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Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency

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Outgoing claims: the papers this work cites, builds on, or argues with.

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The Exonuclease Activity of HSV-1 UL12 Is Required forin VivoFunction
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Prospects of a novel vaccination strategy for human gamma-herpesviruses
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A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity
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A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription
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Conserved Herpesviral Kinase Promotes Viral Persistence by Inhibiting the IRF-3-Mediated Type I Interferon Response
inferredcites →https://doi.org/10.1016/j.chom.2010.05.005openalex-snapshot
Redefining the Genetics of Murine Gammaherpesvirus 68 via Transcriptome-Based Annotation
inferredcites →https://doi.org/10.1016/j.chom.2010.06.014openalex-snapshot
Viral Latency and Its Regulation: Lessons from the γ-Herpesviruses
inferredcites →https://doi.org/10.1016/j.jmb.2009.06.034openalex-snapshot
A Bridge Crosses the Active-Site Canyon of the Epstein–Barr Virus Nuclease with DNase and RNase Activities
inferredcites →https://doi.org/10.1016/j.virol.2010.05.027openalex-snapshot
Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo
inferredcites →https://doi.org/10.1016/s0021-9258(18)69588-2openalex-snapshot
Poliovirus Protein: Source of Amino Acids and Time Course of Synthesis
inferredcites →https://doi.org/10.1016/s0264-410x(97)00164-3openalex-snapshot
Protection from primary infection and establishment of latency by vaccination with a herpes simplex virus type 1 recombinant deficient in the virion host shutoff (vhs) function
inferredcites →https://doi.org/10.1016/s1097-2765(04)00091-7openalex-snapshot
Lytic KSHV Infection Inhibits Host Gene Expression by Accelerating Global mRNA Turnover
inferredcites →https://doi.org/10.1016/s1369-5274(00)00106-5openalex-snapshot
Regulation of host cell translation by viruses and effects on cell function
inferredcites →https://doi.org/10.1073/pnas.0603144103openalex-snapshot
Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation
inferredcites →https://doi.org/10.1073/pnas.0611128104openalex-snapshot
Host shutoff during productive Epstein–Barr virus infection is mediated by BGLF5 and may contribute to immune evasion
inferredcites →https://doi.org/10.1073/pnas.0905316106openalex-snapshot
Toll-like receptor signaling controls reactivation of KSHV from latency
inferredcites →https://doi.org/10.1084/jem.20071135openalex-snapshot
A gammaherpesvirus-secreted activator of Vβ4+ CD8+ T cells regulates chronic infection and immunopathology
inferredcites →https://doi.org/10.1089/088282404322875467openalex-snapshot
Mouse Strain Differences in the Chemokine Response to Acute Lung Infection with a Murine Gammaherpesvirus
inferredcites →https://doi.org/10.1089/vim.2005.18.445openalex-snapshot
Immune Mechanisms in Murine Gammaherpesvirus-68 Infection
inferredcites →https://doi.org/10.1093/nar/gkr111openalex-snapshot
Crystal structure of a KSHV–SOX–DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff
inferredcites →https://doi.org/10.1093/nar/gkr1111openalex-snapshot
Modulation of CRISPR locus transcription by the repeat-binding protein Cbp1 in Sulfolobus
inferredcites →https://doi.org/10.1099/0022-1317-3-3-337openalex-snapshot
A New DNA-exonuclease in Cells Infected with Herpes Virus: Partial Purification and Properties of the Enzyme
inferredcites →https://doi.org/10.1099/0022-1317-73-12-3275openalex-snapshot
Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo
inferredcites →https://doi.org/10.1099/0022-1317-73-9-2347openalex-snapshot
Virological and pathological features of mice infected with murine gammaherpesvirus 68
inferredcites →https://doi.org/10.1099/0022-1317-78-11-2953openalex-snapshot
The human cytomegalovirus UL98 gene encodes the conserved herpesvirus alkaline nuclease.
