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Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Timing of New Black Box Warnings and Withdrawals for Prescription Medications
inferredcites →https://doi.org/10.1002/hep.22674openalex-snapshot
Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function #
inferredcites →https://doi.org/10.1002/hep.24760openalex-snapshot
Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing
inferredcites →https://doi.org/10.1002/hep.26414openalex-snapshot
Proteome-Wide Analyses of Human Hepatocytes During Differentiation and Dedifferentiation
inferredcites →https://doi.org/10.1006/bbrc.2000.3219openalex-snapshot
Interleukin-6 Negatively Regulates the Expression of Pregnane X Receptor and Constitutively Activated Receptor in Primary Human Hepatocytes
inferredcites →https://doi.org/10.1006/excr.2001.5467openalex-snapshot
Structural Polarity and Functional Bile Canaliculi in Rat Hepatocyte Spheroids
inferredcites →https://doi.org/10.1006/taap.1997.8315openalex-snapshot
Antioxidant and Cytoprotective Properties ofd-Tagatose in Cultured Murine Hepatocytes
inferredcites →https://doi.org/10.1007/10_029openalex-snapshot
Integration of Technologies for Hepatic Tissue Engineering
inferredcites →https://doi.org/10.1007/bf03188857openalex-snapshot
Influence of rifampicin on the toxicity and the analgesic effect of acetaminophen
inferredcites →https://doi.org/10.1007/s00204-012-0968-2openalex-snapshot
Multi-cell type human liver microtissues for hepatotoxicity testing
inferredcites →https://doi.org/10.1007/s00204-013-1080-yopenalex-snapshot
Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity
inferredcites →https://doi.org/10.1007/s00204-017-2002-1openalex-snapshot
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
inferredcites →https://doi.org/10.1007/s002800050893openalex-snapshot
Fractionated administration of high-dose cyclophosphamide: influence on dose-dependent changes in pharmacokinetics and metabolism
inferredcites →https://doi.org/10.1016/j.biomaterials.2007.08.033openalex-snapshot
Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system
inferredcites →https://doi.org/10.1016/j.mcna.2008.03.005openalex-snapshot
Acute Liver Failure Including Acetaminophen Overdose
inferredcites →https://doi.org/10.1016/j.taap.2006.05.015openalex-snapshot
Energy metabolism and biotransformation as endpoints to pre-screen hepatotoxicity using a liver spheroid model
inferredcites →https://doi.org/10.1016/j.tig.2012.07.003openalex-snapshot
Coordinating genome expression with cell size
inferredcites →https://doi.org/10.1016/s0003-9861(03)00174-7openalex-snapshot
Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues
inferredcites →https://doi.org/10.1016/s0022-3549(15)00192-6openalex-snapshot
Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity
inferredcites →https://doi.org/10.1016/s0022-3565(25)38197-8openalex-snapshot
Dosing rate-dependent relationship between propranolol plasma concentration and beta-blockade.
inferredcites →https://doi.org/10.1016/s0026-895x(24)12255-9openalex-snapshot
Cholestatic Potential of Troglitazone as a Possible Factor Contributing to Troglitazone-Induced Hepatotoxicity: In Vivo and in Vitro Interaction at the Canalicular Bile Salt Export Pump (Bsep) in the Rat
inferredcites →https://doi.org/10.1021/acs.chemrestox.6b00150openalex-snapshot
Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates
inferredcites →https://doi.org/10.1038/nbt1361openalex-snapshot
Microscale culture of human liver cells for drug development
inferredcites →https://doi.org/10.1038/nprot.2008.73openalex-snapshot
Analyzing real-time PCR data by the comparative CT method
inferredcites →https://doi.org/10.1038/nrd1329openalex-snapshot
First dose of potential new medicines to humans: how animals help
inferredcites →https://doi.org/10.1038/nrgastro.2017.38openalex-snapshot
Mechanisms of hepatic stellate cell activation
inferredcites →https://doi.org/10.1038/s41575-018-0020-yopenalex-snapshot
Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity
inferredcites →https://doi.org/10.1038/srep17455openalex-snapshot
Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model
inferredcites →https://doi.org/10.1038/srep21373openalex-snapshot
Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction
inferredcites →https://doi.org/10.1038/srep25187openalex-snapshot
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
inferredcites →https://doi.org/10.1053/gast.1996.v110.pm8613007openalex-snapshot
Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells
inferredcites →https://doi.org/10.1055/s-0034-1375960openalex-snapshot
Drug-Induced Hepatic Steatosis
inferredcites →https://doi.org/10.1055/s-2001-17550openalex-snapshot
History, Heterogeneity, Developmental Biology, and Functions of Quiescent Hepatic Stellate Cells
inferredcites →https://doi.org/10.1080/00498250210128675openalex-snapshot
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells
inferredcites →https://doi.org/10.1080/01480545.2016.1255953openalex-snapshot
Acetaminophen toxicity in rat and mouse hepatocytesin vitro
inferredcites →https://doi.org/10.1083/jcb.101.3.914openalex-snapshot
Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities.
