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Targeting the pancreatic β-cell to treat diabetes

https://doi.org/10.1038/nrd4231
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1 of the 176 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1016/j.cell.2013.04.008 (notice 2017-01-01).

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/med.10011openalex-snapshot
Glycogen synthase kinase 3 (GSK‐3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
inferredcites →https://doi.org/10.1006/bbrc.1994.1962openalex-snapshot
Interleukin-1 Receptor Antagonist Prevents Low-Dose Streptozotocin-Induced Diabetes in Mice
inferredcites →https://doi.org/10.1006/bbrc.1998.9166openalex-snapshot
Protein Kinase B Is Expressed in Pancreatic β Cells and Activated upon Stimulation with Insulin-like Growth Factor I
inferredcites →https://doi.org/10.1007/s00125-002-1017-0openalex-snapshot
IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice
inferredcites →https://doi.org/10.1007/s00125-006-0562-3openalex-snapshot
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells
inferredcites →https://doi.org/10.1007/s00125-008-0999-7openalex-snapshot
Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells
inferredcites →https://doi.org/10.1007/s00125-008-1025-9openalex-snapshot
Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?
inferredcites →https://doi.org/10.1007/s00125-010-1733-9openalex-snapshot
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
inferredcites →https://doi.org/10.1007/s00125-010-1809-6openalex-snapshot
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
inferredcites →https://doi.org/10.1007/s00125-011-2283-5openalex-snapshot
Transcriptomes of the major human pancreatic cell types
inferredcites →https://doi.org/10.1007/s00125-012-2615-0openalex-snapshot
Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children
inferredcites →https://doi.org/10.1007/s00125-012-2675-1openalex-snapshot
Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse
inferredcites →https://doi.org/10.1007/s001250100021openalex-snapshot
A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis
inferredcites →https://doi.org/10.1007/s12020-010-9421-6openalex-snapshot
Molecular mechanism of pancreatic β-cell adaptive proliferation: studies during pregnancy in rats and in vitro
inferredcites →https://doi.org/10.1016/j.ajhg.2011.12.022openalex-snapshot
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
inferredcites →https://doi.org/10.1016/j.bbrc.2007.12.052openalex-snapshot
Quantitative differential expression analysis reveals miR-7 as major islet microRNA
inferredcites →https://doi.org/10.1016/j.biocel.2007.11.019openalex-snapshot
Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic β-cell line
inferredcites →https://doi.org/10.1016/j.cell.2006.07.024openalex-snapshot
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
inferredcites →https://doi.org/10.1016/j.cell.2007.12.015openalex-snapshot
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
inferredcites →https://doi.org/10.1016/j.cell.2009.05.035openalex-snapshot
The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells
inferredcites →https://doi.org/10.1016/j.cell.2010.02.034openalex-snapshot
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
inferredcites →https://doi.org/10.1016/j.cell.2012.02.010openalex-snapshot
Diabetes Mellitus and the β Cell: The Last Ten Years
inferredcites →https://doi.org/10.1016/j.cell.2012.02.017openalex-snapshot
Mechanisms for Insulin Resistance: Common Threads and Missing Links
inferredcites →https://doi.org/10.1016/j.cell.2013.04.008openalex-snapshot
RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation
inferredcites →https://doi.org/10.1016/j.celrep.2013.01.007openalex-snapshot
Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States
inferredcites →https://doi.org/10.1016/j.chembiol.2012.05.010openalex-snapshot
Inhibition of Histone Deacetylase 3 Protects Beta Cells from Cytokine-Induced Apoptosis
inferredcites →https://doi.org/10.1016/j.chembiol.2013.10.013openalex-snapshot
A Small-Molecule Inducer of PDX1 Expression Identified by High-Throughput Screening
inferredcites →https://doi.org/10.1016/j.cmet.2010.04.009openalex-snapshot
The Stunned β Cell: A Brief History
inferredcites →https://doi.org/10.1016/j.cmet.2012.04.018openalex-snapshot
Adenosine Signaling Promotes Regeneration of Pancreatic β Cells In Vivo
inferredcites →https://doi.org/10.1016/j.devcel.2013.05.018openalex-snapshot
Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes
inferredcites →https://doi.org/10.1016/j.diabres.2003.09.015openalex-snapshot
Prevention of type 1 diabetes: from the view point of β cell damage
inferredcites →https://doi.org/10.1016/j.gep.2008.10.001openalex-snapshot
Expression of islet-specific microRNAs during human pancreatic development
inferredcites →https://doi.org/10.1016/j.gep.2008.12.003openalex-snapshot
MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas
inferredcites →https://doi.org/10.1016/j.jim.2008.03.007openalex-snapshot
Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells
inferredcites →https://doi.org/10.1016/j.mce.2008.08.033openalex-snapshot
Regulation of beta cell replication
inferredcites →https://doi.org/10.1016/j.mce.2011.04.008openalex-snapshot
Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers
inferredcites →https://doi.org/10.1016/j.tem.2009.11.001openalex-snapshot
Expansion of β-cell mass in response to pregnancy
inferredcites →https://doi.org/10.1016/j.trsl.2011.01.009openalex-snapshot
Diabetes mellitus, a microRNA-related disease?
inferredcites →https://doi.org/10.1016/s0006-2952(02)00860-2openalex-snapshot
Troglitazone does not protect rat pancreatic β cells against free fatty acid-induced cytotoxicity
inferredcites →https://doi.org/10.1016/s0021-9258(18)93432-0openalex-snapshot
Metabolism of Glucose in the Islets of Langerhans
inferredcites →https://doi.org/10.1016/s0021-9258(19)86498-0openalex-snapshot
Purification and properties of human placental adenosine kinase.