inferredcites →https://doi.org/10.1099/vir.0.006569-0openalex-snapshot
In vivo imaging of murid herpesvirus-4 infection
inferredcites →https://doi.org/10.1099/vir.0.18639-0openalex-snapshot
Transcriptome profile of murine gammaherpesvirus-68 lytic infection
inferredcites →https://doi.org/10.1099/vir.0.19599-0openalex-snapshot
Forced lytic replication impairs host colonization by a latency-deficient mutant of murine gammaherpesvirus-68
inferredcites →https://doi.org/10.1111/j.1742-4658.2009.07374.xopenalex-snapshot
Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi’s sarcoma‐associated herpesvirus
inferredcites →https://doi.org/10.1128/jvi.00133-10openalex-snapshot
Murine Gammaherpesvirus 68 LANA Is Essential for Virus Reactivation from Splenocytes but Not Long-Term Carriage of Viral Genome
inferredcites →https://doi.org/10.1128/jvi.00170-09openalex-snapshot
The Epstein-Barr Virus Alkaline Exonuclease BGLF5 Serves Pleiotropic Functions in Virus Replication
inferredcites →https://doi.org/10.1128/jvi.00297-09openalex-snapshot
Identification of Infected B-Cell Populations by Using a Recombinant Murine Gammaherpesvirus 68 Expressing a Fluorescent Protein
inferredcites →https://doi.org/10.1128/jvi.00702-07openalex-snapshot
Severe Acute Respiratory Syndrome Coronavirus Evades Antiviral Signaling: Role of nsp1 and Rational Design of an Attenuated Strain
inferredcites →https://doi.org/10.1128/jvi.01051-09openalex-snapshot
Host Shutoff Is a Conserved Phenotype of Gammaherpesvirus Infection and Is Orchestrated Exclusively from the Cytoplasm
inferredcites →https://doi.org/10.1128/jvi.01152-08openalex-snapshot
Persistent Gammaherpesvirus Replication and Dynamic Interaction with the Host In Vivo
inferredcites →https://doi.org/10.1128/jvi.01400-09openalex-snapshot
Toll-Like Receptor Agonists Synergistically Increase Proliferation and Activation of B Cells by Epstein-Barr Virus
inferredcites →https://doi.org/10.1128/jvi.01946-07openalex-snapshot
The DNase of Gammaherpesviruses Impairs Recognition by Virus-Specific CD8+T Cells through an Additional Host Shutoff Function
inferredcites →https://doi.org/10.1128/jvi.02047-07openalex-snapshot
Herpes Simplex Virus Virion Host Shutoff Attenuates Establishment of the Antiviral State
inferredcites →https://doi.org/10.1128/jvi.02409-07openalex-snapshot
Selective Ablation of Virion Host Shutoff Protein RNase Activity Attenuates Herpes Simplex Virus 2 in Mice
inferredcites →https://doi.org/10.1128/jvi.62.3.912-921.1988openalex-snapshot
Herpes simplex virus virion host shutoff function
inferredcites →https://doi.org/10.1128/jvi.63.11.4834-4839.1989openalex-snapshot
The herpes simplex virus virion host shutoff function
inferredcites →https://doi.org/10.1128/jvi.69.11.6779-6786.1995openalex-snapshot
Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis
inferredcites →https://doi.org/10.1128/jvi.70.4.2075-2085.1996openalex-snapshot
Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates
inferredcites →https://doi.org/10.1128/jvi.71.8.5894-5904.1997openalex-snapshot
Complete sequence and genomic analysis of murine gammaherpesvirus 68
inferredcites →https://doi.org/10.1128/jvi.73.4.3273-3283.1999openalex-snapshot
Macrophages Are the Major Reservoir of Latent Murine Gammaherpesvirus 68 in Peritoneal Cells
inferredcites →https://doi.org/10.1128/jvi.73.8.6405-6414.1999openalex-snapshot
Construction and Transposon Mutagenesis in Escherichia coli of a Full-Length Infectious Clone of Pseudorabies Virus, an Alphaherpesvirus
inferredcites →https://doi.org/10.1128/jvi.74.15.6964-6974.2000openalex-snapshot
Cloning and Mutagenesis of the Murine Gammaherpesvirus 68 Genome as an Infectious Bacterial Artificial Chromosome
inferredcites →https://doi.org/10.1128/jvi.74.16.7451-7461.2000openalex-snapshot
The Murine Gammaherpesvirus 68 v-Cyclin Is a Critical Regulator of Reactivation from Latency
inferredcites →https://doi.org/10.1128/jvi.74.22.10401-10406.2000openalex-snapshot
Toward a Comprehensive Phylogeny for Mammalian and Avian Herpesviruses
inferredcites →https://doi.org/10.1128/jvi.77.13.7308-7318.2003openalex-snapshot
Selective Gene Expression of Latent Murine Gammaherpesvirus 68 in B Lymphocytes
