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The molecular mechanisms of chemoresistance in cancers
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inferredcites →https://doi.org/10.1002/ijc.23049openalex-snapshotPhosphoinositide 3‐kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
inferredcites →https://doi.org/10.1002/jcb.26107openalex-snapshotLong Noncoding RNA lncARSR Promotes Doxorubicin Resistance in Hepatocellular Carcinoma via Modulating PTEN‐PI3K/Akt Pathway
inferredcites →https://doi.org/10.1002/mc.22526openalex-snapshotCancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibition
inferredcites →https://doi.org/10.1007/s13277-016-4848-xopenalex-snapshotNANOG regulates epithelial-mesenchymal transition and chemoresistance through activation of the STAT3 pathway in epithelial ovarian cancer
inferredcites →https://doi.org/10.1016/j.biocel.2008.04.011openalex-snapshotThe strand separation and nuclease activities associated with YB-1 are dispensable for cisplatin resistance but overexpression of YB-1 in MCF7 and MDA-MB-231 breast tumor cells generates several chemoresistance signatures
inferredcites →https://doi.org/10.1038/cddis.2011.33openalex-snapshotDisruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway
inferredcites →https://doi.org/10.1038/cddis.2016.370openalex-snapshotERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells
inferredcites →https://doi.org/10.1038/ncomms9904openalex-snapshotWnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
inferredcites →https://doi.org/10.1038/onc.2011.149openalex-snapshotHAb18G/CD147 promotes epithelial–mesenchymal transition through TGF-β signaling and is transcriptionally regulated by Slug
inferredcites →https://doi.org/10.1038/onc.2011.426openalex-snapshotCisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance
inferredcites →https://doi.org/10.1038/onc.2017.152openalex-snapshotProteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp
inferredcites →https://doi.org/10.1038/oncsis.2017.25openalex-snapshotmiRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway
inferredcites →https://doi.org/10.1038/srep41942openalex-snapshotMicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway
inferredcites →https://doi.org/10.1073/pnas.0510834103openalex-snapshotMAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents
inferredcites →https://doi.org/10.1074/jbc.m115.700021openalex-snapshotUp-regulation of Histone Methyltransferase, DOT1L, by Matrix Hyaluronan Promotes MicroRNA-10 Expression Leading to Tumor Cell Invasion and Chemoresistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma
inferredcites →https://doi.org/10.1093/nar/gks818openalex-snapshotDNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy
inferredcites →https://doi.org/10.1111/cas.12712openalex-snapshotSrc/ STAT 3‐dependent heme oxygenase‐1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy
inferredcites →https://doi.org/10.1111/cas.13150openalex-snapshotIncreasing circulating exosomes‐carrying TRPC 5 predicts chemoresistance in metastatic breast cancer patients
inferredcites →https://doi.org/10.1111/cas.13275openalex-snapshotβ2‐AR activation induces chemoresistance by modulating p53 acetylation through upregulating Sirt1 in cervical cancer cells
inferredcites →https://doi.org/10.1158/0008-5472.can-15-1360openalex-snapshotAspirin Suppresses the Acquisition of Chemoresistance in Breast Cancer by Disrupting an NFκB–IL6 Signaling Axis Responsible for the Generation of Cancer Stem Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-14-0610openalex-snapshotLow Expression of the E3 Ubiquitin Ligase CBL Confers Chemoresistance in Human Pancreatic Cancer and Is Targeted by Epidermal Growth Factor Receptor Inhibition
inferredcites →https://doi.org/10.1159/000430191openalex-snapshotβ-Elemene Reverses Chemoresistance of Breast Cancer Cells by Reducing Resistance Transmission via Exosomes
inferredcites →https://doi.org/10.1182/blood-2005-09-3926openalex-snapshotOncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance
inferredcites →https://doi.org/10.1186/s12885-015-1239-4openalex-snapshotChemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101)
inferredcites →https://doi.org/10.1186/s12943-017-0586-yopenalex-snapshotRETRACTED ARTICLE: Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway
inferredcites →https://doi.org/10.18632/oncotarget.10326openalex-snapshotCapsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner
inferredcites →https://doi.org/10.18632/oncotarget.12718openalex-snapshotActivation of endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance of human small cell lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway
inferredcites →https://doi.org/10.18632/oncotarget.1471openalex-snapshotChemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway
inferredcites →https://doi.org/10.18632/oncotarget.15001openalex-snapshotDerlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling
inferredcites →https://doi.org/10.18632/oncotarget.3563openalex-snapshotMiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2
inferredcites →https://doi.org/10.18632/oncotarget.8049openalex-snapshotIncreased chemoresistance via Snail-Raf kinase inhibitor protein signaling in colorectal cancer in response to a nicotine derivative
inferredcites →https://doi.org/10.3390/cancers8120111openalex-snapshotThe Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance
inferredcites →https://doi.org/10.3390/ijms18010163openalex-snapshotEstrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2—Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors
inferredcites →https://doi.org/10.3892/ijo.2015.2898openalex-snapshotContinuous exposure of non-small cell lung cancer cells with wild-type EGFR to an inhibitor of EGFR tyrosine kinase induces chemoresistance by activating STAT3
inferredcites →https://doi.org/10.3892/mmr.2015.3356openalex-snapshotChemoresistance to doxorubicin induces epithelial-mesenchymal transition via upregulation of transforming growth factor β signaling in HCT116 colon cancer cells
inferredcites →https://doi.org/10.3892/mmr.2015.4217openalex-snapshotDAL-1/4.1B contributes to epithelial-mesenchymal transition via regulation of transforming growth factor-β in lung cancer cell lines
inferredcites →https://doi.org/10.3892/or.2015.4497openalex-snapshotMicroRNA-30a downregulation contributes to chemoresistance of osteosarcoma cells through activating Beclin-1-mediated autophagy
inferredcites →https://doi.org/10.3892/or.2016.4549openalex-snapshotREV3L, the catalytic subunit of DNA polymerase ζ, is involved in the progression and chemoresistance of esophageal squamous cell carcinoma
inferredcites →https://doi.org/10.3892/or.2016.4991openalex-snapshotDownregulation of DNA-PKcs suppresses P-gp expression via inhibition of the Akt/NF-κB pathway in CD133-positive osteosarcoma MG-63 cells
inferredcites →https://doi.org/10.3892/or.2016.5154openalex-snapshotProton pump inhibitor pantoprazole inhibits the proliferation, self-renewal and chemoresistance of gastric cancer stem cells via the EMT/β-catenin pathways
inferredcites →https://doi.org/10.7314/apjcp.2015.16.15.6663openalex-snapshotHigh Expression of Lung Resistance Protein mRNA at Diagnosis Predicts Poor Early Response to Induction Chemotherapy in Childhood Acute Lymphoblastic Leukemia
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/2211-5463.12412openalex-snapshotLoss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration‐resistant prostate cancer cells
inferred← citeshttps://doi.org/10.1002/btm2.10741openalex-snapshotEstablishment of a chemoresistant laryngeal cancer cell model to study chemoresistance and chemosensitization responses via transcriptomic analysis and a tumor‐on‐a‐chip platform
inferred← citeshttps://doi.org/10.1002/cam4.1993openalex-snapshotResveratrol promotes sensitization to Doxorubicin by inhibiting epithelial‐mesenchymal transition and modulating SIRT1/β‐catenin signaling pathway in breast cancer
inferred← citeshttps://doi.org/10.1002/cnr2.70448openalex-snapshotTransmembrane Protein TMEM59L Modulates 5‐ FU Resistance via PTPRN ‐Mediated DNA Damage Repair in Colorectal Cancer
inferred← citeshttps://doi.org/10.1002/ddr.21834openalex-snapshotCircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR ‐665‐dependent regulation of EGFR
inferred← citeshttps://doi.org/10.1002/ddr.21994openalex-snapshotα‐Pinene inhibits the growth of cervical cancer cells through its proapoptotic activity by regulating the miR‐34a‐5p/Bcl‐2 signaling axis
inferred← citeshttps://doi.org/10.1002/ddr.22105openalex-snapshotFAM64A aggravates proliferation, invasion, lipid droplet formation, and chemoresistance in gastric cancer: A biomarker for aggressiveness and a gene therapy target
inferred← citeshttps://doi.org/10.1002/fsn3.72027openalex-snapshotDietary Polyphenols as Natural Modulators of NF ‐ κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer
inferred← citeshttps://doi.org/10.1002/iub.2773openalex-snapshotTherapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy
inferred← citeshttps://doi.org/10.1002/jbt.23732openalex-snapshotUsing nanotechnology to progress the utilization of marine natural products in combating multidrug resistance in cancer: A prospective strategy
inferred← citeshttps://doi.org/10.1002/jbt.71028openalex-snapshotApigenin, Selenium, and Combinations Are Effective in Preventing 5‐Fluorouracil Induced Cardiovascular Damage
inferred← citeshttps://doi.org/10.1002/jcb.27063openalex-snapshotScutellaria baicalensis targets the hypoxia‐inducible factor‐1α and enhances cisplatin efficacy in ovarian cancer