inferredcites →https://doi.org/10.1016/s0140-6736(05)61032-xopenalex-snapshot
Type 2 diabetes: principles of pathogenesis and therapy
inferredcites →https://doi.org/10.1016/s0140-6736(11)61879-5openalex-snapshot
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial
inferredcites →https://doi.org/10.1016/s0140-6736(13)60023-9openalex-snapshot
Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials
inferredcites →https://doi.org/10.1016/s1097-2765(05)00015-8openalex-snapshot
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction
inferredcites →https://doi.org/10.1021/cb100129dopenalex-snapshot
Small-Molecule Suppressors of Cytokine-Induced β-Cell Apoptosis
inferredcites →https://doi.org/10.1021/ja309304mopenalex-snapshot
Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening
inferredcites →https://doi.org/10.1021/jm400397xopenalex-snapshot
Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility
inferredcites →https://doi.org/10.1021/jm701582fopenalex-snapshot
9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) Inhibitor Activating Pancreatic β Cell Protection and Replication
inferredcites →https://doi.org/10.1021/ml200120mopenalex-snapshot
Synthesis of a Novel Suppressor of β-Cell Apoptosis via Diversity-Oriented Synthesis
inferredcites →https://doi.org/10.1038/cdd.2009.165openalex-snapshot
The role of perforin and granzymes in diabetes
inferredcites →https://doi.org/10.1038/cddis.2011.15openalex-snapshot
Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin
inferredcites →https://doi.org/10.1038/emm.2007.17openalex-snapshot
Coptidis rhizoma extract protects against cytokine-induced death of pancreatic β-cells through suppression of NF-κ B activation
inferredcites →https://doi.org/10.1038/icb.2010.144openalex-snapshot
Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice
inferredcites →https://doi.org/10.1038/nature03076openalex-snapshot
A pancreatic islet-specific microRNA regulates insulin secretion
inferredcites →https://doi.org/10.1038/nature05092openalex-snapshot
p16INK4a induces an age-dependent decline in islet regenerative potential
inferredcites →https://doi.org/10.1038/nature05616openalex-snapshot
A genome-wide association study identifies novel risk loci for type 2 diabetes
inferredcites →https://doi.org/10.1038/nature07314openalex-snapshot
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
inferredcites →https://doi.org/10.1038/nature08894openalex-snapshot
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
inferredcites →https://doi.org/10.1038/nature08933openalex-snapshot
Genetics, pathogenesis and clinical interventions in type 1 diabetes
inferredcites →https://doi.org/10.1038/nbt1393openalex-snapshot
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
inferredcites →https://doi.org/10.1038/nchembio.154openalex-snapshot
A small molecule that directs differentiation of human ESCs into the pancreatic lineage
inferredcites →https://doi.org/10.1038/nchembio.472openalex-snapshot
Grand Challenge Commentary: Chemical transdifferentiation and regenerative medicine
inferredcites →https://doi.org/10.1038/ng.120openalex-snapshot
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
inferredcites →https://doi.org/10.1038/ng.2383openalex-snapshot
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
inferredcites →https://doi.org/10.1038/ng.2385openalex-snapshot
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
inferredcites →https://doi.org/10.1038/ng.520openalex-snapshot
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
inferredcites →https://doi.org/10.1038/ng.609openalex-snapshot
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
inferredcites →https://doi.org/10.1038/nm.2173openalex-snapshot
Serotonin regulates pancreatic beta cell mass during pregnancy
inferredcites →https://doi.org/10.1038/nm1001-1133openalex-snapshot
Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
inferredcites →https://doi.org/10.1038/nmeth.1557openalex-snapshot
Development and applications of single-cell transcriptome analysis
inferredcites →https://doi.org/10.1038/nrd2782openalex-snapshot
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
inferredcites →https://doi.org/10.1038/nrd2850openalex-snapshot
Assessing the potential of glucokinase activators in diabetes therapy
inferredcites →https://doi.org/10.1038/onc.2009.411openalex-snapshot
Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity
inferredcites →https://doi.org/10.1038/sj.bjp.0706770openalex-snapshot
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules
inferredcites →https://doi.org/10.1038/sj.emboj.7600742openalex-snapshot
Stress response gene ATF3 is a target of c‐myc in serum‐induced cell proliferation
inferredcites →https://doi.org/10.1038/sj.onc.1207579openalex-snapshot
EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes
inferredcites →https://doi.org/10.1042/bj20111678openalex-snapshot
Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA
inferredcites →https://doi.org/10.1056/nejmoa065213openalex-snapshot
Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus
inferredcites →https://doi.org/10.1056/nejmra0808284openalex-snapshot
Genetics of Type 1A Diabetes
inferredcites →https://doi.org/10.1073/pnas.0508166103openalex-snapshot
Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents
inferredcites →https://doi.org/10.1073/pnas.1113081108openalex-snapshot
Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation
inferredcites →https://doi.org/10.1073/pnas.1201149109openalex-snapshot
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication
inferredcites →https://doi.org/10.1073/pnas.96.20.11513openalex-snapshot
Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats
inferredcites →https://doi.org/10.1074/jbc.273.6.3547openalex-snapshot
Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats
inferredcites →https://doi.org/10.1074/jbc.m108658200openalex-snapshot
A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells
inferredcites →https://doi.org/10.1074/jbc.m110.162131openalex-snapshot
STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation
inferredcites →https://doi.org/10.1074/jbc.m111.253591openalex-snapshot
Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation
inferredcites →https://doi.org/10.1074/jbc.m609637200openalex-snapshot
Inhibition of GSK3 Promotes Replication and Survival of Pancreatic Beta Cells
inferredcites →https://doi.org/10.1097/01.mjt.0000178767.67857.63openalex-snapshot
Autoimmune Destruction of Pancreatic β Cells
inferredcites →https://doi.org/10.1101/cshperspect.a007666openalex-snapshot
Endoplasmic Reticulum Stress, Pancreatic -Cell Degeneration, and Diabetes
inferredcites →https://doi.org/10.1101/gad.16875711openalex-snapshot
Context-specific α-to-β-cell reprogramming by forced Pdx1 expression
inferredcites →https://doi.org/10.1101/gad.1742509openalex-snapshot
Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in diabetes mellitus
inferredcites →https://doi.org/10.1101/gad.269003openalex-snapshot
Opposing actions of Arx and Pax4 in endocrine pancreas development
inferredcites →https://doi.org/10.1111/acel.12132openalex-snapshot
PTEN controls β‐cell regeneration in aged mice by regulating cell cycle inhibitor p16 ink4a
inferredcites →https://doi.org/10.1111/dom.12162openalex-snapshot
Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β ‐cell apoptosis
inferredcites →https://doi.org/10.1111/j.0105-2896.2005.00244.xopenalex-snapshot
The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice
inferredcites →https://doi.org/10.1111/j.1463-1326.2009.01115.xopenalex-snapshot
Genetic and biochemical pathways of β‐cell failure in type 2 diabetes
inferredcites →https://doi.org/10.1111/j.1476-5381.2012.02201.xopenalex-snapshot
Small molecular glucokinase activators: has another new anti‐diabetic therapeutic lost favour?
inferredcites →https://doi.org/10.1111/j.1582-4934.2007.00191.xopenalex-snapshot
Cytokine‐induced β‐cell apoptosis is NO‐dependent, mitochondria‐mediated and inhibited by BCL‐XL
inferredcites →https://doi.org/10.1111/j.1742-1241.2009.02332.xopenalex-snapshot
Key considerations around the risks and consequences of hypoglycaemia in people with type 2 diabetes
inferredcites →https://doi.org/10.1111/j.1749-6632.2010.05838.xopenalex-snapshot
The genetics of type 2 diabetes: what have we learned from GWAS?
inferredcites →https://doi.org/10.1126/science.1104345openalex-snapshot
Type 2 Diabetes-a Matter of ß-Cell Life and Death?
