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Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies

https://doi.org/10.15252/emmm.201707567
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Translation and Clinical Development of Bispecific T‐cell Engaging Antibodies for Cancer Treatment
inferredcites →https://doi.org/10.1002/ijc.10557openalex-snapshot
Extremely potent, rapid and costimulation‐independent cytotoxic T‐cell response against lymphoma cells catalyzed by a single‐chain bispecific antibody
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Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells
inferredcites →https://doi.org/10.1007/s00109-016-1453-9openalex-snapshot
Oncolytic viruses—immunotherapeutics on the rise
inferredcites →https://doi.org/10.1016/0167-5699(96)80606-2openalex-snapshot
The expanding universe of T-cell subsets: Th1, Th2 and more
inferredcites →https://doi.org/10.1016/j.cellimm.2008.08.007openalex-snapshot
Relationship between CD107a expression and cytotoxic activity
inferredcites →https://doi.org/10.1016/j.coi.2015.12.007openalex-snapshot
The urgent need to recover MHC class I in cancers for effective immunotherapy
inferredcites →https://doi.org/10.1016/j.jim.2008.02.008openalex-snapshot
Detection of metastatic colon cancer cells in sentinel nodes by flow cytometry
inferredcites →https://doi.org/10.1016/j.molimm.2005.03.007openalex-snapshot
Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells
inferredcites →https://doi.org/10.1016/j.molimm.2005.07.034openalex-snapshot
MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors
inferredcites →https://doi.org/10.1016/j.omto.2016.11.003openalex-snapshot
Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators
inferredcites →https://doi.org/10.1016/j.omto.2017.03.003openalex-snapshot
Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus
inferredcites →https://doi.org/10.1016/j.yexmp.2012.09.018openalex-snapshot
Oncosis: An important non-apoptotic mode of cell death
inferredcites →https://doi.org/10.1016/s1359-6446(05)03554-3openalex-snapshot
BiTEs: bispecific antibody constructs with unique anti-tumor activity
inferredcites →https://doi.org/10.1038/bjc.2015.481openalex-snapshot
Oncolytic viruses: finally delivering
inferredcites →https://doi.org/10.1038/gt.2014.2openalex-snapshot
Activity of a group B oncolytic adenovirus (ColoAd1) in whole human blood
inferredcites →https://doi.org/10.1038/icb.2016.126openalex-snapshot
Targeting cancer‐related inflammation in the era of immunotherapy
inferredcites →https://doi.org/10.1038/nmeth.1318openalex-snapshot
Enzymatic assembly of DNA molecules up to several hundred kilobases
inferredcites →https://doi.org/10.1038/onc.2010.335openalex-snapshot
Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer
inferredcites →https://doi.org/10.1038/sj.cgt.7700542openalex-snapshot
Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes
inferredcites →https://doi.org/10.1053/j.seminoncol.2016.10.005openalex-snapshot
Talimogene laherparepvec (T-Vec) for the treatment of melanoma and other cancers
inferredcites →https://doi.org/10.1093/annonc/mdu342.17openalex-snapshot
A Phase 1 Study of Enadenotucirev, an Oncolytic Ad11/Ad3 Chimeric Group B Adenovirus, Administered Intravenously - Analysis of Dose Expansion and Repeat Cycle Cohorts in Patients with Metastatic Colorectal Cancer (Mcrc)
inferredcites →https://doi.org/10.1097/cji.0b013e318156750copenalex-snapshot
Strictly Target Cell-dependent Activation of T Cells by Bispecific Single-chain Antibody Constructs of the BiTE Class
inferredcites →https://doi.org/10.1111/cas.12208openalex-snapshot
Telomelysin shows potent antitumor activity through apoptotic and non‐apoptotic cell death in soft tissue sarcoma cells
inferredcites →https://doi.org/10.1126/science.1158545openalex-snapshot
Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody
inferredcites →https://doi.org/10.1158/0008-5472.can-09-0547openalex-snapshot
Bispecific T-Cell Engaging Antibodies for Cancer Therapy
inferredcites →https://doi.org/10.1158/0008-5472.can-16-1708openalex-snapshot
Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy
inferredcites →https://doi.org/10.1158/1078-0432.ccr-15-0612openalex-snapshot
FDA Approval: Blinatumomab
inferredcites →https://doi.org/10.1182/blood-2012-01-400515openalex-snapshot
Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell–engaging CD19/CD3-bispecific BiTE antibody blinatumomab
inferredcites →https://doi.org/10.1182/blood-2013-02-485623openalex-snapshot
Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy
inferredcites →https://doi.org/10.1200/jco.2010.32.7270openalex-snapshot
Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival
inferredcites →https://doi.org/10.1371/journal.pone.0002409openalex-snapshot
Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0136417openalex-snapshot
Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome
inferredcites →https://doi.org/10.1371/journal.pone.0177810openalex-snapshot
Development of a versatile oncolytic virus platform for local intra-tumoural expression of therapeutic transgenes
