.org/10.1002/sctm.17-0078openalex-snapshot
Platelet-Derived Mitochondria Display Embryonic Stem Cell Markers and Improve Pancreatic Islet β-cell Function in Humans
inferred← citeshttps://doi.org/10.1002/sctm.19-0043openalex-snapshot
Cell Mass Increase Associated with Formation of Glucose-Controlling β-Cell Mass in Device-Encapsulated Implants of hiPS-Derived Pancreatic Endoderm
inferred← citeshttps://doi.org/10.1002/sctm.21-0161openalex-snapshot
Process Parameter Development for the Scaled Generation of Stem Cell-Derived Pancreatic Endocrine Cells
inferred← citeshttps://doi.org/10.1002/stem.1457openalex-snapshot
Concise review: Clinical programs of stem cell therapies for liver and pancreas
inferred← citeshttps://doi.org/10.1002/term.2228openalex-snapshot
Production of pancreatic progenitor cells from human induced pluripotent stem cells using a three-dimensional suspension bioreactor system
inferred← citeshttps://doi.org/10.1007/10_2019_117openalex-snapshot
Human Pluripotent Stem Cells: Applications and Challenges for Regenerative Medicine and Disease Modeling
inferred← citeshttps://doi.org/10.1007/5584_2020_592openalex-snapshot
Embryonic Stem Cells in Clinical Trials: Current Overview of Developments and Challenges
inferred← citeshttps://doi.org/10.1007/7651_2015_217openalex-snapshot
Pancreatic Differentiation from Murine Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1007/978-1-0716-0215-7_32openalex-snapshot
Clinical Applications of Cell Encapsulation Technology
inferred← citeshttps://doi.org/10.1007/978-1-4614-7696-2_20openalex-snapshot
Progenitors of Islet Cells
inferred← citeshttps://doi.org/10.1007/978-1-4614-9569-7_14openalex-snapshot
Lineage-Committed Pancreatic Progenitors and Stem Cells
inferred← citeshttps://doi.org/10.1007/978-3-030-55359-3_6openalex-snapshot
Stem Cell Applications in Metabolic Disorders: Diabetes Mellitus
inferred← citeshttps://doi.org/10.1007/978-3-030-77052-5_12openalex-snapshot
Stem Cells: A Renewable Source of Pancreatic β-Cells and Future for Diabetes Treatment
inferred← citeshttps://doi.org/10.1007/978-3-030-82735-9_6openalex-snapshot
The Most Ideal Pancreas Extracellular Matrix as a Platform for Pancreas Bioengineering: Decellularization/Recellularization Protocols
inferred← citeshttps://doi.org/10.1007/978-3-030-98927-9_16openalex-snapshot
Evolving Approaches to Type 1 Diabetes Management
inferred← citeshttps://doi.org/10.1007/978-3-031-25378-2_12openalex-snapshot
Stammzellen: Eine erneuerbare Quelle für β-Zellen der Bauchspeicheldrüse und die Zukunft der Diabetesbehandlung
inferred← citeshttps://doi.org/10.1007/978-3-031-41943-0_18openalex-snapshot
Safety Issues Related to Pluripotent Stem Cell-Based Therapies: Tumour Risk
inferred← citeshttps://doi.org/10.1007/978-3-031-41943-0_5openalex-snapshot
The Promises of Pancreatic Progenitor Proliferation and Differentiation
inferred← citeshttps://doi.org/10.1007/978-3-031-41943-0_9openalex-snapshot
3D Organoids of Mesenchymal Stromal and Pancreatic Islet Cells
inferred← citeshttps://doi.org/10.1007/978-3-319-21705-5_6openalex-snapshot
The Elusive Pancreatic Stem Cell
inferred← citeshttps://doi.org/10.1007/978-3-319-27317-4_23-1openalex-snapshot
Islet Cell or Pancreas Transplantation
inferred← citeshttps://doi.org/10.1007/978-3-319-27610-6_3openalex-snapshot
Induced Pluripotent Stem Cells in Regenerative Medicine
inferred← citeshttps://doi.org/10.1007/978-3-319-29149-9_2openalex-snapshot
Stem Cell Therapy in Diabetes Mellitus
inferred← citeshttps://doi.org/10.1007/978-3-319-30582-0_15openalex-snapshot
Pancreatic Differentiation from Human Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1007/978-3-319-33270-3_6openalex-snapshot
Pluripotent Stem Cell-Derived Pancreatic β Cells: From In Vitro Maturation to Clinical Application
inferred← citeshttps://doi.org/10.1007/978-3-319-45015-5_23openalex-snapshot
Islet Cell or Pancreas Transplantation
inferred← citeshttps://doi.org/10.1007/978-3-319-45307-1_8openalex-snapshot
