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Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hep.22159openalex-snapshot
Loss of the glycine N‐methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice†
inferredcites →https://doi.org/10.1002/hep.23860openalex-snapshot
Activation of LKB1-Akt Pathway Independent of Phosphoinositide 3-Kinase Plays a Critical Role in the Proliferation of Hepatocellular Carcinoma From Nonalcoholic Steatohepatitis
inferredcites →https://doi.org/10.1002/hep.23919openalex-snapshot
Liver-Specific Deletion of Prohibitin 1 Results in Spontaneous Liver Injury, Fibrosis, and Hepatocellular Carcinoma in Mice
inferredcites →https://doi.org/10.1002/hep.24795openalex-snapshot
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation
inferredcites →https://doi.org/10.1002/hep.26399openalex-snapshot
Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis
inferredcites →https://doi.org/10.1002/iub.222openalex-snapshot
Over‐expression of pemt2 into rat hepatoma cells contributes to the mitochondrial apoptotic pathway
inferredcites →https://doi.org/10.1002/jcp.10314openalex-snapshot
Chromatin sphingomyelin changes in cell proliferation and/or apoptosis induced by ciprofibrate
inferredcites →https://doi.org/10.1016/j.canlet.2013.11.003openalex-snapshot
Cancer metabolism and mass spectrometry-based proteomics
inferredcites →https://doi.org/10.1016/j.ccr.2004.11.022openalex-snapshot
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
inferredcites →https://doi.org/10.1016/j.cell.2004.06.016openalex-snapshot
Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity
inferredcites →https://doi.org/10.1016/j.mehy.2013.02.008openalex-snapshot
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: The heme connection
inferredcites →https://doi.org/10.1016/j.semcancer.2008.11.010openalex-snapshot
Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis
inferredcites →https://doi.org/10.1016/s0140-6736(11)61347-0openalex-snapshot
Hepatocellular carcinoma
inferredcites →https://doi.org/10.1038/embor.2009.178openalex-snapshot
Regulation of nucleolar signalling to p53 through NEDDylation of L11
inferredcites →https://doi.org/10.1038/nature07884openalex-snapshot
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
inferredcites →https://doi.org/10.1038/ng0802-339openalex-snapshot
Molecular pathogenesis of human hepatocellular carcinoma
inferredcites →https://doi.org/10.1038/nrc2676openalex-snapshot
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
inferredcites →https://doi.org/10.1038/nrg1879openalex-snapshot
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
inferredcites →https://doi.org/10.1038/sj.onc.1209594openalex-snapshot
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer
inferredcites →https://doi.org/10.1038/sj.onc.1209951openalex-snapshot
Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer
inferredcites →https://doi.org/10.1042/bj2780347openalex-snapshot
Phosphatidylcholine metabolism in rat liver after partial hepatectomy. Evidence for increased activity and amount of CTP:phosphocholine cytidylyltransferase
inferredcites →https://doi.org/10.1042/bst0360802openalex-snapshot
Novel substrates and functions for the ubiquitin-like molecule NEDD8
inferredcites →https://doi.org/10.1053/j.gastro.2012.05.050openalex-snapshot
Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1
inferredcites →https://doi.org/10.1074/jbc.m212948200openalex-snapshot
NEDP1, a Highly Conserved Cysteine Protease That deNEDDylates Cullins
inferredcites →https://doi.org/10.1096/fasebj.9.7.7737456openalex-snapshot
Protein kinase C and lipid signaling for sustained cellular responses
inferredcites →https://doi.org/10.1101/sqb.2005.70.035openalex-snapshot
Mitochondria and Cancer: Warburg Addressed
inferredcites →https://doi.org/10.1126/science.1175065openalex-snapshot
The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
inferredcites →https://doi.org/10.1128/mcb.24.8.3251-3261.2004openalex-snapshot
pVHL Modification by NEDD8 Is Required for Fibronectin Matrix Assembly and Suppression of Tumor Development
inferredcites →https://doi.org/10.1152/ajpcell.00238.2004openalex-snapshot
Glycolate and glyoxylate metabolism in HepG2 cells
inferredcites →https://doi.org/10.1158/0008-5472.can-10-2062openalex-snapshot
NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-10-2607openalex-snapshot
A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients
inferredcites →https://doi.org/10.1158/0008-5472.can-12-0388openalex-snapshot
The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth
inferredcites →https://doi.org/10.1159/000072341openalex-snapshot
Expression of Phosphatidylethanolamine N-Methyltransferase in Human Hepatocellular Carcinomas
inferredcites →https://doi.org/10.1182/blood-2009-11-254862openalex-snapshot
Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia
inferredcites →https://doi.org/10.1186/1741-7007-11-36openalex-snapshot
LKB1 and AMPK and the cancer-metabolism link - ten years after
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4633119openalex-extracted
Design, Synthesis and in Vitro Antitumor Activity Evaluation of a Novel Neddylation Inhibitor
inferred← citeshttps://doi.org/10.1002/cam4.1578openalex-snapshot
Overactivated neddylation pathway in human hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1002/hep.28933openalex-snapshot
Deregulated neddylation in liver fibrosis
inferred← citeshttps://doi.org/10.1002/ueg2.12126openalex-snapshot
Inhibition of NAE‐dependent protein hyper‐NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
inferred← citeshttps://doi.org/10.1007/978-1-0716-2859-1_11openalex-snapshot
Isolation of the Hepatic Ubiquitome/NEDDylome by Streptavidin Pull-Down Assay in the Biotinylated Ubiquitin (bioUb)/Biotinylated NEDD8 (bioNEDD8) Transgenic Mice
inferred← citeshttps://doi.org/10.1007/978-981-15-1025-0_18openalex-snapshot
Targeting Protein Neddylation for Cancer Therapy
inferred← citeshttps://doi.org/10.1007/s00280-018-3541-8openalex-snapshot
Targeting the neddylation pathway in cells as a potential therapeutic approach for diseases
inferred← citeshttps://doi.org/10.1007/s00705-023-05930-3openalex-snapshot
Effects of neddylation on viral infection: an overview
inferred← citeshttps://doi.org/10.1007/s12032-025-03079-4openalex-snapshot
Post-translational modifications in hepatocellular carcinoma: mechanisms and therapeutic potential
inferred← citeshttps://doi.org/10.1016/b978-0-323-98807-0.00017-xopenalex-snapshot
LKB1/STK11-mediated signal transduction in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.apsb.2019.09.005openalex-snapshot
Anticancer drug discovery by targeting cullin neddylation
inferred← citeshttps://doi.org/10.1016/j.bbcan.2016.09.006openalex-snapshot
Functional characterization of AMP-activated protein kinase signaling in tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117356openalex-snapshot
Discovery of small molecule inhibitors of neddylation catalyzing enzymes for anticancer therapy
inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.129647openalex-snapshot
Identification of novel benzothiazole derivatives as inhibitors of NEDDylation pathway to inhibit the progression of gastric cancer
inferred← citeshttps://doi.org/10.1016/j.cellsig.2018.01.009openalex-snapshot
Protein neddylation and its alterations in human cancers for targeted therapy
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.08.070openalex-snapshot
The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.113749openalex-snapshot
Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition
inferred← citeshttps://doi.org/10.1016/j.cmet.2023.07.003openalex-snapshot
Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
inferred← citeshttps://doi.org/10.1016/j.ebiom.2018.12.031openalex-snapshot
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer
inferred← citeshttps://doi.org/10.1016/j.ebiom.2019.06.005openalex-snapshot
Validation of NEDD8-Conjugating Enzyme UBC12 As a New Therapeutic Target in Lung Cancer
inferred← citeshttps://doi.org/10.1016/j.gendis.2024.101483openalex-snapshot
Deciphering the roles of neddylation modification in hepatocellular carcinoma: Molecular mechanisms and targeted therapeutics
inferred← citeshttps://doi.org/10.1016/j.jare.2025.11.010openalex-snapshot
Neddylation: from regulatory mechanisms to clinical implications in cancer
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.104570openalex-snapshot
Posttranslational regulation of liver kinase B1 in human cancer
inferred← citeshttps://doi.org/10.1016/j.jpha.2024.101140openalex-snapshot
Inhibiting neddylation: A new strategy for tumor therapy
inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120322openalex-snapshot
Ubiquitination regulation of aerobic glycolysis in cancer
inferred← citeshttps://doi.org/10.1016/j.molmet.2019.08.008openalex-snapshot
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101275openalex-snapshot
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107532openalex-snapshot
A novel approach to explore metabolic diseases: Neddylation
inferred← citeshttps://doi.org/10.1016/j.phrs.2026.108151openalex-snapshot