inferredcites →https://doi.org/10.1517/14712598.2015.1044433openalex-snapshot
Arming oncolytic viruses to leverage antitumor immunity
inferredcites →https://doi.org/10.15252/emmm.201707567openalex-snapshot
Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies
inferredcites →https://doi.org/10.4049/jimmunol.176.12.7308openalex-snapshot
Quantifying and Imaging NY-ESO-1/LAGE-1-Derived Epitopes on Tumor Cells Using High Affinity T Cell Receptors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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An Oncolytic Vaccinia Virus Expressing EpCAM Bispecific T-Cell Engager Enhances Immune Response in Solid Tumors
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Peritoneal Immunosurgery: Immunotherapy Augmented Surgery for the Treatment of Peritoneal Cancers
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Solid Tumor Immunotherapy with T Cell Engager‐Armed Oncolytic Viruses
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In Vitro Functional Assay Using Real-Time Cell Analysis for Assessing Cancer Immunotherapeutic Agents
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Use of Liquid Patient Ascites Fluids as a Preclinical Model for Oncolytic Virus Activity
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Mathematical Modeling of Oncolytic Virotherapy
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Current Challenges and Applications of Oncolytic Viruses in Overcoming the Development of Resistance to Therapies in Cancer
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Artificial intelligence and machine learning approaches for drug design: challenges and opportunities for the pharmaceutical industries
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The evolving landscape of oncolytic virus immunotherapy: combinatorial strategies and novel engineering approaches
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Oncolytic Viruses: Priming Time for Cancer Immunotherapy
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Oncolytic adenovirus: Challenges and advancements of clinical translation
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Advancing clinical translation of oncolytic adenoviruses
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Genetic modification of oncolytic viruses to enhance antitumor immunity
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Synergistic combination of oncolytic virotherapy with CAR T-cell therapy
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Arming oncolytic viruses with bispecific T cell engagers: The evolution and current status
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A review exploring the fusion of oncolytic viruses and cancer immunotherapy: An innovative strategy in the realm of cancer treatment
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Bispecific T-cell engager therapy for gastrointestinal cancers
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Design and application of oncolytic viruses for cancer immunotherapy
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Unlocking precision: Bispecific T cell engagers and the next frontier in uro-oncology
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Oncolytic virotherapy – Forging its place in the immunomodulatory paradigm for Multiple Myeloma
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Oncolytic virotherapy at the tumor microenvironment–CAR Therapy interface: Mechanisms, clinical translation, and future directions
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Bispecific antibodies in haematological malignancies
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Redirecting oncolytic viruses: Engineering opportunists to take control of the tumour microenvironment
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Immune cell engagers in solid tumors: promises and challenges of the next generation immunotherapy
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Multi-targeted immunotherapeutics to treat B cell malignancies
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Hopf bifurcation without parameters in deterministic and stochastic modeling of cancer virotherapy, part I
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Updates on Oncolytic Virus Immunotherapy for Cancers
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Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation
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Current strategies in engaging oncolytic viruses with antitumor immunity
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A one-step construction of adenovirus (OSCA) system using the Gibson DNA Assembly technology
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Current development in adenoviral vectors for cancer immunotherapy
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Claudin18.2 bispecific T cell engager armed oncolytic virus enhances antitumor effects against pancreatic cancer
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DARPin-fused T cell engager for adenovirus-mediated cancer therapy