Transdifferentiation of Extra-Pancreatic Tissues for Cell Replacement Therapy for Diabetes
inferred← citeshttps://doi.org/10.1007/978-3-319-65720-2_2openalex-snapshot
In Vivo Reprogramming for Regenerating Insulin-Secreting Cells
inferred← citeshttps://doi.org/10.1007/978-94-007-6686-0_49openalex-snapshot
Generating Pancreatic Endocrine Cells from Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1007/978-94-007-6884-0_49-2openalex-snapshot
Generating Pancreatic Endocrine Cells from Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1007/978-981-10-7904-7_2openalex-snapshot
Encapsulation of Stem Cells in Research and Therapy
inferred← citeshttps://doi.org/10.1007/978-981-99-0846-2_18-1openalex-snapshot
Scaling Stem Cells to Cure Millions of Patients with Diabetes: Approaches, Technology, and Future Directions
inferred← citeshttps://doi.org/10.1007/978-981-99-2119-5_29openalex-snapshot
Role of Stem Cells in the Delivery of Essential Pharmaceuticals
inferred← citeshttps://doi.org/10.1007/978-981-99-7119-0_18openalex-snapshot
Scaling Stem Cells to Cure Millions of Patients with Diabetes: Approaches, Technology, and Future Directions
inferred← citeshttps://doi.org/10.1007/s00125-013-2921-1openalex-snapshot
Islet encapsulation: advances and obstacles
inferred← citeshttps://doi.org/10.1007/s00125-016-4125-yopenalex-snapshot
Immunogenicity of human embryonic stem cell-derived beta cells
inferred← citeshttps://doi.org/10.1007/s00125-017-4302-7openalex-snapshot
Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells
inferred← citeshttps://doi.org/10.1007/s00216-016-0006-yopenalex-snapshot
Continuous collection and simultaneous detection of picoliter volume of nucleic acid samples using a mille-feuille probe
inferred← citeshttps://doi.org/10.1007/s00418-025-02400-6openalex-snapshot
Differentiation to insulin-positive cells from human amnion epithelial cells using a pancreatic development mimicry protocol
inferred← citeshttps://doi.org/10.1007/s00418-025-02423-zopenalex-snapshot
August in focus in HCB
inferred← citeshttps://doi.org/10.1007/s00441-023-03789-zopenalex-snapshot
Minor salivary gland stem cells: a comparative study of the biological properties under clinical-grade culture conditions
inferred← citeshttps://doi.org/10.1007/s00449-016-1680-zopenalex-snapshot
Culture medium refinement by dialysis for the expansion of human induced pluripotent stem cells in suspension culture
inferred← citeshttps://doi.org/10.1007/s00592-016-0847-zopenalex-snapshot
The state of the art of islet transplantation and cell therapy in type 1 diabetes
inferred← citeshttps://doi.org/10.1007/s00592-021-01737-3openalex-snapshot
Felix dies natalis, insulin… ceterum autem censeo “beta is better”
inferred← citeshttps://doi.org/10.1007/s10517-025-06444-5openalex-snapshot
Cell Therapy for Type 1 Diabetes Mellitus: a Review of Clinical Trials
inferred← citeshttps://doi.org/10.1007/s10616-014-9802-4openalex-snapshot
Blastema cells derived from New Zealand white rabbit’s pinna carry stemness properties as shown by differentiation into insulin producing, neural, and osteogenic lineages representing three embryonic germ layers
inferred← citeshttps://doi.org/10.1007/s11427-016-0211-3openalex-snapshot
How to make insulin-producing pancreatic β cells for diabetes treatment
inferred← citeshttps://doi.org/10.1007/s11428-022-00954-wopenalex-snapshot
Stammzellen für die Wiederherstellung der endogenen Insulinsekretion
inferred← citeshttps://doi.org/10.1007/s11626-024-00991-3openalex-snapshot
Controlling spheroid attachment improves pancreatic beta cell differentiation from human iPS cells
inferred← citeshttps://doi.org/10.1007/s11892-013-0469-6openalex-snapshot
The Potential of Cell-based Therapy for Diabetes and Diabetes-related Vascular Complications
inferred← citeshttps://doi.org/10.1007/s11892-016-0764-0openalex-snapshot
Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?