DCN-type NEDD8 E3 ligases: Structure, biological function and small-molecule inhibitor
inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101653openalex-snapshot
Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway
inferred← citeshttps://doi.org/10.1021/acs.jproteome.0c00685openalex-snapshot
Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease
inferred← citeshttps://doi.org/10.1038/s41388-018-0145-zopenalex-snapshot
Controlling the master—upstream regulation of the tumor suppressor LKB1
inferred← citeshttps://doi.org/10.1038/s41392-020-0196-9openalex-snapshot
Regulating tumor suppressor genes: post-translational modifications
inferred← citeshttps://doi.org/10.1038/s41392-024-01800-9openalex-snapshot
Protein neddylation and its role in health and diseases
inferred← citeshttps://doi.org/10.1038/s41401-022-00992-6openalex-snapshot
Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells
inferred← citeshttps://doi.org/10.1038/s41419-021-03827-0openalex-snapshot
Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity
inferred← citeshttps://doi.org/10.1038/s41422-020-00443-zopenalex-snapshot
Neddylation of PTEN regulates its nuclear import and promotes tumor development
inferred← citeshttps://doi.org/10.1038/s41467-022-35525-6openalex-snapshot
Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-κB-inducing kinase in mice
inferred← citeshttps://doi.org/10.1038/s41598-017-10807-yopenalex-snapshot
A Metabolomics Signature Linked To Liver Fibrosis In The Serum Of Transplanted Hepatitis C Patients
inferred← citeshttps://doi.org/10.1038/s41598-020-66458-zopenalex-snapshot
The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1038/s41598-020-77001-5openalex-snapshot
Characterization of Plasmodium falciparum NEDD8 and identification of cullins as its substrates
inferred← citeshttps://doi.org/10.1038/srep37775openalex-snapshot
The use of the NEDD8 inhibitor MLN4924 (Pevonedistat) in a cyclotherapy approach to protect wild-type p53 cells from MLN4924 induced toxicity
inferred← citeshttps://doi.org/10.1042/bsr20220994openalex-snapshot
Inhibition of NEDD8 NEDDylation induced apoptosis in acute myeloid leukemia cells via p53 signaling pathway
inferred← citeshttps://doi.org/10.1073/pnas.1910765117openalex-snapshot
Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation
inferred← citeshttps://doi.org/10.1073/pnas.2411429122openalex-snapshot
Neddylation modification stabilizes LC3B by antagonizing its ubiquitin-mediated degradation and promoting autophagy in skin
inferred← citeshttps://doi.org/10.1073/pnas.2424061122openalex-snapshot
The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8 + T cells
inferred← citeshttps://doi.org/10.1093/neuonc/nov066openalex-snapshot
Suppression of glioblastoma by targeting the overactivated protein neddylation pathway
inferred← citeshttps://doi.org/10.1096/fj.202000530rrropenalex-snapshot
Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival
inferred← citeshttps://doi.org/10.1097/hep.0000000000001614openalex-snapshot
NEDD8-specific protease 1 deficiency as a novel driver of hepatoblastoma development through dysregulation of the CAND1–NEDD8 pathway
inferred← citeshttps://doi.org/10.1101/583864openalex-snapshot
The NEDD8 cycle controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity
inferred← citeshttps://doi.org/10.1111/cpr.12536openalex-snapshot
The Nedd8‐activating enzyme inhibitor MLN 4924 ( TAK ‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.1111/febs.15584openalex-snapshot
Diverse and pivotal roles of neddylation in metabolism and immunity
inferred← citeshttps://doi.org/10.1124/pharmrev.120.000053openalex-snapshot
E1 Enzymes as Therapeutic Targets in Cancer
inferred← citeshttps://doi.org/10.1159/000495956openalex-snapshot
Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview
inferred← citeshttps://doi.org/10.1177/13872877261447533openalex-snapshot
The role of neddylation in mediating radiation-induced neuronal DNA damage and neuroinflammation: Implications for neurodegenerative diseases
inferred← citeshttps://doi.org/10.1179/1973947815y.0000000066openalex-snapshot
MLN4924 therapy as a novel approach in cancer treatment modalities
inferred← citeshttps://doi.org/10.1186/s12964-024-01689-5openalex-snapshot
LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors
inferred← citeshttps://doi.org/10.1186/s12967-025-07531-xopenalex-snapshot
UBE2M inhibits neoplastic cell proliferation via MKK7–JNK–EGR1 axis in melanoma
inferred← citeshttps://doi.org/10.1186/s13578-021-00569-6openalex-snapshot