inferredcites →https://doi.org/10.1126/science.1142358openalex-snapshot
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
inferredcites →https://doi.org/10.1126/science.1142364openalex-snapshot
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
inferredcites →https://doi.org/10.1126/science.1142382openalex-snapshot
A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
inferredcites →https://doi.org/10.1126/science.1239278openalex-snapshot
Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
inferredcites →https://doi.org/10.1128/mcb.25.9.3752-3762.2005openalex-snapshot
Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth
inferredcites →https://doi.org/10.1146/annurev-genet-102209-163607openalex-snapshot
Genomic Analysis at the Single-Cell Level
inferredcites →https://doi.org/10.1146/annurev-genom-091212-153435openalex-snapshot
Genome Engineering at the Dawn of the Golden Age
inferredcites →https://doi.org/10.1146/annurev.cellbio.22.010305.104425openalex-snapshot
Intrinsic Regulators of Pancreatic β-Cell Proliferation
inferredcites →https://doi.org/10.1152/ajpendo.00496.2010openalex-snapshot
Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas
inferredcites →https://doi.org/10.1155/2012/925143openalex-snapshot
Chemical Methods to Induce Beta-Cell Proliferation
inferredcites →https://doi.org/10.1159/000137662openalex-snapshot
Rosiglitazone Inhibits Early Stage of Glucolipotoxicity-Induced Beta-Cell Apoptosis
inferredcites →https://doi.org/10.1172/jci20016openalex-snapshot
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells
inferredcites →https://doi.org/10.1172/jci35197openalex-snapshot
Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells
inferredcites →https://doi.org/10.1172/jci58056openalex-snapshot
Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice
inferredcites →https://doi.org/10.1172/jci58447openalex-snapshot
A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
inferredcites →https://doi.org/10.1172/jci64151openalex-snapshot
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity
inferredcites →https://doi.org/10.1172/jci66514openalex-snapshot
Epigenomic plasticity enables human pancreatic α to β cell reprogramming
inferredcites →https://doi.org/10.1172/jci68807openalex-snapshot
The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance
inferredcites →https://doi.org/10.1177/1087057107313763openalex-snapshot
Identification of Glucose-Dependant Insulin Secretion Targets in Pancreatic β Cells by Combining Defined-Mechanism Compound Library Screening and siRNA Gene Silencing
inferredcites →https://doi.org/10.1177/1087057111405379openalex-snapshot
Open Innovation for Phenotypic Drug Discovery: The PD2 Assay Panel
inferredcites →https://doi.org/10.1186/gm277openalex-snapshot
Stem cell approaches for diabetes: towards beta cell replacement
inferredcites →https://doi.org/10.1210/en.130.3.1459openalex-snapshot
Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion
inferredcites →https://doi.org/10.1210/en.2002-220058openalex-snapshot
Activation of Phosphatidylinositol 3-Kinase Contributes to Insulin-Like Growth Factor I-Mediated Inhibition of Pancreatic β-Cell Death
inferredcites →https://doi.org/10.1210/er.2006-0004openalex-snapshot
Molecular Control of Cell Cycle Progression in the Pancreatic β-Cell
inferredcites →https://doi.org/10.1210/er.2007-0015openalex-snapshot
The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus
inferredcites →https://doi.org/10.1210/er.2007-0023openalex-snapshot
Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction
inferredcites →https://doi.org/10.1242/jcs.02513openalex-snapshot
ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity
inferredcites →https://doi.org/10.1371/journal.pgen.1002449openalex-snapshot
An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production
inferredcites →https://doi.org/10.1371/journal.pone.0012958openalex-snapshot
A Multi-Parameter, High-Content, High-Throughput Screening Platform to Identify Natural Compounds that Modulate Insulin and Pdx1 Expression
inferredcites →https://doi.org/10.1371/journal.pone.0037004openalex-snapshot
A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells
inferredcites →https://doi.org/10.1371/journal.pone.0037055openalex-snapshot
Plasticity of Adult Human Pancreatic Duct Cells by Neurogenin3-Mediated Reprogramming
inferredcites →https://doi.org/10.1371/journal.pone.0055272openalex-snapshot
The miRNA Profile of Human Pancreatic Islets and Beta-Cells and Relationship to Type 2 Diabetes Pathogenesis
inferredcites →https://doi.org/10.1515/bc.2008.026openalex-snapshot
Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs
inferredcites →https://doi.org/10.1530/eje-08-0596openalex-snapshot
Impaired islet turnover in human donor pancreata with aging
inferredcites →https://doi.org/10.1530/joe-12-0474openalex-snapshot
Activin A, exendin-4, and glucose stimulate differentiation of human pancreatic ductal cells
inferredcites →https://doi.org/10.2119/molmed.2010.00152openalex-snapshot
The Oral Histone Deacetylase Inhibitor ITF2357 Reduces Cytokines and Protects Islet β Cells In Vivo and In Vitro
inferredcites →https://doi.org/10.2174/1381612043452668openalex-snapshot
Discovery and Development of GSK3 Inhibitors for the Treatment of Type 2 Diabetes
inferredcites →https://doi.org/10.2174/138161207780249155openalex-snapshot
Pancreatic Islets Under Attack: Cellular and Molecular Effectors
inferredcites →https://doi.org/10.2337/db06-0249openalex-snapshot
p27 Regulates the Transition of β-Cells From Quiescence to Proliferation
inferredcites →https://doi.org/10.2337/db07-0052openalex-snapshot
Deletion of STAT-1 Pancreatic Islets Protects Against Streptozotocin-Induced Diabetes and Early Graft Failure but Not Against Late Rejection
inferredcites →https://doi.org/10.2337/db07-0175openalex-snapshot
MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
inferredcites →https://doi.org/10.2337/db07-1369openalex-snapshot
β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans
inferredcites →https://doi.org/10.2337/db07-1692openalex-snapshot
Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells
inferredcites →https://doi.org/10.2337/db07-1795openalex-snapshot
Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway
inferredcites →https://doi.org/10.2337/db09-0551openalex-snapshot
Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants
inferredcites →https://doi.org/10.2337/db09-1776openalex-snapshot
Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
inferredcites →https://doi.org/10.2337/db10-0676openalex-snapshot
Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study
inferredcites →https://doi.org/10.2337/db11-0415openalex-snapshot
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
inferredcites →https://doi.org/10.2337/db11-0758openalex-snapshot
PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
inferredcites →https://doi.org/10.2337/db11-1033openalex-snapshot
Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade
inferredcites →https://doi.org/10.2337/db11-1784openalex-snapshot
Cytotoxic Mechanisms Employed by Mouse T Cells to Destroy Pancreatic β-Cells
inferredcites →https://doi.org/10.2337/db12-0451openalex-snapshot
MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic β-Cells
inferredcites →https://doi.org/10.2337/db12-0777openalex-snapshot
Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas
inferredcites →https://doi.org/10.2337/db12-0778openalex-snapshot
Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human β-Cell Replication
inferredcites →https://doi.org/10.2337/db12-1001openalex-snapshot
Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells
inferredcites →https://doi.org/10.2337/db13-0160openalex-snapshot
Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication
inferredcites →https://doi.org/10.2337/db13-er09openalex-snapshot
Systemic regulation of the age-related decline of pancreatic β-cell replication. Diabetes 2013;62:2843–2848
inferredcites →https://doi.org/10.2337/dc10-1970openalex-snapshot
Depression in Diabetes: Have We Been Missing Something Important?
