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Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s10517-005-0389-9openalex-snapshot
Metformin Decelerates Aging and Development of Mammary Tumors in HER-2/neu Transgenic Mice
inferredcites →https://doi.org/10.1007/s10522-007-9105-7openalex-snapshot
Pioglitazone: an anti-diabetic compound with anti-aging properties
inferredcites →https://doi.org/10.1007/s11357-011-9224-6openalex-snapshot
Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span
inferredcites →https://doi.org/10.1016/j.bbrc.2010.02.126openalex-snapshot
A critical role of SNF1A/dAMPKα (Drosophila AMP-activated protein kinase α) in muscle on longevity and stress resistance in Drosophila melanogaster
inferredcites →https://doi.org/10.1016/j.bbrc.2011.01.090openalex-snapshot
A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila
inferredcites →https://doi.org/10.1016/j.cell.2009.07.034openalex-snapshot
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
inferredcites →https://doi.org/10.1016/j.cmet.2004.12.003openalex-snapshot
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
inferredcites →https://doi.org/10.1016/j.cmet.2010.03.014openalex-snapshot
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
inferredcites →https://doi.org/10.1016/j.cmet.2010.12.010openalex-snapshot
Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis
inferredcites →https://doi.org/10.1016/j.cmet.2011.12.010openalex-snapshot
Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis
inferredcites →https://doi.org/10.1016/j.cub.2004.03.059openalex-snapshot
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
inferredcites →https://doi.org/10.1016/j.cub.2004.09.057openalex-snapshot
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
inferredcites →https://doi.org/10.1016/j.cub.2007.08.047openalex-snapshot
An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans
inferredcites →https://doi.org/10.1016/j.exger.2005.07.007openalex-snapshot
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
inferredcites →https://doi.org/10.1016/j.exger.2007.03.009openalex-snapshot
Caloric restriction in humans
inferredcites →https://doi.org/10.1016/j.mad.2004.09.026openalex-snapshot
Modelling the disposable soma theory of ageing
inferredcites →https://doi.org/10.1016/j.neulet.2006.10.039openalex-snapshot
Metformin therapy in a transgenic mouse model of Huntington's disease
inferredcites →https://doi.org/10.1016/j.physbeh.2008.04.017openalex-snapshot
Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes
inferredcites →https://doi.org/10.1038/nature05837openalex-snapshot
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
inferredcites →https://doi.org/10.1073/pnas.252625599openalex-snapshot
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
inferredcites →https://doi.org/10.1074/jbc.275.1.223openalex-snapshot
Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I
inferredcites →https://doi.org/10.1074/jbc.m110.121806openalex-snapshot
Metformin Activates AMP Kinase through Inhibition of AMP Deaminase
inferredcites →https://doi.org/10.1074/jbc.m202489200openalex-snapshot
The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways
inferredcites →https://doi.org/10.1080/11956860.1997.11682389openalex-snapshot
Starvation and desiccation tolerances inDrosophila: Comparison of species from different climatic origins
inferredcites →https://doi.org/10.1093/gerona/62.10.1071openalex-snapshot
Optimization of Dietary Restriction Protocols in Drosophila
inferredcites →https://doi.org/10.1093/gerona/glq033openalex-snapshot
Metformin Supplementation and Life Span in Fischer-344 Rats
inferredcites →https://doi.org/10.1101/gad.1255404openalex-snapshot
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
inferredcites →https://doi.org/10.1111/j.1474-9726.2007.00362.xopenalex-snapshot
Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster : not required, but its activity modulates the response
inferredcites →https://doi.org/10.1111/j.1474-9726.2008.00400.xopenalex-snapshot
Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster
inferredcites →https://doi.org/10.1111/j.1474-9726.2009.00459.xopenalex-snapshot
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
inferredcites →https://doi.org/10.1126/science.1069366openalex-snapshot
Dietary Restriction in Long-Lived Dwarf Flies
inferredcites →https://doi.org/10.1126/science.1120781openalex-snapshot
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
inferredcites →https://doi.org/10.1126/science.1172539openalex-snapshot
Extending Healthy Life Span—From Yeast to Humans
inferredcites →https://doi.org/10.1126/science.1173635openalex-snapshot
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
inferredcites →https://doi.org/10.1152/ajpendo.00272.2005openalex-snapshot
Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle
inferredcites →https://doi.org/10.1152/ajpheart.1994.267.4.h1250openalex-snapshot
Metformin decreases plasma insulin levels and systolic blood pressure in spontaneously hypertensive rats
inferredcites →https://doi.org/10.1152/physiolgenomics.00069.2005openalex-snapshot
Identification of potential caloric restriction mimetics by microarray profiling
inferredcites →https://doi.org/10.1158/1940-6207.capr-11-0228openalex-snapshot
Metformin Prevents Liver Tumorigenesis by Inhibiting Pathways Driving Hepatic Lipogenesis
inferredcites →https://doi.org/10.1159/000327151openalex-snapshot
Use of Metformin in Patients with Kidney and Cardiovascular Diseases
inferredcites →https://doi.org/10.1172/jci13505openalex-snapshot
Role of AMP-activated protein kinase in mechanism of metformin action