inferred← citeshttps://doi.org/10.1007/s11892-017-0863-6openalex-snapshot
Cell Therapy for Type 1 Diabetes: Current and Future Strategies
inferred← citeshttps://doi.org/10.1007/s11892-017-0901-4openalex-snapshot
Immunological Issues After Stem Cell-Based β Cell Replacement
inferred← citeshttps://doi.org/10.1007/s11892-017-0947-3openalex-snapshot
Gene Editing and Human Pluripotent Stem Cells: Tools for Advancing Diabetes Disease Modeling and Beta-Cell Development
inferred← citeshttps://doi.org/10.1007/s11892-019-1203-9openalex-snapshot
Economics of Beta-Cell Replacement Therapy
inferred← citeshttps://doi.org/10.1007/s12015-013-9435-6openalex-snapshot
Role of BMP Signaling in Pancreatic Progenitor Differentiation from Human Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1007/s12015-014-9544-xopenalex-snapshot
Production of Human Pluripotent Stem Cell Therapeutics under Defined Xeno-free Conditions: Progress and Challenges
inferred← citeshttps://doi.org/10.1007/s12015-017-9783-8openalex-snapshot
3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets
inferred← citeshttps://doi.org/10.1007/s12015-018-9845-6openalex-snapshot
Islet-Like Structures Generated In Vitro from Adult Human Liver Stem Cells Revert Hyperglycemia in Diabetic SCID Mice
inferred← citeshttps://doi.org/10.1007/s12015-020-10018-5openalex-snapshot
In Vivo Differentiation of Stem Cell-derived Human Pancreatic Progenitors to Treat Type 1 Diabetes
inferred← citeshttps://doi.org/10.1007/s12017-015-8369-3openalex-snapshot
Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders
inferred← citeshttps://doi.org/10.1007/s12020-024-03855-8openalex-snapshot
The efficiency of stem cell differentiation into functional beta cells for treating insulin-requiring diabetes: Recent advances and current challenges
inferred← citeshttps://doi.org/10.1007/s12195-014-0333-zopenalex-snapshot
Developing Defined and Scalable 3D Culture Systems for Culturing Human Pluripotent Stem Cells at High Densities
inferred← citeshttps://doi.org/10.1007/s12253-015-9936-5openalex-snapshot
Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1007/s40472-016-0103-zopenalex-snapshot
Islet Cell Transplantion: Update on Current Clinical Trials
inferred← citeshttps://doi.org/10.1007/s40883-019-00125-2openalex-snapshot
Development of Nanoporous Polyurethane Hydrogel Membranes for Cell Encapsulation
inferred← citeshttps://doi.org/10.1016/b978-0-08-100623-8.00044-xopenalex-snapshot
Bioprocesses for Cell Therapies
inferred← citeshttps://doi.org/10.1016/b978-0-12-394810-6.00015-0openalex-snapshot
Considerations in the Development of Pluripotent Stem Cell-based Therapies
inferred← citeshttps://doi.org/10.1016/b978-0-12-398358-9.00006-9openalex-snapshot
Tissue Engineering
inferred← citeshttps://doi.org/10.1016/b978-0-12-398358-9.00029-xopenalex-snapshot
Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-398523-1.00042-2openalex-snapshot
Pancreatic Islet Regeneration
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12296-6openalex-snapshot
Regenerative Medicine
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.66107-xopenalex-snapshot
Transplantation: Pancreatic and Islet Cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-803581-8.09316-4openalex-snapshot
6.24 Bioengineering Approaches to Islet Transplantation for Management of Diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-12-809880-6.00021-7openalex-snapshot
From Adult Pancreatic Islets to Stem Cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-809880-6.00056-4openalex-snapshot
Islet Cell Transplantation
inferred← citeshttps://doi.org/10.1016/b978-0-12-812034-7.00006-6openalex-snapshot
Pluripotent Stem Cell–Derived Islet Replacement Therapy for Diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-12-814831-0.00028-2openalex-snapshot