inferredcites →https://doi.org/10.2337/dc11-2219openalex-snapshot
Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes
inferredcites →https://doi.org/10.2337/dc11-s236openalex-snapshot
Glucokinase Activators for Diabetes Therapy
inferredcites →https://doi.org/10.2337/dc12-1835openalex-snapshot
Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients With Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diabetes.50.1.77openalex-snapshot
Cell-Permeable Peptide Inhibitors of JNK
inferredcites →https://doi.org/10.2337/diabetes.50.2007.s64openalex-snapshot
beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes.
inferredcites →https://doi.org/10.2337/diabetes.50.5.1021openalex-snapshot
β-Cell Mass Dynamics in Zucker Diabetic Fatty Rats
inferredcites →https://doi.org/10.2337/diabetes.50.8.1778openalex-snapshot
Acute and Short-Term Administration of a Sulfonylurea (Gliclazide) Increases Pulsatile Insulin Secretion in Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diabetes.52.1.102openalex-snapshot
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diabetes.53.2007.s119openalex-snapshot
β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diabetes.54.suppl_2.s97openalex-snapshot
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes
inferredcites →https://doi.org/10.3389/fendo.2011.00112openalex-snapshot
Drug Discovery Opportunities and Challenges at G Protein Coupled Receptors for Long Chain Free Fatty Acids
inferredcites →https://doi.org/10.3892/ijmm.19.3.535openalex-snapshot
Inhibitory effect of Artemisia capillaris extract on cytokine-induced nitric oxide formation and cytotoxicity of RINm5F cells
inferredcites →https://doi.org/10.3892/ijmm.20.5.769openalex-snapshot
Radix asari extract protects pancreatic β cells against cytokine-induced toxicity: Implication of the NF-κB-iNOS signaling cascade
inferredcites →https://doi.org/10.4049/jimmunol.175.1.293openalex-snapshot
Transgenic Expression of Dominant-Negative Fas-Associated Death Domain Protein in β Cells Protects against Fas Ligand-Induced Apoptosis and Reduces Spontaneous Diabetes in Nonobese Diabetic Mice
inferredcites →https://doi.org/10.7326/0003-4819-147-6-200709180-00178openalex-snapshot
Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes Mellitus

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Diverse gallotannins with α-glucosidase and α-amylase inhibitory activity from the roots of Euphorbia fischeriana steud.
inferred← citeshttps://doi.org/10.1002/adhm.201701111openalex-snapshot
Microphysiological Analysis Platform of Pancreatic Islet β‐Cell Spheroids
inferred← citeshttps://doi.org/10.1002/advs.202505659openalex-snapshot
BRD4 Signaling Maintains the Differentiated State of β Cells
inferred← citeshttps://doi.org/10.1002/cbin.11302openalex-snapshot
Gimmicks of gamma‐aminobutyric acid (GABA) in pancreatic β‐cell regeneration through transdifferentiation of pancreatic α‐ to β‐cells
inferred← citeshttps://doi.org/10.1002/dmrr.2663openalex-snapshot
Bariatric surgery: beta cells in type 2 diabetes remission
inferred← citeshttps://doi.org/10.1002/dmrr.2894openalex-snapshot
Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus
inferred← citeshttps://doi.org/10.1002/ijch.202300165openalex-snapshot
Cellular Metabolic Labeling of Nucleic Acids and Its Applications
inferred← citeshttps://doi.org/10.1002/jbm.a.36647openalex-snapshot
Redox‐active injectable gel using polyion complex to achieve sustained release of exenatide and enhance therapeutic efficacy for the treatment of type 2 diabetes
inferred← citeshttps://doi.org/10.1002/jbt.23669openalex-snapshot
Spinal microglial M1 polarization contributes paclitaxel‐induced neuropathic pain by triggering cells necroptosis
inferred← citeshttps://doi.org/10.1002/jcb.28050openalex-snapshot
Adenosine protects pancreatic beta cells against apoptosis induced by endoplasmic reticulum stress
inferred← citeshttps://doi.org/10.1002/mnfr.201700810openalex-snapshot
Naringin Protects Pancreatic β‐Cells Against Oxidative Stress‐Induced Apoptosis by Inhibiting Both Intrinsic and Extrinsic Pathways in Insulin‐Deficient Diabetic Mice
inferred← citeshttps://doi.org/10.1002/mnfr.201901009openalex-snapshot
Aspalathin Protects Insulin‐Producing β Cells against Glucotoxicity and Oxidative Stress‐Induced Cell Death
inferred← citeshttps://doi.org/10.1002/ptr.6462openalex-snapshot
Tinospora cordifolia preserves pancreatic beta cells and enhances glucose uptake in adipocytes to regulate glucose metabolism in diabetic rats
inferred← citeshttps://doi.org/10.1002/vjch.201800062openalex-snapshot
Protective effect of pancreatic β‐cells MIN6 by some medicinal plants in the Mekong Delta
inferred← citeshttps://doi.org/10.1007/978-1-0716-2807-2_15openalex-snapshot
miRNA Theranostic Nanoparticles Promote Pancreatic Beta Cell Proliferation in Type 1 Diabetes Model
inferred← citeshttps://doi.org/10.1007/978-3-030-11815-0_12openalex-snapshot
Dysfunction and Death of Pancreatic Beta Cells in Type 2 Diabetes
inferred← citeshttps://doi.org/10.1007/978-3-031-25519-9_13openalex-snapshot
Dysfunction and Death of Pancreatic Beta-Cells in Type 2 Diabetes
inferred← citeshttps://doi.org/10.1007/978-3-319-45307-1_4openalex-snapshot
Epigenetic Regulation of Islet Development and Regeneration
inferred← citeshttps://doi.org/10.1007/978-981-15-1761-7_11openalex-snapshot
Antidiabetic Phytochemicals and Their Applications in Modern Medicine
inferred← citeshttps://doi.org/10.1007/s00125-014-3251-7openalex-snapshot
The regulation of pre- and post-maturational plasticity of mammalian islet cell mass
inferred← citeshttps://doi.org/10.1007/s00125-018-4576-4openalex-snapshot
Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets
inferred← citeshttps://doi.org/10.1007/s00125-018-4639-6openalex-snapshot
Advances in drug discovery for human beta cell regeneration
inferred← citeshttps://doi.org/10.1007/s00216-019-01694-5openalex-snapshot
Fluorescence imaging-based methods for single-cell protein analysis
inferred← citeshttps://doi.org/10.1007/s00464-015-4236-4openalex-snapshot
Sleeve gastrectomy, but not duodenojejunostomy, preserves total beta-cell mass in Goto-Kakizaki rats evaluated by three-dimensional optical projection tomography
inferred← citeshttps://doi.org/10.1007/s00726-016-2208-1openalex-snapshot
Physiological and therapeutic effects of carnosine on cardiometabolic risk and disease
inferred← citeshttps://doi.org/10.1007/s10967-017-5615-1openalex-snapshot
99mTc-labeled glimepiride as a tracer for targeting pancreatic β-cells mass: preparation and preclinical evaluation
inferred← citeshttps://doi.org/10.1007/s11030-026-11690-4openalex-snapshot
Design, synthesis and biological evaluation of quinazoline-carbazole derivatives as dual TXNIP/DYRK1A inhibitors for the treatment of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s11154-021-09668-8openalex-snapshot
Therapeutic potentials of agonist and antagonist of adenosine receptors in type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s11356-018-1337-3openalex-snapshot
In type 2 diabetes induced by cigarette smoking, activation of p38 MAPK is involved in pancreatic β-cell apoptosis
inferred← citeshttps://doi.org/10.1007/s12020-016-1160-xopenalex-snapshot
Exendin-4 promotes pancreatic β-cell proliferation via inhibiting the expression of Wnt5a
inferred← citeshttps://doi.org/10.1007/s12020-024-03909-xopenalex-snapshot
Dyslipidemia and ANGPTL8 evaluation in young females with Type 1 diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s12291-017-0668-zopenalex-snapshot
A Narrative Review of Potential Future Antidiabetic Drugs: Should We Expect More?