inferredcites →https://doi.org/10.1210/jc.81.11.4059openalex-snapshot
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus
inferredcites →https://doi.org/10.1371/journal.pone.0008758openalex-snapshot
Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
inferredcites →https://doi.org/10.1371/journal.pone.0012799openalex-snapshot
Altered Metabolism and Persistent Starvation Behaviors Caused by Reduced AMPK Function in Drosophila
inferredcites →https://doi.org/10.18632/aging.100245openalex-snapshot
Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice
inferredcites →https://doi.org/10.18632/aging.100273openalex-snapshot
If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
inferredcites →https://doi.org/10.2337/dc11-0857openalex-snapshot
Lower Risk of Cancer in Patients on Metformin in Comparison With Those on Sulfonylurea Derivatives
inferredcites →https://doi.org/10.2337/diacare.13.6.696openalex-snapshot
Cellular Mechanism of Action of Metformin
inferredcites →https://doi.org/10.3109/00498259409043220openalex-snapshot
Accumulation of metformin by tissues of the normal and diabetic mouse
inferredcites →https://doi.org/10.4161/cc.7.17.6625openalex-snapshot
Metformin slows down aging and extends life span of female SHR mice
inferredcites →https://doi.org/10.4161/cc.9.1.10407openalex-snapshot
Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Drug Synergy Slows Ageing and Improves Health Span through TGFF and SREBP Lipid Signaling
inferred← citeshttps://doi.org/10.1002/2211-5463.13338openalex-snapshot
5‐Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila
inferred← citeshttps://doi.org/10.1002/adbi.202400138openalex-snapshot
Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe
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Clinical perspectives and concerns of metformin as an anti‐aging drug
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Synthesis, Characterization, and Antidiabetic Evaluation of Sequence‐Modified Liraglutide Analogs in a Drosophila melanogaster Model
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Age‐related AMP‐activated protein kinase alterations: From cellular energetics to longevity
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Regulation of organelle function by metformin
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Coenzyme Q and Aging in the Fruit Fly Drosophila melanogaster
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The Biology of Aging: Role in Cancer, Metabolic Dysfunction, and Health Disparities
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Calorie Restriction Mimetics: Progress and Potential
inferred← citeshttps://doi.org/10.1007/978-3-319-18326-8_10openalex-snapshot
Life-Extending Effect of Phytochemicals in Drosophila
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AMPK as a Pro-longevity Target
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Anti-diabetic drug pioglitazone reduces Islet amyloid aggregation overload in the Drosophila neuronal cells
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Korean mistletoe (Viscum album coloratum) extract extends the lifespan of nematodes and fruit flies
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Metformin as a geroprotector: experimental and clinical evidence
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Toxin-induced hormesis may restrain aging
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An overview of two decades of diet restriction studies using Drosophila
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The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice
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Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?
inferred← citeshttps://doi.org/10.1007/s11357-019-00146-3openalex-snapshot
Metformin and cognition from the perspectives of sex, age, and disease
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Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment
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Testing the evidence that lifespan-extending compound interventions are conserved across laboratory animal model species
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Current Perspective in the Discovery of Anti-aging Agents from Natural Products
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Metabolic Regulation of Stem Cells in Aging
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Genetics and Pharmacology of Longevity
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Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity
inferred← citeshttps://doi.org/10.1016/j.arr.2014.11.005openalex-snapshot
Calorie restriction mimetics: Can you have your cake and eat it, too?
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Anti-aging pharmacology: Promises and pitfalls
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The road ahead for health and lifespan interventions
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Targeting metabolic pathways for extension of lifespan and healthspan across multiple species
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Neurogenesis in aging and age-related neurodegenerative diseases
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Adipose tissue and ovarian aging: Potential mechanism and protective strategies
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Compound combinations targeting longevity: Challenges and perspectives
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Mitochondrial reactive oxygen species: Do they extend or shorten animal lifespan?
