On the public citation graph

An Optimization-Based Framework to Define the Probabilistic Design Space of Pharmaceutical Processes with Model Uncertainty

0 signed · 85 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/aic.16214openalex-snapshot
An optimization framework to combine operable space maximization with design of experiments
inferredcites →https://doi.org/10.1002/aic.690290312openalex-snapshot
Optimal process design under uncertainty
inferredcites →https://doi.org/10.1002/aic.690310412openalex-snapshot
An index for operational flexibility in chemical process design. Part I: Formulation and theory
inferredcites →https://doi.org/10.1002/aic.690310413openalex-snapshot
An index for operational flexibility in chemical process design. Part II: Computational algorithms
inferredcites →https://doi.org/10.1002/aic.690420814openalex-snapshot
Optimal design of dynamic systems under uncertainty
inferredcites →https://doi.org/10.1002/aic.690430415openalex-snapshot
Integrated flexibility and controllability analysis in design of chemical processes
inferredcites →https://doi.org/10.1002/aic.690440908openalex-snapshot
Robust optimization framework for process parameter and tolerance design
inferredcites →https://doi.org/10.1002/aic.690471013openalex-snapshot
Operational envelopes for batch processes
inferredcites →https://doi.org/10.1002/cem.2808openalex-snapshot
An approach for simultaneous estimation of reaction kinetics and curve resolution from process and spectral data
inferredcites →https://doi.org/10.1007/978-1-4757-3532-1openalex-snapshot
Convexification and Global Optimization in Continuous and Mixed-Integer Nonlinear Programming
inferredcites →https://doi.org/10.1007/978-3-319-58821-6openalex-snapshot
Pyomo — Optimization Modeling in Python
inferredcites →https://doi.org/10.1007/978-3-319-58821-6_2openalex-snapshot
Mathematical Modeling and Optimization
inferredcites →https://doi.org/10.1007/bf00138693openalex-snapshot
BARON: A general purpose global optimization software package
inferredcites →https://doi.org/10.1007/s10107-004-0559-yopenalex-snapshot
On the implementation of an interior-point filter line-search algorithm for large-scale nonlinear programming
inferredcites →https://doi.org/10.1007/s10107-005-0581-8openalex-snapshot
A polyhedral branch-and-cut approach to global optimization
inferredcites →https://doi.org/10.1007/s12247-008-9028-0openalex-snapshot
The Use of Routine Process Capability for the Determination of Process Parameter Criticality in Small-molecule API Synthesis
inferredcites →https://doi.org/10.1007/s12532-011-0026-8openalex-snapshot
Pyomo: modeling and solving mathematical programs in Python
inferredcites →https://doi.org/10.1016/0098-1354(87)85014-7openalex-snapshot
Synthesis of flexible heat exchanger networks with uncertain flowrates and temperatures
inferredcites →https://doi.org/10.1016/0098-1354(87)87011-4openalex-snapshot
Active constraint strategy for flexibility analysis in chemical processes
inferredcites →https://doi.org/10.1016/0098-1354(90)87055-topenalex-snapshot
A novel flexibility analysis approach for processes with stochastic parameters
inferredcites →https://doi.org/10.1016/j.compchemeng.2013.12.013openalex-snapshot
Evolution of concepts and models for quantifying resiliency and flexibility of chemical processes
inferredcites →https://doi.org/10.1016/j.ijpharm.2009.07.031openalex-snapshot
Quality by design case study: An integrated multivariate approach to drug product and process development
inferredcites →https://doi.org/10.1016/j.ijpharm.2013.12.039openalex-snapshot
Quality by Design approach to spray drying processing of crystalline nanosuspensions
inferredcites →https://doi.org/10.1021/acs.iecr.5b00863openalex-snapshot
Bracketing the Design Space within the Knowledge Space in Pharmaceutical Product Development
inferredcites →https://doi.org/10.1021/acs.oprd.5b00158openalex-snapshot
Definition of Design Spaces Using Mechanistic Models and Geometric Projections of Probability Maps
inferredcites →https://doi.org/10.1021/cg2003029openalex-snapshot
Quality by Design (QbD)-Based Crystallization Process Development for the Polymorphic Drug Tolbutamide
inferredcites →https://doi.org/10.1021/ie001014gopenalex-snapshot
Global Optimization in Design under Uncertainty: Feasibility Test and Flexibility Index Problems
inferredcites →https://doi.org/10.1021/ie5050567openalex-snapshot
Dissolution Efficiency and Design Space for an Oral Pharmaceutical Product in Tablet Form
inferredcites →https://doi.org/10.1021/op4001127openalex-snapshot
Model-Based Scale-up and Design Space Determination for a Batch Reactive Distillation with a Dean–Stark Trap
inferredcites →https://doi.org/10.1080/10543400802278197openalex-snapshot
A Bayesian Approach to the ICH Q8 Definition of Design Space
inferredcites →https://doi.org/10.1515/revce-2015-0022openalex-snapshot
Data cleaning in the process industries