inferredcites →https://doi.org/10.1083/jcb.43.3.506openalex-snapshot
HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS
inferredcites →https://doi.org/10.1089/aivt.2016.0016openalex-snapshot
Hepatic Spheroids for Long-Term Toxicity Studies
inferredcites →https://doi.org/10.1093/jac/dkl224openalex-snapshot
Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines
inferredcites →https://doi.org/10.1093/toxsci/kfn109openalex-snapshot
Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury
inferredcites →https://doi.org/10.1093/toxsci/kfv136openalex-snapshot
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
inferredcites →https://doi.org/10.1111/j.1440-169x.2007.00918.xopenalex-snapshot
Growth potential of adult hepatocytes in mammals: Highly replicative small hepatocytes with liver progenitor‐like traits
inferredcites →https://doi.org/10.1111/j.1478-3231.2006.01342.xopenalex-snapshot
Role of Kupffer cells in host defense and liver disease
inferredcites →https://doi.org/10.1124/dmd.114.061317openalex-snapshot
Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters
inferredcites →https://doi.org/10.1124/dmd.116.071456openalex-snapshot
Modeling Therapeutic Antibody–Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform
inferredcites →https://doi.org/10.1124/mol.109.062364openalex-snapshot
Hepatic Clearance of Reactive Glucuronide Metabolites of Diclofenac in the Mouse Is Dependent on Multiple ATP-Binding Cassette Efflux Transporters
inferredcites →https://doi.org/10.1124/mol.54.2.273openalex-snapshot
Down-Regulation of Cytochrome P450 mRNAs and Proteins in Mice Lacking a Functional NOS2 Gene
inferredcites →https://doi.org/10.1146/annurev-pharmtox-010617-052722openalex-snapshot
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery
inferredcites →https://doi.org/10.1159/000272316openalex-snapshot
Comparative Analysis of Gene Expression in Rat Liver Tissue and Monolayer- and Spheroid-Cultured Hepatocytes
inferredcites →https://doi.org/10.1177/00912700122010582openalex-snapshot
Pharmacokinetics of Buspirone Extended‐Release Tablets: A Single‐Dose Study
inferredcites →https://doi.org/10.1208/s12248-008-9027-6openalex-snapshot
In Vitro Studies are Sometimes Better than Conventional Human Pharmacokinetic In Vivo Studies in Assessing Bioequivalence of Immediate-Release Solid Oral Dosage Forms
inferredcites →https://doi.org/10.1248/bpb.35.473openalex-snapshot
Effect of Lipopolysaccharide on the Xenobiotic-Induced Expression and Activity of Hepatic Cytochrome P450 in Mice
inferredcites →https://doi.org/10.1358/mf.2003.25.7.778092openalex-snapshot
Bioavailability of two new formulations of paracetamol, compared with three marketed formulations, in healthy volunteers
inferredcites →https://doi.org/10.1517/17425250903160664openalex-snapshot
Liver tissue engineering in the evaluation of drug safety
inferredcites →https://doi.org/10.1517/17425255.2.6.875openalex-snapshot
Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction
inferredcites →https://doi.org/10.1517/17425255.2014.967680openalex-snapshot
Competency of different cell models to predict human hepatotoxic drugs
inferredcites →https://doi.org/10.2147/ijn.s133034openalex-snapshot
Liposomal formulation of a methotrexate lipophilic prodrug: assessment in tumor cells and mouse T-cell leukemic lymphoma
inferredcites →https://doi.org/10.2165/00003088-200038020-00002openalex-snapshot
Effects of the Antifungal Agents on Oxidative Drug Metabolism
inferredcites →https://doi.org/10.2174/138920006778017759openalex-snapshot