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Drosophila as a model for ageing
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Deficiency of Atg6 impairs beneficial effect of metformin on intestinal stem cell aging in Drosophila
inferred← citeshttps://doi.org/10.1016/j.cbpa.2017.09.006openalex-snapshot
AMP-activated protein kinase protects against anoxia in Drosophila melanogaster
inferred← citeshttps://doi.org/10.1016/j.cbpa.2017.10.011openalex-snapshot
High amylose starch consumption induces obesity in Drosophila melanogaster and metformin partially prevents accumulation of storage lipids and shortens lifespan of the insects
inferred← citeshttps://doi.org/10.1016/j.cbpa.2018.09.027openalex-snapshot
Interplay between diet-induced obesity and oxidative stress: Comparison between Drosophila and mammals
inferred← citeshttps://doi.org/10.1016/j.cbpa.2020.110746openalex-snapshot
Mutations in genes cnc or dKeap1 modulate stress resistance and metabolic processes in Drosophila melanogaster
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Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
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Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy
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Metformin decelerates aging clock in male monkeys
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The antibiotic jinggangmycin increases brown planthopper (BPH) fecundity by enhancing rice plant sugar concentrations and BPH insulin-like signaling
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Tipping the Energy Balance toward Longevity
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AMPK at the Nexus of Energetics and Aging
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Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan
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Benefits of Metformin in Attenuating the Hallmarks of Aging
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Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila
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Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling
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High fat diet induced abnormalities in metabolism, growth, behavior, and circadian clock in Drosophila melanogaster
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Metformin inhibits age-related centrosome amplification in Drosophila midgut stem cells through AKT/TOR pathway
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Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders
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Metformin mitigates stress-induced premature senescence by upregulating AMPKα at Ser485 phosphorylation induced SIRT3 expression and inactivating mitochondrial oxidants
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A blast from the past: To tame time with metformin
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Gender-specific effects of pro-longevity interventions in Drosophila
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Nutritional signals and reproduction
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Metformin: Is it a drug for all reasons and diseases?
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Dietary infection of Enterobacter ludwigii causes fat accumulation and resulted in the diabetes-like condition in Drosophila melanogaster
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DDS promotes longevity through a microbiome-mediated starvation signal
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Effects of lifespan-extending interventions on cognitive healthspan
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Dietary restriction and the pursuit of effective mimetics
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FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment
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Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model
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Gut microbiota–generated metabolites in animal health and disease
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Metformin improves healthspan and lifespan in mice
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Tumor suppressor function of SHMT in a Drosophila RasV12DlgRNAi model: DNA damage and synergistic gene-nutrient interaction with PLP
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Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling
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The quest to slow ageing through drug discovery
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Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts
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Development of a silkworms-based evaluation system for the extracts and compounds for their obesity and lipid metabolism improving activity
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Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction
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Too old for healthy aging? Exploring age limits of longevity treatments