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4639264openalex-extracted
inferred← citeshttps://doi.org/10.1002/aic.16744openalex-snapshot
Bayesian probabilistic modeling in pharmaceutical process development
inferred← citeshttps://doi.org/10.1002/aic.17095openalex-snapshot
A novel adaptive sampling based methodology for feasible region identification of compute intensive models using artificial neural network
inferred← citeshttps://doi.org/10.1002/aic.17189openalex-snapshot
Flexibility index of black‐box models with parameter uncertainty through derivative‐free optimization
inferred← citeshttps://doi.org/10.1002/aic.17604openalex-snapshot
Design space description through adaptive sampling and symbolic computation
inferred← citeshttps://doi.org/10.1002/aic.18071openalex-snapshot
Probabilistic predictions for partial least squares using bootstrap
inferred← citeshttps://doi.org/10.1002/aic.18142openalex-snapshot
Techno‐economic analysis of dynamic, end‐to‐end optimal pharmaceutical campaign manufacturing using PharmaPy
inferred← citeshttps://doi.org/10.1007/978-3-030-90924-6_10openalex-snapshot
Integrated Synthesis, Crystallization, Filtration, and Drying of Active Pharmaceutical Ingredients: A Model-Based Digital Design Framework for Process Optimization and Control
inferred← citeshttps://doi.org/10.1016/b978-0-12-823377-1.50327-xopenalex-snapshot
Nested Sampling Strategy for Bayesian Design Space Characterization
inferred← citeshttps://doi.org/10.1016/b978-0-323-85159-6.50355-9openalex-snapshot
Determination of probabilistic design spaces in the hybrid manufacture of an active pharmaceutical ingredient using PharmaPy
inferred← citeshttps://doi.org/10.1016/j.ces.2023.118591openalex-snapshot
Reaction kinetics determination and uncertainty analysis for the synthesis of the cancer drug lomustine
inferred← citeshttps://doi.org/10.1016/j.ces.2026.124255openalex-snapshot
Adaptive framework for data-driven probabilistic design space identification
inferred← citeshttps://doi.org/10.1016/j.chemolab.2019.103848openalex-snapshot
New tools for the design and manufacturing of new products based on Latent Variable Model Inversion
inferred← citeshttps://doi.org/10.1016/j.cjche.2021.10.019openalex-snapshot
Flexibility analysis for continuous ibuprofen manufacturing processes
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2019.05.019openalex-snapshot
Design space maintenance by online model adaptation in pharmaceutical manufacturing
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2019.106608openalex-snapshot
Computationally efficient identification of probabilistic design spaces through application of metamodeling and adaptive sampling
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2021.107284openalex-snapshot
Novel flexibility index formulations for the selection of the operating range within a design space
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2021.107408openalex-snapshot
PharmaPy: An object-oriented tool for the development of hybrid pharmaceutical flowsheets
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2021.107537openalex-snapshot
Developing new products with kernel partial least squares model inversion
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2022.107969openalex-snapshot
Novel formulations of flexibility index and design centering for design space definition
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2022.108127openalex-snapshot
Hybrid modeling supported development of an industrial small-molecule flow chemistry process
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2023.108427openalex-snapshot
A novel framework for the identification of complex feasible space
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2023.108461openalex-snapshot
Feasibility/Flexibility-based optimization for process design and operations
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2023.108555openalex-snapshot
Identifying design spaces as linear combinations of parameter ranges for biopharmaceutical control strategies
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2024.108727openalex-snapshot
Design space identification of a coupled two-stage batch reactor system
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2025.109159openalex-snapshot
Fast-tracking design space identification with the prediction reliability enhancing parameter (PREP)
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2025.109198openalex-snapshot
A multi-parametric programming approach for combined flexibility, availability, and resilience in process design
inferred← citeshttps://doi.org/10.1016/j.ejpb.2023.12.008openalex-snapshot
Design space determination of pharmaceutical processes: Effects of control strategies and uncertainty
inferred← citeshttps://doi.org/10.1016/j.ifacol.2020.12.122openalex-snapshot
Assessing Observability using Supervised Autoencoders with Application to Tennessee Eastman Process