inferred← citeshttps://doi.org/10.1002/jmr.3109openalex-snapshotRole of Circular RNA MMP9 in Glioblastoma Progression: From Interaction With hnRNPC and hnRNPA1 to Affecting the Expression of BIRC5 by Sequestering miR ‐149
inferred← citeshttps://doi.org/10.1002/mc.23878openalex-snapshotHGF/c‐Met Promotes Breast Cancer Tamoxifen Resistance Through the EZH2/HOTAIR‐miR‐141/200a Feedback Signaling Pathway
inferred← citeshttps://doi.org/10.1002/pbc.28764openalex-snapshotA pediatric case of acute myeloid leukemia with KMT2A gene rearrangement t(10;11) and 16p11.2 microdeletion syndrome
inferred← citeshttps://doi.org/10.1002/ptr.7291openalex-snapshotPiperine for treating breast cancer: A review of molecular mechanisms, combination with anticancer drugs, and nanosystems
inferred← citeshttps://doi.org/10.1002/ptr.7808openalex-snapshotOxymatrine suppresses colorectal cancer progression by inhibiting NLRP3 inflammasome activation through mitophagy induction in vitro and in vivo
inferred← citeshttps://doi.org/10.1002/tox.22942openalex-snapshotHyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR / ERK / NF‐κB ‐mediated anti‐apoptotic potential in glioblastoma
inferred← citeshttps://doi.org/10.1002/tox.23484openalex-snapshotInvolvement of the NF‐κB and PI3K /Akt/ mTOR pathways in cell death triggered by stypoldione, an o‐quinone isolated from the brown algae Stypopodium zonale
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inferred← citeshttps://doi.org/10.1007/s00210-025-03879-5openalex-snapshotMetformin reverses 5-FU chemoresistance by downregulating DKK1, WNT5A, and ABCB1 expressions in gastric cancer: An experimental and bioinformatic study
inferred← citeshttps://doi.org/10.1007/s10238-022-00951-9openalex-snapshotBim downregulation by activation of NF-κB p65, Akt, and ERK1/2 is associated with adriamycin and dexamethasone resistance in multiple myeloma cells
inferred← citeshttps://doi.org/10.1007/s10495-024-01981-2openalex-snapshotIntegrated analysis reveals a novel 5-fluorouracil resistance-based prognostic signature with promising implications for predicting the efficacy of chemotherapy and immunotherapy in patients with colorectal cancer
inferred← citeshttps://doi.org/10.1007/s11033-020-05261-5openalex-snapshotImplication and role of neutrophil gelatinase-associated lipocalin in cancer: lipocalin-2 as a potential novel emerging comprehensive therapeutic target for a variety of cancer types
inferred← citeshttps://doi.org/10.1007/s11033-020-05609-xopenalex-snapshotEmerging role of long non-coding RNAs in cancer chemoresistance: unravelling the multifaceted role and prospective therapeutic targeting
inferred← citeshttps://doi.org/10.1007/s12275-022-1533-1openalex-snapshotLactobacillus plantarum-derived metabolites sensitize the tumor-suppressive effects of butyrate by regulating the functional expression of SMCT1 in 5-FU-resistant colorectal cancer cells
inferred← citeshttps://doi.org/10.1007/s12672-025-02198-8openalex-snapshotAdvancements and limitations in traditional anti-cancer therapies: a comprehensive review of surgery, chemotherapy, radiation therapy, and hormonal therapy
inferred← citeshttps://doi.org/10.1007/s12672-026-04660-7openalex-snapshotIntegrative single-cell transcriptomic and multi-dimensional bioinformatic analysis reveals proliferation-associated gene expression signatures and cellular heterogeneity in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2018.03.001openalex-snapshotDecrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.11.181openalex-snapshotASPP2 enhances chemotherapeutic sensitivity through the down-regulation of XIAP expression in a p53 independent manner in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.cbi.2022.110056openalex-snapshotA novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116774openalex-snapshotLactylation-stabilized NOL6 promotes colorectal cancer progression via STAMBP-mediated YY1 deubiquitination and c-Myc transcription upregulation
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2019.102818openalex-snapshotClinical significance of aberrant microRNAs expression in predicting disease relapse/refractoriness to treatment in diffuse large B-cell lymphoma: A meta-analysis
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.114200openalex-snapshotDkk3 inhibits the aggressiveness and mitigates chemoresistance through low lipid droplet formation in gastric cancer: A biomarker and gene therapy target
inferred← citeshttps://doi.org/10.1016/j.jare.2025.10.067openalex-snapshotFlavonoid-modulated JAK-STAT signaling mitigates malignant transformation and drug resistance in breast tumors: A clinically relevant 3PM-guided innovation
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inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118523openalex-snapshotParacrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro
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