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Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes

https://doi.org/10.1371/journal.ppat.1003338

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Outgoing claims: the papers this work cites, builds on, or argues with.

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HIV‐1 Tat protein promotes formation of more‐processive elongation complexes.

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T‐loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P‐TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes

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Cdk9 T‐loop phosphorylation is regulated by the calcium signaling pathway

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Direct evidence that HIV-1 tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation

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Mechanisms of HIV Latency: an Emerging Picture of Complexity

inferredcites →https://doi.org/10.1016/j.ceb.2008.04.008openalex-snapshot

The multi-tasking P-TEFb complex

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Reactivation of Latent HIV-1 by Inhibition of BRD4

inferredcites →https://doi.org/10.1016/j.drudis.2012.12.008openalex-snapshot

Targeting HIV latency: pharmacologic strategies toward eradication

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A Proteomic Study of Myosin II Motor Proteins during Tumor Cell Migration

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T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway

inferredcites →https://doi.org/10.1016/j.molcel.2005.06.027openalex-snapshot

The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription

inferredcites →https://doi.org/10.1016/j.molcel.2005.06.029openalex-snapshot

Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4

inferredcites →https://doi.org/10.1016/j.molcel.2005.11.024openalex-snapshot

P-TEFb-Mediated Phosphorylation of hSpt5 C-Terminal Repeats Is Critical for Processive Transcription Elongation

inferredcites →https://doi.org/10.1016/j.molcel.2010.04.012openalex-snapshot

HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

inferredcites →https://doi.org/10.1016/j.molcel.2010.04.013openalex-snapshot

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

inferredcites →https://doi.org/10.1016/j.molcel.2012.03.007openalex-snapshot

The Ubiquitin Ligase Siah1 Controls ELL2 Stability and Formation of Super Elongation Complexes to Modulate Gene Transcription

inferredcites →https://doi.org/10.1016/j.molmed.2004.09.006openalex-snapshot

The multifactorial nature of HIV-1 latency

inferredcites →https://doi.org/10.1016/j.ymeth.2010.10.002openalex-snapshot

Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells

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NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation

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A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

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The T Cell Activation Factor NF-ATc Positively Regulates HIV-1 Replication and Gene Expression in T Cells

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Inhibition of P-TEFb (CDK9/Cyclin T) Kinase and RNA Polymerase II Transcription by the Coordinated Actions of HEXIM1 and 7SK snRNA

inferredcites →https://doi.org/10.1038/35104575openalex-snapshot

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

inferredcites →https://doi.org/10.1038/35104581openalex-snapshot

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

inferredcites →https://doi.org/10.1038/375148a0openalex-snapshot

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

inferredcites →https://doi.org/10.1038/384375a0openalex-snapshot

Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain

inferredcites →https://doi.org/10.1038/77447openalex-snapshot

HIV-1 rebound after anti-retroviral therapy

inferredcites →https://doi.org/10.1038/8394openalex-snapshot

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

inferredcites →https://doi.org/10.1038/emboj.2008.121openalex-snapshot

The structure of P‐TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

inferredcites →https://doi.org/10.1038/emboj.2009.99openalex-snapshot

Acetylation of cyclin T1 regulates the equilibrium between active and inactive P‐TEFb in cells

inferredcites →https://doi.org/10.1038/embor.2008.72openalex-snapshot

The La‐related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes

inferredcites →https://doi.org/10.1038/nature09131openalex-snapshot

Crystal structure of HIV-1 Tat complexed with human P-TEFb

inferredcites →https://doi.org/10.1038/ng.116openalex-snapshot

Transient-mediated fate determination in a transcriptional circuit of HIV

inferredcites →https://doi.org/10.1038/nm.1972openalex-snapshot

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

inferredcites →https://doi.org/10.1038/nrmicro1580openalex-snapshot

Experimental approaches to the study of HIV-1 latency

inferredcites →https://doi.org/10.1038/nrmicro2223openalex-snapshot

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

inferredcites →https://doi.org/10.1038/nsb0896-696openalex-snapshot

Structural basis of cyclin-dependent kinase activation by phosphorylation

inferredcites →https://doi.org/10.1038/nsmb.1827openalex-snapshot

RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation

inferredcites →https://doi.org/10.1038/sj.emboj.7601074openalex-snapshot

Requirement for SWI/SNF chromatin‐remodeling complex in Tat‐mediated activation of the HIV‐1 promoter