inferred← citeshttps://doi.org/10.1016/j.ifacol.2021.08.222openalex-snapshot
A Design Centering Methodology for Probabilistic Design Space
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2022.121715openalex-snapshot
A review on the modernization of pharmaceutical development and manufacturing – Trends, perspectives, and the role of mathematical modeling
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2025.125663openalex-snapshot
A hybrid system for design space estimation in a rotary tablet press
inferred← citeshttps://doi.org/10.1016/j.jchromb.2020.122300openalex-snapshot
QbD-steered development and validation of an RP-HPLC method for quantification of ferulic acid: Rational application of chemometric tools
inferred← citeshttps://doi.org/10.1016/j.jchromb.2025.124566openalex-snapshot
QbD and green metric based HPLC method development and validation of bromocriptine mesylate in bulk product and biological samples
inferred← citeshttps://doi.org/10.1021/acs.iecr.2c00374openalex-snapshot
A Dynamic and Probabilistic Design Space Determination Method for Mesenchymal Stem Cell Cultivation Processes
inferred← citeshttps://doi.org/10.1021/acs.iecr.2c01636openalex-snapshot
Simulation–Optimization Framework for the Digital Design of Pharmaceutical Processes Using Pyomo and PharmaPy
inferred← citeshttps://doi.org/10.1021/acs.iecr.5c02392openalex-snapshot
Model Assisted Development of an Amorphous Solid Dispersion Formulation in a Dry Granulated and Film Coated Tablet Considering Dissolution As the Process and Material-Dependent Response
inferred← citeshttps://doi.org/10.1021/acs.iecr.5c03037openalex-snapshot
A Comparative Study of Strategies for Incorporating Uncertainty in Design Space Determination for Pharmaceutical Manufacturing
inferred← citeshttps://doi.org/10.1021/acs.iecr.5c04321openalex-snapshot
Design Centering via Bayesian Optimization for Robust Operation of Chemical Processes
inferred← citeshttps://doi.org/10.1021/acs.iecr.9b05006openalex-snapshot
Bayesian Approach to Probabilistic Design Space Characterization: A Nested Sampling Strategy
inferred← citeshttps://doi.org/10.1080/10826076.2023.2299670openalex-snapshot
Development and validation of simultaneous HPLC-PDA analysis method for quality control of Hwang-ryeon-hae-dok-tang: An analytical quality by design approach
inferred← citeshttps://doi.org/10.1080/22297928.2021.1888793openalex-snapshot
Implementation of Analytical Quality-by-Design for Developing a Robust HPLC Method for Quantitative Estimation of Voriconazole: Application in Drug Formulations
inferred← citeshttps://doi.org/10.1093/jaoacint/qsab014openalex-snapshot
Developing a Validated HPLC Method for Quantification of Ceftazidime Employing Analytical Quality by Design and Monte Carlo Simulations
inferred← citeshttps://doi.org/10.1134/s1061934826700747openalex-snapshot
Analytical Quantification of Tofacitinib Citrate in Bulk and Nanostructured Lipidic Formulations by HPLC Using a Quality by Design Approach Integrated with Monte Carlo Simulations
inferred← citeshttps://doi.org/10.1208/s12249-025-03103-wopenalex-snapshot
Integration of Synchronizing In Silico, In Vitro, and In Vivo Strategies for the Development of Antipsoriatic Apremilast-loaded Nanostructured Lipid Carrier Embedded in Hydrogel
inferred← citeshttps://doi.org/10.3390/analytica7010024openalex-snapshot
ICH Q14-Based Development of a Chaotropic Chromatography Method for the Determination of Olanzapine and Its Two Oxidative Degradation Products in Tablets
inferred← citeshttps://doi.org/10.3390/books978-3-03928-425-2openalex-snapshot
Model-Based Tools for Pharmaceutical Manufacturing Processes
inferred← citeshttps://doi.org/10.3390/pharmaceutics18081014openalex-snapshot
QbD-Based Design Space Development for Honey-Containing Traditional Chinese Medicine Tablets Assisted by the SeDeM Expert System and Machine Learning
inferred← citeshttps://doi.org/10.3390/pr10030454openalex-snapshot
Investigating the Trade-Off between Design and Operational Flexibility in Continuous Manufacturing of Pharmaceutical Tablets: A Case Study of the Fluid Bed Dryer
inferred← citeshttps://doi.org/10.3390/pr7080492openalex-snapshot
Change of Data-Driven Drug Design Trends Through Patent Analysis
inferred← citeshttps://doi.org/10.3390/pr8010049openalex-snapshot
Model-Based Tools for Pharmaceutical Manufacturing Processes
inferred← citeshttps://doi.org/10.69997/sct.107168openalex-snapshot
Probabilistic design spaces from small DoEs – A boundary-focused workflow using quantile surrogates
inferred← citeshttps://doi.org/10.69997/sct.166359openalex-snapshot
Probabilistic Design Space Identification for Upstream Bioprocesses under Limited Data Availability�
inferred← citeshttps://doi.org/10.69997/sct.189137openalex-snapshot
Identification and Self-optimization of Robust Nominal Operating Ranges Using Proximal Policy Optimization
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.