Human-induced pluripotent stem cells (iPSC) as a source of insulin-producing cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-822229-4.00012-7openalex-snapshot
Considerations in using human pluripotent stem cell–derived pancreatic beta cells to treat type 1 diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-12-824459-3.00013-5openalex-snapshot
Bioreactors: enabling technologies for research and manufacturing
inferred← citeshttps://doi.org/10.1016/b978-0-323-18907-1.00050-0openalex-snapshot
Beta Cell Transplantation and Regeneration
inferred← citeshttps://doi.org/10.1016/b978-0-443-13344-2.00004-3openalex-snapshot
Considerations in the development of pluripotent stem cell–based therapies
inferred← citeshttps://doi.org/10.1016/b978-0-443-13825-6.00396-4openalex-snapshot
Transplantation: Pancreatic and Islet Cells
inferred← citeshttps://doi.org/10.1016/b978-0-444-63265-4.00009-1openalex-snapshot
Enrichment and Separation Technologies for Stem Cell-Based Therapies
inferred← citeshttps://doi.org/10.1016/b978-0-444-64301-8.00002-0openalex-snapshot
Biopharmaceutical molecules
inferred← citeshttps://doi.org/10.1016/bs.pbr.2017.02.007openalex-snapshot
Preparation, characterization, and banking of clinical-grade cells for neural transplantation
inferred← citeshttps://doi.org/10.1016/bs.pmbts.2023.03.001openalex-snapshot
Pluripotent stem cells as a therapy for type 1 diabetes
inferred← citeshttps://doi.org/10.1016/j.actbio.2016.02.025openalex-snapshot
Capsule stiffness regulates the efficiency of pancreatic differentiation of human embryonic stem cells
inferred← citeshttps://doi.org/10.1016/j.actbio.2018.12.011openalex-snapshot
Nanotopographical regulation of pancreatic islet-like cluster formation from human pluripotent stem cells using a gradient-pattern chip
inferred← citeshttps://doi.org/10.1016/j.actbio.2019.05.014openalex-snapshot
Bioprinting of stem cell expansion lattices
inferred← citeshttps://doi.org/10.1016/j.addr.2013.11.012openalex-snapshot
Exploiting pluripotent stem cell technology for drug discovery, screening, safety, and toxicology assessments
inferred← citeshttps://doi.org/10.1016/j.bcp.2015.08.107openalex-snapshot
The bioartificial pancreas (BAP): Biological, chemical and engineering challenges
inferred← citeshttps://doi.org/10.1016/j.bea.2024.100113openalex-snapshot
Optimizing alginate tubes for cell culture
inferred← citeshttps://doi.org/10.1016/j.beem.2015.10.011openalex-snapshot
Differentiation of human pluripotent stem cells into β-cells: Potential and challenges
inferred← citeshttps://doi.org/10.1016/j.beem.2015.10.012openalex-snapshot
Human pluripotent stem cell based islet models for diabetes research
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2013.02.026openalex-snapshot
Treatment of diabetes mellitus with microencapsulated fetal human liver (FH-B-TPN) engineered cells
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2018.05.031openalex-snapshot
3D heterogeneous islet organoid generation from human embryonic stem cells using a novel engineered hydrogel platform
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2024.122947openalex-snapshot
A 3D-printed microdevice encapsulates vascularized islets composed of iPSC-derived β-like cells and microvascular fragments for type 1 diabetes treatment
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2013.08.009openalex-snapshot
Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies
inferred← citeshttps://doi.org/10.1016/j.ceb.2016.03.022openalex-snapshot
Replication timing and transcriptional control: beyond cause and effect — part III
inferred← citeshttps://doi.org/10.1016/j.cell.2014.09.040openalex-snapshot
Generation of Functional Human Pancreatic β Cells In Vitro
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.10.049openalex-snapshot
A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.03.032openalex-snapshot
Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111238openalex-snapshot
Characterization of stem-cell-derived islets during differentiation and after implantation
inferred← citeshttps://doi.org/10.1016/j.chembiol.2016.07.007openalex-snapshot
Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine
inferred← citeshttps://doi.org/10.1016/j.cmet.2013.08.010openalex-snapshot
New Opportunities: Harnessing Induced Pluripotency for Discovery in Diabetes and Metabolism
inferred← citeshttps://doi.org/10.1016/j.cmet.2016.03.005openalex-snapshot
ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.02.007openalex-snapshot
Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy
inferred← citeshttps://doi.org/10.1016/j.cmet.2021.03.021openalex-snapshot
Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective
inferred← citeshttps://doi.org/10.1016/j.cobme.2017.09.010openalex-snapshot
Synthetic biology – Engineering cell-based biomedical devices
inferred← citeshttps://doi.org/10.1016/j.coph.2018.07.007openalex-snapshot
Pluripotent stem cell replacement approaches to treat type 1 diabetes
inferred← citeshttps://doi.org/10.1016/j.diabet.2026.101738openalex-snapshot
Overview of the major clinical trials investigating stem cells–based therapies for diabetes
inferred← citeshttps://doi.org/10.1016/j.diabres.2021.109084openalex-snapshot
Cell therapy research for Diabetes: Pancreatic β cell differentiation from pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.gene.2015.08.027openalex-snapshot
MicroRNA dynamics during human embryonic stem cell differentiation to pancreatic endoderm
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e19972openalex-snapshot
The functional maturity of grafted human pluripotent stem cell derived-islets (hSC-Islets) evaluated by the glycemic set point during blood glucose normalizing process in diabetic mice
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.03.041openalex-snapshot
Current advanced therapy cell-based medicinal products for type-1-diabetes treatment
inferred← citeshttps://doi.org/10.1016/j.jconrel.2026.114914openalex-snapshot
Cryopreservation of stem cell-derived aggregates for type 1 diabetes cell therapy: Considerations and challenges
inferred← citeshttps://doi.org/10.1016/j.jdiacomp.2015.03.017openalex-snapshot
Current status of encapsulated islet transplantation
inferred← citeshttps://doi.org/10.1016/j.lpm.2022.104139openalex-snapshot
From islet of Langerhans transplantation to the bioartificial pancreas
inferred← citeshttps://doi.org/10.1016/j.mce.2013.08.008openalex-snapshot
The role of renin-angiotensin system in cellular differentiation: Implications in pancreatic islet cell development and islet transplantation
inferred← citeshttps://doi.org/10.1016/j.metabol.2018.10.005openalex-snapshot
Stem cells in the treatment of diabetes mellitus — Focus on mesenchymal stem cells
inferred← citeshttps://doi.org/10.1016/j.mmm.2026.09.023openalex-snapshot
La thérapie cellulaire du diabète de type 1 en 2035, évolutions scientifiques et nouvelles indications à court terme
inferred← citeshttps://doi.org/10.1016/j.mod.2020.103647openalex-snapshot
Pancreas development and the Polycomb group protein complexes
inferred← citeshttps://doi.org/10.1016/j.molmet.2024.102017openalex-snapshot
An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells
inferred← citeshttps://doi.org/10.1016/j.numecd.2017.02.004openalex-snapshot
Stem cells to restore insulin production and cure diabetes
inferred← citeshttps://doi.org/10.1016/j.procbio.2016.05.024openalex-snapshot
Characterization of 3D pluripotent stem cell aggregates and the impact of their properties on bioprocessing
inferred← citeshttps://doi.org/10.1016/j.rbmo.2013.07.005openalex-snapshot
A rapidly evolving revolution in stem cell biology and medicine
inferred← citeshttps://doi.org/10.1016/j.reth.2018.11.003openalex-snapshot