inferred← citeshttps://doi.org/10.1007/s13238-014-0123-3openalex-snapshot
Recent progress in studies of factors that elicit pancreatic β-cell expansion
inferred← citeshttps://doi.org/10.1007/s13238-016-0258-5openalex-snapshot
Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival
inferred← citeshttps://doi.org/10.1007/s40618-016-0440-xopenalex-snapshot
Peripheral activities of growth hormone-releasing hormone
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12296-6openalex-snapshot
Regenerative Medicine
inferred← citeshttps://doi.org/10.1016/b978-0-12-801585-8.00010-5openalex-snapshot
High-Fat Diets and β-Cell Dysfunction
inferred← citeshttps://doi.org/10.1016/b978-0-12-801585-8.00027-0openalex-snapshot
NRF2-Mediated Gene Regulation and Glucose Homeostasis
inferred← citeshttps://doi.org/10.1016/b978-0-12-812019-4.00035-0openalex-snapshot
HDACs in Diabetes
inferred← citeshttps://doi.org/10.1016/j.abb.2014.12.012openalex-snapshot
The Keap1–Nrf2 system and diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.addr.2023.115131openalex-snapshot
Interaction of 2D nanomaterial with cellular barrier: Membrane attachment and intracellular trafficking
inferred← citeshttps://doi.org/10.1016/j.autrev.2015.11.008openalex-snapshot
Adaptive immune regulation in autoimmune diabetes
inferred← citeshttps://doi.org/10.1016/j.autrev.2025.103816openalex-snapshot
The role of CRISPR-Cas9 and CRISPR interference technologies in the treatment of autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2018.07.006openalex-snapshot
Egr-1 transactivates WNT5A gene expression to inhibit glucose-induced β-cell proliferation
inferred← citeshttps://doi.org/10.1016/j.bbalip.2016.01.010openalex-snapshot
MicroRNA transport in cardiovascular complication of diabetes
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2015.09.012openalex-snapshot
TRPV6 channel modulates proliferation of insulin secreting INS-1E beta cell line
inferred← citeshttps://doi.org/10.1016/j.bbrc.2014.11.048openalex-snapshot
DPP IV inhibitor suppresses STZ-induced islets injury dependent on activation of the IGFR/Akt/mTOR signaling pathways by GLP-1 in monkeys
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.10.030openalex-snapshot
Carbon monoxide enhances calcium transients and glucose-stimulated insulin secretion from pancreatic β-cells by activating Phospholipase C signal pathway in diabetic mice
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116499openalex-snapshot
Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2022.02.025openalex-snapshot
Advances in oral peptide drug nanoparticles for diabetes mellitus treatment
inferred← citeshttps://doi.org/10.1016/j.biochi.2016.12.009openalex-snapshot
Emerging role of Hippo signalling in pancreatic biology: YAP re-expression and plausible link to islet cell apoptosis and replication
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2020.119986openalex-snapshot
Biomimetic carbon monoxide nanogenerator ameliorates streptozotocin induced type 1 diabetes in mice
inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.103366openalex-snapshot
Optimization of the benzamide fragment targeting the S2′ site leads to potent dipeptidyl peptidase-IV inhibitors
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108472openalex-snapshot
Benzimidazole derivatives protect pancreatic β-cells against cytokine-induced apoptosis
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.10.133openalex-snapshot
In vitro and in vivo immunomodulatory potential of Pedicularis longiflora and Allium carolinianum in alloxan-induced diabetes in rats
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.10.152openalex-snapshot
Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.12.126openalex-snapshot
Novel protective effect of O-1602 and abnormal cannabidiol, GPR55 agonists, on ER stress-induced apoptosis in pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.01.001openalex-snapshot
Identification of novel uracil derivatives incorporating benzoic acid moieties as highly potent Dipeptidyl Peptidase-IV inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.06.032openalex-snapshot
Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists
inferred← citeshttps://doi.org/10.1016/j.canlet.2018.01.038openalex-snapshot
The interplay between noncoding RNAs and insulin in diabetes
inferred← citeshttps://doi.org/10.1016/j.cclet.2024.109570openalex-snapshot
Design, synthesis and evaluation of the first DYRK1A degrader for promoting the proliferation of pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.cell.2014.09.040openalex-snapshot
Generation of Functional Human Pancreatic β Cells In Vitro
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.05.088openalex-snapshot
Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.06.058openalex-snapshot
Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos
inferred← citeshttps://doi.org/10.1016/j.chembiol.2021.05.011openalex-snapshot
Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets
inferred← citeshttps://doi.org/10.1016/j.coi.2014.09.001openalex-snapshot
Inflammasome activation in response to dead cells and their metabolites
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2026.109131openalex-snapshot
Integrated metabolomics and computational pharmacology to reveal the complementary antidiabetic mechanisms of Tithonia–Curcuma–Moringa (TCM) polyherbal
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2023.107481openalex-snapshot
Pharmacophore-based virtual screening, 3D QSAR, Docking, ADMET, and MD simulation studies: An in silico perspective for the identification of new potential HDAC3 inhibitors
inferred← citeshttps://doi.org/10.1016/j.coph.2017.08.007openalex-snapshot
Catching new targets in metabolic disease with a zebrafish
inferred← citeshttps://doi.org/10.1016/j.devcel.2016.10.003openalex-snapshot
Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion
inferred← citeshttps://doi.org/10.1016/j.diabres.2016.11.009openalex-snapshot
Epigenetic control of β-cell function and failure
inferred← citeshttps://doi.org/10.1016/j.dsx.2018.11.016openalex-snapshot
Circulating betatrophin in relation to metabolic, inflammatory parameters, and oxidative stress in patients with type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.07.045openalex-snapshot
Rapid generation of novel benzoic acid–based xanthine derivatives as highly potent, selective and long acting DPP-4 inhibitors: Scaffold-hopping and prodrug study
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111976openalex-snapshot
Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic β-cells protective agents for the treatment of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.112017openalex-snapshot
The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119
inferred← citeshttps://doi.org/10.1016/j.ejphar.2019.04.050openalex-snapshot
G-protein coupled receptor 55 agonists increase insulin secretion through inositol trisphosphate-mediated calcium release in pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.gendis.2014.06.003openalex-snapshot
The myriad essential roles of microRNAs in cardiovascular homeostasis and disease
inferred← citeshttps://doi.org/10.1016/j.gene.2018.11.100openalex-snapshot
KEAP1/NRF2 axis regulates H2O2-induced apoptosis of pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.genrep.2020.100863openalex-snapshot
Harmine, a natural β-carboline alkaloid, ameliorates apoptosis by decreasing the expression of caspase-3 in the kidney of diabetic male Wistar rats
inferred← citeshttps://doi.org/10.1016/j.isci.2018.02.003openalex-snapshot
Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response
inferred← citeshttps://doi.org/10.1016/j.jare.2020.02.013openalex-snapshot
Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review
inferred← citeshttps://doi.org/10.1016/j.jare.2025.09.051openalex-snapshot
The rise of dehydrated ginsenosides: phytochemistry and pharmacology
inferred← citeshttps://doi.org/10.1016/j.jchromb.2016.11.012openalex-snapshot
Untargeted serum metabolomics reveals Fu-Zhu-Jiang-Tang tablet and its optimal combination improve an impaired glucose and lipid metabolism in type II diabetic rats
inferred← citeshttps://doi.org/10.1016/j.jdiacomp.2016.05.023openalex-snapshot
Circulating betatrophin in healthy control and type 2 diabetic subjects and its association with metabolic parameters
inferred← citeshttps://doi.org/10.1016/j.jdiacomp.2017.12.002openalex-snapshot
An overview of type 2 diabetes and importance of vitamin D3-vitamin D receptor interaction in pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.jnim.2018.05.001openalex-snapshot
Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2020.108461openalex-snapshot
Carob fruit extract-enriched meat improves pancreatic beta-cell dysfunction, hepatic insulin signaling and lipogenesis in late-stage type 2 diabetes mellitus model
inferred← citeshttps://doi.org/10.1016/j.jprot.2022.104796openalex-snapshot
TiCPG - a strategy for the simultaneous enrichment of reversibly modified cysteine peptides, phosphopeptides, and sialylated N-Glycopeptides to study cytokines stimulated beta-cells
inferred← citeshttps://doi.org/10.1016/j.mam.2015.01.001openalex-snapshot
Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes☆
inferred← citeshttps://doi.org/10.1016/j.mce.2018.01.010openalex-snapshot
Determination of EPAC2 function using EPAC2 null Min6 sublines generated through CRISPR-Cas9 technology
inferred← citeshttps://doi.org/10.1016/j.mce.2020.111026openalex-snapshot
Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a PKA-dependent mechanism
inferred← citeshttps://doi.org/10.1016/j.metabol.2018.03.010openalex-snapshot
The role of glucokinase and insulin receptor substrate-2 in the proliferation of pancreatic beta cells induced by short-term high-fat diet feeding in mice
inferred← citeshttps://doi.org/10.1016/j.molmed.2016.12.005openalex-snapshot
Beta-Cell Fragility As a Common Underlying Risk Factor in Type 1 and Type 2 Diabetes
inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101775openalex-snapshot
Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety
inferred← citeshttps://doi.org/10.1016/j.nutres.2019.09.005openalex-snapshot
Phenolic-enriched blueberry-leaf extract attenuates glucose homeostasis, pancreatic β-cell function, and insulin sensitivity in high-fat diet–induced diabetic mice
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.104983openalex-snapshot
Ternary complex factor regulates pancreatic islet size and blood glucose homeostasis in transgenic mice
inferred← citeshttps://doi.org/10.1016/j.tem.2014.08.006openalex-snapshot
Epigenetic modifiers of islet function and mass
inferred← citeshttps://doi.org/10.1016/j.tem.2015.12.005openalex-snapshot
Chromatin Regulators in Pancreas Development and Diabetes
inferred← citeshttps://doi.org/10.1016/j.tem.2016.02.008openalex-snapshot
Unraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease
inferred← citeshttps://doi.org/10.1016/j.tifs.2021.04.033openalex-snapshot
Lotus (Nelumbo nucifera Gaertn.) leaf: A narrative review of its Phytoconstituents, health benefits and food industry applications
inferred← citeshttps://doi.org/10.1016/j.tips.2016.01.007openalex-snapshot
Repurposing Drugs to Target the Diabetes Epidemic
inferred← citeshttps://doi.org/10.1016/j.trsl.2021.10.005openalex-snapshot
Cholecystokinin attenuates β-cell apoptosis in both mouse and human islets
inferred← citeshttps://doi.org/10.1016/s0254-6272(16)30011-5openalex-snapshot
Nelumbo Nucifera leaf extract attenuated pancreatic ß-cells toxicity induced by interleukin-1ß and interferon-γ, and increased insulin secrection of pancreatic ß-cells in streptozotocin-induced diabetic rats
inferred← citeshttps://doi.org/10.1017/s1431927615015020openalex-snapshot
Ultrastructural Analysis of In Vivo Hypoglycemiant Effect of Two Polyoxometalates in Rats with Streptozotocin-Induced Diabetes
inferred← citeshttps://doi.org/10.1021/acs.chemrev.4c00417openalex-snapshot
Opportunities for Therapeutic Modulation of O-GlcNAc
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00844openalex-snapshot
Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β‑Cell Apoptosis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c02050openalex-snapshot
DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00926openalex-snapshot
Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00323openalex-snapshot
Discovery of Dimethyl Shikonin Oxime 5a, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00041openalex-snapshot
Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00435openalex-snapshot
Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress
inferred← citeshttps://doi.org/10.1021/acsami.4c12567openalex-snapshot
Artificial Nanovesicles Derived from Cells: A Promising Alternative to Extracellular Vesicles
inferred← citeshttps://doi.org/10.1021/acsami.6b10568openalex-snapshot
Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy
inferred← citeshttps://doi.org/10.1021/acschembio.5b00640openalex-snapshot
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection
inferred← citeshttps://doi.org/10.1021/acschembio.5b00993openalex-snapshot
Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells
inferred← citeshttps://doi.org/10.1021/acsnano.5b02997openalex-snapshot
In Vivo Differentiation of Therapeutic Insulin-Producing Cells from Bone Marrow Cells via Extracellular Vesicle-Mimetic Nanovesicles
inferred← citeshttps://doi.org/10.1021/acsomega.7b01988openalex-snapshot
Effect of γ-Aminobutyric Acid–Chitosan Nanoparticles on Glucose Homeostasis in Mice
inferred← citeshttps://doi.org/10.1021/acsomega.8b03050openalex-snapshot
Discovery of 5-(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β-Cell Survival in Type 1 Diabetes
inferred← citeshttps://doi.org/10.1021/jacs.0c00099openalex-snapshot
Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells
inferred← citeshttps://doi.org/10.1038/gt.2015.23openalex-snapshot
Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo
inferred← citeshttps://doi.org/10.1038/mtm.2015.11openalex-snapshot
Reversal of diabetes following transplantation of an insulin-secreting human liver cell line: Melligen cells
inferred← citeshttps://doi.org/10.1038/nm.3779openalex-snapshot
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes
inferred← citeshttps://doi.org/10.1038/s41387-022-00186-3openalex-snapshot
MST1 deletion protects β-cells in a mouse model of diabetes
inferred← citeshttps://doi.org/10.1038/s41392-023-01352-4openalex-snapshot
Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus
inferred← citeshttps://doi.org/10.1038/s41392-024-01755-xopenalex-snapshot
Metabolic memory: mechanisms and diseases
inferred← citeshttps://doi.org/10.1038/s41467-019-12880-5openalex-snapshot
Neratinib protects pancreatic beta cells in diabetes
inferred← citeshttps://doi.org/10.1038/s41467-021-25145-xopenalex-snapshot
The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
inferred← citeshttps://doi.org/10.1038/s41467-022-29377-3openalex-snapshot
RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells
inferred← citeshttps://doi.org/10.1038/s41598-020-62269-4openalex-snapshot
miR-216a-targeting theranostic nanoparticles promote proliferation of insulin-secreting cells in type 1 diabetes animal model
inferred← citeshttps://doi.org/10.1038/s41598-020-76600-6openalex-snapshot
TBK1 regulates regeneration of pancreatic β-cells
inferred← citeshttps://doi.org/10.1038/s41598-025-24091-8openalex-snapshot
Network pharmacology and molecular docking reveal multi-target mechanisms of Butea monosperma stem bark extract in ulcerative colitis
inferred← citeshttps://doi.org/10.1038/s42255-022-00629-2openalex-snapshot
Independent phenotypic plasticity axes define distinct obesity sub-types
inferred← citeshttps://doi.org/10.1039/9781839165498-00001openalex-snapshot
Chemical Approaches for Beta-cell Biology
inferred← citeshttps://doi.org/10.1039/d3lc00371jopenalex-snapshot
Islet-on-chip: promotion of islet health and function via encapsulation within a polymerizable fibrillar collagen scaffold
inferred← citeshttps://doi.org/10.1051/medsci/20163204019openalex-snapshot
La thérapie cellulaire du diabète
inferred← citeshttps://doi.org/10.1074/jbc.ra119.007755openalex-snapshot
MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways
inferred← citeshttps://doi.org/10.1074/jbc.ra119.011389openalex-snapshot
“Register-shift” insulin analogs uncover constraints of proteotoxicity in protein evolution
inferred← citeshttps://doi.org/10.1080/03602532.2018.1497645openalex-snapshot
Alterations of drug-metabolizing enzymes and transporters under diabetic conditions: what is the potential clinical significance?
inferred← citeshttps://doi.org/10.1080/10408398.2025.2505240openalex-snapshot
Systematic review of hypoglycemic polysaccharides: sources, preparation, and identification techniques, evaluation models, structure–activity relationships, and mechanistic insights
inferred← citeshttps://doi.org/10.1080/13813455.2021.1946561openalex-snapshot
miR-765 targeting PDX1 impairs pancreatic β-cell function to induce type 2 diabetes
inferred← citeshttps://doi.org/10.1080/14756366.2018.1437156openalex-snapshot
The discovery of novel HDAC3 inhibitors via virtual screening and in vitro bioassay
inferred← citeshttps://doi.org/10.1080/14756366.2023.2166937openalex-snapshot
TXNIP inhibition in the treatment of type 2 diabetes mellitus: design, synthesis, and biological evaluation of quinazoline derivatives
inferred← citeshttps://doi.org/10.1080/14786419.2021.1931187openalex-snapshot
Ethnopharmacological perspectives of glucokinase activators in the treatment of diabetes mellitus
inferred← citeshttps://doi.org/10.1080/19382014.2019.1617621openalex-snapshot
Class IIa HDACs do not influence beta-cell function under normal or high glucose conditions
inferred← citeshttps://doi.org/10.1080/21655979.2021.1996314openalex-snapshot
Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic β cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression
inferred← citeshttps://doi.org/10.1080/21691401.2019.1624368openalex-snapshot
RETRACTED ARTICLE: Notoginsenoside R1 alleviates TNF-α-induced pancreatic β-cell Min6 apoptosis and dysfunction through up-regulation of miR-29a
inferred← citeshttps://doi.org/10.1093/bja/aex229openalex-snapshot
Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review
inferred← citeshttps://doi.org/10.1096/fj.15-275826openalex-snapshot
Cathelicidins positively regulate pancreatic β‐cell functions
inferred← citeshttps://doi.org/10.1096/fj.202301479ropenalex-snapshot
Loss of mitogen‐activated protein kinase phosphate‐5 aggravates islet dysfunction in mice with type 1 and type 2 diabetes
inferred← citeshttps://doi.org/10.1101/2021.03.02.433645openalex-snapshot
Cholecystokinin Suppresses β-Cell Apoptosis, Including in Human Islets in a Transplant Model
inferred← citeshttps://doi.org/10.1101/2021.09.24.461687openalex-snapshot
Age of diabetes onset in the mutant proinsulin syndrome correlates with mutational impairment of protein foldability and stability
inferred← citeshttps://doi.org/10.1101/2021.11.07.467656openalex-snapshot
Bayesian Metamodeling of pancreatic islet architecture and functional dynamics
inferred← citeshttps://doi.org/10.1101/509125openalex-snapshot
Simultaneous proteomics and three PTMomics characterization of pro-inflammatory cytokines stimulated INS-1E cells using TiO 2 enrichment strategy
inferred← citeshttps://doi.org/10.1111/1753-0407.13252openalex-snapshot
Targeting the PI3K /Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes
inferred← citeshttps://doi.org/10.1111/1756-185x.12712openalex-snapshot
Musculoskeletal manifestations in diabetic versus prediabetic patients
inferred← citeshttps://doi.org/10.1111/bph.13907openalex-snapshot