inferredcites →https://doi.org/10.1038/sj.emboj.7601248openalex-snapshot

Recruitment of TFIIH to the HIV LTR is a rate‐limiting step in the emergence of HIV from latency

inferredcites →https://doi.org/10.1038/sj.emboj.7601516openalex-snapshot

Recruitment of chromatin‐modifying enzymes by CTIP2 promotes HIV‐1 transcriptional silencing

inferredcites →https://doi.org/10.1073/pnas.0705053104openalex-snapshot

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

inferredcites →https://doi.org/10.1073/pnas.0804192105openalex-snapshot

HIV rebounds from latently infected cells, rather than from continuing low-level replication

inferredcites →https://doi.org/10.1073/pnas.1002894107openalex-snapshot

Establishment of HIV-1 latency in resting CD4 + T cells depends on chemokine-induced changes in the actin cytoskeleton

inferredcites →https://doi.org/10.1073/pnas.1107107108openalex-snapshot

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

inferredcites →https://doi.org/10.1073/pnas.94.24.13193openalex-snapshot

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

inferredcites →https://doi.org/10.1073/pnas.95.15.8869openalex-snapshot

Early establishment of a pool of latently infected, resting CD4 + T cells during primary HIV-1 infection

inferredcites →https://doi.org/10.1073/pnas.96.26.15109openalex-snapshot

HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression

inferredcites →https://doi.org/10.1073/pnas.96.4.1285openalex-snapshot

Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T

inferredcites →https://doi.org/10.1074/jbc.274.12.8085openalex-snapshot

Structure and Function of the Human Transcription Elongation Factor DSIF

inferredcites →https://doi.org/10.1074/jbc.274.32.22127openalex-snapshot

A Role for the TFIIH XPB DNA Helicase in Promoter Escape by RNA Polymerase II

inferredcites →https://doi.org/10.1074/jbc.m111.282855openalex-snapshot

Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

inferredcites →https://doi.org/10.1074/jbc.m310044200openalex-snapshot

Phosphorylated Positive Transcription Elongation Factor b (P-TEFb) Is Tagged for Inhibition through Association with 7SK snRNA

inferredcites →https://doi.org/10.1074/jbc.m502712200openalex-snapshot

Analysis of the Large Inactive P-TEFb Complex Indicates That It Contains One 7SK Molecule, a Dimer of HEXIM1 or HEXIM2, and Two P-TEFb Molecules Containing Cdk9 Phosphorylated at Threonine 186

inferredcites →https://doi.org/10.1074/jbc.m610688200openalex-snapshot

Negative Elongation Factor NELF Represses Human Immunodeficiency Virus Transcription by Pausing the RNA Polymerase II Complex