Induction of functional islet-like cells from human iPS cells by suspension culture
inferred← citeshttps://doi.org/10.1016/j.scr.2013.10.004openalex-snapshot
Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies
inferred← citeshttps://doi.org/10.1016/j.scr.2014.03.003openalex-snapshot
Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape
inferred← citeshttps://doi.org/10.1016/j.scr.2015.01.007openalex-snapshot
Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells
inferred← citeshttps://doi.org/10.1016/j.scr.2017.08.010openalex-snapshot
Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.scr.2017.09.005openalex-snapshot
The contribution of human/non-human animal chimeras to stem cell research
inferred← citeshttps://doi.org/10.1016/j.semcdb.2017.01.005openalex-snapshot
The molecular and morphogenetic basis of pancreas organogenesis
inferred← citeshttps://doi.org/10.1016/j.stem.2012.11.023openalex-snapshot
Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1016/j.stem.2014.12.001openalex-snapshot
Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm
inferred← citeshttps://doi.org/10.1016/j.stem.2015.02.013openalex-snapshot
Epigenetic Priming of Enhancers Predicts Developmental Competence of hESC-Derived Endodermal Lineage Intermediates
inferred← citeshttps://doi.org/10.1016/j.stem.2015.06.007openalex-snapshot
Stem Cell Therapies in Clinical Trials: Progress and Challenges
inferred← citeshttps://doi.org/10.1016/j.stem.2016.05.014openalex-snapshot
Closing in on Mass Production of Mature Human Beta Cells
inferred← citeshttps://doi.org/10.1016/j.stem.2021.10.003openalex-snapshot
Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes
inferred← citeshttps://doi.org/10.1016/j.stemcr.2015.01.019openalex-snapshot
CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation
inferred← citeshttps://doi.org/10.1016/j.stemcr.2017.05.004openalex-snapshot
Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site
inferred← citeshttps://doi.org/10.1016/j.stemcr.2017.08.025openalex-snapshot
Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes
inferred← citeshttps://doi.org/10.1016/j.stemcr.2018.01.040openalex-snapshot
Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control
inferred← citeshttps://doi.org/10.1016/j.stemcr.2018.11.008openalex-snapshot
Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors
inferred← citeshttps://doi.org/10.1016/j.stemcr.2019.01.012openalex-snapshot
A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1016/j.stemcr.2019.02.002openalex-snapshot
Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice
inferred← citeshttps://doi.org/10.1016/j.stemcr.2019.05.021openalex-snapshot
Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment
inferred← citeshttps://doi.org/10.1016/j.tem.2014.05.006openalex-snapshot
In search of a surrogate: engineering human beta cell lines for therapy
inferred← citeshttps://doi.org/10.1016/j.tem.2015.12.003openalex-snapshot
The Human Endocrine Pancreas: New Insights on Replacement and Regeneration
inferred← citeshttps://doi.org/10.1016/j.tibtech.2020.08.005openalex-snapshot
Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip
inferred← citeshttps://doi.org/10.1016/j.tice.2021.101661openalex-snapshot
Preconditioned human dental pulp stem cells with cerium and yttrium oxide nanoparticles effectively ameliorate diabetic hyperglycemia while combatting hypoxia
inferred← citeshttps://doi.org/10.1016/j.xcrm.2021.100466openalex-snapshot
Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device
inferred← citeshttps://doi.org/10.1016/j.ymthe.2017.08.014openalex-snapshot
Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice
inferred← citeshttps://doi.org/10.1016/s1957-2557(21)00180-2openalex-snapshot
Insulines intelligentes et pancréas bioartificiel dans le DT1 : acteurs de demain, vraiment?