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First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase
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Repurposing metformin: an old drug with new tricks in its binding pockets
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Approaches for extending human healthspan: from antioxidants to healthspan pharmacology
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NHX-5, an Endosomal Na+/H+ Exchanger, Is Associated with Metformin Action
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Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu
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Convergent and divergent roles of the glucose-responsive kinase SNF4 in Candida tropicalis
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Nutrient-sensing pathways and metabolic regulation in stem cells
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Advancing Longevity: Exploring Antiaging Pharmaceuticals in Contemporary Clinical Trials Amid Aging Dynamics
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Cell death in Ustilago maydis: comparison with other fungi and the effect of metformin and curcumin on its chronological lifespan
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Metformin extends the chronological lifespan of fission yeast by altering energy metabolism and stress resistance capacity
inferred← citeshttps://doi.org/10.1093/jee/toaa295openalex-snapshot
Combined Effects of Methoprene and Metformin on Reproduction, Longevity, and Stress Resistance inAnastrepha ludens(Diptera: Tephritidae): Implications for the Sterile Insect Technique
inferred← citeshttps://doi.org/10.1096/fj.201800634ropenalex-snapshot
Carnitine acetyltransferase (Crat) in hunger‐sensing AgRP neurons permits adaptation to calorie restriction
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The Endosomal pH Regulator NHE6 is Required for Insulin-Stimulated Glucose Uptake in Adipocytes
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Metabolic slowdown as the proximal cause of ageing and death
inferred← citeshttps://doi.org/10.1101/cshperspect.a025932openalex-snapshot
Metformin: A Hopeful Promise in Aging Research
inferred← citeshttps://doi.org/10.1111/acel.12463openalex-snapshot
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic
inferred← citeshttps://doi.org/10.1111/acel.12689openalex-snapshot
TOR ‐mediated regulation of metabolism in aging
inferred← citeshttps://doi.org/10.1111/acel.13488openalex-snapshot
Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes
inferred← citeshttps://doi.org/10.1111/acel.14208openalex-snapshot
Translatability of life‐extending pharmacological treatments between different species
inferred← citeshttps://doi.org/10.1111/acel.70113openalex-snapshot
Metformin and Dietary Restriction Counteract Aging via Reducing m6A –Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)
inferred← citeshttps://doi.org/10.1111/acel.70721openalex-snapshot
Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies
inferred← citeshttps://doi.org/10.1111/cmi.12234openalex-snapshot
Commensals, probiotics and pathogens in the C aenorhabditis elegans model
inferred← citeshttps://doi.org/10.1111/nyas.13032openalex-snapshot
From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span
inferred← citeshttps://doi.org/10.1113/jp270543openalex-snapshot
Calorie restriction as an intervention in ageing
inferred← citeshttps://doi.org/10.1117/12.3042659openalex-snapshot
Multimodal imaging of subcellular metabolic dynamics reveals the anti-aging effect of metformin
inferred← citeshttps://doi.org/10.1128/mcb.00562-16openalex-snapshot
Caloric Restriction Extends Yeast Chronological Life Span by Optimizing the Snf1 (AMPK) Signaling Pathway
inferred← citeshttps://doi.org/10.1155/2018/2640342openalex-snapshot
mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?
inferred← citeshttps://doi.org/10.1155/2022/4201533openalex-snapshot
Pharmacological Approaches to Decelerate Aging: A Promising Path
inferred← citeshttps://doi.org/10.1186/s12889-023-15764-yopenalex-snapshot
Comparison of long-term effects of metformin on longevity between people with type 2 diabetes and matched non-diabetic controls
inferred← citeshttps://doi.org/10.1186/s12906-016-1265-zopenalex-snapshot
KBH-1, an herbal composition, improves hepatic steatosis and leptin resistance in high-fat diet-induced obese rats
inferred← citeshttps://doi.org/10.1242/dmm.012989openalex-snapshot
Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases
inferred← citeshttps://doi.org/10.1242/dmm.049627openalex-snapshot
Molecular inhibition of RAS signalling to target ageing and age-related health
inferred← citeshttps://doi.org/10.12688/f1000research.7821.1openalex-snapshot
Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules
inferred← citeshttps://doi.org/10.13005/bpj/2977openalex-snapshot
Effect of Metformin on Interleukin-6 Expression in Human Fibroblast Cell Aging Model
inferred← citeshttps://doi.org/10.1364/translational.2024.ts3b.3openalex-snapshot
Multimodal Subcellular Imaging of Lipid Metabolism Delineates Anti-Aging Effects of Metformin in Drosophila
inferred← citeshttps://doi.org/10.1371/journal.pbio.1002131openalex-snapshot
Why Is Aging Conserved and What Can We Do about It?