inferredcites →https://doi.org/10.1083/jcb.201010118openalex-snapshot

Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation

inferredcites →https://doi.org/10.1084/jem.185.10.1859openalex-snapshot

Degradation of T Cell Receptor (TCR)–CD3-ζ Complexes after Antigenic Stimulation

inferredcites →https://doi.org/10.1093/emboj/17.23.7056openalex-snapshot

Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV‐1 Tat

inferredcites →https://doi.org/10.1093/nar/gkm063openalex-snapshot

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription

inferredcites →https://doi.org/10.1093/nar/gkm443openalex-snapshot

Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR

inferredcites →https://doi.org/10.1093/nar/gkp977openalex-snapshot

A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP

inferredcites →https://doi.org/10.1093/nar/gks682openalex-snapshot

PKC phosphorylates HEXIM1 and regulates P-TEFb activity

inferredcites →https://doi.org/10.1093/nar/gks976openalex-snapshot

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

inferredcites →https://doi.org/10.1097/00002030-200405210-00003openalex-snapshot

Coaxing HIV-1 from resting CD4 T cells

inferredcites →https://doi.org/10.1097/coh.0b013e328340ffbbopenalex-snapshot

The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit

inferredcites →https://doi.org/10.1097/coh.0b013e3283412384openalex-snapshot

Epigenetic regulation of HIV latency

inferredcites →https://doi.org/10.1101/gad.1636008openalex-snapshot

PP2B and PP1α cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+signaling

inferredcites →https://doi.org/10.1126/science.1165706openalex-snapshot

The Challenge of Finding a Cure for HIV Infection

inferredcites →https://doi.org/10.1126/science.1191047openalex-snapshot

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

inferredcites →https://doi.org/10.1126/science.278.5341.1295openalex-snapshot

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

inferredcites →https://doi.org/10.1128/jvi.00836-11openalex-snapshot

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

inferredcites →https://doi.org/10.1128/jvi.01383-08openalex-snapshot

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

inferredcites →https://doi.org/10.1128/jvi.01519-09openalex-snapshot

Establishment of HIV Latency in Primary CD4 + Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

inferredcites →https://doi.org/10.1128/jvi.01920-10openalex-snapshot

Chromatin Reassembly Factors Are Involved in Transcriptional Interference Promoting HIV Latency

inferredcites →https://doi.org/10.1128/jvi.02074-06openalex-snapshot

Sustained Induction of NF-κB Is Required for Efficient Expression of Latent Human Immunodeficiency Virus Type 1

inferredcites →https://doi.org/10.1128/jvi.02413-12openalex-snapshot

Cyclin T1 and CDK9 T-Loop Phosphorylation Are Downregulated during Establishment of HIV-1 Latency in Primary Resting Memory CD4+T Cells

inferredcites →https://doi.org/10.1128/jvi.05065-11openalex-snapshot

Regulation of Cyclin T1 and HIV-1 Replication by MicroRNAs in Resting CD4 + T Lymphocytes

inferredcites →https://doi.org/10.1128/jvi.72.12.9881-9888.1998openalex-snapshot

Tat-Associated Kinase, TAK, Activity Is Regulated by Distinct Mechanisms in Peripheral Blood Lymphocytes and Promonocytic Cell Lines

inferredcites →https://doi.org/10.1128/jvi.78.23.13190-13196.2004openalex-snapshot

Sequence Variation within the Dominant Amino Terminus Epitope Affects Antibody Binding and Neutralization of Human Immunodeficiency Virus Type 1 Tat Protein

inferredcites →https://doi.org/10.1128/mcb.18.5.2535openalex-snapshot

Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter

inferredcites →https://doi.org/10.1128/mcb.22.13.4622-4637.2002openalex-snapshot

Phosphorylation of the RNA Polymerase II Carboxyl-Terminal Domain by CDK9 Is Directly Responsible for Human Immunodeficiency Virus Type 1 Tat-Activated Transcriptional Elongation

inferredcites →https://doi.org/10.1128/mcb.22.4.1079-1093.2002openalex-snapshot

Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences

inferredcites →https://doi.org/10.1128/mcb.22.9.2918-2927.2002openalex-snapshot

Evidence that Negative Elongation Factor Represses Transcription Elongation through Binding to a DRB Sensitivity-Inducing Factor/RNA Polymerase II Complex and RNA

inferredcites →https://doi.org/10.1128/mcb.23.14.4859-4869.2003openalex-snapshot

MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner

inferredcites →https://doi.org/10.1128/mcb.24.2.787-795.2004openalex-snapshot

Dynamics of Human Immunodeficiency Virus Transcription: P-TEFb Phosphorylates RD and Dissociates Negative Effectors from the Transactivation Response Element