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An αvβ6-specific virotherapy expressing bispecific immune cell activators induces immune cell activation to mediate tumor cell death
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Oncolytic adenoviruses encoding bispecific T cell engagers or a novel trispecific T cell engager for dual-targeting of c-MET and EGFR
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Potential targeting of the tumor microenvironment to improve cancer virotherapy
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Nanotechnology and nano-sized tools: Newer approaches to circumvent oncolytic adenovirus limitations
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Development of oncolytic viruses for cancer therapy
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Oncolytic Virus Combination Therapy: Killing One Bird with Two Stones
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Oncolytic Viruses on Drugs: Achieving Higher Therapeutic Efficacy
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Oncolytic virotherapy: basic principles, recent advances and future directions
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Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression
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Turning cold tumours hot: oncolytic virotherapy gets up close and personal with other therapeutics at the 11th Oncolytic Virus Conference
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Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer
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Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics
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Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
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Oncolytic viruses as engineering platforms for combination immunotherapy
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Optimizing oncolytic virotherapy in cancer treatment
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Oncolytic viruses expressing MATEs facilitate target-independent T-cell activation in tumors
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Oncolytic adenoviruses: a game changer approach in the battle between cancer and the immune system.
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Combination therapy with oncolytic viruses and immune checkpoint inhibitors
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Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma
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Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics
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Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors
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Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer
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Principles and current clinical landscape of NK cell engaging bispecific antibody against cancer
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Immuno-Oncology—The Translational Runway for Gene Therapy: Gene Therapeutics to Address Multiple Immune Targets
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Combination therapies for the optimisation of Bispecific T-cell Engagers in cancer treatment
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Pouring petrol on the flames: Using oncolytic virotherapies to enhance tumour immunogenicity
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Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy
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Oncolytic herpesvirus expressing PD-L1 BiTE for cancer therapy: exploiting tumor immune suppression as an opportunity for targeted immunotherapy
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Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy
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Safety and efficacy of the tumor-selective adenovirus enadenotucirev with or without paclitaxel in platinum-resistant ovarian cancer: a phase 1 clinical trial
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Oncolytic viruses and antibodies: are they more successful when delivered separately or when engineered as a single agent?
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Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells
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A Roadmap for the Success of Oncolytic Parvovirus-Based Anticancer Therapies
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An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
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Targeted BiTE Expression by an Oncolytic Vector Augments Therapeutic Efficacy Against Solid Tumors
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Evolving Status of Clinical Immunotherapy with Oncolytic Adenovirus
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CARs versus BiTEs: A Comparison between T Cell–Redirection Strategies for Cancer Treatment
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Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand?