inferredcites →https://doi.org/10.1128/jvi.77.17.9337-9345.2003openalex-snapshot
Herpes Simplex Virus Type 2 Virion Host Shutoff Protein Regulates Alpha/Beta Interferon but Not Adaptive Immune Responses during Primary Infection In Vivo
inferredcites →https://doi.org/10.1128/jvi.77.17.9700-9709.2003openalex-snapshot
Murid Herpesvirus 4 Strain 68 M2 Protein Is a B-Cell-Associated Antigen Important for Latency but Not Lymphocytosis
inferredcites →https://doi.org/10.1128/jvi.77.19.10295-10303.2003openalex-snapshot
The Gammaherpesvirus 68 Latency-Associated Nuclear Antigen Homolog Is Critical for the Establishment of Splenic Latency
inferredcites →https://doi.org/10.1128/jvi.77.19.10488-10503.2003openalex-snapshot
Transcription Program of Murine Gammaherpesvirus 68
inferredcites →https://doi.org/10.1128/jvi.77.6.3768-3776.2003openalex-snapshot
Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs−HSV Vectors for Dendritic Cell-Mediated Immunotherapy
inferredcites →https://doi.org/10.1128/jvi.78.17.9215-9223.2004openalex-snapshot
Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary Infection
inferredcites →https://doi.org/10.1128/jvi.78.19.10282-10290.2004openalex-snapshot
Identification of Candidate Gammaherpesvirus 68 Genes Required for Virus Replication by Signature-Tagged Transposon Mutagenesis
inferredcites →https://doi.org/10.1128/jvi.79.12.7396-7401.2005openalex-snapshot
The Exonuclease and Host Shutoff Functions of the SOX Protein of Kaposi's Sarcoma-Associated Herpesvirus Are Genetically Separable
inferredcites →https://doi.org/10.1128/jvi.79.4.2261-2273.2005openalex-snapshot
The Murine Gammaherpesvirus 68 M2 Gene Is Required for Efficient Reactivation from Latently Infected B Cells
inferredcites →https://doi.org/10.1128/jvi.79.8.5227-5231.2005openalex-snapshot
Ex Vivo Stimulation of B Cells Latently Infected with Gammaherpesvirus 68 Triggers Reactivation from Latency
inferredcites →https://doi.org/10.1128/mcb.00600-10openalex-snapshot
Nuclear Import of Cytoplasmic Poly(A) Binding Protein Restricts Gene Expression via Hyperadenylation and Nuclear Retention of mRNA
inferredcites →https://doi.org/10.1128/mcb.4.10.2198openalex-snapshot
Metabolism and Expression of RNA Polymerase II Transcripts in Influenza Virus-Infected Cells
inferredcites →https://doi.org/10.1146/annurev-immunol-072710-081639openalex-snapshot
Pathogenesis and Host Control of Gammaherpesviruses: Lessons from the Mouse
inferredcites →https://doi.org/10.1186/gb-2009-10-8-234openalex-snapshot
Virus-mediated mRNA decay by hyperadenylation
inferredcites →https://doi.org/10.1371/journal.pbio.1000107openalex-snapshot
Aberrant Herpesvirus-Induced Polyadenylation Correlates With Cellular Messenger RNA Destruction
inferredcites →https://doi.org/10.1371/journal.pone.0000560openalex-snapshot
IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68
inferredcites →https://doi.org/10.4049/jimmunol.0903120openalex-snapshot
EBV Lytic-Phase Protein BGLF5 Contributes to TLR9 Downregulation during Productive Infection
inferredcites →https://doi.org/10.4049/jimmunol.165.2.1074openalex-snapshot
Latent Murine γ-Herpesvirus Infection Is Established in Activated B Cells, Dendritic Cells, and Macrophages
inferredcites →https://doi.org/10.4049/jimmunol.174.8.4972openalex-snapshot
Early Establishment of γ-Herpesvirus Latency: Implications for Immune Control

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3867728openalex-extracted
The N-Terminal and Central Domains of CoV-2 nsp1 Play Key Functional Roles in Suppression of Cellular Gene Expression and Preservation of Viral Gene Expression
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Hypoxia and hypoxia‐inducible factors in Kaposi sarcoma‐associated herpesvirus infection and disease pathogenesis
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African Swine Fever Virus Biology and Vaccine Approaches
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The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression
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Epstein-Barr virus induces host shutoff extensively via BGLF5-independent mechanisms