Neddylation regulation of mitochondrial structure and functions
inferred← citeshttps://doi.org/10.1194/jlr.m078980openalex-snapshot
Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver
inferred← citeshttps://doi.org/10.13140/rg.2.2.10284.90246openalex-snapshot
Pharmacologic Inhibition of Ubiquitin Activation as a Novel Therapeutic Strategy in Acute Myeloid Leukemia
inferred← citeshttps://doi.org/10.14800/rd.1123openalex-snapshot
The levels of the RNA binding protein Hu antigen R determine the druggability of the neddylation pathway in liver cancer
inferred← citeshttps://doi.org/10.1631/jzus.b2100114openalex-snapshot
Emerging role of protein modification in inflammatory bowel disease
inferred← citeshttps://doi.org/10.18632/oncotarget.6154openalex-snapshot
A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation
inferred← citeshttps://doi.org/10.18632/oncotarget.9481openalex-snapshot
MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma
inferred← citeshttps://doi.org/10.21037/tgh.2018.06.05openalex-snapshot
Neddylation, a novel paradigm in liver cancer
inferred← citeshttps://doi.org/10.2147/jhc.s169585openalex-snapshot
Post-translational modifiers of liver kinase B1/serine/threonine kinase 11 in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.2174/0113892037274615240528113148openalex-snapshot
Exploring the Role of Unconventional Post-Translational Modifications in Cancer Diagnostics and Therapy
inferred← citeshttps://doi.org/10.3389/fcell.2021.653882openalex-snapshot
Advances in Cancer Treatment by Targeting the Neddylation Pathway
inferred← citeshttps://doi.org/10.3389/fmed.2020.586881openalex-snapshot
Neddylation: A Versatile Pathway Takes on Chronic Liver Diseases
inferred← citeshttps://doi.org/10.3390/cancers11121849openalex-snapshot
The Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling
inferred← citeshttps://doi.org/10.3390/cancers11121933openalex-snapshot
SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets
inferred← citeshttps://doi.org/10.3390/cancers12102848openalex-snapshot
Ubiquitin and Ubiquitin-Like Proteins Are Essential Regulators of DNA Damage Bypass
inferred← citeshttps://doi.org/10.3390/cancers16040825openalex-snapshot
ncRNAs Orchestrate Chemosensitivity Induction by Neddylation Blockades
inferred← citeshttps://doi.org/10.3390/cells8121575openalex-snapshot
Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis
inferred← citeshttps://doi.org/10.3390/ijms21010040openalex-snapshot
Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover
inferred← citeshttps://doi.org/10.3390/ijms23073480openalex-snapshot
The Next Frontier: Translational Development of Ubiquitination, SUMOylation, and NEDDylation in Cancer
inferred← citeshttps://doi.org/10.3390/ijms24043415openalex-snapshot
Neddylation of EphB1 Regulates Its Activity and Associates with Liver Fibrosis
inferred← citeshttps://doi.org/10.3390/nu11040844openalex-snapshot
A Slow-Digesting Carbohydrate Diet during Rat Pregnancy Protects Offspring from Non-Alcoholic Fatty Liver Disease Risk through the Modulation of the Carbohydrate-Response Element and Sterol Regulatory Element Binding Proteins
inferred← citeshttps://doi.org/10.3390/pharmaceutics14112460openalex-snapshot
MLN4924 Treatment Diminishes Excessive Lipid Storage in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Stimulating Hepatic Mitochondrial Fatty Acid Oxidation and Lipid Metabolites
inferred← citeshttps://doi.org/10.3748/wjg.v25.i31.4300openalex-snapshot
Methionine adenosyltransferases in liver cancer
inferred← citeshttps://doi.org/10.3748/wjg.v26.i34.5101openalex-snapshot
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation
inferred← citeshttps://doi.org/10.3892/etm.2017.4833openalex-snapshot
Marsdeniae tenacissima extract-induced growth inhibition and apoptosis in hepatoma carcinoma cells is mediated through the p53/nuclear factor-κB signaling pathway
inferred← citeshttps://doi.org/10.3892/ol.2017.6038openalex-snapshot
The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway
inferred← citeshttps://doi.org/10.3892/ol.2018.9445openalex-snapshot
EMT induced by loss of LKB1 promotes migration and invasion of liver cancer cells through ZEB1‑induced YAP signaling
inferred← citeshttps://doi.org/10.3892/ol.2018.9730openalex-snapshot
Paeonol‑mediated apoptosis of hepatocellular carcinoma cells by NF‑κB pathway
inferred← citeshttps://doi.org/10.70675/a9a79207z0857z4ed5zb207z749cdceb9430openalex-snapshot
The role of NEDD8 pathway in cell invasion and strategies for the use of NEDD8 inhibitors in the clinic
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