Molecular Mechanisms Underlying the Dedifferentiation Process of Isolated Hepatocytes and Their Cultures
inferredcites →https://doi.org/10.2174/1389200219666180523095355openalex-snapshot
Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives
inferredcites →https://doi.org/10.2174/1874143600701010030openalex-snapshot
Cyclophosphamide Pharmacokinetics in Mice: A Comparison Between Retro Orbital Sampling Versus Serial Tail Vein Bleeding
inferredcites →https://doi.org/10.3109/03602530903491881openalex-snapshot
Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity
inferredcites →https://doi.org/10.4103/0975-7406.124301openalex-snapshot
Use of rodents as models of human diseases
inferredcites →https://doi.org/10.4172/2157-7552.1000130openalex-snapshot
Characterization of a Rat Multi-Cell Type 3D-Liver Microtissue System
inferredcites →https://doi.org/10.7326/0003-4819-98-5-690_3openalex-snapshot
The Liver: Biology and Pathobiology.
inferredcites →https://doi.org/10.7554/elife.11214openalex-snapshot
A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/jat.4538openalex-snapshot
Investigation of TGF‐α‐overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates
inferred← citeshttps://doi.org/10.1007/978-3-031-82076-2_2openalex-snapshot
3D MicroOrganoSpheres Formation of Hepatocellular Carcinoma on Chip as a Novel in Vitro Model for Physiological and Therapeutic Studies
inferred← citeshttps://doi.org/10.1016/j.actbio.2021.11.027openalex-snapshot
Constructing Vascularized Hepatic Tissue by Cell Assembled Viscous Tissue Sedimentation Method and Its Application for Vascular Toxicity Assessment
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121817openalex-snapshot
Modelling fatty liver disease with mouse liver-derived multicellular spheroids
inferred← citeshttps://doi.org/10.1016/j.fshw.2021.02.030openalex-snapshot
Moringa oleifera Lam. leaf extract mitigates carbon tetrachloride-mediated hepatic inflammation and apoptosis via targeting oxidative stress and toll-like receptor 4/nuclear factor kappa B pathway in mice
inferred← citeshttps://doi.org/10.1016/j.jpha.2023.04.007openalex-snapshot
Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids
inferred← citeshttps://doi.org/10.1016/j.tiv.2020.105010openalex-snapshot
Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury
inferred← citeshttps://doi.org/10.1039/d2ma00144fopenalex-snapshot
Engineered liver tissue in vitro to mimic liver functions and its biomedical applications
inferred← citeshttps://doi.org/10.1039/d3ay01267kopenalex-snapshot
Recent developments and applications of ambient mass spectrometry imaging in pharmaceutical research: an overview
inferred← citeshttps://doi.org/10.1093/mutage/geac009openalex-snapshot
A novel in vitro 3D model of the human bone marrow to bridge the gap between in vitro and in vivo genotoxicity testing
inferred← citeshttps://doi.org/10.1093/toxsci/kfad101openalex-snapshot
A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment
inferred← citeshttps://doi.org/10.1111/cts.13132openalex-snapshot
Microphysiological systems in absorption, distribution, metabolism, and elimination sciences
inferred← citeshttps://doi.org/10.3389/fcell.2021.626805openalex-snapshot
A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1721974openalex-snapshot
Mechanistic investigation into the differences in growth performance and resistance to spring viremia of carp virus in common carp
inferred← citeshttps://doi.org/10.3390/cimb47010007openalex-snapshot
Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects
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