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Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy
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Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy
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Oncolytic viruses for cancer immunotherapy
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Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
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Combination strategies to maximize the benefits of cancer immunotherapy
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Preparation and identification of a single domain antibody specific for adenovirus vectors and its application to the immunoaffinity purification of adenoviruses
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Expression of human CD46 and trans-complementation by murine adenovirus 1 fails to allow productive infection by a group B oncolytic adenovirus in murine cancer cells
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Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager
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A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE)
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Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples
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In silico clinical trials of BiTE expression by oncolytic viruses reveal the impact of patient heterogeneity on dosage protocol
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Live vaccines—a short‐cut to cancer viro‐immunotherapy
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The emerging role of oncolytic virus therapy against cancer
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Bispecific antibodies: design, therapy, perspectives
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Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy
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Cancer stem cell plasticity in glioblastoma multiforme: a perspective on future directions in oncolytic virotherapy
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Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer
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Combining Oncolytic Viruses With Cancer Immunotherapy: Establishing a New Generation of Cancer Treatment
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Immunovirotherapy: The role of antibody based therapeutics combination with oncolytic viruses
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Oncolytic vaccinia virus expressing a bispecific T-cell engager enhances immune responses in EpCAM positive solid tumors
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Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer
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Revolutionizing cancer immunotherapy: unleashing the potential of bispecific antibodies for targeted treatment
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Oncolytic virotherapy in cancer treatment: challenges and optimization prospects
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Revolutionizing cancer treatment: the power of bi- and tri-specific T-cell engagers in oncolytic virotherapy
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Bispecific immunotherapy based on antibodies, T-cell receptors, and aptamers: mechanisms of action, adverse effects, and future perspectives
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Molecular biology of canine parainfluenza virus V protein and its potential applications in tumor immunotherapy
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Cancer immunotherapies: A hope for the uncurable?
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Remodeling of Tumor Immune Microenvironment by Oncolytic Viruses
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Role of Adenoviruses in Cancer Therapy
inferred← citeshttps://doi.org/10.3390/biomedicines8070204openalex-snapshot
Bi- and Tri-Specific T Cell Engager-Armed Oncolytic Viruses: Next-Generation Cancer Immunotherapy
inferred← citeshttps://doi.org/10.3390/cancers10080244openalex-snapshot
Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics
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External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase
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Effect of Transgene Location, Transcriptional Control Elements and Transgene Features in Armed Oncolytic Adenoviruses
inferred← citeshttps://doi.org/10.3390/cancers12051295openalex-snapshot
Adenovirus and Immunotherapy: Advancing Cancer Treatment by Combination
inferred← citeshttps://doi.org/10.3390/cancers12061504openalex-snapshot
Oncolytic Adenoviruses: Strategies for Improved Targeting and Specificity
inferred← citeshttps://doi.org/10.3390/cancers12113354openalex-snapshot
Oncolytic Adenovirus in Cancer Immunotherapy
inferred← citeshttps://doi.org/10.3390/cancers13020287openalex-snapshot
Overcoming Challenges for CD3-Bispecific Antibody Therapy in Solid Tumors
inferred← citeshttps://doi.org/10.3390/cancers13040719openalex-snapshot
Tackling HLA Deficiencies Head on with Oncolytic Viruses
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Validating Cell Surface Proteases as Drug Targets for Cancer Therapy: What Do We Know, and Where Do We Go?
inferred← citeshttps://doi.org/10.3390/ijms22052517openalex-snapshot
Oncolytic Adenoviruses for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/ijms22169051openalex-snapshot
Immunomodulatory Arming Factors—The Current Paradigm for Oncolytic Vectors Relies on Immune Stimulating Molecules
inferred← citeshttps://doi.org/10.3390/pathogens11101146openalex-snapshot
Engineered Oncolytic Adenoviruses: An Emerging Approach for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/pharmaceutics14091811openalex-snapshot
Strategies for Advanced Oncolytic Virotherapy: Current Technology Innovations and Clinical Approaches
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Fighting Cancer with Mathematics and Viruses
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ĐẶC ĐIỂM SINH HỌC VÀ CHIẾN LƯỢC TĂNG HOẠT ĐỘNG CỦA ADENOVIRUS ĐỂ GÂY TAN TẾ BÀO UNG THƯ
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Double hit — bispecific antibodies in cancer therapy
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Viral immunotherapy: Oncolytic approaches for solid tumors
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Additional file 1 of Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy
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T immune responses to SARS-CoV-2 : identification of the immunogenic region associated with protection against infection
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