inferred← citeshttps://doi.org/10.1021/acs.analchem.5b03295openalex-snapshot
Process Analytical Utility of Raman Microspectroscopy in the Directed Differentiation of Human Pancreatic Insulin-Positive Cells
inferred← citeshttps://doi.org/10.1021/acsami.2c12939openalex-snapshot
Fas Ligand-Modified Scaffolds Protect Stem Cell Derived β-Cells by Modulating Immune Cell Numbers and Polarization
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.1c00269openalex-snapshot
Pancreatic Extracellular Matrix/Alginate Hydrogels Provide a Supportive Microenvironment for Insulin-Producing Cells
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.7b00912openalex-snapshot
Microporous Polymer Scaffolds for the Transplantation of Embryonic Stem Cell Derived Pancreatic Progenitors to a Clinically Translatable Site for the Treatment of Type I Diabetes
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.9b01406openalex-snapshot
Engineering Strategies to Improve Islet Transplantation for Type 1 Diabetes Therapy
inferred← citeshttps://doi.org/10.1021/acsnano.5b06985openalex-snapshot
Nanotopography Promotes Pancreatic Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1038/cdd.2012.138openalex-snapshot
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions
inferred← citeshttps://doi.org/10.1038/cr.2013.20openalex-snapshot
hESC-derived pancreatic progenitors
inferred← citeshttps://doi.org/10.1038/ctg.2015.42openalex-snapshot
Capturing Islet Stem Cells for a Bio-Artificial Pancreas
inferred← citeshttps://doi.org/10.1038/nbt.3033openalex-snapshot
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
inferred← citeshttps://doi.org/10.1038/ncomms5242openalex-snapshot
FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures
inferred← citeshttps://doi.org/10.1038/nm.3627openalex-snapshot
Translational strategies and challenges in regenerative medicine
inferred← citeshttps://doi.org/10.1038/nrd4231openalex-snapshot
Targeting the pancreatic β-cell to treat diabetes
inferred← citeshttps://doi.org/10.1038/nrd4738openalex-snapshot
Current status of pluripotent stem cells: moving the first therapies to the clinic
inferred← citeshttps://doi.org/10.1038/nrendo.2013.145openalex-snapshot
The use of stem cells for pancreatic regeneration in diabetes mellitus
inferred← citeshttps://doi.org/10.1038/nrendo.2014.18openalex-snapshot
Solving human β-cell development—what does the mouse say?
inferred← citeshttps://doi.org/10.1038/nrendo.2015.9openalex-snapshot
Diabetes mellitus—advances and challenges in human β-cell proliferation
inferred← citeshttps://doi.org/10.1038/nrm.2016.10openalex-snapshot
Pluripotent stem cells progressing to the clinic
inferred← citeshttps://doi.org/10.1038/s41467-020-16017-xopenalex-snapshot
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
inferred← citeshttps://doi.org/10.1038/s41467-021-26950-0openalex-snapshot
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
inferred← citeshttps://doi.org/10.1038/s41467-022-29646-1openalex-snapshot
Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling
inferred← citeshttps://doi.org/10.1038/s41467-026-70666-yopenalex-snapshot
Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors
inferred← citeshttps://doi.org/10.1038/s41556-019-0445-8openalex-snapshot
Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids
inferred← citeshttps://doi.org/10.1038/s41573-021-00262-wopenalex-snapshot
Engineering islets from stem cells for advanced therapies of diabetes
inferred← citeshttps://doi.org/10.1038/s41574-020-0325-0openalex-snapshot
Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
inferred← citeshttps://doi.org/10.1038/s41574-020-0375-3openalex-snapshot
Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy
inferred← citeshttps://doi.org/10.1038/s41587-020-0430-6openalex-snapshot
Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
inferred← citeshttps://doi.org/10.1038/s41587-023-02055-5openalex-snapshot
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
inferred← citeshttps://doi.org/10.1038/s41591-025-03767-8openalex-snapshot
Stem cell therapies for diabetes
inferred← citeshttps://doi.org/10.1038/s41596-022-00743-1openalex-snapshot
Isolation of ready-made rat microvessels and its applications in effective in vivo vascularization and in angiogenic studies in vitro
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