inferred← citeshttps://doi.org/10.1371/journal.pgen.1004109openalex-snapshot
DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1371/journal.pone.0061922openalex-snapshot
Anti-Hyperlipidemic Effects and Potential Mechanisms of Action of the Caffeoylquinic Acid-Rich Pandanus tectorius Fruit Extract in Hamsters Fed a High Fat-Diet
inferred← citeshttps://doi.org/10.1371/journal.pone.0063886openalex-snapshot
Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction
inferred← citeshttps://doi.org/10.1371/journal.pone.0108635openalex-snapshot
Diet Modification and Metformin Have a Beneficial Effect in a Fly Model of Obesity and Mucormycosis
inferred← citeshttps://doi.org/10.1371/journal.pone.0132720openalex-snapshot
Wedelolactone Regulates Lipid Metabolism and Improves Hepatic Steatosis Partly by AMPK Activation and Up-Regulation of Expression of PPARα/LPL and LDLR
inferred← citeshttps://doi.org/10.1371/journal.pone.0326100openalex-snapshot
Metformin modulates the unfolded protein responses, altering lifespan and health-promoting effects in UPR-activated worms
inferred← citeshttps://doi.org/10.1371/journal.pone.0346347openalex-snapshot
REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect
inferred← citeshttps://doi.org/10.1371/journal.pone.0359638openalex-snapshot
Metformin modulates survival, oxidative stress, and gene expression in a high-sucrose Drosophila diabetes model
inferred← citeshttps://doi.org/10.14336/ad.2016.1022openalex-snapshot
Geroprotectors: A Unified Concept and Screening Approaches
inferred← citeshttps://doi.org/10.14336/ad.2020.0702openalex-snapshot
Metformin: A Potential Candidate for Targeting Aging Mechanisms
inferred← citeshttps://doi.org/10.14336/ad.2021.1213openalex-snapshot
Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease
inferred← citeshttps://doi.org/10.14336/ad.2022.1116openalex-snapshot
Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity
inferred← citeshttps://doi.org/10.14336/ad.2023.0122openalex-snapshot
Probiotic Limosilactobacillus Reuteri (Lactobacillus Reuteri) Extends the Lifespan of Drosophila Melanogaster through Insulin/IGF-1 Signaling
inferred← citeshttps://doi.org/10.14341/dm13044openalex-snapshot
Metformin as an activator of AMP-activated protein kinase. Known and new mechanisms of action
inferred← citeshttps://doi.org/10.14348/molcells.2021.2245openalex-snapshot
Cucurbitacin B Suppresses Hyperglycemia Associated with a High Sugar Diet and Promotes Sleep in Drosophila melanogaster
inferred← citeshttps://doi.org/10.14393/ufu.te.2019.2193openalex-snapshot
Teste de drogas do metabolismo em modelo transgênico de Drosophila melanogaster para doença de Alzheimer
inferred← citeshttps://doi.org/10.1530/rep-15-0595openalex-snapshot
Modeling dietary influences on offspring metabolic programming in Drosophila melanogaster
inferred← citeshttps://doi.org/10.15330/jpnu.2.1.100-106openalex-snapshot
Influence of Amylose Starch on Development and Lifespan of Fruit Fly Drosophila Melanogaster
inferred← citeshttps://doi.org/10.1534/genetics.118.300224openalex-snapshot
Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
inferred← citeshttps://doi.org/10.17179/excli2023-6300openalex-snapshot
Relating aging and autophagy – a new perspective towards the welfare of human health
inferred← citeshttps://doi.org/10.18632/aging.100523openalex-snapshot
One-carbon metabolism: An aging-cancer crossroad for the gerosuppressant metformin
inferred← citeshttps://doi.org/10.18632/aging.100593openalex-snapshot
Berberine suppresses gero-conversion from cell cycle arrest to senescence
inferred← citeshttps://doi.org/10.18632/aging.101319openalex-snapshot
Towards natural mimetics of metformin and rapamycin
inferred← citeshttps://doi.org/10.18632/aging.101746openalex-snapshot
Metformin prolongs lifespan through remodeling the energy distribution strategy in silkworm, Bombyx mori
inferred← citeshttps://doi.org/10.18632/aging.102016openalex-snapshot
Metformin prevents murine ovarian aging
inferred← citeshttps://doi.org/10.18632/aging.204498openalex-snapshot
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
inferred← citeshttps://doi.org/10.1891/0198-8794.34.1openalex-snapshot
Longevity Pathways in Mammalian Stem Cells
inferred← citeshttps://doi.org/10.2147/cia.s126458openalex-snapshot
Does eating less make you live longer and better? An update on calorie restriction
inferred← citeshttps://doi.org/10.2147/dddt.s141675openalex-snapshot
Metformin: a review of its potential indications
inferred← citeshttps://doi.org/10.2174/1381612826666200716161610openalex-snapshot
Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective
inferred← citeshttps://doi.org/10.21857/9e31lhnddmopenalex-snapshot
Aging, Calorie Restriction and Calorie Restriction Mimetics
inferred← citeshttps://doi.org/10.22541/au.159372989.91282630openalex-snapshot
Mechanisms under Metformin and Rapamycin as Anti-aging Drugs
inferred← citeshttps://doi.org/10.3233/nha-160007openalex-snapshot
Targeting glucose metabolism for healthy aging