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An endonuclease inhibitor unlocks the PA-X shutoff mechanism in influenza A virus
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Host Translation at the Nexus of Infection and Immunity
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Viral Nucleases Induce an mRNA Degradation-Transcription Feedback Loop in Mammalian Cells
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Emerging roles for RNA degradation in viral replication and antiviral defense
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African swine fever virus controls the host transcription and cellular machinery of protein synthesis
inferred← citeshttps://doi.org/10.1073/pnas.2116662119openalex-snapshot
The m 6 A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay
inferred← citeshttps://doi.org/10.1080/10409238.2019.1679083openalex-snapshot
Feedback to the central dogma: cytoplasmic mRNA decay and transcription are interdependent processes
inferred← citeshttps://doi.org/10.1093/nar/gkac1190openalex-snapshot
DNA processing by the Kaposi's sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion production
inferred← citeshttps://doi.org/10.1093/nar/gkx180openalex-snapshot
Genome-wide mapping of infection-induced SINE RNAs reveals a role in selective mRNA export
inferred← citeshttps://doi.org/10.1093/nar/gky932openalex-snapshot
Site specific target binding controls RNA cleavage efficiency by the Kaposi's sarcoma-associated herpesvirus endonuclease SOX
inferred← citeshttps://doi.org/10.1099/vir.0.059329-0openalex-snapshot
A shutoff and exonuclease mutant of murine gammaherpesvirus-68 yields infectious virus and causes RNA loss in type I interferon receptor knockout cells
inferred← citeshttps://doi.org/10.1101/2019.12.22.886382openalex-snapshot
Alteration of the premature tRNA landscape by gammaherpesvirus infection
inferred← citeshttps://doi.org/10.1101/2022.02.18.480778openalex-snapshot
Shiftless Restricts Viral Gene Expression and Influences RNA Granule Formation during KSHV lytic replication
inferred← citeshttps://doi.org/10.1101/2024.02.16.580780openalex-snapshot
WITHDRAWN: Gammaherpesvirus infection alters transfer RNA splicing and triggers tRNA cleavage
inferred← citeshttps://doi.org/10.1101/2025.10.24.684417openalex-snapshot
FlAsH-ID: A short peptide tag for live cell photoproximity labeling
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Herpesvirus infection reduces Pol II occupancy of host promoters but spares viral promoters
inferred← citeshttps://doi.org/10.1101/cshperspect.a012351openalex-snapshot
Tinkering with Translation: Protein Synthesis in Virus-Infected Cells
inferred← citeshttps://doi.org/10.1128/jvi.00159-13openalex-snapshot
An RNA Element in Human Interleukin 6 Confers Escape from Degradation by the Gammaherpesvirus SOX Protein
inferred← citeshttps://doi.org/10.1128/jvi.00309-12openalex-snapshot
The “Bridge” in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection
inferred← citeshttps://doi.org/10.1128/jvi.00361-13openalex-snapshot
Rotavirus Prevents the Expression of Host Responses by Blocking the Nucleocytoplasmic Transport of Polyadenylated mRNAs
inferred← citeshttps://doi.org/10.1128/jvi.00373-19openalex-snapshot
C19ORF66 Broadly Escapes Virus-Induced Endonuclease Cleavage and Restricts Kaposi’s Sarcoma-Associated Herpesvirus
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Cytoplasmic Relocalization and Colocalization with Viroplasms of Host Cell Proteins, and Their Role in Rotavirus Infection
inferred← citeshttps://doi.org/10.1128/jvi.00990-17openalex-snapshot
Characterization of the African Swine Fever Virus Decapping Enzyme during Infection
inferred← citeshttps://doi.org/10.1128/jvi.01173-18openalex-snapshot
Endosomal Toll-Like Receptors 7 and 9 Cooperate in Detection of Murine Gammaherpesvirus 68 Infection
inferred← citeshttps://doi.org/10.1128/jvi.01469-22openalex-snapshot
Shiftless Restricts Viral Gene Expression and Influences RNA Granule Formation during Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication
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The DNase Activity of Kaposi’s Sarcoma-Associated Herpesvirus SOX Protein Serves an Important Role in Viral Genome Processing during Lytic Replication