inferredcites →https://doi.org/10.1182/blood-2008-07-168393openalex-snapshot

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

inferredcites →https://doi.org/10.1189/jlb.0509309openalex-snapshot

Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4+ T lymphocytes

inferredcites →https://doi.org/10.1371/journal.pbio.1001206openalex-snapshot

Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency

inferredcites →https://doi.org/10.1371/journal.pone.0012335openalex-snapshot

The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK

inferredcites →https://doi.org/10.1371/journal.pone.0018985openalex-snapshot

Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175

inferredcites →https://doi.org/10.1371/journal.ppat.1000495openalex-snapshot

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

inferredcites →https://doi.org/10.1371/journal.ppat.1000554openalex-snapshot

CpG Methylation Controls Reactivation of HIV from Latency

inferredcites →https://doi.org/10.1371/journal.ppat.1001303openalex-snapshot

Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure

inferredcites →https://doi.org/10.2174/1570162033485186openalex-snapshot

Chromatin Remodeling and Modification during HIV-1 Tat-activated Transcription

inferredcites →https://doi.org/10.2174/157016211798998736openalex-snapshot

Control of HIV Latency by Epigenetic and Non-Epigenetic Mechanisms

inferredcites →https://doi.org/10.4049/jimmunol.163.1.50openalex-snapshot

Degradation of ZAP-70 Following Antigenic Stimulation in Human T Lymphocytes: Role of Calpain Proteolytic Pathway

inferredcites →https://doi.org/10.4161/cc.23309openalex-snapshot

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1111/febs.17264openalex-snapshot

MOF ‐mediated acetylation of CDK 9 promotes global transcription by modulating P‐ TEF b complex formation

inferred← citeshttps://doi.org/10.1126/scitranslmed.abl3836openalex-snapshot

Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy

inferred← citeshttps://doi.org/10.1128/jvi.00034-17openalex-snapshot

Imaging HIV-1 Genomic DNA from Entry through Productive Infection

inferred← citeshttps://doi.org/10.1128/jvi.00379-22openalex-snapshot

Heterogeneity of Latency Establishment in the Different Human CD4 + T Cell Subsets Stimulated with IL-15

inferred← citeshttps://doi.org/10.1128/jvi.01165-13openalex-snapshot

Latent HIV-1 Can Be Reactivated by Cellular Superinfection in a Tat-Dependent Manner, Which Can Lead to the Emergence of Multidrug-Resistant Recombinant Viruses

inferred← citeshttps://doi.org/10.1128/jvi.02086-18openalex-snapshot

Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1 + and TIGIT + CD4 T Cells

inferred← citeshttps://doi.org/10.1128/jvi.02394-20openalex-snapshot

CAGE-Seq Reveals that HIV-1 Latent Infection Does Not Trigger Unique Cellular Responses in a Jurkat T Cell Model

inferred← citeshttps://doi.org/10.1128/mbio.00133-17openalex-snapshot

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

inferred← citeshttps://doi.org/10.1128/mbio.00337-19openalex-snapshot

Entry of Polarized Effector Cells into Quiescence Forces HIV Latency

inferred← citeshttps://doi.org/10.1146/annurev-virology-101416-041646openalex-snapshot

The Molecular Basis for Human Immunodeficiency Virus Latency

inferred← citeshttps://doi.org/10.1155/2014/867235openalex-snapshot

The Domain Landscape of Virus-Host Interactomes

inferred← citeshttps://doi.org/10.1155/2014/964964openalex-snapshot

Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation

inferred← citeshttps://doi.org/10.11606/d.75.2015.tde-16062015-091524openalex-snapshot

Obtenção das quinases dependentes de ciclinas CDK9 e CDK11 humanas utilizando um sistema bacteriano de expressão (E. coli)

inferred← citeshttps://doi.org/10.1172/jci80565openalex-snapshot

Molecular mechanisms of HIV latency

inferred← citeshttps://doi.org/10.1186/s12964-023-01468-8openalex-snapshot

Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections

inferred← citeshttps://doi.org/10.1186/s12977-015-0190-4openalex-snapshot

Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1

inferred← citeshttps://doi.org/10.1186/s12977-017-0328-7openalex-snapshot

HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells

inferred← citeshttps://doi.org/10.1186/s12977-017-0335-8openalex-snapshot

Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells

inferred← citeshttps://doi.org/10.1186/s12977-024-00639-wopenalex-snapshot

The cell biology of HIV-1 latency and rebound

inferred← citeshttps://doi.org/10.1186/s12985-019-1128-6openalex-snapshot

Regulation of cyclin T1 during HIV replication and latency establishment in human memory CD4 T cells

inferred← citeshttps://doi.org/10.1371/journal.pone.0119451openalex-snapshot

Molecular Dynamics Simulation and Experimental Verification of the Interaction between Cyclin T1 and HIV-1 Tat Proteins