inferred← citeshttps://doi.org/10.3389/fcell.2019.00140openalex-snapshot
On the Fly: Recent Progress on Autophagy and Aging in Drosophila
inferred← citeshttps://doi.org/10.3389/fcell.2021.628157openalex-snapshot
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies
inferred← citeshttps://doi.org/10.3389/fgene.2016.00142openalex-snapshot
Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan
inferred← citeshttps://doi.org/10.3389/fnins.2015.00235openalex-snapshot
AMPK: a master energy regulator for gonadal function
inferred← citeshttps://doi.org/10.3389/fphar.2022.865524openalex-snapshot
The Function of Metformin in Aging-Related Musculoskeletal Disorders
inferred← citeshttps://doi.org/10.3389/fphar.2024.1373458openalex-snapshot
Repurposing effect of cardiovascular-metabolic drug to increase lifespan: a systematic review of animal studies and current clinical trial progress
inferred← citeshttps://doi.org/10.3389/fragi.2024.1452453openalex-snapshot
The genetic advantage of healthy centenarians: unraveling the central role of NLRP3 in exceptional healthspan
inferred← citeshttps://doi.org/10.3390/biom13060912openalex-snapshot
The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective
inferred← citeshttps://doi.org/10.3390/cells12222650openalex-snapshot
Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling
inferred← citeshttps://doi.org/10.3390/cells9010100openalex-snapshot
Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction
inferred← citeshttps://doi.org/10.3390/genes12010119openalex-snapshot
Overexpression of Activated AMPK in the Anopheles stephensi Midgut Impacts Mosquito Metabolism, Reproduction and Plasmodium Resistance
inferred← citeshttps://doi.org/10.3390/ijms19123810openalex-snapshot
Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
inferred← citeshttps://doi.org/10.3390/ijms23010398openalex-snapshot
Metformin Repurposing for Parkinson Disease Therapy: Opportunities and Challenges
inferred← citeshttps://doi.org/10.3390/ijms25179705openalex-snapshot
The Role of Molecular and Cellular Aging Pathways on Age-Related Hearing Loss
inferred← citeshttps://doi.org/10.3390/nu10121821openalex-snapshot
Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism
inferred← citeshttps://doi.org/10.3390/nu11123068openalex-snapshot
Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction
inferred← citeshttps://doi.org/10.3390/nu12020422openalex-snapshot
Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept
inferred← citeshttps://doi.org/10.3390/nu12051529openalex-snapshot
Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology
inferred← citeshttps://doi.org/10.3390/nu16040493openalex-snapshot
Effects of Clostridium tyrobutyricum on Lipid Metabolism, Intestinal Barrier Function, and Gut Microbiota in Obese Mice Induced by High-Fat Diet
inferred← citeshttps://doi.org/10.3410/f.718049635.793481277openalex-snapshot
Faculty Opinions recommendation of Metformin improves healthspan and lifespan in mice.
inferred← citeshttps://doi.org/10.3410/f.736512366.793566892openalex-snapshot
Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
inferred← citeshttps://doi.org/10.3410/f.736512366.793568917openalex-snapshot
Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
inferred← citeshttps://doi.org/10.3410/f.736512366.793573403openalex-snapshot
Faculty Opinions recommendation of Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
inferred← citeshttps://doi.org/10.4161/cc.26928openalex-snapshot
Metformin: Do we finally have an anti-aging drug?
inferred← citeshttps://doi.org/10.5281/zenodo.200158openalex-snapshot
FIGURE 7 in Two new species of the spider genus Cataleptoneta from Balkan Peninsula (Araneae, Leptonetidae)
inferred← citeshttps://doi.org/10.5483/bmbrep.2013.46.4.033openalex-snapshot
Caloric restriction and its mimetics
inferred← citeshttps://doi.org/10.5772/intechopen.89431openalex-snapshot
Metformin Modulates the Mechanisms of Ageing
inferred← citeshttps://doi.org/10.59368/agingbio.20240034openalex-snapshot
Pharmacology of Aging: Drosophila as a Tool to Validate Drug Targets for Healthy Lifespan
inferred← citeshttps://doi.org/10.70675/55881bfbza629z4e0ez86b6z6709f5af7619openalex-snapshot
Caractérisation fonctionnelle de jouvence, un petit ARN nucléolaire requis dans l’épithélium de l’intestin chez la drosophile
inferred← citeshttps://doi.org/10.70675/ea0d9b85zd8b9z4fedzae80z738885fb5ca4openalex-snapshot
Natural variations in yeast aging reveal genetic and environmental factors
inferred← citeshttps://doi.org/10.7554/elife.111611openalex-snapshot
Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life
inferred← citeshttps://doi.org/10.7554/elife.111611.1openalex-snapshot
Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life
inferred← citeshttps://doi.org/10.7554/elife.111611.2openalex-snapshot
Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life
inferred← citeshttps://doi.org/10.7554/elife.111611.3openalex-snapshot
Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life
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