The Arg–Phe‐amide peptide 26RFa/glutamine RF‐amide peptide and its receptor: IUPHAR Review 24
inferred← citeshttps://doi.org/10.1111/bph.14757openalex-snapshot
The plant product quinic acid activates Ca 2+ ‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells
inferred← citeshttps://doi.org/10.1111/bph.14821openalex-snapshot
The ellagitannin metabolite urolithin C is a glucose‐dependent regulator of insulin secretion through activation of L‐type calcium channels
inferred← citeshttps://doi.org/10.1111/jfbc.14191openalex-snapshot
Ferula assa‐foetida oleo gum resin ethanolic extract alleviated the pancreatic changes and antioxidant status in streptozotocin‐induced diabetic rats: A biochemical, histopathological, and ultrastructural study
inferred← citeshttps://doi.org/10.1124/pharmrev.121.000302openalex-snapshot
β−Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives
inferred← citeshttps://doi.org/10.1142/s0192415x23500775openalex-snapshot
Effects and Mechanistic Role of Mulberry Leaves in Treating Diabetes and its Complications
inferred← citeshttps://doi.org/10.1146/annurev-nutr-071715-050808openalex-snapshot
Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells
inferred← citeshttps://doi.org/10.1152/ajpendo.00335.2020openalex-snapshot
The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation
inferred← citeshttps://doi.org/10.1152/ajpendo.00649.2020openalex-snapshot
Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes
inferred← citeshttps://doi.org/10.1155/2015/357357openalex-snapshot
Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes
inferred← citeshttps://doi.org/10.1155/2017/4826724openalex-snapshot
The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus
inferred← citeshttps://doi.org/10.1155/2018/4204519openalex-snapshot
Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats
inferred← citeshttps://doi.org/10.1155/2019/6378786openalex-snapshot
Chinese Medicine FTZ Recipe Protects against High-Glucose-Induced Beta Cell Injury through Alleviating Oxidative Stress
inferred← citeshttps://doi.org/10.1172/jci.insight.86326openalex-snapshot
Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic β cells
inferred← citeshttps://doi.org/10.1177/2042018816652059openalex-snapshot
β-cell replacement sources for type 1 diabetes: a focus on pancreatic ductal cells
inferred← citeshttps://doi.org/10.1186/s12906-017-1762-8openalex-snapshot
Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin
inferred← citeshttps://doi.org/10.1186/s13619-025-00255-9openalex-snapshot
Drug-induced regeneration of pancreatic beta cells: An approach to cellular therapeutic targets
inferred← citeshttps://doi.org/10.1201/b19653-5openalex-snapshot
References
inferred← citeshttps://doi.org/10.1210/endrev/bnab010openalex-snapshot
The Human Islet: Mini-Organ With Mega-Impact
inferred← citeshttps://doi.org/10.1210/endrev/bnag014openalex-snapshot
Insulin/IGF signaling in islet biology and its therapeutic implications
inferred← citeshttps://doi.org/10.1210/er.2017-00167openalex-snapshot
The Hippo Signaling Pathway in Pancreatic β-Cells: Functions and Regulations
inferred← citeshttps://doi.org/10.1210/er.2018-00251openalex-snapshot
The Liver–α-Cell Axis and Type 2 Diabetes
inferred← citeshttps://doi.org/10.1210/me.2015-1059openalex-snapshot
DICER Inactivation Identifies Pancreatic β-Cell “Disallowed” Genes Targeted by MicroRNAs
inferred← citeshttps://doi.org/10.1210/me.2015-1085openalex-snapshot
Minireview: Directed Differentiation and Encapsulation of Islet β-Cells—Recent Advances and Future Considerations
inferred← citeshttps://doi.org/10.12677/bp.2022.122005openalex-snapshot
Multiple Factors Affecting Insulin Resistance
inferred← citeshttps://doi.org/10.12968/npre.2014.12.12.604openalex-snapshot
The pharmacology of oral antidiabetic agents
inferred← citeshttps://doi.org/10.1371/journal.pone.0105829openalex-snapshot
Antidiabetic Property of Symplocos cochinchinensis Is Mediated by Inhibition of Alpha Glucosidase and Enhanced Insulin Sensitivity
inferred← citeshttps://doi.org/10.1371/journal.pone.0128012openalex-snapshot
Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia
inferred← citeshttps://doi.org/10.1371/journal.pone.0146843openalex-snapshot
Black Ginseng Extract Counteracts Streptozotocin-Induced Diabetes in Mice
inferred← citeshttps://doi.org/10.1371/journal.pone.0150010openalex-snapshot
β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development
inferred← citeshttps://doi.org/10.1371/journal.pone.0151617openalex-snapshot
Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy
inferred← citeshttps://doi.org/10.1371/journal.pone.0157604openalex-snapshot
Phenylpropenoic Acid Glucoside from Rooibos Protects Pancreatic Beta Cells against Cell Death Induced by Acute Injury
inferred← citeshttps://doi.org/10.1371/journal.pone.0176341openalex-snapshot
Sibling method increases risk assessment estimates for type 1 diabetes
inferred← citeshttps://doi.org/10.1371/journal.pone.0237669openalex-snapshot
ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells
inferred← citeshttps://doi.org/10.14814/phy2.14479openalex-snapshot
Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions
inferred← citeshttps://doi.org/10.1507/endocrj.ej14-0525openalex-snapshot
Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes
inferred← citeshttps://doi.org/10.1515/rjdnmd-2015-0038openalex-snapshot
New Therapeutic Approaches to Prevent or Delay Beta-Cell Failure in Diabetes
inferred← citeshttps://doi.org/10.1517/17460441.2015.995759openalex-snapshot
Thoughts on the progression of type 2 diabetes drug discovery
inferred← citeshttps://doi.org/10.1523/jneurosci.0315-17.2017openalex-snapshot
Chemokine CCL2–CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus
inferred← citeshttps://doi.org/10.15252/embj.2020105242openalex-snapshot
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system
inferred← citeshttps://doi.org/10.15252/emmm.202317928openalex-snapshot
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy
inferred← citeshttps://doi.org/10.1530/endoabs.56.s24.2openalex-snapshot
Peripheral activities of growth hormone-releasing hormone (GHRH)
inferred← citeshttps://doi.org/10.1530/jme-16-0052openalex-snapshot
Transcriptome landmarks of the functional maturity of rat beta-cells, from lactation to adulthood
inferred← citeshttps://doi.org/10.1530/joe-18-0432openalex-snapshot
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
inferred← citeshttps://doi.org/10.17113/ftb.58.02.20.6308openalex-snapshot
Antidiabetic and Hypolipidaemic Action of Finger Millet ( Eleusine coracana )-Enriched Probiotic Fermented Milk
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