inferred← citeshttps://doi.org/10.1371/journal.pone.0123624openalex-snapshot

Evolutionary Distance of Amino Acid Sequence Orthologs across Macaque Subspecies: Identifying Candidate Genes for SIV Resistance in Chinese Rhesus Macaques

inferred← citeshttps://doi.org/10.1371/journal.pone.0171727openalex-snapshot

MD simulation of the Tat/Cyclin T1/CDK9 complex revealing the hidden catalytic cavity within the CDK9 molecule upon Tat binding

inferred← citeshttps://doi.org/10.1371/journal.ppat.1005950openalex-snapshot

An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4

inferred← citeshttps://doi.org/10.1371/journal.ppat.1009581openalex-snapshot

Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways

inferred← citeshttps://doi.org/10.1371/journal.ppat.1010245openalex-snapshot

The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription

inferred← citeshttps://doi.org/10.1371/journal.ppat.1012083openalex-snapshot

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal

inferred← citeshttps://doi.org/10.1631/jzus.b1400059openalex-snapshot

Mechanism and factors that control HIV-1 transcription and latency activation

inferred← citeshttps://doi.org/10.1631/jzus.b2500021openalex-snapshot

Exploiting targeted degradation of cyclins and cyclin-dependent kinases for cancer therapeutics: a review

inferred← citeshttps://doi.org/10.18632/oncotarget.5222openalex-snapshot

Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescence

inferred← citeshttps://doi.org/10.2174/1381612823666170622104355openalex-snapshot

Role of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription

inferred← citeshttps://doi.org/10.2174/1381612823666170704123620openalex-snapshot

Protein Phosphatase-1 –targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals

inferred← citeshttps://doi.org/10.2217/fvl.14.86openalex-snapshot

Mass Spectrometry-Based Proteomic Approaches for Discovery of HIV–Host Interactions

inferred← citeshttps://doi.org/10.29086/10413/23002openalex-snapshot

Effect of HIV-1 subtype C Transactivator of transcription (Tat) A21P variant on TAR binding ability, nuclear levels of active positive transcription elongation factor b (P-TEFb) and viral latency.

inferred← citeshttps://doi.org/10.3389/fonc.2021.678559openalex-snapshot

CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents

inferred← citeshttps://doi.org/10.3390/cancers13092181openalex-snapshot

Targeting CDK9 for Anti-Cancer Therapeutics

inferred← citeshttps://doi.org/10.3390/cancers14225500openalex-snapshot

Prognostic Impact of Caspase-8, CDK9 and Phospho-CDK9 (Thr 186) Expression in Patients with Uterine Cervical Cancer Treated with Definitive Chemoradiation and Brachytherapy

inferred← citeshttps://doi.org/10.3390/molecules25040838openalex-snapshot

P-TEFb as A Promising Therapeutic Target

inferred← citeshttps://doi.org/10.3390/pathogens14030232openalex-snapshot

Latency Reversing Agents and the Road to an HIV Cure

inferred← citeshttps://doi.org/10.3390/v12080868openalex-snapshot

Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome

inferred← citeshttps://doi.org/10.3390/vetsci2040293openalex-snapshot

Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses

inferred← citeshttps://doi.org/10.3797/scipharm.1502-01openalex-snapshot

Activation of HIV-1 with Nanoparticle-Packaged Small Molecule Protein Phosphatase-1-Targeting Compound

inferred← citeshttps://doi.org/10.53846/goediss-8486openalex-snapshot

The role of histone 2B monoubiquitination (H2Bub1) in HER2-driven mammary carcinoma

inferred← citeshttps://doi.org/10.64898/2026.01.14.699500openalex-snapshot

RasGRP1 agonists stimulate P-TEFb biogenesis via MEK-ERK-mTORC1 signaling to reverse HIV latency with minimal CD4 downregulation

inferred← citeshttps://doi.org/10.70675/4bab1779z812bz45d6zbcd4z9eea765b52e7openalex-snapshot

Contrôle de l'expression génique par la RNP 7SK

inferred← citeshttps://doi.org/10.7150/ijbs.10366openalex-snapshot

Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination

inferred← citeshttps://doi.org/10.7554/elife.31879openalex-snapshot

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

inferred← citeshttps://doi.org/10.7554/elife.68473openalex-snapshot

Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb

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