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https://doi.org/10.2139/ssrn.4639264
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Optimal process design under uncertainty
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An index for operational flexibility in chemical process design. Part I: Formulation and theory
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Determination of operability limits using simplicial approximation
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A Framework for the Development of Design and Control Spaces
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Modeling and Control of Roller Compaction for Pharmaceutical Manufacturing. Part I: Process Dynamics and Control Framework
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Modeling and Control of Roller Compaction for Pharmaceutical Manufacturing
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Model-Guided Design Space Development for a Drug Substance Manufacturing Process
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Surrogate-Based Optimization of Expensive Flowsheet Modeling for Continuous Pharmaceutical Manufacturing
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Some considerations on powder compression equations
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Design optimization of stochastic flexibility
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Feasibility analysis of black-box processes using an adaptive sampling kriging based method
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Fast construction of the Vietoris-Rips complex
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Feasibility and flexibility analysis of black-box processes Part 1: Surrogate-based feasibility analysis
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An effective computation strategy for assessing operational flexibility of high-dimensional systems with complicated feasible regions
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Digital design of new products: accounting for output correlation via a novel algebraic formulation of the latent-variable model inversion problem
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Computationally efficient black-box modeling for feasibility analysis
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Handling uncertainty in the establishment of a design space for the manufacture of a pharmaceutical product
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Feasibility analysis of black-box processes using an adaptive sampling Kriging-based method
inferredcites →https://doi.org/10.1016/j.compchemeng.2013.12.013openalex-extracted
Evolution of concepts and models for quantifying resiliency and flexibility of chemical processes
inferredcites →https://doi.org/10.1016/j.compchemeng.2017.02.030openalex-extracted
Process analysis and optimization of continuous pharmaceutical manufacturing using flowsheet models
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Uncertainty back-propagation in PLS model inversion for design space determination in pharmaceutical product development
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Advances in surrogate based modeling, feasibility analysis, and optimization: A review
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Design space maintenance by online model adaptation in pharmaceutical manufacturing
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Smart process analytics for predictive modeling
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The Euler characteristic: A general topological descriptor for complex data
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A novel framework for the identification of complex feasible space
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Variance based sensitivity analysis of model output. Design and estimator for the total sensitivity index
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Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives
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Multi-scale flowsheet simulation of an integrated continuous purification–downstream pharmaceutical manufacturing process
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A review on the modernization of pharmaceutical development and manufacturing – Trends, perspectives, and the role of mathematical modeling
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Selection of alpha for alpha-hull in 2
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Support vector machines: relevance feedback and information retrieval
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A new theoretical approach to tablet strength of a binary mixture consisting of a well and a poorly compactable substance
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Global Optimization in Design under Uncertainty: Feasibility Test and Flexibility Index Problems
inferredcites →https://doi.org/10.1021/ie049294dopenalex-extracted
Feasibility Evaluation of Nonconvex Systems Using Shape Reconstruction Techniques
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General Framework for Latent Variable Model Inversion for the Design and Manufacturing of New Products
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A Bayesian Approach to the ICH Q8 Definition of Design Space
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A Rolling Theory for Granular Solids
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The ICH Q8 Definition of Design Space: A Comparison of the Overlapping Means and the Bayesian Predictive Approaches
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Estimating the Dimension of a Model
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A Simple Test for Heteroscedasticity and Random Coefficient Variation
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An Optimization-Based Framework to Define the Probabilistic Design Space of Pharmaceutical Processes with Model Uncertainty
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Exploring multi-dimensional spaces: a Comparison of Latin Hypercube and Quasi Monte Carlo Sampling Techniques
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