inferred← citeshttps://doi.org/10.1128/jvi.02867-15openalex-snapshot
Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication
inferred← citeshttps://doi.org/10.1128/jvi.05892-11openalex-snapshot
Tiled Microarray Identification of Novel Viral Transcript Structures and Distinct Transcriptional Profiles during Two Modes of Productive Murine Gammaherpesvirus 68 Infection
inferred← citeshttps://doi.org/10.1128/mbio.00875-25openalex-snapshot
Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs
inferred← citeshttps://doi.org/10.1128/mbio.02664-20openalex-snapshot
Alteration of the Premature tRNA Landscape by Gammaherpesvirus Infection
inferred← citeshttps://doi.org/10.1128/mcb.05402-11openalex-snapshot
Importin α-Mediated Nuclear Import of Cytoplasmic Poly(A) Binding Protein Occurs as a Direct Consequence of Cytoplasmic mRNA Depletion
inferred← citeshttps://doi.org/10.1128/spectrum.00908-21openalex-snapshot
PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy
inferred← citeshttps://doi.org/10.1146/annurev-virology-100114-054839openalex-snapshot
Modulation of the Translational Landscape During Herpesvirus Infection
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The Role of Viral RNA Degrading Factors in Shutoff of Host Gene Expression
inferred← citeshttps://doi.org/10.1172/jci.insight.184843openalex-snapshot
CD154:CD11b blockade enhances CD8+ T cell differentiation during infection but not transplantation
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The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation
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Host shutoff activity of VHS and SOX-like proteins: role in viral survival and immune evasion
inferred← citeshttps://doi.org/10.1186/s12985-024-02305-1openalex-snapshot
Mechanisms and consequences of mRNA destabilization during viral infections
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Tracking Murine Gammaherpesvirus 68 Infection of Germinal Center B Cells In Vivo
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Gammaherpesviral Gene Expression and Virion Composition Are Broadly Controlled by Accelerated mRNA Degradation
inferred← citeshttps://doi.org/10.1371/journal.ppat.1004899openalex-snapshot
A Ribonucleoprotein Complex Protects the Interleukin-6 mRNA from Degradation by Distinct Herpesviral Endonucleases
inferred← citeshttps://doi.org/10.1371/journal.ppat.1006593openalex-snapshot
Nuclease escape elements protect messenger RNA against cleavage by multiple viral endonucleases
inferred← citeshttps://doi.org/10.1371/journal.ppat.1008269openalex-snapshot
RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters
inferred← citeshttps://doi.org/10.1371/journal.ppat.1010930openalex-snapshot
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus
inferred← citeshttps://doi.org/10.1371/journal.ppat.1012341openalex-snapshot
Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression
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Inhibition of Host Gene Expression by KSHV: Sabotaging mRNA Stability and Nuclear Export
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SUMO and KSHV Replication
inferred← citeshttps://doi.org/10.3390/v14061338openalex-snapshot
Shiftless, a Critical Piece of the Innate Immune Response to Viral Infection
inferred← citeshttps://doi.org/10.3390/v15030726openalex-snapshot
EBV Reactivation from Latency Is a Degrading Experience for the Host
inferred← citeshttps://doi.org/10.3390/v16030474openalex-snapshot
A Balancing Act: The Viral–Host Battle over RNA Binding Proteins
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Shutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common Themes
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Faculty Opinions recommendation of Gammaherpesviral gene expression and virion composition are broadly controlled by accelerated mRNA degradation.
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Brf1-Mediated RNA Polymerase III Activity Limits Murine Gammaherpesvirus Spread
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Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription
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